Intraocular Pressure Spikes after Aflibercept Intravitreal Injections

The objective of this study was to assess the intraocular pressure (IOP) as well as the anatomical modifications of the anterior segment following an aflibercept injection. Patients underwent an aflibercept intravitreal injection (IVI) (0.05 ml) with a 30.5-gauge needle and an antireflux system. IOP was assessed before injection (T0), immediately after (T1), and 5 min (T5), 15 min (T15), and 45 min (T45) after the IVI. Before the IVI and immediately after the T1 measurement, a PENTACAM® acquisition was used to evaluate the anterior chamber parameters (anterior chamber volume, depth and measure of the iridocorneal angle). At T0, IOP was 12.9 ± 1.3 mm Hg. IOP significantly increased after IVI (42.7 ± 3 mm Hg, p < 0.001). IOP returned to baseline at T45 (13.0 ± 1.2 mm Hg, p = 0.877). Anterior chamber volume decreased after IVI (160.6 vs. 168.3 mm3, p = 0.002). No significant changes were found for iridocorneal angle and anterior chamber depth. Aflibercept IVI causes an acute increase in IOP over a short period without iridocorneal angle closure.

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Evaluation the Acute Effects of Hyperbaric Oxygen Therapy on Eye Anterior Segment Morphology and on İntraocular Pressure

10.21203/rs.3.rs-528769/v1 ◽

2021 ◽

Author(s):

Fatih Akıncı ◽

Abdullah Arslan ◽

Muammer Özcimen

Keyword(s):

Intraocular Pressure ◽

Anterior Chamber ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Central Corneal Thickness ◽

Oxygen Therapy ◽

Corneal Thickness ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Iridocorneal Angle

Abstract Purpose: In this study the acute effects of 1 session of hyperbaric oxygen therapy on eye anterior segment morphology and on intraocular pressure was evaluated.Materials and methods: 30 patients taking hyperbaric oxygen therapy for different indications were included in this prospective study. Only the right eye per patient was included in the study. The refractive errors were measured with autorefractometry, intraocular pressures were measured with pneumatic tonometry; anterior segment parameters pachymetry, keratometry, anterior chamber depth and iridocorneal angle values were measured with corneal topography prior to and 24 hours after 1 session of hyperbaric oxygen therapy.Results: In this study 30 eyes from a total of 30 patients were evaluated; 19 men (% 64) and 11 women (% 36). Median age was 44.33 ±16.12 (Age range 18-80 years). Mean intraocular pressure was 13.7 ±4,16 mmHg (milimetermercuries), mean central corneal thickness was 531.9 ±28.24 μm, mean anterior chamber depth was 3.30 ±0.375 mm, mean iridocorneal angle value was 35.3± 6.61 degrees before hyperbaric oxygen therapy. The mean intraocular pressure was 12.66±4,54 mmHg, mean central corneal thickness was 529.43± 26.68 μm, mean anterior chamber depth was 3.28±0.372 mm, mean iridocorneal angle value was 34.5±6.42 degrees after HBOT. A statistically significant decrease in these values were recorded. No statistically significant changes were found in spheric equivalent and keratometry values of the patients before and after HBOT.Conclusions: After one session of HBOT a decrease in intraocular pressure, central corneal thickness, anterior chamber depth and iridocorneal angles of patients were observed; keratometry and spheric equivalent values remained unchanged. More studies are needed in order to use the effects of HBOT on anterior segment morphology and on intraocular pressure for situations like glaucoma, corneal edema etc.

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Changes in Anterior Segment Morphology of Iris Bombe before and after Laser Peripheral Iridotomy in Patients with Uveitic Secondary Glaucoma

Journal of Ophthalmology ◽

10.1155/2016/8496201 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Wakako Ikegawa ◽

Takashi Suzuki ◽

Koji Namiguchi ◽

Shiro Mizoue ◽

Atsushi Shiraishi ◽

...

Keyword(s):

Anterior Chamber ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Anterior Chamber Angle ◽

Laser Peripheral Iridotomy ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

Before And After ◽

The Mean ◽

Peripheral Iridotomy

Purpose. To quantify changes in anterior segment (AS) parameters after laser peripheral iridotomy (LPI) using AS-optical coherence tomography (OCT) of iris bombe. Method. AS images of eight eyes were captured before and after iris bombe and more than 2 weeks after LPI (post-LPI) using AS-OCT. We compared the following AS parameters: anterior chamber depth (ACD), anterior chamber volume (ACV), iris curvature (IC), iris thickness at 500 μm from the scleral spur (IT-1) in the middle between the iris root and pupillary margin (IT-2) and 500 μm from the pupillary margin (IT-3) to the anterior chamber angle (ACA) (angle opening distance [AOD750]), and trabecular iris space area. Results. Mean IT-1 and IT-3, but not IT-2, were lower after iris bombe (IT-1, P=0.001; IT-2, P=0.081; and IT-3, P=0.001). There were no significant differences between ACD at pre-LPI and before iris bombe (P=0.096). The mean ACV and AOD750 of iris bombe increased at post-LPI (ACV, P<0.01, and AOD750, P<0.05). The mean IT-1, IT-2, and IT-3 increased at post-LPI (all, P≤0.01). IC decreased at post-LPI (P<0.001), and ACD at post-LPI did not change. Conclusions. The iris extends and becomes thinner during iris bombe. LPI during bombe decreases the IC and increases the ACV and ACA.

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Genetic Covariance Between Central Corneal Thickness and Anterior Chamber Volume: A Hungarian Twin Study

Twin Research and Human Genetics ◽

10.1017/thg.2014.54 ◽

2014 ◽

Vol 17 (5) ◽

pp. 397-404 ◽

Cited By ~ 2

Author(s):

Georgina Zsofia Toth ◽

Adel Racz ◽

Adam Domonkos Tarnoki ◽

David Laszlo Tarnoki ◽

Zita Szekelyhidi ◽

...

Keyword(s):

Anterior Chamber ◽

Central Corneal Thickness ◽

Genetic Factors ◽

Corneal Thickness ◽

Anterior Segment ◽

Angle Closure ◽

Genetic Covariance ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

High Heritability

Background: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). Methods: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry. Results: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (rph = −0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. Conclusion: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.

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Association of anterior segment parameters and 5-year incident narrow angles: findings from an older Chinese population

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-315852 ◽

2020 ◽

pp. bjophthalmol-2020-315852

Author(s):

Yu Jiang ◽

Wei Wang ◽

Lanhua Wang ◽

Mingguang He

Keyword(s):

Anterior Chamber ◽

Multiple Logistic Regression Analysis ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Narrow Angle ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

Oct Imaging ◽

Older Chinese ◽

Analysis Models

PurposeTo assess the association of anterior segment optical coherence tomography (AS-OCT) parameters and 5-year incident narrow angle in China.MethodsThis was a prospective cohort study of people aged 50 and older residing in Liwan District, Guangzhou, China. Random clustering sampling was used to identify adults aged 50 years and older in Liwan District, Guangzhou. In 2008 and 2013, this study was repeated and added AS-OCT imaging under dark and light conditions. Customised software (ZAAP) was used to analyse horizontal AS-OCT scans. Angle opening distance (AOD), trabecular iris space area (TISA), anterior chamber volume (ACV) and maximal iris thickness (ITM) were measured. Multiple logistic regression analysis models were used to investigate the associations of the final angle status with baseline AS-OCT parameters. ORs and 95% CIs were calculated.ResultsOf the 220 subjects with eligible AS-OCT images and gonioscopic results in 2008, the response rate was 77.3%. A total of 27 (15.9%) subjects developed narrow angles and 143 (84.1%) had open angles on gonioscopy in 2013. Subjects developed narrow angles had greater spherical equivalent and shallower anterior chamber depth, smaller angle parameters, thicker IT750 and ITM, smaller anterior chamber parameters, greater lens vault, and smaller dynamic parameters (ΔITM, ΔACA, ΔACV) at baseline. After adjusting confounders, the predictors of incident narrow angles included smaller AOD750, TISA750, ΔACA and greater ITM, ΔIarea.ConclusionsIncident narrow angles were associated with smaller anterior ocular dimensions, thicker iris and smaller light-to-dark changes at baseline. These findings can help in early diagnosis in this population.

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Repeatability of Ocular Measurements with a Dual-Scheimpflug Analyzer in Healthy Eyes

BioMed Research International ◽

10.1155/2014/808646 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Carmen Lopez de la Fuente ◽

Ana Sanchez-Cano ◽

Francisco Segura ◽

Lorena Fuentes-Broto ◽

Isabel Pinilla

Keyword(s):

Anterior Chamber ◽

Corneal Thickness ◽

Intraclass Correlation ◽

Anterior Segment ◽

Clinical Results ◽

Complete Characterization ◽

Repeated Measurements ◽

Iridocorneal Angle ◽

Chamber Volume ◽

Anterior Chamber Volume

Purpose. To assess the repeatability of the Galilei dual Scheimpflug analyzer (GDSA) in anterior segment examination.Methods. Fifty-two eyes from 52 healthy volunteers were prospectively and consecutively recruited. Anatomic, axial, refractive, and instantaneous parameters were measured with GDSA to provide a complete characterization of the anterior segment. Repeatability was assessed calculating intraclass correlation coefficient (ICC), and coefficient of variation (COV).Results. Correlation among repeated measurements showed almost perfect reliability (ICC > 0.81) for all parameters except thinnest central corneal thickness (CCT) (0.78), corneal thickness average out (0.79), and posterior axial curvature average out (0.60). Repeatability was excellent (COV<10%) for all parameters except anterior chamber volume and, superior iridocorneal angle and eccentricities. In these last three parameters, repeatability limits were excessively high compared to the mean.Conclusions. GDSA in healthy young persons had an almost perfect correlation in measuring anatomic, axial, instantaneous, and refractive parameters with greater variability for peripheral terms. Repeatability of anatomical parameters like pachymetry, anterior chamber, or iridocorneal angle and eccentricity were limited. In healthy young persons, the other evaluated parameters had very good repeatability and their limits of agreement showed excellent clinical results for this device.

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Two-Year Outcomes of Visian Implantable Collamer Lens with a Central Hole for Correcting High Myopia

Journal of Ophthalmology ◽

10.1155/2018/8678352 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Zhipeng Yan ◽

Huamao Miao ◽

Feng Zhao ◽

Xiaoying Wang ◽

Xun Chen ◽

...

Keyword(s):

Intraocular Pressure ◽

Anterior Chamber ◽

High Myopia ◽

Imaging System ◽

Anterior Chamber Depth ◽

Central Hole ◽

Implantable Collamer Lens ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

Icl V4c

Purpose. To investigate two-year outcomes of Visian Implantable Collamer Lens with a central hole (ICL V4c) implantation for correcting high myopia.Methods. Sixty-one eyes of 32 patients went through ICL V4c implantation. Safety, efficacy, predictability, and intraocular pressure were evaluated 2 years postoperatively. Anterior chamber volume (ACV), anterior chamber depth (ACD), anterior chamber angle width (ACAW), and vault were measured using a Scheimpflug tomography imaging system.Results. At 2 years, the spherical equivalent refraction decreased from preoperative −14.62 ± 4.29 D to −0.90 ± 0.95 D, with 79% of the eyes within ±0.50 D and 98% within ±1.00 D of the intended correction. The efficacy index was 1.03 ± 0.23, and the safety index was 1.24 ± 0.26. Corrected distance visual acuity (CDVA) remained unchanged in 23% of the eyes, 75% gained one or more lines of CDVA, and 2% lost one line. The ACV, ACD, and ACAW, respectively, decreased from 193.28 ± 29.15 mm3, 3.15 ± 0.23 mm, and 36.51 ± 6.54 degree to 112.48 ± 17.01 mm3, 2.99 ± 0.23 mm, and 22.54 ± 5.27 degree (p=0.0008, 0.008, and 0.0003, resp.). Intraocular pressure was 15.39 ± 2.88 mmHg before surgery and was 15.86 ± 4.11 mmHg at 2 years (p=0.11).Conclusion. Implantation of ICL V4c is a safe, effective, and predictable procedure for correcting high myopia. Reduction of anterior chamber space after surgery did not induce intraocular pressure increase during the 2-year follow-up.

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Pupil Size Associated with the Largest Iris Volume in Normal Chinese Eyes

Journal of Ophthalmology ◽

10.1155/2018/8058951 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Shuning Li ◽

Jing Jiang ◽

Yiquan Yang ◽

Gewei Wu ◽

Shi-Ming Li ◽

...

Keyword(s):

Anterior Chamber ◽

Pupil Size ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Quadratic Equation ◽

Swept Source ◽

Chamber Volume ◽

Anterior Chamber Volume ◽

The Relationship ◽

Pupillary Size

Background. To determine the range of pupil size that has the largest iris volume in normal eyes. Methods. 31 healthy adult Chinese volunteers underwent swept-source anterior segment OCT examination in both eyes. Pilocarpine 1% was instilled in a randomly selected eye (eye with induced miosis (ME)) of each participant to obtain iris volume (IV) measurements over a range of pupil sizes. OCT was performed prior to and one hour after pilocarpine in both ME and fellow eye (FE). Iris volume (IV), anterior chamber volume (ACV), anterior chamber depth (ACD), and pupil size (PS) were recorded. A scatter plot was used to depict the association between each pupil size and IV. Results. The pupillary sizes for which IV was recorded in ME and FE ranged from 1.161 mm to 6.665 mm. The mean IV increased with miosis in both ME and FE; in 13 eyes, IV decreased with a decrease in pupillary size. PS between 3.812 and 6.665 mm was associated with an increase in IV, while PS between 3.159 and 5.54 mm was associated with a decrease. The relationship between PS and IV was in the shape of a downward parabola and was modeled using a quadratic equation (y = −1.3121x2 + 8.8429x + 16.423, R2 = 0.26886). The largest IV occurred at PS between 3 and 4 mm. Conclusions. The relationship between PS and IV in this study was in the shape of a downward parabola. The largest IV was recorded at a pupillary size between 3 and 4 mm. This trial is registered with ChiCTR-ROC-17013572.

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Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Journal of Ophthalmology ◽

10.1155/2017/6762047 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Yuan Zong ◽

Qian Xu ◽

Chunhui Jiang ◽

Haohao Zhu ◽

Jian Yu ◽

...

Keyword(s):

Anterior Chamber ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Chinese Adults ◽

Factors Associated ◽

Chamber Volume ◽

Significant Difference ◽

Anterior Chamber Volume ◽

Anterior Segment Parameters ◽

Healthy Chinese

Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults.Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined.Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility. There was a significant difference between the horizontal and vertical anterior chamber widths (ACW) (P<0.05), with a mean difference of 390 μm. The ACV (mean153.83±32.42 mm3) was correlated with most of the anterior segment parameters, especially anterior chamber depth (ACD), which accounted for about 85% of the variation of ACV. Most of the anterior segment parameters were significantly correlated with age, and the relative changes in ACV and ACD were greatest in subjects aged 41–50 years.Conclusion. ACV was correlated with most of the anterior segment parameters measured in this study, particularly ACD. The relatively large difference between horizontal and vertical ACW suggests that the ACV could and should be measured using multiple OCT scans.

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Prediction of anterior chamber volume after implantation of posterior chamber phakic intraocular lens

PLoS ONE ◽

10.1371/journal.pone.0242434 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0242434

Author(s):

Yuki Takagi ◽

Takashi Kojima ◽

Tomoya Nishida ◽

Tomoaki Nakamura ◽

Kazuo Ichikawa

Keyword(s):

Anterior Chamber ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Absolute Error ◽

Prediction Equation ◽

Stepwise Multiple Regression ◽

Posterior Chamber ◽

Implantable Collamer Lens ◽

Chamber Volume ◽

Anterior Chamber Volume

Purpose To predict the anterior chamber volume (ACV) after implantable collamer lens (ICL) implantation based on ICL size and parameters of anterior segment optical coherence tomography (AS-OCT). Design Retrospective study. Methods This study included 222 eyes of 222 patients who underwent ICL implantation at Nagoya Eye Clinic. The patients were divided into two groups: prediction group, for creating the prediction equation (148 eyes, mean age: 32.11 ± 8.04 years), and verification group, for verifying the equation (74 eyes, mean age: 33.03 ± 6.74 years). The angle opening distance (AOD), anterior chamber width (ACW), ACV, anterior chamber depth, lens vault, angle-to-angle distance, angle recess area, and trabecular iris space area were calculated using AS-OCT. A stepwise multiple regression analysis was performed. After the creation of the prediction equation, its accuracy was verified in the verification group. Results The ACV, AOD750, ACW, and ICL size were selected as explanatory variables to predict postoperative ACV. Mean predicted (114.2 ± 21.83 mm3) and actual postoperative ACVs (116.1 ± 25.41 mm3) were not significantly different (P = 0.269); absolute error was 10.59 ± 9.13 mm3. In addition, there was high correlation between actual and predictive ACV (adjusted R2 = 0.6996, p < 0.0001). Bland-Altman plot revealed that there was no addition or proportional error between predicted and actual postoperative ACV. Conclusion Postoperative ACV was accurately predicted using AS-OCT parameters and ICL size. This prediction equation may be useful for making decisions regarding ICL size.

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Potential of the Pentacam in Screening for Narrow Angles in Patients with Chronic Angle-Closure Glaucoma

Annals of African Surgery ◽

10.4314/aas.v18i1.8 ◽

2021 ◽

Vol 18 (1) ◽

pp. 39-44

Author(s):

Seth Lartey ◽

Abdul-Kabir Mohammed ◽

Emmanuel Appiagyei ◽

Kojo Akuffo

Keyword(s):

Anterior Chamber ◽

Anterior Chamber Depth ◽

Area Under The Curve ◽

Angle Closure Glaucoma ◽

Receiver Operating Curve ◽

Angle Closure ◽

Effective Management ◽

Narrow Angle ◽

Chamber Volume ◽

Anterior Chamber Volume

Background: Chronic angle-closure glaucoma (CACG) is a visually destructive disease. Effective management of CACG requires identifying eyes with narrow angle. Objective: To compare pentacam with gonioscopy in detecting narrow angles in eyes with CACG. Method: We enrolled 101 eyes with glaucoma. Gonioscopy was performed on all eyes. Using Shaffer’s grading, subjects were classified into angle closure and open angle. Anterior chamber volume (ACV) and anterior chamber depth (ACD) were measured with the pentacam. Receiver operating curve was constructed for each parameter and the area under the curve (AUC) was calculated. Results: Ten eyes (9.9%) were classified as angle closure on gonioscopy. To detect narrow angles, ACV (AUC 0.956; 95% confidence interval (CI) 0.894–0.987) performed similar to ACD (AUC=0.930, p=0.33). Using a cutoff of 102 mm3 , ACV had 100% sensitivity and 88.5% specificity for detecting narrow angles in CACG patients. With an ACV cutoff of 102 mm3 , the PPV for detecting angle closure was 48.9% (95% CI, 34.8–68.2), while the NPV was 100% (94.1– 100%), using 9.9% prevalence of angle closure from this study. Conclusion: ACV and ACD measured by the pentacam have the potential to determine narrow angles in eyes with CACG. Keywords: Chronic angle-closure glaucoma, Pentacam HR, Anterior chamber volume, Gonioscopy

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