Intestinal Ischemia and Reperfusion

2015 ◽  
pp. 109-125 ◽  
Author(s):  
M. H. Schoenberg ◽  
E. Paes
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia And Reperfusion

scholarly journals Peroxynitrite Decomposition Catalyst FeTMPyP Provides Partial Protection Against Intestinal Ischemia and Reperfusion Injury in Infant Rats

2007 ◽  
Vol 62 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Giorgio Stefanutti ◽  
Agostino Pierro ◽  
Virpi V Smith ◽  
Nigel J Klein ◽  
Simon Eaton
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Partial Protection ◽  
Infant Rats

scholarly journals Heparin modulates the expression of genes encoding pro and anti-apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats

2014 ◽  
Vol 29 (7) ◽  
pp. 445-449 ◽  
Author(s):  
Murched Omar Taha ◽  
Regiane Miranda Ferreira ◽  
Nabiha Saadi Abrahão Taha ◽  
Hugo Pequeno Monteiro ◽  
Afonso Caricati-Neto ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Apoptotic Proteins

C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion

Surgery ◽  
2007 ◽  
Vol 142 (5) ◽  
pp. 722-733 ◽  
Author(s):  
Niubel Diaz Padilla ◽  
Arlène K. van Vliet ◽  
Ivo G. Schoots ◽  
Mercedes Valls Seron ◽  
M. Adrie Maas ◽  
...  
Keyword(s):  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Igm Antibodies ◽  
Natural Igm

Leukocyte Mobilization, Chemiluminescence Response, and Antioxidative Capacity of the Blood in Intestinal Ischemia and Reperfusion

1997 ◽  
Vol 27 (4) ◽  
pp. 359-367 ◽  
Author(s):  
Antonín Lojek ◽  
Milanĉízˆ ◽  
Hana Slavíková ◽  
Monika Duŝková ◽  
Jan Vondráĉek ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
Antioxidative Capacity ◽  
Leukocyte Mobilization

scholarly journals Small intestinal ischemia and reperfusion—bioimpedance measurements

2018 ◽  
Vol 39 (2) ◽  
pp. 025001 ◽  
Author(s):  
Runar J Strand-Amundsen ◽  
Christian Tronstad ◽  
Håvard Kalvøy ◽  
Tom E Ruud ◽  
Jan O Høgetveit ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
Small Intestinal

Mucosal arachidonate metabolism and intestinal ischemia-reperfusion injury

1989 ◽  
Vol 257 (2) ◽  
pp. G299-G307 ◽  
Author(s):  
M. J. Mangino ◽  
C. B. Anderson ◽  
M. K. Murphy ◽  
E. Brunt ◽  
J. Turk
Keyword(s):  
Blood Flow ◽  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Leukotriene B4 ◽  
Time Dependent ◽  
Ischemia And Reperfusion ◽  
Synthesis Inhibitor ◽  
Intestinal Ischemia Reperfusion

Mucosal arachidonic acid metabolism was examined after 3 h of ischemia and 1 h of reperfusion in isolated ileal segments in the dog. The cyclooxygenase products thromboxane B2, 6-ketoprostaglandin F1 alpha, and prostaglandin E2 increased by 365%, 97%, and 158%, respectively, after ischemia and reperfusion but were not altered after 3 h of ischemia alone. The potent chemotactic lipoxygenase product leukotriene B4 (LTB4) increased by 687% after ischemia and reperfusion and was not affected by ischemia without reperfusion. In addition, tissue production of the thiol ether leukotrienes (LTC4, LTD4, and LTE4) increased threefold after ischemia and reperfusion. Quantitation of regionally isomeric hydroxy acids produced from arachidonate revealed a 300% increase in 12-hydroxyeicosatetraenoate (12-HETE) after intestinal ischemia and reperfusion without a change in other isomers (15-HETE and 5-HETE). Stereochemical analysis of 12-HETE demonstrated exclusive synthesis of the S-enantiomer. A significant and time-dependent decrease in intestinal blood flow also occurred during reperfusion. Administration of the dual cyclooxygenase-lipoxygenase synthesis inhibitor BW755C (1 mg/kg ia) did not alter time-dependent decreases in blood flow and failed to inhibit eicosanoid synthesis. Histologic examinations of intestinal samples revealed significant mucosal damage associated with ischemia alone and ischemia after reperfusion. This study indicates that intestinal ischemia-reperfusion injury is associated with dramatic alterations in mucosal production of vasoactive eicosanoids and with changes in blood flow that occur during reperfusion but not during ischemia alone. These events may be involved in the pathology characteristic of this injury.

Intestinal ischemia and reperfusion injury in transgenic mice overexpressing copper-zinc superoxide dismutase

1997 ◽  
Vol 273 (4) ◽  
pp. C1130-C1135 ◽  
Author(s):  
Devendra R. Deshmukh ◽  
Oleg Mirochnitchenko ◽  
Vikram S. Ghole ◽  
Doreen Agnese ◽  
Pritesh C. Shah ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Transgenic Mice ◽  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Neutrophil Infiltration ◽  
Myeloperoxidase Activity ◽  
Ischemia And Reperfusion ◽  
Intestinal Ischemia Reperfusion

Superoxide dismutase (SOD) scavenges oxygen radicals that are implicated in the pathogenesis of intestinal ischemia-reperfusion injury. The effect of intestinal ischemia and reperfusion was investigated in transgenic mice overexpressing human Cu-Zn SOD. Ischemia was induced by occluding the superior mesenteric artery. Myeloperoxidase activity was determined as an index of neutrophil infiltration, and malondialdehyde levels were measured as an indicator of lipid peroxidation. Forty-five minutes of intestinal ischemia followed by 4 h of reperfusion caused an increase in intestinal levels of malondialdehyde in both nontransgenic and transgenic mice, but the concentration of malondialdehyde was significantly greater in nontransgenic mice. Intestinal ischemia-reperfusion also caused an increase in intestinal and pulmonary myeloperoxidase activity in nontransgenic and transgenic mice, but the transgenic mice had significantly lower levels of myeloperoxidase activity than nontransgenic mice. Transgenic mice had higher levels of intestinal SOD activity than nontransgenic mice. There were no significant differences in the catalase or glutathione peroxidase activities. In conclusion, our study demonstrates that the overexpression of SOD protects tissues from neutrophil infiltration and lipid peroxidation during intestinal ischemia-reperfusion.

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