Immunohistochemical Correlation between the Expression of Vitamin D receptor (VDR) and Triple Negative Invasive Ductal Carcinoma Tissues

Introduction: Metastasis to the gallbladder is not common and usually manifests an advanced stage of malignancy. Herein, we report a case of triple negative high grade invasive ductal carcinoma of breast with a metastatic lesion to the gallbladder. Case Presentation: The patient is a 52-year-old female diagnosed with invasive ductal carcinoma treated with mastectomy and chemotherapy. After 12 months, she presented to the emergency department with right upper quadrant pain and elevated liver chemistries. Abdominal enhanced computed tomography showed periportal and gallbladder wall edema. After cholecystectomy, the resected gallbladder was histologically considered to be a metastatic lesion arising from the primary lung cancer. The second case describes a case of a 77-year-old woman with multiple co-morbidities who presented to the hospital with sepsis secondary to biliary source. Abdominal enhanced computed tomography findings were concerning for acute cholecystitis. After cholecystectomy, the pathology of the resected gallbladder demonstrated cholecystitis and plasmacytoma. Conclusion: The atypical presentation of gallbladder metastases could mislead treating providers. The diagnosis might alter management decisions and prognosis.

Download Full-text

Invasive ductal carcinoma (IDC), triple negative (TN) and inflammatory breast cancer (IBC): A Brazilian single institution experience

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.11548 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 11548-11548

Author(s):

S. O. Ramalho ◽

O. Martucci ◽

G. Redi ◽

A. Garcia ◽

J. Oliveira

Keyword(s):

Breast Cancer ◽

Invasive Ductal Carcinoma ◽

Inflammatory Breast Cancer ◽

Triple Negative ◽

Ductal Carcinoma ◽

Single Institution

Download Full-text

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

eLife ◽

10.7554/elife.65145 ◽

2021 ◽

Vol 10 ◽

Author(s):

Fernanda I Staquicini ◽

Amin Hajitou ◽

Wouter HP Driessen ◽

Bettina Proneth ◽

Marina Cardó-Vila ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Immune Response ◽

Cell Surface ◽

Vitamin D Receptor ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Antitumor Immune Response ◽

Tumor Associated Macrophages ◽

A Cell

Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a strategy for non-malignant target discovery. We identified a cyclic peptide (CSSTRESAC) that specifically binds to a vitamin D receptor, protein disulfide-isomerase A3 (PDIA3) expressed on the cell surface of tumor-associated macrophages (TAM), and targets breast cancer in syngeneic TNBC, non-TNBC xenograft, and transgenic mouse models. Systemic administration of CSSTRESAC to TNBC-bearing mice shifted the cytokine profile toward an antitumor immune response and delayed tumor growth. Moreover, CSSTRESAC enabled ligand-directed theranostic delivery to tumors and a mathematical model confirmed our experimental findings. Finally, in silico analysis showed PDIA3-expressing TAM in TNBC patients. This work uncovers a functional interplay between a cell surface vitamin D receptor in TAM and antitumor immune response that could be therapeutically exploited.

Download Full-text

Main phenotypes and histological types of breast cancer in young women attended at a reference hospital in women’s health in the city of São Paulo

Breast Cancer Management ◽

10.2217/bmt-2020-0021 ◽

2020 ◽

pp. BMT53

Author(s):

Guilherme Moreno Rodrigues de Souza ◽

Anderson Fernandes Carvalho ◽

Simone Ferreira Santiago ◽

Maria Aparecida M R Pinho ◽

Débora Ribeiro Ramadan ◽

...

Keyword(s):

Breast Cancer ◽

Invasive Ductal Carcinoma ◽

Young Women ◽

Triple Negative ◽

Ductal Carcinoma ◽

Luminal B ◽

High Prevalence ◽

Reference Hospital ◽

Triple Negative Phenotype ◽

The City

It is estimated that there were 198,840 new cases of breast cancer (BC) in Brazil between 2020 and 2022. Young women who are affected by invasive BC with a triple-negative phenotype generally present more aggressive tumors that are intrinsically resistant to targeted therapies. This study evaluated the phenotypic and histological profile of BC in women up to the age of 40 years. Between 2015 and 2017, we identified 255 women with positive biopsy for carcinoma and with immunohistochemical panel, 51.76% who had a profile for luminal B (n = 132); 22.74% for triple-negative (n = 58). Of the samples, 65.88% presented histology as invasive ductal carcinoma – nonspecial type (n = 168). The results are in accordance with the literature regarding the high prevalence of triple-negative BC in young women and histological type invasive ductal carcinoma – nonspecial type.

Download Full-text

Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma

Medicine ◽

10.1097/md.0000000000015449 ◽

2019 ◽

Vol 98 (18) ◽

pp. e15449 ◽

Cited By ~ 5

Author(s):

Jing-ping Li ◽

Xiang-mei Zhang ◽

Zhenzhen Zhang ◽

Li-hua Zheng ◽

Sonali Jindal ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Poor Prognosis ◽

Triple Negative ◽

Ductal Carcinoma ◽

P53 Expression ◽

Breast Invasive Ductal Carcinoma

Download Full-text

DCE-MRI Pharmacokinetic-Based Phenotyping of Invasive Ductal Carcinoma: A Radiomic Study for Prediction of Histological Outcomes

Contrast Media & Molecular Imaging ◽

10.1155/2018/5076269 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 14

Author(s):

Serena Monti ◽

Marco Aiello ◽

Mariarosaria Incoronato ◽

Anna Maria Grimaldi ◽

Michela Moscarino ◽

...

Keyword(s):

Invasive Ductal Carcinoma ◽

Outcome Prediction ◽

Triple Negative ◽

Ductal Carcinoma ◽

Tumor Grade ◽

Imaging Biomarker ◽

Diagnostic Tools ◽

Dce Mri ◽

Made In ◽

Treatment Personalization

Breast cancer is a disease affecting an increasing number of women worldwide. Several efforts have been made in the last years to identify imaging biomarker and to develop noninvasive diagnostic tools for breast tumor characterization and monitoring, which could help in patients’ stratification, outcome prediction, and treatment personalization. In particular, radiomic approaches have paved the way to the study of the cancer imaging phenotypes. In this work, a group of 49 patients with diagnosis of invasive ductal carcinoma was studied. The purpose of this study was to select radiomic features extracted from a DCE-MRI pharmacokinetic protocol, including quantitative maps of ktrans, kep, ve, iAUC, and R1 and to construct predictive models for the discrimination of molecular receptor status (ER+/ER-, PR+/PR-, and HER2+/HER2-), triple negative (TN)/non-triple negative (NTN), ki67 levels, and tumor grade. A total of 163 features were obtained and, after feature set reduction step, followed by feature selection and prediction performance estimations, the predictive model coefficients were computed for each classification task. The AUC values obtained were 0.826±0.006 for ER+/ER-, 0.875±0.009 for PR+/PR-, 0.838±0.006 for HER2+/HER2-, 0.876±0.007 for TN/NTN, 0.811±0.005 for ki67+/ki67-, and 0.895±0.006 for lowGrade/highGrade. In conclusion, DCE-MRI pharmacokinetic-based phenotyping shows promising for discrimination of the histological outcomes.

Download Full-text

Triple Negative Breast Cancer in Pregnancy and Postpartum: Two Case Reports in Hispanic Women

Case Reports in Obstetrics and Gynecology ◽

10.1155/2015/856931 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Ruchi Upadhyay ◽

Qurat-Ul-Ain Butt ◽

Abraham Hamaoui ◽

Cassandra Henderson ◽

Sydney McCalla ◽

...

Keyword(s):

Breast Cancer ◽

Invasive Ductal Carcinoma ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Ductal Carcinoma ◽

Hispanic Women ◽

African Ancestry ◽

Radical Mastectomy ◽

Unique Challenge ◽

Pregnancy And Postpartum

Objective. Despite studies suggesting that triple negative breast cancer is more often seen in women of African ancestry, we report here two cases of pregnancy associated triple negative breast cancer in Hispanic women.Cases. Case one is a 37-year-old female para 2-0-0-2, who presented with a left breast mass, at 19 weeks of gestation, the biopsy of which reported an invasive ductal carcinoma, found to be triple receptor negative. The patient underwent chemotherapy during the pregnancy and was delivered with a cesarean at 37 weeks for obstetric indication. After delivery, the patient completed her chemotherapy that was followed by radical mastectomy and radiotherapy. Case two is a 28-year-old female para 6-0-1-5, who presented while breast-feeding with signs and symptoms of mastitis, and an engorged and tender right breast, five months postpartum. However, the sonogram revealed a fluid filled cavity. Aspiration and cytology did not reflect an infection and were negative for malignancy. High suspicion and lack of improvement led to biopsy that identified an invasive ductal carcinoma, found to be triple negative. The patient underwent chemotherapy followed by modified radical mastectomy.Conclusions. Triple negative breast cancer, during pregnancy or postpartum, poses a unique challenge and requires a multidisciplinary team to optimize treatment for these women.

Download Full-text

Evaluation of CD30/CD4/CD8 in triple-negative invasive ductal carcinoma of breast in association with clinicopathological prognostic factors

Indian Journal of Pathology and Microbiology ◽

10.4103/ijpm.ijpm_67_18 ◽

2018 ◽

Vol 61 (4) ◽

pp. 500 ◽

Cited By ~ 1

Author(s):

NemaMohamadian Roshan ◽

AmirHossein Jafarian ◽

Aida Tasbandi ◽

Hamed Gilan ◽

Maryam Sheikhi

Keyword(s):

Prognostic Factors ◽

Invasive Ductal Carcinoma ◽

Triple Negative ◽

Ductal Carcinoma

Download Full-text

Concurrent Down-regulation of the EAF1 and the EAF2 Genes in the Invasive Ductal Carcinoma Type of Breast Cancer

Revista Gestão Inovação e Tecnologias ◽

10.47059/revistageintec.v11i2.1785 ◽

2021 ◽

Vol 11 (2) ◽

pp. 1620-1628

Author(s):

Sogand Heydaran

Keyword(s):

Breast Cancer ◽

Tumor Suppressor ◽

Real Time ◽

Invasive Ductal Carcinoma ◽

Triple Negative ◽

Ductal Carcinoma ◽

Rna Extraction ◽

P Value ◽

Control Analysis ◽

Down Regulation

In mammals, the EAF1 and EAF2 genes build an active transcription module with other components. These genes code for factors acting as potent inhibitor of the Wnt-β catenin pathway, which might be due to their function as tumor suppressor gene. Recently, the involvement of both above-mentioned factors was described in some human tumors, but not yet in breast cancer. Breast cancer is one of the most cancer cases in Iran after colon and stomach carcinoma. We aimed therefore to investigate for the first time a possible correlation between breast cancer and the EAF1 and the EAF2 gene expression. We collected invasive ductal carcinoma tumor grading (grade 1 to 3) with marginal normal tissue from forty women diagnosed with breast cancer with the average age of 50 years old. All patients underwent triple marker test (ER/PR and Her2/neu), indeed the most of them were triple positive with few triple negative individuals. After RNA extraction, cDNA was synthesized for subsequent real-time polymerase chain reaction. The humanRPL27 gene wasusedas endogenous control. Analysis of real-time PCR results showeda significant down-regulation of EAF1 (p-value: 0.028), and of EAF2 (p-value: 0.0134) in tumor tissue samples in comparison to normal one.There was no correlation between clinical parameters and the target genes. We could find significant connection between both tumor suppressor genes in triple positive and triple negative breast cancer patients, which deserves more attention.

Download Full-text