scholarly journals Acute Myeloid Leukemia Presenting as a Cardiac Mass

2020 ◽  
Vol 3 (3) ◽  
pp. 109-114
Author(s):  
Alia Magzoub Mohamed ◽  
Maysa Saleh ◽  
Fatima Alzarawani ◽  
Nermeen El-kholy
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Surgical Intervention ◽  
Systemic Disease ◽  
Signs And Symptoms ◽  
Cardiac Mass ◽  
Childhood Malignancy ◽  
Multi Agent ◽  
The Right ◽  
Acute Myeloid

Leukemias are the most common childhood malignancy. It is a systemic disease presenting with different signs and symptoms. Extramedullary manifestations, in particular myeloid sarcoma (MS), are extremely rare, often challenging to identify, even more challenging to diagnose, and more than often misdiagnosed owing to its similarity with other solid tumors. We describe a previously healthy boy, aged 4 years, who had a cardiac mass lesion, presumed to be a MS, noted in the right atrium at the time of initial routine echocardiography. The lesion resolved without surgical intervention following the institution of multi-agent chemotherapy.

Venetoclax for the treatment of elderly or chemotherapy-ineligible patients with acute myeloid leukemia: a step in the right direction or a game changer?

2021 ◽  
Vol 14 (2) ◽  
pp. 199-210
Author(s):  
Sonal Agarwal ◽  
Andrew Kowalski ◽  
Molly Schiffer ◽  
Jennifer Zhao ◽  
Jan Philipp Bewersdorf ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
The Right ◽  
Acute Myeloid ◽  
Game Changer

scholarly journals Acute Myeloid Leukemia: Advanced Practice Management From Presentation to Cure

2020 ◽  
Vol 11 (8) ◽  
Author(s):  
Meredith Beaton, RN, MSN, AG-ACNP ◽  
Glen J. Peterson, RN, DNP, ACNP ◽  
Kelly O'Brien, RN, MSN, ANP-C, ACNP-BC
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Performance Status ◽  
Treatment Options ◽  
Signs And Symptoms ◽  
The Elderly ◽  
Poor Performance Status ◽  
Curative Therapy ◽  
Initial Symptoms ◽  
Acute Myeloid

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, diagnosed in approximately 21,450 individuals annually in the US with nearly 11,000 deaths attributable to this disease (National Cancer Institute, 2020). Acute myeloid leukemia is a disease of the elderly, with the average age of diagnosis being 68 years old (Kouchkovsky & Abdul-Hay, 2016). It is a heterogeneous disease with widely varying presentations but universally carries a poor prognosis in the majority of those affected. Unfortunately, the 5-year overall survival rate remains poor, at less than 5% in patients over 65 years of age (Thein, Ershler, Jemal, Yates, & Baer, 2013). The landscape of AML is beginning to change, however, as new and improved treatments are emerging. Advanced practitioners (APs) are often involved in the care of these complex patients from the time of initial symptoms through diagnosis, treatment, and potentially curative therapy. It is vitally important for APs to understand and be aware of the various presentations, initial management strategies, diagnostic workup, and treatment options for patients with AML, especially in the elderly population, which until recently had few treatment options. This Grand Rounds article highlights the common presenting signs and symptoms of patients with AML in the hospital, including a discussion of the upfront clinical stability issues, oncologic emergencies, diagnostic evaluation, and current treatment options for elderly patients and those with poor performance status.

scholarly journals Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

2019 ◽  
Vol 9 (2) ◽  
pp. 133-135
Author(s):  
Meher Afsun ◽  
Rokon Uddin ◽  
Md Abu Baker ◽  
Iftekhar Ahmed
Keyword(s):  
Acute Myeloid Leukemia ◽  
Male Patient ◽  
Myeloid Leukemia ◽  
Clinical Presentation ◽  
Systemic Disease ◽  
Cutaneous Manifestation ◽  
Cutaneous Lesions ◽  
Initial Manifestation ◽  
Leukemia Cutis ◽  
Acute Myeloid

Leukemia cutis (LC) is a rare cutaneous manifestation of leukemia. Clinical presentation of the disease differs among patients depending on types. LC can precede, follow, occur simultaneously with, or present in the absence of the systemic leukemia. Leukemic involvement of the skin may appear as initial manifestation of recurrence or dissemination of systemic disease. Here we report a case of a 32-year-old male patient known to have acute myeloid leukemia with multiple cutaneous lesions diagnosed as LC. J Enam Med Col 2019; 9(2): 133-135

Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia.

1993 ◽  
Vol 11 (4) ◽  
pp. 690-697 ◽  
Author(s):  
M S Tallman ◽  
D Hakimian ◽  
J M Shaw ◽  
G S Lissner ◽  
E J Russell ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
World Literature ◽  
Granulocytic Sarcoma ◽  
Signs And Symptoms ◽  
Free Survival ◽  
A Cell ◽  
Karyotype Analyses ◽  
French American British ◽  
Acute Myeloid

PURPOSE Since the only three cases of granulocytic sarcoma among patients with acute myeloid leukemia (AML) seen at our institution during the last 12 years were each associated with the 8;21 translocation [t(8;21)], we sought to determine if this association is specific and more frequent than previously recognized. PATIENTS AND METHODS We report three patients with AML and t(8;21) who developed granulocytic sarcomas, and review the world literature. RESULTS Between 1980 and 1992, 53 cases of AML French-American-British (FAB) M2 were identified at our institution. Eight (15%) patients had t(8;21). Three of these eight patients (38%) developed granulocytic sarcoma. All three of our patients received conventional intensive antileukemic chemotherapy yet had short relapse-free survival durations. Several series of patients with t(8;21) report that granulocytic sarcomas occur in approximately 18% of this population, which is four times the expected incidence in AML. Thirty-seven cases have been previously reported. Although karyotype analyses were not reported in many cases of granulocytic sarcoma in the literature, the vast majority of abnormal karyotypes in patients with AML involved t(8;21). Recent work with a cell line derived from a patient with t(8;21) indicates that such cells are unusually adherent to culture bottles and are aggregable CONCLUSION Our data suggest that this association is more common than generally recognized and may be specific. Patients with t(8;21) should be observed closely for signs and symptoms of granulocytic sarcoma. These patients may have a less favorable prognosis than other patients with t(8;21). Cooperative oncology groups should retrospectively identify patients with AML and t(8;21) who had a poor outcome to determine if they had a disproportionate incidence of granulocytic sarcoma. If so, aggressive therapy such as bone marrow transplantation may be warranted early in the therapeutic strategy.

Cytogenetic and Molecular Characterization of Sweet's Syndrome in Patients with Acute Myeloid Leukemia.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2587-2587
Author(s):  
Syed M. Kazmi ◽  
Hagop M. Kantarjian ◽  
Kathy M. Tran ◽  
Jorge E. Cortes ◽  
Farhad Ravandi ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Skin Biopsy ◽  
Gene Mutation ◽  
Induction Chemotherapy ◽  
Retrospective Review ◽  
Myeloid Leukemia ◽  
Signs And Symptoms ◽  
Newly Diagnosed ◽  
Acute Myeloid

Abstract Abstract 2587 Background: Sweet's syndrome (SS), also known as acute febrile dermatosis, has been associated with hematologic malignancies including acute myeloid leukemia (AML). We sought to identify the disease characteristics of AML patients (pts) who develop SS, and to report the cytogenetic (CG) and molecular genetic (MG) abnormalities observed. Methods: We conducted a retrospective review of charts of newly diagnosed AML pts that underwent induction chemotherapy and had follow up at our institution. Pts with SS were identified if both the clinical signs and symptoms and a biopsy of the skin lesion were consistent with SS. CG and MG abnormalities are reported here as part of our descriptive analysis. Results: Between years 2000 to 2011, we identified a total of 2178 newly diagnosed AML pts that underwent induction chemotherapy and had follow-up at our institution. During this time, 697 pts (32%) underwent skin biopsies in the course of their AML treatment and follow-up. 21 pts (1% of all pts and 3% of all who underwent skin biopsy) demonstrated signs and symptoms and had skin biopsy consistent with SS. Table 1 summarizes the baseline characteristics of pts with AML at the time of dx of SS, including the CG and MG abnormalities observed. Myelodysplastic syndrome (MDS) prior to diagnosis of AML and SS was present in 9 pts (43%). CG analysis revealed diploid karyotype in 7 pts (33%), deletion 5p in 8 pts (38%; 4 pts had del5p as sole abnormality, and 4 pts with del5p as part of other accompanying/complex CG) and 4 patients had complex CG (19%). Most common MG abnormality was seen in the FLT3 gene, found in 7 out of 18 pts (39%) tested (FLT3 –ITD present in 4 pts while mutation of FLT3 codon 835 occurred in 3 pts). In addition, two out of 7 (28%) pts tested, had NPM1 gene mutation (one pt had concomitant FLT3 gene mutation). Other CG and MG abnormalities are summarized in Table 1. Eight pts (38%) with SS received systemic steroids for treatment, 1 pt (5%) received topical steroids while 19 (90%) received antibiotics and supportive care. The treatment for SS was effective in 16 out of 16 pts (100%) for whom follow-up information was available. Three pts required multiple courses of steroids while 5 pts required one course of steroids. The median time to improvement reported in the signs and symptoms of SS was 14 days (range 4–153). The median overall survival of AML pts who developed SS during course of their management was 14 months (95% confidence interval 12.6 – 15.4 months). Conclusions: SS is a frequent occurrence among AML pts as compared to its incidence in the general population. It can occur in AML pts during all phases of the disease. In this retrospective review, we found that SS frequently occurs in AML that has developed in the setting of prior MDS and where leukemic cells carry CG and MG abnormalities of del5p and FLT3 gene respectively. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The More, The Better: “Do the Right Thing” For Natural Killer Immunotherapy in Acute Myeloid Leukemia

2017 ◽  
Vol 8 ◽  
Author(s):  
Sarah Parisi ◽  
Mariangela Lecciso ◽  
Darina Ocadlikova ◽  
Valentina Salvestrini ◽  
Marilena Ciciarello ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
The Right ◽  
Do The Right Thing ◽  
Acute Myeloid

scholarly journals MANIFESTAÇÃO ORAL DA LEUCEMIA MIELÓIDE AGUDA COMO PRIMEIRO SINAL PARA O DIAGNÓSTICO: RELATO DE CASO

2014 ◽  
Vol 5 (2) ◽  
Author(s):  
Dhiancarlo Rocha Macedo ◽  
Carlos Henrique Alves De Rezende ◽  
Rogério Moreira Arcieri ◽  
Renata Silva Barbosa
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
Cervical Lymph Node ◽  
Malignant Disease ◽  
Medical Service ◽  
Oral Manifestation ◽  
The Right ◽  
Acute Myeloid

Acute myeloid leukemia (AML) is a malignant disease of the bone marrow that can present systemic and oral manifestation. In this case report we describe a patient, 16 years of age, who presented the oral manifestation ulcerated lesions on the dorsum of the tongue and cervical lymph node in the right region. After clinical examination and complementary tests, it was taken as a hypothesis the diagnosis of acute leukemia, and the patient was referred to a specialized medical service. Showing the importance of the dentist in the initial diagnosis of leukemia.

scholarly journals Gingival enlargement as oral manifestation in acute myeloid leukemia patient

2018 ◽  
Vol 50 (3) ◽  
pp. 154
Author(s):  
Sandra Olivia Kuswandani ◽  
Yuniarti Soeroso ◽  
Sri Lelyati C. Masulili
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Dental Health ◽  
Systemic Disease ◽  
Nutritional Intake ◽  
Gingival Hyperplasia ◽  
Oral Manifestation ◽  
Dental Management ◽  
Gingival Enlargement ◽  
Acute Myeloid

Background: Acute myeloid leukemia (AML) is a bone marrow cancer, a malignant disease that triggering the cells develops into different types of blood cells. It is widely recognized that the main manifestation of AML could be gingival hyperplasia and bleeding. Occasionally, an initial diagnosis of leukemia is made after a dental examination. In relation to systemic diseases, gingival enlargement could constitute the intensification of an existing inflammation initiated by dental plaque, or a manifestation of the systemic disease independent of the inflammatory condition of the gingiva. Gingival enlargement negatively affects the quality of life, especially nutritional intake. Purpose: This study aimed to report on gingival enlargement in AML patients, dental management of this condition and considerations when treating patients. Case: A 46 year-old woman diagnosed with AML who chiefly complained of gingival enlargement in all parts of the mouth which restricted her nutritional intake. Case management: The subject attended the clinic twice where nonsurgical treatment for the gingival enlargement, supragingival scaling and dental health education to maintain her oral hygiene was carried out. Unfortunately, she did not return for follow-up appointments due to having already passed away. Information about AML and its relation to gingival enlargement contained in the literature is also reviewed. Conclusion: In conclusion, gingival enlargement represents one oral manifestation of AML. This condition is related to and affects the nutritional intake of the patient.

scholarly journals Massive Thrombosis of the Right Atrium Extended to the Superior Vena Cava at the Diagnosis of Acute Myeloid Leukemia

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Bienvenu Houssou ◽  
Gnon Gourou Orou-Guiwa ◽  
Rachida Habbal ◽  
Meryem Qachouh ◽  
Asmaa Quessar
Keyword(s):  
Acute Myeloid Leukemia ◽  
Superior Vena Cava ◽  
Right Atrium ◽  
Myeloid Leukemia ◽  
Superior Vena ◽  
Vena Cava ◽  
Venous Thromboembolic ◽  
Pubmed Search ◽  
The Right ◽  
Acute Myeloid

Introduction. Venous thromboembolic disease is a common complication found in 8% of patients with acute myeloid leukemia. The location at the right atrium is exceptional. These last fifty years, only 6 cases of thrombosis of the atrium in the diagnosis of acute myeloid leukemia were published on PubMed search engine. Case Presentation. 35-year-old farmer, who had been admitted by emergency department for superior vena cava syndrome and had a hyperleukocytic AML with complex karyotype associated with a significant thrombosis of the right atrium, extended all along the superior vena cava. He has been treated by the 2011 AML protocol using low molecular weight heparin and died from respiratory distress. Conclusions. If thrombosis is common in AML, the location in right atrium is rare. Its management requires surgery that is sometimes difficult to achieve.

scholarly journals Severe lower limb ischemia by massive arterial thrombosis revealing an acute myeloid leukemia needing for leg amputation: clinical and emotional aspects related to the communication with the patient and his family

2016 ◽  
Vol 8 (4) ◽  
Author(s):  
Paolo D'Angelo ◽  
Calogero Taormina ◽  
Clara Mosa ◽  
Floriana Di Marco ◽  
Fabrizio Valentino ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Lower Limb ◽  
Myeloid Leukemia ◽  
External Iliac Artery ◽  
Acute Ischemia ◽  
Thrombotic Complication ◽  
Emotional Aspects ◽  
The Right ◽  
Leg Amputation ◽  
Acute Myeloid

Large vessel thrombosis is a very rare clinical presentation of acute leukemia, generally associated with coagulopathy, usually characteristic of acute promyelocytic leukemia. A 13- year-old boy with a previously undiagnosed acute myeloid leukemia was referred to our hospital with acute ischemia of the right lower limb due to occlusion of the right external iliac artery, treated with emergency double surgical thromboembolectomy and chemotherapy. The thrombotic complication resulted in leg amputation. Now the boy is well in complete remission, with a good social integration and quality of life, 30 months after completing treatment. The report highlights the crucial role of early diagnosis and subsequent chemotherapy in avoiding amputation. We particularly focused critical and emotional aspects related to the communication about the leg amputation with the patient and his family.

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