scholarly journals Hepatocellular Carcinoma Metastasis to the Orbit in a Coinfected HIV+ HBV+ Patient Previously Treated with Orthotopic Liver Transplantation: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
S. Guerriero ◽  
G. Infante ◽  
E. Giancipoli ◽  
S. Cocchi ◽  
M. G. Fiore ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Past History ◽  
Bone Biopsy ◽  
Biopsy Specimens ◽  
First Case ◽  
History Of ◽  
Previously Treated ◽  
Carcinoma Metastasis ◽  
End Stage ◽  
Irregular Mass

Hepatocellular carcinoma rarely metastasizes to the orbit. We report a 45-year-old male, HBV+, HIV+, with a past history of a liver transplant for ELSD (end-stage liver disease) with hepatocellular carcinoma and recurrent HCC, who presented with proptosis and diplopia of the left eye. CT scans of the head revealed a large, irregular mass in the left orbit causing superior and lateral destruction of the orbital bone. Biopsy specimens of the orbital tumor showed features of metastatic foci of hepatocellular carcinoma. Only 16 other cases of HCC metastasis to the orbit have been described in literature, and this is the first case in a previously transplanted HIV+, HBV+ patient.

scholarly journals Peritoneal Dialysis and Malignancy: An Experience With a Patient Complicated by Gastric Carcinoma

2019 ◽  
Vol 12 ◽  
pp. 117954761983517 ◽  
Author(s):  
Tetsu Akimoto ◽  
Shigeaki Muto ◽  
Tatsuya Kutsuwada ◽  
Keiko Kutsuwada ◽  
Daisuke Nagata
Keyword(s):  
Peritoneal Dialysis ◽  
End Stage Kidney Disease ◽  
Cytological Examination ◽  
Hypertensive Nephrosclerosis ◽  
Biopsy Specimens ◽  
Borrmann Type ◽  
History Of ◽  
End Stage ◽  
Lesser Curvature ◽  
Type 3

An 86-year-old man who had been treated with peritoneal dialysis for 14°months due to end-stage kidney disease secondary to hypertensive nephrosclerosis presented with a recent history of malaise, abdominal discomfort, and anorexia. An endoscopic evaluation revealed an elevated, ulcerated, and friable lesion around the lesser curvature of the stomach. The concurrent gastric biopsy specimens revealed moderately differentiated adenocarcinoma, while a cytological examination of the dialysis fluid revealed clusters of malignant cells. This is the first report illustrating a case of a Borrmann type 3 gastric cancer with synchronous peritoneal involvement in which the assessment of the disease state was aided by the cytological analysis of peritoneal effluent. Several concerns relating to this pathology are also discussed.

scholarly journals Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Toufik Mahfood Haddad ◽  
Muhammad Sarfraz Nawaz ◽  
Ahmed S. Abuzaid ◽  
Smrithy Upadhyay ◽  
Pallavi Bellamkonda ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Past History ◽  
Uncontrolled Hypertension ◽  
African American Female ◽  
Pericardial Disease ◽  
First Case ◽  
Segmental Wall Motion ◽  
Segmental Wall ◽  
History Of ◽  
Artery Disease

Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.

Probable Tolosa-Hunt syndrome with a normal MRI

Cephalalgia ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 449-452 ◽  
Author(s):  
Mahmoud Abdelghany ◽  
Daniel Orozco ◽  
William Fink ◽  
Christopher Begley
Keyword(s):  
Past History ◽  
Cranial Nerves ◽  
Non Hodgkin Lymphoma ◽  
Hunt Syndrome ◽  
Unilateral Headache ◽  
Mild Improvement ◽  
History Of ◽  
Magnetic Resonance Imaging Mri ◽  
Stage Renal Disease ◽  
End Stage

Background We are reporting a rare case of a 60-year-old woman with a past history of end-stage renal disease and non-Hodgkin lymphoma who presented to our hospital with confusion, unilateral headache, painful ophthalmoplegia and ptosis. The patient was diagnosed clinically with Tolosa-Hunt syndrome (THS). Results THS is a diagnosis of exclusion. Other diseases were ruled out. Magnetic resonance imaging (MRI) of the brain and orbit was negative twice within a week. The patient was treated with corticosteroids with marked improvement of the orbital pain and headache and mild improvement of the cranial nerves palsy. Conclusion Clinical diagnosis of THS could be supported by radiological findings. According to the International Classification of Headache Disorders (ICHD)-3 beta diagnostic criteria, the diagnosis must be confirmed with an abnormal MRI and/or pathological sample. We add to the previous findings of THS with a normal MRI. Although MRI plays a crucial role in differential diagnosis, it should not, nor should the biopsy, be a must for the diagnosis. Limitations of using MRI in some patients are another problem.

scholarly journals Mixed cortico-medullary adrenal carcinoma in children: looks are deceptive!!

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Arti Khatri ◽  
Nidhi Mahajan ◽  
Niyaz Ahmed Khan ◽  
Natasha Gupta
Keyword(s):  
Past History ◽  
Case Reports ◽  
Final Diagnosis ◽  
Adrenal Carcinoma ◽  
Case Presentation ◽  
First Case ◽  
Contrast Enhanced ◽  
Paediatric Age ◽  
History Of ◽  
Enhanced Computed Tomography

Abstract Background Mixed cortico-medullary adrenal carcinoma (MCMAC) is an extremely rare entity with scarce literature on its cytomorphology. Case presentation A 2-year-old girl presented with abdominal pain for 3 days and a past history of fever with significant weight loss. On examination, a non-tender left hypochondrial firm mass and an enlarged left supraclavicular node were found. Twenty-four-hour urinary levels of VMA were marginally high. Contrast-enhanced computed tomography of the abdomen showed a suprarenal heterogeneous mass encasing major vessels. Aspiration cytology of both mass and node showed similar features comprising a predominant population of singly scattered large cells with moderate cytoplasm, eccentric nucleus and prominent nucleolus in a necrotic background. Tumour cells expressed Synaptophysin and Melan-A. In view of increasing respiratory distress, debulking surgery was performed, and histopathology of the specimen revealed the presence of both malignant medullary and cortical components supported by immunohistochemistry making a final diagnosis of MCMAC. The patient succumbed to death in the postoperative period. The cytology slides were reviewed and were seen to show a dual cell population. Conclusion Coexistent malignant cortical and medullary tumour of the adrenal gland is the first case reported in the paediatric age group in the literature with only three previous case reports in adults.

Modelling the past, current and future HCV burden in France: detailed analysis and perspectives

2008 ◽  
Vol 18 (3) ◽  
pp. 233-252 ◽  
Author(s):  
Sylvie Deuffic-Burban ◽  
Philippe Mathurin ◽  
Alain-Jacques Valleron
Keyword(s):  
Public Health ◽  
Hepatocellular Carcinoma ◽  
Public Health Policy ◽  
Past History ◽  
Epidemiological Data ◽  
The Past ◽  
Preliminary Model ◽  
History Of ◽  
Back Calculation ◽  
Related Mortality

Two national HCV projections have been published in France which assumed that a part of observed hepatocellular carcinoma (HCC) deaths is a consequence of HCV epidemic. They applied the back-calculation method, in combination with a Markov model, to reconstruct the past history of HCV infection and then to predict HCV-related mortality. A preliminary model was first developed in the absence of effective therapy. It allowed testing many assumptions to model HCV natural history that were compatible with observed incidence of HCV-related HCC deaths. This model was then updated to take into account the availability of treatment and more recent epidemiological data. These two models are described in detail and results are discussed with a view to addressing the models' limitations. The models offered a useful tool to assess public health policy scenarios in planning healthcare responses to the HCV epidemic.

scholarly journals Misled by the Xpert-Kikuchi’s disease masquerading as tuberculosis

2020 ◽  
Vol 8 (1) ◽  
pp. 174
Author(s):  
Aparna Krishnakumar ◽  
Elayaraja Sivaprakasam ◽  
Latha Ravichandran ◽  
Umapathy Pasupathy ◽  
Sarala Premkumar ◽  
...  
Keyword(s):  
Past History ◽  
Previous Treatment ◽  
Lymph Node Biopsy ◽  
Tuberculous Lymphadenitis ◽  
Intact Cells ◽  
Node Biopsy ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
Previously Treated ◽  
Tuberculosis Therapy

Kikuchi-Fujimoto disease (KFD), also called histiocytic-necrotizing lymphadenitis is a rare, idiopathic and self-limiting cause of lymphadenitis. Clinical presentation of KFD closely resembles nodal tuberculosis (TB). Here we present a case of an adolescent female whose diagnosis of KFD was made despite being misled in the course. A 15-year-old female, previously treated for tuberculous lymphadenitis was brought with complaints of fever for 1 month. Various possibilities considered were TB reactivation, autoimmune disorders, lymphoma. Lymph node biopsy for gene Xpert showed TB bacilli detected but low with no RIF resistance. Despite anti tuberculous treatment initiation, there was no improvement in the clinical condition. Histopathology of cervical node showed features of Kikuchi lymphadenitis. Literature search revealed that gene Xpert can detect the intact DNA of Mycobacterium tuberculosis even years after the previous treatment. On stopping anti tuberculosis therapy (ATT) and starting IV steroid, she started improving dramatically. KFD should always be kept as a differential diagnosis in any individual with fever and lymphadenopathy. Diagnosis can be misled in any patient based on gene Xpert reports alone which often turns out to be positive if there is past history of TB as gene Xpert detects DNA from non-intact cells suggesting that dead bacilli contribute to the false positivity.

scholarly journals Are we missing ‘previously treated’ smear-positive pulmonary tuberculosis under programme settings in India? A cross-sectional study

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 338
Author(s):  
Hemant Deepak Shewade ◽  
Vivek Gupta ◽  
Srinath Satyanarayana ◽  
Atul Kharate ◽  
Lakshmi Murali ◽  
...  
Keyword(s):  
Vulnerable Populations ◽  
Past History ◽  
National Level ◽  
Previous History ◽  
Case Finding ◽  
Active Case Finding ◽  
Active Case ◽  
Tb Treatment ◽  
History Of ◽  
Previously Treated

Background: In 2007, a field observation from India reported 11% misclassification among ‘new’ patients registered under the revised national tuberculosis (TB) control programme. Ten years down the line, it is important to know what proportion of newly registered patients has a past history of TB treatment. Methods: A study was conducted among new smear-positive pulmonary TB patients registered between March 2016 and February 2017 in 18 randomly selected districts to determine the effectiveness of an active case-finding strategy in marginalised and vulnerable populations. We included all patients detected through active case-finding. An equal number of randomly selected patients registered through passive case-finding from marginalised and vulnerable populations in the same districts were included. Before enrolment, we enquired about any history of previous TB treatment through interviews. Results: Of 629 patients, we interviewed 521, of whom, 11% (n=56) had past history of TB treatment (public or private) for at least a month: 13% (34/268) among the active case-finding group and 9% (22/253) among the passive case-finding group (p=0.18). No factors were found to be significantly associated with misclassification. Conclusion: Around one in every ten patients registered as ‘new’ had previous history of TB treatment. Corrective measures need to be implemented, followed by monitoring of any change in the proportion of ‘previously treated’ patients among all registered patients treated under the programme at national level.

scholarly journals HBV/HIV Coinfection: Impact on the Development and Clinical Treatment of Liver Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhimeng Cheng ◽  
Panpan Lin ◽  
Nansheng Cheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural History ◽  
Hepatitis B ◽  
Liver Diseases ◽  
Antiviral Treatment ◽  
Hiv Coinfection ◽  
B Virus ◽  
History Of ◽  
Chronic Hbv ◽  
End Stage

Hepatitis B virus (HBV) infection is a common contributor to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Approximately 10% of people with human immunodeficiency virus (HIV) also have chronic HBV co-infection, owing to shared transmission routes. HIV/HBV coinfection accelerates the progression of chronic HBV to cirrhosis, end-stage liver disease, or hepatocellular carcinoma compared to chronic HBV mono-infection. HBV/HIV coinfection alters the natural history of hepatitis B and renders the antiviral treatment more complex. In this report, we conducted a critical review on the epidemiology, natural history, and pathogenesis of liver diseases related to HBV/HIV coinfection. We summarized the novel therapeutic options for these coinfected patients.

scholarly journals A Cribriform Cancer Metastatic to Liver: Case Report and Literature Review

2019 ◽  
Vol 12 (2) ◽  
pp. 681-687 ◽  
Author(s):  
Annu Gupta ◽  
Padmaja V. Mallidi ◽  
Douglas J. Grider
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Past History ◽  
Hepatic Metastases ◽  
Distant Metastases ◽  
First Case ◽  
Complete Surgical Resection ◽  
History Of ◽  
Grade Malignancy ◽  
Hepatic Lesions

Metastasis from salivary gland tumors to liver is exceedingly uncommon. Reported is the first case of a mammary analog secretory carcinoma (MASC) of salivary gland origin metastasized to the liver, even after complete surgical resection. A 76 year old female, with past history of a completely extirpated right parotid gland MASC, presented 2 years after right superficial parotidectomy and right neck dissection, with back and flank pain. Subsequent abdominal and pelvic CT revealed multiple small hepatic lesions. Biopsy of the largest hepatic lesion confirmed metastatic MASC of primary parotid gland origin. Both the parotid primary and the hepatic metastases had the confirmatory ETV6 rearrangement by fluorescence in situ hybridization. Although high-grade malignancy and distant metastases of MASC of salivary gland origin to liver is rare, recognizing metastatic MASC potentially alters prognosis and determines therapeutic options.

Sign in / Sign up

Export Citation Format

Share Document