What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient

Pseudoexfoliation syndrome (PXS) and pigment dispersion syndrome (PDS) are two of the commonest disorders to produce secondary open-angle glaucoma through trabecular meshwork blockage. Each is a defined clinical entity, and while genetics likely play a significant role in the pathogenesis of both, the specific genes involved appear to be distinct. There is surprisingly little published in the literature regarding the coexistence of PDS and PXS in the same patient. We present the intriguing case of a patient who developed PDS in one eye and PXS in the other. This unusual case acts as a platform for an interesting discussion of the genomics of PXS and PDS.

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Intraocular Pressure-Lowering Potential of Subthreshold Selective Laser Trabeculoplasty in Patients with Primary Open-Angle Glaucoma

Journal of Ophthalmology ◽

10.1155/2016/2153723 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Hong Yang Zhang ◽

Yong Jie Qin ◽

Yang Fan Yang ◽

Jian Gang Xu ◽

Min Bin Yu

Keyword(s):

Intraocular Pressure ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Initial Energy ◽

The Other ◽

Open Angle ◽

Selective Laser Trabeculoplasty ◽

Laser Trabeculoplasty ◽

Pressure Lowering ◽

Laser Flare

Purpose.To compare the efficacy of subthreshold and conventional selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) in the patients with primary open-angle glaucoma (POAG).Methods.Fifty-two eyes from fifty-two POAG patients were randomized into two groups, one group treated with subthreshold SLT using two-thirds of the conventional energy and the other one treated with the conventional energy. IOP was measured with the Goldmann tonometer and the anterior chamber inflammation was determined using laser flare meter.Results.The initial energy dosage used in subthreshold SLT group was significantly lower than the amount of the energy used in conventional SLT group (0.4±0.1 mJ versus0.6±0.1 mJ,P=0.030). The total energy dosage was also significantly lower in subthreshold SLT group compared to the other group (37.6±3.3 mJ versus51.8±5.7 mJ,P=0.036). However, the level of inflammation in aqueous humor, amount of reduction in IOP, and the success rate in controlling IOP was the same in both groups.Conclusion.The efficacy of subthreshold SLT group in reducing IOP in POAG patients is comparable to the efficacy of conventional SLT group.

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Schlemm’s Canal and Trabecular Meshwork in Eyes with Primary Open Angle Glaucoma: A Comparative Study Using High-Frequency Ultrasound Biomicroscopy

PLoS ONE ◽

10.1371/journal.pone.0145824 ◽

2016 ◽

Vol 11 (1) ◽

pp. e0145824 ◽

Cited By ~ 27

Author(s):

Xiaoqin Yan ◽

Mu Li ◽

Zhiqi Chen ◽

Ying Zhu ◽

Yinwei Song ◽

...

Keyword(s):

Comparative Study ◽

Trabecular Meshwork ◽

High Frequency ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Ultrasound Biomicroscopy ◽

Open Angle ◽

High Frequency Ultrasound ◽

Schlemm's Canal ◽

Frequency Ultrasound

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Neuroinflammation in Primary Open-Angle Glaucoma

Journal of Clinical Medicine ◽

10.3390/jcm9103172 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3172 ◽

Cited By ~ 1

Author(s):

Stefania Vernazza ◽

Sara Tirendi ◽

Anna Maria Bassi ◽

Carlo Enrico Traverso ◽

Sergio Claudio Saccà

Keyword(s):

Oxidative Stress ◽

Immune Response ◽

Trabecular Meshwork ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Glaucoma Surgery ◽

Open Angle ◽

Antioxidant Defences ◽

Age Related ◽

Wide Range

Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide. Increasing evidence suggests oxidative damage and immune response defects are key factors contributing to glaucoma onset. Indeed, both the failure of the trabecular meshwork tissue in the conventional outflow pathway and the neuroinflammation process, which drives the neurodegeneration, seem to be linked to the age-related over-production of free radicals (i.e., mitochondrial dysfunction) and to oxidative stress-linked immunostimulatory signaling. Several previous studies have described a wide range of oxidative stress-related makers which are found in glaucomatous patients, including low levels of antioxidant defences, dysfunction/activation of glial cells, the activation of the NF-κB pathway and the up-regulation of pro-inflammatory cytokines, and so on. However, the intraocular pressure is still currently the only risk factor modifiable by medication or glaucoma surgery. This present review aims to summarize the multiple cellular processes, which promote different risk factors in glaucoma including aging, oxidative stress, trabecular meshwork defects, glial activation response, neurodegenerative insults, and the altered regulation of immune response.

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Role of Fibronectin in Primary Open Angle Glaucoma

Cells ◽

10.3390/cells8121518 ◽

2019 ◽

Vol 8 (12) ◽

pp. 1518 ◽

Cited By ~ 6

Author(s):

Jennifer A. Faralli ◽

Mark S. Filla ◽

Donna M. Peters

Keyword(s):

United States ◽

Trabecular Meshwork ◽

Vision Loss ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

The United States ◽

Open Angle ◽

Cell Matrix ◽

Fibronectin Fibrils

Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an elevation in intraocular pressure (IOP). The increase in IOP is believed to be caused by an increase in the deposition of extracellular matrix proteins, in particular fibronectin, in a region of the eye known as the trabecular meshwork (TM). How fibronectin contributes to the increase in IOP is not well understood. The increased density of fibronectin fibrils is thought to increase IOP by altering the compliance of the trabecular meshwork. Recent studies, however, also suggest that the composition and organization of fibronectin fibrils would affect IOP by changing the cell-matrix signaling events that control the functional properties of the cells in the trabecular meshwork. In this article, we will discuss how changes in the properties of fibronectin and fibronectin fibrils could contribute to the regulation of IOP.

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