Sirolimus in Infants with Multiple Cardiac Rhabdomyomas Associated with Tuberous Sclerosis Complex

Introduction: Cardiac rhabdomyomas represent a frequent manifestation of tuberous sclerosis. Tumor growth, mainly prenatally, can result in intrauterine fetal or neonatal deaths in almost 10% of patients. Case Report: We treated 3 consecutive infants aged less than 12 months with sirolimus, an oral mTOR inhibitor. All patients achieved significant reductions in cardiac rhabdomyomas. A complete response was documented in 2 patients, while a partial response with tumor debulking greater than 50% was seen in the other one. The median time to best cardiac response was 1.9 months in all patients, and 3.3 months in those with complete response. The side effects profile was acceptable. Conclusion: Sirolimus may have a significant role in promoting natural regression of cardiac rhabdomyomas. Prospective clinical trials are needed.

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Herbal Home Remedies for Toothache during the COVID-19 Pandemic: A Review

Himalayan Journal of Health Sciences ◽

10.22270/hjhs.v6i3.104 ◽

2021 ◽

pp. 18-29

Author(s):

Abhishek Kumar ◽

Akash Kumar Giri ◽

Bibek Kattel

Keyword(s):

Clinical Trials ◽

Side Effects ◽

Dental Care ◽

Symptomatic Treatment ◽

Dental Pain ◽

The Other ◽

Commercial Products ◽

Plant Products ◽

Home Remedies ◽

The World

The COVID-19 pandemic resulted in the halt of proper dental care in most of the world, except for emergency cases. And, this resulted in a lot of people seek some home remedies for relieve in dental pain. So, this article aims to list down herbal home remedies which can be very helpful in such conditions. The use of medicinal herbs for dental pain can be traced back to history in some form or the other in almost every country. These herbal home remedies have no significant side effects as compared to other chemical-based alternatives, are also easy to obtain and cheaper as well. Clove, Olive, Miswak, Babool and other herbs listed in the article have significant dental properties which have been validated scientifically through various researches. These plant products can be hence used in commercial products as well but only after proper clinical trials. Further research should be encouraged in this field as herbal alternatives can be very beneficial with no such side effects. However, these home remedies are only useful for symptomatic treatment and undergoing proper dental care is advised.

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Comparative assessment of clinical trials, indications, pharmacokinetic parameters and side effects of approved platinum drugs

Pharmacia ◽

10.3897/pharmacia.69.e78813 ◽

2022 ◽

Vol 69 (1) ◽

pp. 1-7

Author(s):

Stefka Ivanova

Keyword(s):

Clinical Trials ◽

Side Effects ◽

Observational Study ◽

Protein Binding ◽

Anticancer Agents ◽

Platinum Complexes ◽

Comparative Assessment ◽

The Other ◽

Pharmacokinetic Parameters ◽

Platinum Drugs

Platinum complexes are among the most commonly applied anticancer agents. The aim of current work is collection, analysing and comparative estimation of clinical trials and pharmacological indications of currently approved for application platinum detivatives: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin (Japan), Lobaplatin (China), Heptaplatin (North Korea), and Satraplatin. The other aim of the study includes the summarizing of the hystoric data for the stages of the developlement of these drugs, and the comparison of pharmacokimetic parameters, side effecs and the dose-liniting factors of the drugs. The observational study on pharmacokinetic parameters shows that protein binding decreases in order: 95% (Cisplatn); 90% (Oxaliplatin); 50% (Nedaplatin); low (Carboplatin). For every of Cisplatin, Carboplatin, Oxaliplatin have been reported more than 1000 clinical trials; for Lobaplatin, Nedaplatin, Satraplatin - about 10 trials. The differenses in dose-limiting effects are: neuro-, nephro-, ototoxicity (Cisplatin); neurotoxicity (Oxaliplatin); nephrotoxicity (Heptaplatin); myelosuppression: thrombocytopenia, neutropenia, leukopenia (Carboplatin, Nedaplatin, Satraplatin).

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Endoscopic and Electroporation Therapy of Paranasal Sinus Tumors

American Journal of Rhinology ◽

10.2500/105065800782102744 ◽

2000 ◽

Vol 14 (3) ◽

pp. 187-192 ◽

Cited By ~ 13

Author(s):

William R. Panje ◽

Nader Sadeghi

Keyword(s):

Clinical Trials ◽

Treatment Options ◽

Complete Response ◽

The Other ◽

Cell Membrane Permeability ◽

Intralesional Injection ◽

Experimental Setting ◽

Sinonasal Cancer ◽

Sinonasal Malignancies ◽

Invasive Method

The purpose of this article is to introduce the concept of endoscopic and electroporation therapy for the treatment of sinonasal carcinomas. Electroporation therapy is a technique that combines intralesional injection of bleomycin combined with application of high-voltage square wave electrical impulse into the tumor. A transient increase in cell membrane permeability allows intracellular entry of bleomycin, with subsequent cytotoxicity. Two cases of sinonasal cancer were treated with this technique. One patient had complete response and is free of disease at 20 months. The other had partial response with control of the disease up to a year. Endoscopic electroporation therapy is potentially a minimally invasive method for the treatment of sinonasal malignancies in an experimental setting where other treatment options do not exist. Phase II/III national clinical trials have been initiated to study the efficacy of electroporation therapy.

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The use of benzodiazepines for tinnitus: systematic review

The Journal of Laryngology & Otology ◽

10.1017/s0022215115000808 ◽

2015 ◽

Vol 129 (S3) ◽

pp. S14-S22 ◽

Cited By ~ 14

Author(s):

N E Jufas ◽

R Wood

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Side Effects ◽

Half Life ◽

Evidence Base ◽

Risk Of Bias ◽

The Other ◽

Subjective Tinnitus ◽

Benzodiazepine Use ◽

Robust Evidence

AbstractObjectives:To investigate the effectiveness of benzodiazepine use for subjective tinnitus and to consider this in the context of the concomitant side effects.Methods:A systematic search of several databases using the terms ‘tinnitus’ and ‘benzodiazepines’ was conducted to find clinical trials of benzodiazepines and comparators in tinnitus patients. These studies were then assessed for risk of bias.Results:Six clinical trials were included. Clonazepam was found to be effective in three studies, but these studies had limitations regarding adequate blinding. The effectiveness of alprazolam was equivocal. Diazepam was not effective in two studies and oxazepam was effective in one study.Conclusion:Benzodiazepine use for subjective tinnitus does not have a robust evidence base. Clonazepam has the most evidence to support its use and is relatively less likely to lead to abuse because of its longer half-life, but caution is still needed given the other serious side effects.

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Successful treatment of acquired haemophila a associated with psoriasis: Case report

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh05s2134m ◽

2005 ◽

Vol 133 (Suppl. 2) ◽

pp. 134-136

Author(s):

Goran Marjanovic ◽

Vesna Marjanovic ◽

Ljubinka Velickovic ◽

Mladen Milenovic ◽

Lana Macukanovic-Golubovic ◽

...

Keyword(s):

Case Report ◽

Side Effects ◽

Bleeding Complication ◽

Complete Response ◽

Immunosuppressive Drugs ◽

Treatment Modalities ◽

Quick Response ◽

Fviii Inhibitor ◽

Frontline Treatment ◽

Cyclophosphamide Treatment

Acquired factor VIII (FVIII) inhibitor causes a rare but lifethreatening form of bleeding disorder, owing to the formation of autoantibodies against FVIII. Treatment modalities include the use of immunosuppressive drugs, such as cyclophosphamide and corticosteroids, plasmapheresis, and i.v. immunoglobulin. The case of a 67-year-old patient with acquired FVIII inhibitor and psoriasis presented us with a serious bleeding complication. Bleeding reacted poorly to therapy with corticosteroids and cyclophosphamide. Treatment with cyclosporin, however, resulted in a prompt and complete response. The lack of side effects and the relatively quick response suggest that cyclosporin A should be tried as a frontline treatment for patients with acquired FVIII inhibitor.

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