scholarly journals DCE-MRI Pharmacokinetic-Based Phenotyping of Invasive Ductal Carcinoma: A Radiomic Study for Prediction of Histological Outcomes

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Serena Monti ◽  
Marco Aiello ◽  
Mariarosaria Incoronato ◽  
Anna Maria Grimaldi ◽  
Michela Moscarino ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Outcome Prediction ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Tumor Grade ◽  
Imaging Biomarker ◽  
Diagnostic Tools ◽  
Dce Mri ◽  
Made In ◽  
Treatment Personalization

Breast cancer is a disease affecting an increasing number of women worldwide. Several efforts have been made in the last years to identify imaging biomarker and to develop noninvasive diagnostic tools for breast tumor characterization and monitoring, which could help in patients’ stratification, outcome prediction, and treatment personalization. In particular, radiomic approaches have paved the way to the study of the cancer imaging phenotypes. In this work, a group of 49 patients with diagnosis of invasive ductal carcinoma was studied. The purpose of this study was to select radiomic features extracted from a DCE-MRI pharmacokinetic protocol, including quantitative maps of ktrans, kep, ve, iAUC, and R1 and to construct predictive models for the discrimination of molecular receptor status (ER+/ER-, PR+/PR-, and HER2+/HER2-), triple negative (TN)/non-triple negative (NTN), ki67 levels, and tumor grade. A total of 163 features were obtained and, after feature set reduction step, followed by feature selection and prediction performance estimations, the predictive model coefficients were computed for each classification task. The AUC values obtained were 0.826±0.006 for ER+/ER-, 0.875±0.009 for PR+/PR-, 0.838±0.006 for HER2+/HER2-, 0.876±0.007 for TN/NTN, 0.811±0.005 for ki67+/ki67-, and 0.895±0.006 for lowGrade/highGrade. In conclusion, DCE-MRI pharmacokinetic-based phenotyping shows promising for discrimination of the histological outcomes.

scholarly journals Immunohistochemical Expression of CD68 in Triple Negative Invasive Ductal Carcinoma of the Breast and its Correlation with Clinicopathological Parameters

2021 ◽  
Vol 107 (1_suppl) ◽  
pp. 6-6
Author(s):  
AA Khalaf ◽  
GA Fadaly ◽  
AI El-Sarha ◽  
AF El-Karmouty
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Tumor Grade ◽  
Tumor Stroma ◽  
Clinicopathological Parameters ◽  
Immunohistochemical Expression ◽  
Cancer Tumor

Introduction: Triple negative breast cancer (TNBC) is an aggressive form of breast cancer associated with a poor prognosis. No targeted treatment is available for this subtype. Tumor microenvironment (TME) has been increasingly considered a diagnostic and a prognostic biomarker and a therapeutic target for breast cancer. Tumor associated macrophages (TAM) are a pivotal member of TME and have been proposed as potential targets of therapy. Material and Methods: The immunohistochemical expression of CD68+ve TAM was studied in both tumor stroma (TS) and tumor nest (TN) in 50 cases of triple negative invasive ductal carcinoma as well as in 10 control cases of benign breast lesions. Results: The cases were divided into high or low density groups according to the median. The median in CD68+ve TAM in TS was (61.88), while in CD68+ve TAM in TN was (49.88). The expression of CD68+ve TAM in TS was low in 22 cases and high in 28 cases, while its expression in TN was low in 35 cases and high in 15 cases. There was no statistical association between high CD68+ve TAM in TN and different clinicopathological parameters, meanwhile a statistically significant association was found between high CD68 +ve TAM in TS and tumor grade, lymph/vascular invasion and lymph node metastasis. Conclusions: High expression of TAM in TS, but not in TN, is of clinical significance in patients with TNBC and highlights the importance of analyzing the localization rather than merely the presence of TAM as a marker for prognosis and a potential target for future treatment of triple negative breast cancer.

scholarly journals Gallbladder Metastases: A Report of Two Cases

2019 ◽  
Vol 12 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Mohamad Mouchli ◽  
Douglas J. Grider ◽  
Paul Yeaton
Keyword(s):  
Computed Tomography ◽  
Invasive Ductal Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Primary Lung Cancer ◽  
Gallbladder Wall ◽  
Metastatic Lesion ◽  
Quadrant Pain ◽  
Case Presentation ◽  
Enhanced Computed Tomography

Introduction: Metastasis to the gallbladder is not common and usually manifests an advanced stage of malignancy. Herein, we report a case of triple negative high grade invasive ductal carcinoma of breast with a metastatic lesion to the gallbladder. Case Presentation: The patient is a 52-year-old female diagnosed with invasive ductal carcinoma treated with mastectomy and chemotherapy. After 12 months, she presented to the emergency department with right upper quadrant pain and elevated liver chemistries. Abdominal enhanced computed tomography showed periportal and gallbladder wall edema. After cholecystectomy, the resected gallbladder was histologically considered to be a metastatic lesion arising from the primary lung cancer. The second case describes a case of a 77-year-old woman with multiple co-morbidities who presented to the hospital with sepsis secondary to biliary source. Abdominal enhanced computed tomography findings were concerning for acute cholecystitis. After cholecystectomy, the pathology of the resected gallbladder demonstrated cholecystitis and plasmacytoma. Conclusion: The atypical presentation of gallbladder metastases could mislead treating providers. The diagnosis might alter management decisions and prognosis.

Introducing a new scoring system based on HER2/neu, p53 oncogenes results and mammographic findings for prediction of tumor grade in breast cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10687-10687
Author(s):  
M. Guity ◽  
M. Mokri ◽  
M. Shakiba ◽  
M. Atri
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Predictive Value ◽  
Scoring System ◽  
Ductal Carcinoma ◽  
Tumor Grade ◽  
High Grade ◽  
Group Iii ◽  
Immunohistochemical Studies ◽  
New Scoring

10687 Background: During recent years, several oncogenes have been introduced in relation to breast cancer including her2 and P53. These are related with initiation, degree of progression, invasion and prognosis of breast cancer. In this research the rate of positivity of these oncogenes in 150 patients with invasive ductal carcinoma is introduced and the correlation of the results of a new scoring system comprised of mammograms, P53 and her2 with the tumor grade is assessed. Methods: 150 cases of invasive ductal carcinoma of a private clinic were chosen. The diagnosis of cancer and its grade was confirmed by pathology. All patients underwent mammography befor surgery and the results were classified according to BIRADS system to benign (groups of I and II in BIRADS): Score I, suspicious (group III in BIRADS): Score II and malignant (groups of IV and V in BIRADS): score III. P53 and her2 presence were assessed by immunohistochemical studies and the results were classified as negative (score I) and positive (score II). The final score of each patients was calculated by adding scores of all three studies (P53, her2, mammography) which ranged between 3 to 7. Results: The average age of the patients was 48.2 + 11.2 years; most of them were between 30–50 years old. Three had benign mammograms (2%), 81 had suspicious (54%) and 66 had malignant findings (44%). We showed positive P53in 59 (39%), positive her2 in 69 (46%) and high grade tumor in 77 (51%) patients. On scoring, 2 patients gained 3 (1.3%), 36 scored 4 (24%), 53 patients received 5 (35.3%), 37 reached 6 scores (24.7%) and 22 patients received 7 scores (14.7%). Placing scores 3 and 4 in one group and scores 5–7 in another, the sensitivity and negative predictive value of the system for high grade tumors reached 97.7% and 89.5% respectively. By placing scores 3–6 in one group and score 7 in another, the specificity and positive predictive value of the system reached to 100%. Conclusions: The results of mammography, P53 and her2 seems to have a good correlation with tumor grade, meaning when all three parameters are positive, the patients’ tumor is almost always high grade. No significant financial relationships to disclose.

scholarly journals Main phenotypes and histological types of breast cancer in young women attended at a reference hospital in women’s health in the city of São Paulo

2020 ◽  
pp. BMT53
Author(s):  
Guilherme Moreno Rodrigues de Souza ◽  
Anderson Fernandes Carvalho ◽  
Simone Ferreira Santiago ◽  
Maria Aparecida M R Pinho ◽  
Débora Ribeiro Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Young Women ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Luminal B ◽  
High Prevalence ◽  
Reference Hospital ◽  
Triple Negative Phenotype ◽  
The City

It is estimated that there were 198,840 new cases of breast cancer (BC) in Brazil between 2020 and 2022. Young women who are affected by invasive BC with a triple-negative phenotype generally present more aggressive tumors that are intrinsically resistant to targeted therapies. This study evaluated the phenotypic and histological profile of BC in women up to the age of 40 years. Between 2015 and 2017, we identified 255 women with positive biopsy for carcinoma and with immunohistochemical panel, 51.76% who had a profile for luminal B (n = 132); 22.74% for triple-negative (n = 58). Of the samples, 65.88% presented histology as invasive ductal carcinoma – nonspecial type (n = 168). The results are in accordance with the literature regarding the high prevalence of triple-negative BC in young women and histological type invasive ductal carcinoma – nonspecial type.

scholarly journals Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma

Medicine ◽  
2019 ◽  
Vol 98 (18) ◽  
pp. e15449 ◽  
Author(s):  
Jing-ping Li ◽  
Xiang-mei Zhang ◽  
Zhenzhen Zhang ◽  
Li-hua Zheng ◽  
Sonali Jindal ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
P53 Expression ◽  
Breast Invasive Ductal Carcinoma
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