Characteristic Motor and Nonmotor Symptoms Related to Quality of Life in Drug-Naïve Patients with Late-Onset Parkinson Disease

2018 ◽  
Vol 18 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Hea Ree Park ◽  
Jinyoung Youn ◽  
Jin Whan Cho ◽  
Eung-Seok Oh ◽  
Ji Sun Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Late Onset ◽  
Nonmotor Symptoms ◽  
Drug Naïve ◽  
Characteristic Motor

Gender Differences of Nonmotor Symptoms Affecting Quality of Life in Parkinson Disease

2017 ◽  
Vol 17 (6) ◽  
pp. 276-280 ◽  
Author(s):  
Jee-Eun Yoon ◽  
Ji Sun Kim ◽  
Wooyoung Jang ◽  
Jinse Park ◽  
Eungseok Oh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gender Differences ◽  
Parkinson Disease ◽  
Nonmotor Symptoms

Expected Improvement in Sleep Quality and Unexpected Improvement in Severe Nightmares After Deep Brain Stimulation in Parkinson Disease

2020 ◽  
pp. 169-172
Author(s):  
Laurice Yang
Keyword(s):  
Quality Of Life ◽  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Vital Role ◽  
Expected Improvement ◽  
Nonmotor Symptoms ◽  
Blood Pressure Lability ◽  
Deep Brain

Managing nonmotor symptoms plays a vital role in the quality of life of patients with Parkinson disease (PD); however, it has been unclear whether deep brain stimulation (DBS) can improve these symptoms. Evidence about the effects of nonmotor symptoms from DBS is limited and has mostly focused on mood and other psychological concerns. However, nonmotor symptoms involve a large array of issues, such as constipation, urinary issues, blood pressure lability, mood disorder, rapid eye movement disorder, insomnia, and vivid dreams. In some cases, nonmotor symptoms dramatically affect the quality of life and threaten a patient’s independence more than the motor symptoms themselves. This chapter presents a case in which a patient with PD had experienced lifelong nightmares. He underwent DBS surgery, and shortly thereafter, his nightmares had mostly resolved.

Stereotactic Lesion in the Forel's Field H: A 2-Years Prospective Open-Label Study on Motor and Nonmotor Symptoms, Neuropsychological Functions, and Quality of Life in Parkinson Disease

Neurosurgery ◽  
2019 ◽  
Vol 85 (4) ◽  
pp. E650-E659 ◽  
Author(s):  
Fabio Godinho ◽  
Michel Magnin ◽  
Paulo Terzian Filho ◽  
Paul Reis ◽  
Osmar Moraes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Global Health ◽  
Parkinson Disease ◽  
Rating Scale ◽  
Nonmotor Symptoms ◽  
Neuropsychological Functions ◽  
Forel's Field H

Abstract BACKGROUND Stereotactic lesion in the Forel's field H (campotomy) was proposed in 1963 to treat Parkinson disease (PD) symptoms. Despite its rationale, very few data on this approach have emerged. Additionally, no study has assessed its effects on nonmotor symptoms, neuropsychological functions and quality of life. OBJECTIVE To provide a prospective 2-yr assessment of motor, nonmotor, neuropsychological and quality of life variables after unilateral campotomy. METHODS Twelve PD patients were prospectively evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS), the Dyskinesia Rating Scale and the Parkinson's disease quality of life questionnaire (PDQ39) before campotomy, and after 6 and 24 mo. Nonmotor, neuropsychiatric, neuropsychological and quality of life variables were assessed. The impact of PD on global health was also rated. RESULTS A significant reduction in contralateral rest tremor (65.7%, P < .001), rigidity (87.8%, P < .001), bradykinesia (68%, P < .001) and axial symptoms (24.2%, P < .05) in offmedication condition led to a 43.9% reduction in UPSDRS III scores 2 yr after campotomy (P < .001). Gait improved by 31.9% (P < .05) and walking time to cover 7 m was reduced by 43.2% (P < .05). Pain decreased by 33.4% (P < .01), while neuropsychiatric and neuropsychological functions did not change. Quality of life improved by 37.8% (P < .05), in line with a 46.7% reduction of disease impact on global health (P < .001). CONCLUSION A significant 2-yr improvement of motor symptoms, gait performance and pain was obtained after unilateral campotomy without significant changes to cognition. Quality of life markedly improved in parallel with a significant reduction of PD burden on global health.

scholarly journals Nonmotor symptoms predict quality of life in patients with early Parkinson disease

2013 ◽  
Vol 9 (10) ◽  
pp. 544-544 ◽  
Author(s):  
Hemi Malkki
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Nonmotor Symptoms

scholarly journals Impact of motor and nonmotor symptoms in Parkinson disease for the quality of life: The Japanese Quality-of-Life Survey of Parkinson Disease (JAQPAD) study

2020 ◽  
Vol 419 ◽  
pp. 117172
Author(s):  
Kanako Kurihara ◽  
Ryoko Nakagawa ◽  
Miwako Ishido ◽  
Yoko Yoshinaga ◽  
Jun Watanabe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Nonmotor Symptoms

Association Between Somatization and Nonmotor Symptoms Severity in People With Parkinson Disease

2020 ◽  
Vol 34 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Aranza Polo-Morales ◽  
Ángel Alcocer-Salas ◽  
Mayela Rodríguez-Violante ◽  
Daniella Pinto-Solís ◽  
Rodolfo Solís-Vivanco ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Motor Symptom ◽  
Control Group ◽  
Nonmotor Symptoms ◽  
Symptom Scale ◽  
Cross Sectional ◽  
Movement Disorder Society ◽  
Control Study

Objective: To assess the frequency of somatization and its association with motor, nonmotor symptoms, and quality of life in persons with Parkinson disease (PD). Methods: A cross-sectional case–control study was carried out. Assessments included the List of 90 Symptoms somatic factor (SCL-90-R SOM), Movement Disorder Society Unified Parkinson’s Ratings Scale (MDS-UPDRS), Non-Motor Symptom Scale (NMSS), Montreal Cognitive Assessment (MoCA), and Parkinson Questionnaire-8 (PDQ-8). Results: A total 93 persons with PD and 93 controls were included. Somatization within the PD group was 2 times more frequent compared to the control group (43% vs 21.5%, P = .003). Persons with PD had higher NMSS total scores (48.6 ± 42.6 vs 28.3 ± 30.4, P = .001). Patients with PD with somatization had worst MDS-UPDRS, NMSS, MoCA, and PDQ-8 (all P < .05). Conclusion: Somatization is more frequent in persons with PD compared to healthy controls. Somatization in PD is associated with nonmotor symptoms and worst quality of life.

scholarly journals Drooling, Swallowing Difficulties and Health Related Quality of Life in Parkinson’s Disease Patients

2021 ◽  
Vol 18 (15) ◽  
pp. 8138
Author(s):  
Gladis Yohana Arboleda-Montealegre ◽  
Roberto Cano-de-la-Cuerda ◽  
César Fernández-de-las-Peñas ◽  
Carlos Sanchez-Camarero ◽  
Ricardo Ortega-Santiago
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Duration ◽  
Health Related Quality ◽  
Nonmotor Symptoms ◽  
Related Quality ◽  
Health Related ◽  
Swallowing Difficulties

Background: Parkinson’s disease (PD) is the most common neurodegenerative disorder associated with motor and nonmotor symptoms. Drooling, one of the nonmotor symptoms, can be present in 70–80% of patients with PD. The aim of this paper is to study the characteristics of PD patients with drooling compared to those without in terms of age, gender, disease duration, stage of the disease, swallowing difficulties, and health-related quality of life; methods: a cross-sectional study was conducted. The sample was divided into two groups: PD with drooling (n = 32) and PD without drooling (n = 30). Age, gender, disease duration and Hoehn & Yahr (H & Y) stage, Sialorrhea Clinical Scale for Parkinson’s Disease (SCS-PD), the 10-item Eating Assessment Tool (EAT-10), and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) were compared between groups; Results: 62 individuals with PD, 40 men and 22 women (mean age 73 ± 8 years), were included. Overall, 32 patients reported drooling, and 30 did not exhibit it. The ANCOVA found significant differences between groups for the EAT-10 score (0.83, 95% CI = 5.62–9.03; p = 0.016) and SCS-PD score (1.48, 95% CI = 0.86–6.81; p < 0.001). Analysis of the PDQ-39 scores revealed no significant differences between groups for the PDQ-39 total score (p > 0.057) and in all subscales. The inclusion of gender, age, disease duration, and H & Y as covariates did not influence the results (all p > 0.05). Conclusions: drooling is related to swallowing difficulties assessed with EAT-10 but not with health-related quality of life assessed with PDQ-39 in PD patients with drooling compared to PD patients without it. Age, gender, duration of the disease, and the H & Y state of PD patients with and without drooling seem to be similar.

scholarly journals Impacts of dance on non-motor symptoms, participation, and quality of life in Parkinson disease and healthy older adults

Maturitas ◽  
2015 ◽  
Vol 82 (4) ◽  
pp. 336-341 ◽  
Author(s):  
M.E. McNeely ◽  
R.P. Duncan ◽  
G.M. Earhart
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Parkinson Disease ◽  
Motor Symptoms ◽  
Healthy Older Adults ◽  
Non Motor Symptoms

Clinical outcomes of asleep vs awake deep brain stimulation for Parkinson disease

Neurology ◽  
2017 ◽  
Vol 89 (19) ◽  
pp. 1944-1950 ◽  
Author(s):  
Matthew A. Brodsky ◽  
Shannon Anderson ◽  
Charles Murchison ◽  
Mara Seier ◽  
Jennifer Wilhelm ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Electrode Placement ◽  
Microelectrode Recording ◽  
Imaging Guidance ◽  
Motor Outcomes ◽  
Deep Brain

Objective:To compare motor and nonmotor outcomes at 6 months of asleep deep brain stimulation (DBS) for Parkinson disease (PD) using intraoperative imaging guidance to confirm electrode placement vs awake DBS using microelectrode recording to confirm electrode placement.Methods:DBS candidates with PD referred to Oregon Health & Science University underwent asleep DBS with imaging guidance. Six-month outcomes were compared to those of patients who previously underwent awake DBS by the same surgeon and center. Assessments included an “off”-levodopa Unified Parkinson’s Disease Rating Scale (UPDRS) II and III, the 39-item Parkinson's Disease Questionnaire, motor diaries, and speech fluency.Results:Thirty participants underwent asleep DBS and 39 underwent awake DBS. No difference was observed in improvement of UPDRS III (+14.8 ± 8.9 vs +17.6 ± 12.3 points, p = 0.19) or UPDRS II (+9.3 ± 2.7 vs +7.4 ± 5.8 points, p = 0.16). Improvement in “on” time without dyskinesia was superior in asleep DBS (+6.4 ± 3.0 h/d vs +1.7 ± 1.2 h/d, p = 0.002). Quality of life scores improved in both groups (+18.8 ± 9.4 in awake, +8.9 ± 11.5 in asleep). Improvement in summary index (p = 0.004) and subscores for cognition (p = 0.011) and communication (p < 0.001) were superior in asleep DBS. Speech outcomes were superior in asleep DBS, both in category (+2.77 ± 4.3 points vs −6.31 ± 9.7 points (p = 0.0012) and phonemic fluency (+1.0 ± 8.2 points vs −5.5 ± 9.6 points, p = 0.038).Conclusions:Asleep DBS for PD improved motor outcomes over 6 months on par with or better than awake DBS, was superior with regard to speech fluency and quality of life, and should be an option considered for all patients who are candidates for this treatment.Clinicaltrials.gov identifier:NCT01703598.Classification of evidence:This study provides Class III evidence that for patients with PD undergoing DBS, asleep intraoperative CT imaging–guided implantation is not significantly different from awake microelectrode recording–guided implantation in improving motor outcomes at 6 months.

scholarly journals Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

2021 ◽  
Vol 17 (4) ◽  
pp. 241-246
Author(s):  
Hélcio Kanegusuku ◽  
Raphael M. Ritti-Dias ◽  
Pâmela Yuki Igarasi Barbosa ◽  
Erica Tardelli das Neves Guelfi ◽  
Erika Okamoto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Healthy Subject ◽  
Exercise Capacity ◽  
Motor Impairment ◽  
Stage Iv ◽  
Summary Index ◽  
The Impact ◽  
Disease Questionnaire

This study evaluated the impact of motor impairment (MI) on exercise capacity and quality of life in patients with Parkinson disease (PD). One hundred ninety-two patients (≥50 years old) were divided according to the Hoehn and Yahr stages in: mild (stage I), mild to moderate (stage II), moderate (stage III), and advanced MI (stage IV). Exercise capacity (6-min walk test [6MWT]) and quality of life (Parkinson’s Disease Questionnaire [PDQ-39]) were obtained. In this context, 6MWT was progressively worse with increasing the severity of MI (P<0.01). Patients with advanced MI achieved 39% of predicted 6MWT of healthy subject, while subjects with mild MI achieved 83% of healthy subject (P<0.01). In addition, patients with advanced MI presented higher (i.e., worse) PDQ-39 scores in summary index, cognition, mobility and activities of daily live domains compared to other groups (P<0.01). Patients with moderate MI also presented worse scores in PDQ-39 summary index, mobility and activities of daily live domains in comparison with mild MI patients (P<0.01). Higher MI was correlated with worse exercise capacity (6MWT: r=-0.46, P<0.01), with worse PDQ-39 summary index and the mobility and activities of daily live domains scores (r=0.38, r=0.46, and r=0.43, P<0.01). In conclusion, MI is related to lower exercise capacity and quality of life (i.e., PDQ-39 summary index and mobility and activities of daily live domains) in patients with PD.

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