scholarly journals Alterations of Serum IP-10 and TARC in Patients with Early Acute Rejection after Liver Transplantation

2017 ◽  
Vol 41 (3) ◽  
pp. 1063-1071 ◽  
Author(s):  
Xingchu Meng ◽  
Wei Gao ◽  
Ying Tang ◽  
Zhongyang Shen ◽  
Zhenglu Wang
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Interferon Γ ◽  
Time Points ◽  
Transplantation Rejection ◽  
Increasing Trend ◽  
Specific Sign

Background/Aims: To analyze alterations of interferon-γ-induced protein 10 (IP-10) and thymus and activation-regulated chemokine (TARC) levels in early acute liver transplantation rejection. Methods: Thirty-six patients with early acute liver transplantation rejection were classified as non-, mild, moderate, and severe rejection groups. The levels of serum IP-10 and TARC were determined on days 3, 2, 1, and 0 before biopsy. Results: The IP-10 activities in all rejection groups were significantly higher (p < 0.05) than those in the non-rejection group at all time points and correlated with the extent of rejection (p < 0.05). The differences in TARC among the three rejection groups were significant (p < 0.05), and its highest level was found in the mild rejection group at all observed time points, whereas its lowest level was detected in the severe rejection group. The analysis of the TARC/IP-10 ratio revealed that the volume was correlated with the rejection degree. This ratio in the moderate and severe rejection groups on days 2, 1, and 0 before biopsy were 20% lower than that before transplantation. Conclusion: Serum IP-10 showed an increasing trend during early acute liver transplantation rejection. IP-10 increase or TARC/IP-10 ratio decrease combining with abnormal hepatic enzymatic alteration could be a valuable and specific sign for early rejection of the transplanted liver.

scholarly journals Multiplex immunofluorescence of spatial distribution of infiltrating T cells in different regions of hepatic lobules during liver transplantation rejection

2021 ◽  
Author(s):  
Shipeng Li ◽  
Guangpeng Zhou ◽  
Jie Sun ◽  
Bin Cui ◽  
Haiming Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cells ◽  
Spatial Distribution ◽  
Regulatory T Cells ◽  
Acute Rejection ◽  
Cd8 T Cells ◽  
Immune Cells ◽  
Cd4 T Cells ◽  
Rejection Level ◽  
Transplantation Rejection

Abstract It is still unclear whether there are differences in the types and functional status of immune cells in different areas of the liver lobules after liver transplantation rejection. The composition of infiltrating T cells in liver allografts during liver transplantation rejection is unclear and difficult to visualize on the same biopsy slide. We used multiplex immunofluorescence assays to study the spatial distribution of various types of infiltrating T cells in different areas of the liver lobules after liver transplantation. In the same area of the hepatic lobules, the percentage of CD4 + T cells, CD8 + T cells and regulatory T cells (Tregs) in the acute rejection group was higher than that in the nonacute rejection and normal groups. Within all three groups, the percentage of CD4 + T cells, CD8 + T cells and Tregs from the periportal to perivenous zones was increased first and then decreased. The percentage of CD8 + T cells increased gradually from the periportal to perivenous zones, the percentage of CD8 + T cells in perivenous zone was higher than in the transitional and periportal zones in the rejection group. In conclusion, the percentage of CD8 + T cells in different regions of liver lobules is closely related to rejection level after liver transplantation. Acute liver transplantation rejection may occur when the percentage of CD8 + T cells in the perivenous zone increases. Although the percentage of regional CD4 + T could not reflect the rejection level, but the number of CD4 + and CD8 + T cells in different regions was closely related to the rejection level.

Primary liver disease as a determinant for acute rejection after liver transplantation

1999 ◽  
Vol 384 (3) ◽  
pp. 259-263 ◽  
Author(s):  
C. A. Seiler ◽  
Jean-Francois Dufour ◽  
Eberhard L. Renner ◽  
Martin Schilling ◽  
Markus W. Büchler ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Acute Rejection

Roles of BATF/JUN/IRF4 complex in tacrolimus mediated immunosuppression on Tfh cells in acute rejection after liver transplantation

2020 ◽  
Vol 236 (3) ◽  
pp. 1776-1786
Author(s):  
Tengqian Tang ◽  
Tao Xu ◽  
Xiangde Liu ◽  
Tongkun Yang ◽  
Leida Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Tfh Cells

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

1998 ◽  
Vol 11 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Sascha Flohé ◽  
Nicola Speidel ◽  
Regina Flach ◽  
Reinhard Lange ◽  
Jochen Erhard ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Prognostic Marker ◽  
Human Liver ◽  
Hsp 70

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

2012 ◽  
Vol 32 (4) ◽  
pp. 837-847 ◽  
Author(s):  
Xing Sun ◽  
Zi-jun Gong ◽  
Zhao-wen Wang ◽  
Tao Li ◽  
Jin-yan Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Rat Liver ◽  
Rat Liver Transplantation ◽  
Ifn Γ

Hepatitis B and C virus–induced diseases and acute rejection after liver transplantation

1998 ◽  
Vol 30 (8) ◽  
pp. 3946-3947
Author(s):  
U Maggi ◽  
G Rossi ◽  
A Vannelli ◽  
L Caccamo ◽  
S Gatti ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Acute Rejection

scholarly journals Safety and Immunogenicity of Standard and Double Doses of Hepatitis B Vaccine in Children after Liver Transplantation: An Open-Label, Randomised Controlled Trial

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 92
Author(s):  
Palittiya Sintusek ◽  
Supranee Buranapraditkun ◽  
Piyaporn Wanawongsawad ◽  
Nawarat Posuwan ◽  
Pattarawat Thantiworasit ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
De Novo ◽  
Controlled Trial ◽  
Geometric Mean ◽  
Interferon Γ ◽  
Specific Response ◽  
Open Label ◽  
High Prevalence ◽  
Randomised Controlled

A high prevalence of hepatitis B (HepB) antibody loss after liver transplantation (LT) and de novo HepB infection (DNH) was documented, hence revaccination to prevent DNH is crucial. This study aimed to compare the safety and immunogenicity of two HepB vaccine regimens in liver-transplanted children. Liver-transplanted children who were previously immunised but showed HepB surface antibodies (anti-HBs) ≤ 100 mIU/mL were randomised to receive a standard three-dose (SD) and double three-dose (DD) vaccine intramuscularly in months 0–1–6. Anti-HBs and T-cell-specific response to the HepB antigen were assessed. A total of 61 children (54.1% male, aged 1.32 ± 1.02 years) completed the study without any serious adverse reaction. The seroprotective rate was 69.6% vs. 60% (p = 0.368) and 91.3% vs. 85% (p = 0.431) in SD and DD after the first and third 3-dose vaccinations, respectively. The geometric mean titre (95% confidence interval) of anti-HBs in SD and DD were 443.33 (200.75–979.07) vs. 446.17 (155.58–1279.50) mIU/mL, respectively, at completion. Numbers of interferon-γ-secreting cells were higher in hyporesponders/responders than in nonresponders (p = 0.003). The significant factors for the immunologic response to HepB vaccination were anti-HB levels prevaccination, tacrolimus trough levels, and time from LT to revaccination. SD and DD had comparative immunogenicity and were safe for liver-transplanted children who were previously immunised.

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