Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation

Objectives: To describe the spectrum of clinical and histopathological features of a case series of basal cell carcinoma (BCC) with spontaneous regression and to discuss this phenomenon. Method: Four cases of BCC with complete/substantial regression were retrospectively identified. Patients’ records were analyzed for demographic data, clinical appearance, and the postoperative course. Formalin-fixed, paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin and periodic acid Schiff. Results: Complete (n = 1) or partial (n = 3) regression of BCC was observed in 4 patients. Two lesions at the medial canthus were histologically diagnosed as nodular BCC with significant regression. One lesion at the lower eyelid exhibited a complete regression which did not require surgical intervention. The other lesion at the lower eyelid presenting with ulceration and madarosis was excised. Scar tissue without evidence for a neoplasm was present histologically. Subsequently, the patient developed a recurrence with a histologically proven micronodular BCC. Conclusions: BCC can show spontaneous substantial or complete regression. Histological tumor absence in lesions which are clinically suspicious for a neoplasm can be a hint for a regressive BCC. Recurrences may develop from remaining tumor islands warranting periodical clinical visits in cases of clinically as well as histologically suspected regressive BCC.

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Pyogenic granuloma associated with conjunctival epithelial neoplasia: report of nine cases

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312960 ◽

2019 ◽

Vol 103 (10) ◽

pp. 1469-1474 ◽

Cited By ~ 2

Author(s):

Martina C Herwig-Carl ◽

Hans E Grossniklaus ◽

Philipp L Müller ◽

Lisa Atzrodt ◽

Karin U Loeffler ◽

...

Keyword(s):

Demographic Data ◽

Periodic Acid ◽

Case Series ◽

Pyogenic Granuloma ◽

R0 Resection ◽

Surgical Removal ◽

Histopathological Analysis ◽

Periodic Acid Schiff ◽

Clinical Appearance ◽

Complete Surgical Excision

AimsTo systematically describe the clinical and histopathological features of a case series of conjunctival carcinomatous lesions underlying as—and also masquerading—pyogenic granuloma.MethodsNine cases of conjunctival carcinomatous lesions underlying a pyogenic granuloma (which were clinically predominant) were retrospectively identified. Patients’ records were analysed for demographic data, clinical appearance and the postoperative course. Formalin-fixed paraffin-embedded specimens were routinely processed and stained with H&E and periodic acid-Schiff. Immunohistochemical stains for cytokeratin were performed in selected cases.ResultsAll nine tumours were located in the conjunctiva (bulbar, tarsal, limbal conjunctiva) of patients between 44 and 80 years. The lesions exhibited clinical features of pyogenic granuloma which dominated the clinical appearance. Additional features comprised a papillomatous appearance of the adjacent conjunctiva, a more whitish aspect of the lesion and a history of squamous cell carcinoma (SCC) respectively surgery for other entities. Histopathological analysis revealed a carcinomatous lesion (conjunctival intraepithelial neoplasia or SCC) at the base of a classic pyogenic granuloma in all nine cases. Surgical removal (R0 resection) was performed. Three cases received adjuvant mitomycin C or interferon α2b treatment. Two lesions locally recurred within 2 years after initial presentation.ConclusionCarcinomatous lesions may be accompanied by a pyogenic granuloma which may dominate the clinical pictures. As the tumour is usually located at the base of the lesion, a complete surgical excision followed by histopathological analysis is mandatory for each lesion appearing as conjunctival pyogenic granuloma.

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Photodynamic therapy for facial skin cancer developed in the zone of previous radiotherapy (clinical case)

Biomedical Photonics ◽

10.24931/2413-9432-2021-10-2-42-50 ◽

2021 ◽

Vol 10 (2) ◽

pp. 42-50

Author(s):

E. V. Filonenko ◽

N. I. Grigoryevykh ◽

V. I. Ivanova-Radkevich

Keyword(s):

Photodynamic Therapy ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Tumor Therapy ◽

Lower Eyelid ◽

Complete Regression ◽

Upper Eyelid ◽

Eyelid Skin ◽

The Right

The results of a 13-year clinical observation of a patient after treatment for basal cell carcinoma of the skin of the right cheek Ist cT1N0M0 are presented. The history of the course of the disease is associated with the fact that the patient underwent radiation therapy in early childhood for hemangioma of the lower eyelid of the right eye and right cheek. In 2008, against the background of post-radiation changes in the area of the right cheek, basal cell carcinoma was diagnosed at the Moscow Oncological Research Institute. P.A. Herzen. At the Center for Laser and Photodynamic Diagnostics and Tumor Therapy, the patient underwent organ-preserving PDT treatment. A course of photodynamic therapy (PDT) with 5-aminolevulic acid was carried out. Subsequently, the patient was followed up until 2021 without relapse in the PDT area. In 2016, the patient was diagnosed with a relapse of the disease in the form of a new focus of basal cell carcinoma of the upper eyelid skin on the right Iast cT1N0M0. The patient underwent a course of PDT with a chlorin e6-based photosensitizer. Complete regression of the tumor was achieved, the period of relapse-free follow-up was 5 years.

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Local Recurrence and Ocular Adnexal Complications Following Electronic Surface Brachytherapy for Basal Cell Carcinoma of the Lower Eyelid

JAMA Dermatology ◽

10.1001/jamadermatol.2015.2613 ◽

2015 ◽

Vol 151 (9) ◽

pp. 1002 ◽

Cited By ~ 1

Author(s):

Kian Eftekhari ◽

Richard L. Anderson ◽

Gita Suneja ◽

Anneli Bowen ◽

Thomas J. Oberg ◽

...

Keyword(s):

Local Recurrence ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Lower Eyelid ◽

Electronic Surface

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Staged excision of primary periocular basal cell carcinoma: absence of residual tumour in re-excised specimens: a 10-year series

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312441 ◽

2018 ◽

Vol 103 (7) ◽

pp. 976-979 ◽

Cited By ~ 2

Author(s):

Lindsay A McGrath ◽

Adam Meeney ◽

Zanna I Currie ◽

Hardeep Singh Mudhar ◽

Jennifer H Tan

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Significant Proportion ◽

Surgical Excision ◽

Lower Eyelid ◽

Growth Patterns ◽

Residual Tumour ◽

Tumour Characteristics

AimsThe aim is to study staged periocular basal cell carcinoma (BCC) excision in a tertiary oculoplastic referral centre in Sheffield, UK. In particular, we examined patients with close or positive margins and no tumour seen on re-excision to identify demographics and tumour characteristics in this population.MethodsA retrospective review of medical records of 437 cases of staged periocular BCC excisions over a 10-year period (2007–2017) was carried out. Patients had surgical excision with 3 mm clinically clear margins. Staged excision was performed for all cases included in this study. Standard reconstruction techniques were employed. Histopathology was analysed for tumour type, subtype and stage.ResultsOver the 10-year period, of the 437 periocular BCCs, 156 had close or involved margins. Residual tumour was found in 29 (18.6%), whereas in 122 eyelids of 120 patients (78.2%) no residual tumour was identified on histological examination. Micronodular (54.1%) and nodular (23.7%) growth patterns of BCC, as well as lower eyelid location (72.1%), were the most prevalent in this population. Two patients (1.6%) had recurrence of BCC over a mean follow-up of 57 months (range 1–125 months).ConclusionsA significant proportion of BCCs transected on initial excision show no residual tumour in the re-excision specimens. In the interval between initial excision and re-excision, there may be eradication of the residual tumour. The exact mechanisms for this are unclear, however, and re-excision remains the appropriate recommended course in the presence of involved surgical margins of periocular BCC, particularly when high-risk tumour subtypes are encountered.

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Tumors associated with radiotherapy: a case series

Journal of Medical Case Reports ◽

10.1186/s13256-020-02482-x ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Mauricio Garcia ◽

Dary L. Hernandez ◽

Sara Mendoza ◽

Nelson Buelvas ◽

Angelina Alvarez ◽

...

Keyword(s):

Breast Cancer ◽

Basal Cell Carcinoma ◽

Cancer Treatment ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Case Series ◽

Breast Cancer Treatment ◽

Induced Tumors ◽

Incidence And Mortality

Abstract Background Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, there is an age-standardized incidence rate of 44 per 100,000 women. Radiotherapy improves local and regional control in patients with breast cancer, and it could even improve relapse-free survival and overall survival in patients with nodal disease. The toxicity of this treatment in most cases is mild and transient, but in a low percentage of patients, radiotherapy-induced tumors may develop. Case presentation Seven Colombian patients treated for breast cancer at our institution developed radiotherapy-induced tumors between 2008 and 2018. The median age was 54.4 (range 35–72) years. Six patients had locally advanced tumors at the time breast cancer was diagnosed, and all of them received neoadjuvant or adjuvant chemotherapy and radiotherapy. The radiotherapy-induced tumors were five sarcomas, one of which was a well-differentiated angiosarcomatous vascular lesion with negative c-Myc (benign lesion), and the remaining patient had basal cell carcinoma associated with radiotherapy. Conclusions Sarcomas are the most common radiotherapy-induced tumors after breast cancer treatment. These are rare, aggressive tumors and represent between 0.5% and 5.5% of all sarcomas. Basal cell carcinoma has also been associated with breast cancer treatment. The management is individualized and multimodal, including surgical resection and chemotherapy. Different studies have shown that radiation therapy is a risk factor for the development of soft tissue tumors.

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Palpebro-orbital Myiasis in a Patient with Basal Cell Carcinoma

European Journal of Ophthalmology ◽

10.1177/112067210901900426 ◽

2009 ◽

Vol 19 (4) ◽

pp. 683-685 ◽

Cited By ~ 5

Author(s):

Jose M. Abalo-Lojo ◽

Maria J. López-Valladares ◽

J. Llovo ◽

Abel Garcia ◽

Francisco Gonzalez

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Lower Eyelid ◽

Lucilia Sericata ◽

Orbital Exenteration ◽

Large Ulcer ◽

Cardiopulmonary Failure ◽

Life Threatening

Purpose We report a patient with basal cell carcinoma presenting with severe myiasis in a large ulcer involving the upper and lower eyelid. Methods Myiasis is an infestation of vertebrate animals by larvae of certain fly species. About 70 larvae were removed manually. A biopsy of the tissue underneath demonstrated a basal cell carcinoma. The myiasis was produced by the fly Lucilia sericata, currently used for treating chronic nonhealing ulcers. Because of the stage of the carcinoma, an orbital exenteration was carried out. Results The patient died 2 days later because of cardiopulmonary failure not related to the myiasis. Conclusions We present a case of a severe orbital myiasis focusing on its management and life-threatening nature.

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Possible recurrence of keratocyst in nevoid basal cell carcinoma syndrome: A review of literature

European Journal of Dentistry ◽

10.4103/1305-7456.119090 ◽

2013 ◽

Vol 07 (S 01) ◽

pp. S126-S134 ◽

Cited By ~ 2

Author(s):

Bassel Tarakji ◽

Kusai Baroudi ◽

Salah Hanouneh ◽

Saleh Naser Azzeghaiby ◽

Mohammad Zakaria Nassani

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Literature Search ◽

Case Series ◽

General Treatment ◽

Review Of Literature ◽

National Library ◽

Growth Capacity ◽

Significant Growth

ABSTRACTThis review will highlight some current areas of difficulty or controversy in diagnosis and treatment of nevoid basal cell carcinoma syndrome (NBCCS). The odontogenic keratocyst (OKC) has significant growth capacity and recurrence potential and is occasionally indicative of the NBCCS. The objective of this study is to clarify the causes of the recurrence of OKC in NBCCS. A literature search was conducted using Medline, accessed via the National Library of Medicine PubMed interface, searching for articles relating to the cause of recurrence of keratocyst in NBCCS written in English. This study has described the previous and the current outcomes of the treatment of OKC (recurrent cause). A protocol was then agreed to search for the possible causes of keratocyst recurrence in NBCCS. The general treatment of other manifestation of NBCCS has excluded from this study. Studies describing cohort, case series and miscellaneous clinical reports were retrieved and evaluated from 2010 to 2012.

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