A New Physiologic Mouse Model of One Anastomosis Gastric Bypass

2018 ◽  
Vol 59 (5-6) ◽  
pp. 320-328
Author(s):  
Andreas Kroh ◽  
Roman M. Eickhoff ◽  
Daniel Heise ◽  
Patrick H. Alizai ◽  
Karl P. Rheinwalt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Mouse Model ◽  
High Fat Diet ◽  
One Anastomosis Gastric Bypass ◽  
Sham Operation ◽  
Significant Weight Loss ◽  
Long Term Effects ◽  
High Fat

Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. Methods: Six-week-old C57Bl/6 mice were fed a high-fat diet for 12 weeks and scheduled for OAGB or sham operation. Mice were observed for 2 weeks after the operation, and weight and metabolic condition were monitored. Results: Six mice were used to adapt the surgical technique. Afterwards, another 7 mice were scheduled for OAGB without further complications. The newly established OAGB procedure resulted in significant weight loss and improvement of glucose metabolism 2 weeks after the operation. Conclusions: The operation presented here is an easy-to-learn and physiologic mouse model of OAGB that can be used for further studies in mice.

Short- and Long-Term Effects of Weight Loss on the Complement Component C3 After Laparoscopic Gastric Bypass in Obese Patients

2016 ◽  
Vol 26 (11) ◽  
pp. 2756-2763 ◽  
Author(s):  
Segundo Á. Gómez-Abril ◽  
Carlos Morillas-Ariño ◽  
Jose L. Ponce-Marco ◽  
Teresa Torres-Sánchez ◽  
Fernando Delgado-Gomis ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Laparoscopic Gastric Bypass ◽  
Complement Component ◽  
Obese Patients ◽  
Long Term Effects ◽  
Complement Component C3 ◽  
Short And Long Term

Long-term abuse of a high-carbohydrate diet is as harmful as a high-fat diet for development and progression of liver injury in a mouse model of NAFLD/NASH

Nutrition ◽  
2020 ◽  
Vol 75-76 ◽  
pp. 110782 ◽  
Author(s):  
Simona Pompili ◽  
Antonella Vetuschi ◽  
Eugenio Gaudio ◽  
Alessandra Tessitore ◽  
Roberta Capelli ◽  
...  
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Carbohydrate Diet ◽  
High Fat ◽  
Carbohydrate Diet ◽  
High Carbohydrate

Long term effects of high fat diet given early in life in prenatally stressed rats: role of the inflammatory response

2019 ◽  
Vol 29 ◽  
pp. S225-S226
Author(s):  
M. Mazzelli ◽  
N. Cattane ◽  
C. Mora ◽  
V. Begni ◽  
A. Berry ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
High Fat Diet ◽  
Long Term Effects ◽  
High Fat ◽  
Prenatally Stressed

scholarly journals Overweight and diabetes prevention: is a low-carbohydrate–high-fat diet recommendable?

2018 ◽  
Vol 57 (4) ◽  
pp. 1301-1312 ◽  
Author(s):  
Fred Brouns
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Carbohydrate Content ◽  
Food Sources ◽  
Long Term Effects ◽  
High Fat ◽  
Functional Changes ◽  
Low Carbohydrate

Abstract In the past, different types of diet with a generally low-carbohydrate content (< 50–< 20 g/day) have been promoted, for weight loss and diabetes, and the effectiveness of a very low dietary carbohydrate content has always been a matter of debate. A significant reduction in the amount of carbohydrates in the diet is usually accompanied by an increase in the amount of fat and to a lesser extent, also protein. Accordingly, using the term “low carb–high fat” (LCHF) diet is most appropriate. Low/very low intakes of carbohydrate food sources may impact on overall diet quality and long-term effects of such drastic diet changes remain at present unknown. This narrative review highlights recent metabolic and clinical outcomes of studies as well as practical feasibility of low LCHF diets. A few relevant observations are as follows: (1) any diet type resulting in reduced energy intake will result in weight loss and related favorable metabolic and functional changes; (2) short-term LCHF studies show both favorable and less desirable effects; (3) sustained adherence to a ketogenic LCHF diet appears to be difficult. A non-ketogenic diet supplying 100–150 g carbohydrate/day, under good control, may be more practical. (4) There is lack of data supporting long-term efficacy, safety and health benefits of LCHF diets. Any recommendation should be judged in this light. (5) Lifestyle intervention in people at high risk of developing type 2 diabetes, while maintaining a relative carbohydrate-rich diet, results in long-term prevention of progression to type 2 diabetes and is generally seen as safe.

scholarly journals Effect of High Fat Diet on Weight Loss Through the Expression of Uncouple Protein 1 in Mice Visceral Fat

2020 ◽  
Vol 56 (3) ◽  
pp. 223
Author(s):  
Indira Syahraya ◽  
Hermina Novida ◽  
Lilik Herawati ◽  
Purwo Sri Rejeki
Keyword(s):  
Weight Loss ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Significant Weight Loss ◽  
Uncouple Protein ◽  
High Fat ◽  
Immunohistochemistry Staining ◽  
Key Factor ◽  
Weight Loss Group ◽  
Ucp1 Expression

Obesity has become an epidemic around the world. High fat diet (HFD) have been implemented as one of intervention to battle obesity. Uncouple protein 1 (UCP1) is one of the key factor on energy expenditure. The aim of this experiment is to see the macronutrients composition on weight loss and UCP1 expression in the visceral fat. Fifty male mice, 2-3 months old, 18-30 grams, were put in five different groups. K1 (20% protein, 62.0% carbohydrate, 12% fat), K2 (60% protein, 0% carbohydrate, 30% fat), K3 (45% protein, 0% carbohydrate, 45% fat), K4 (30% protein, 0% carbohydrate, 60% fat), K5 (15% protein, 0% carbohydrate, 75% fat). The experiment was done in four weeks, mice body weight was measured every week. UCP1 expression seen using immunohistochemistry staining was measured at the end of the fourth week. Significant weight loss was achieved by K4 (-9.60±3.81) gram by the end of week four (p<0.05). K4 had the least amount of visceral fat. The result was that K4 achieved a significant visceral fat mass (0.02±0.06) gram compared to K1 (0.53±0.08) gram. Compared to other groups K5 expressed UCP1 more than the others (3.78±3.72) cphfp. HFD fed groups produced significant weight loss, group that had the greatest weight loss is K4. Meanwhile, each group had a variety of UCP1 expression.

Long-term effects of one-anastomosis gastric bypass on liver histopathology in NAFLD cases: a prospective study

2020 ◽  
Author(s):  
Mohamed Abdalla Salman ◽  
Ahmed Abdallah Salman ◽  
Haitham S. E. Omar ◽  
Ahmed Abdelsalam ◽  
Mohamed Saber Mostafa ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Prospective Study ◽  
One Anastomosis Gastric Bypass ◽  
Long Term Effects ◽  
Liver Histopathology ◽  
A Prospective Study
Sign in / Sign up

Export Citation Format

Share Document