Pru p 3 Sublingual Immunotherapy in Patients with Lipid Transfer Protein Syndrome: Is It Worth?

2021 ◽  
pp. 1-8
Author(s):  
Juan María Beitia ◽  
Arantza Vega Castro ◽  
Remedios Cárdenas ◽  
Maria Isabel Peña-Arellano
Keyword(s):  
Sublingual Immunotherapy ◽  
Lipid Transfer Protein ◽  
Real Life ◽  
Food Challenge ◽  
Mediterranean Area ◽  
Tertiary Hospital ◽  
Control Group ◽  
Lipid Transfer ◽  
The Real ◽  
Pru P 3

<b><i>Background:</i></b> Lipid transfer proteins (LTPs) syndrome is an important cause of multiple plant food allergy in the Mediterranean area. The effectiveness of sublingual immunotherapy (SLIT) with the LTP Pru p 3 extract has been little investigated in the real-world setting. This study aimed to investigate the outcome of Pru p 3 SLIT in real-life patients with LTP syndrome with/without concurrent reactions to peanut and/or nuts. <b><i>Methods:</i></b> This was a prospective real-life study including all patients diagnosed with LTP allergy and treated with Pru p 3 SLIT between 2011 and 2018 in a tertiary hospital in Spain. Patients underwent open oral food challenge (OFC) tests for unpeeled peach and nuts/peanuts 1 year after the treatment started to assess food tolerance. A control group of patients diagnosed with LTP allergy who refused treatment with immunotherapy were included. Severity of symptoms and diet avoidance was recorded in both groups. <b><i>Results:</i></b> Twenty-nine patients with a median age of 24.7 years (range 5.5–43.1) were included: 100% were allergic to fruit; 72%, to peanut and/or nuts; 19 had a history of severe systemic reactions. Seven patients discontinued therapy; 3 (10%), due to adverse events. One year after SLIT start, 16 (73%) patients had negative OFC to peach; 95%, after 2 years; 69% had negative OFC to nuts/peanuts. The control group included 13 patients: 53.8% experienced reactions with new foods; severity of symptoms increased significantly (<i>p</i> &#x3c; 0.001), and diet restrictions were maintained in this group. <b><i>Conclusions:</i></b> SLIT with Pru p 3 shows a good safety profile, and avoid dietary restrictions in patients with LTP syndrome treated in the real-life setting.

scholarly journals Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe

Allergy ◽  
2017 ◽  
Vol 72 (9) ◽  
pp. 1415-1418 ◽  
Author(s):  
N. Mothes-Luksch ◽  
M. Raith ◽  
G. Stingl ◽  
M. Focke-Tejkl ◽  
E. Razzazi-Fazeli ◽  
...  
Keyword(s):  
Central Europe ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
Protein Sensitization ◽  
Pru P 3

Rice Allergy Demonstrated by Double-Blind Placebo-Controlled Food Challenge in Peach-Allergic Patients Is Related to Lipid Transfer Protein Reactivity

2013 ◽  
Vol 161 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Elide Anna Pastorello ◽  
Joseph Scibilia ◽  
Laura Farioli ◽  
Laura Primavesi ◽  
Maria Gabriella Giuffrida ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Food Challenge ◽  
Lipid Transfer ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Transfer Protein

scholarly journals Lipid Transfer Protein Syndrome in a Non-Mediterranean Area

2016 ◽  
Vol 169 (3) ◽  
pp. 181-188 ◽  
Author(s):  
Julian Azofra ◽  
Felicia Berroa ◽  
Gabriel Gastaminza ◽  
Noemi Saiz ◽  
Pedro M. Gamboa ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Mediterranean Area ◽  
Lipid Transfer ◽  
Transfer Protein

Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients

2020 ◽  
pp. 1-8
Author(s):  
Maria Ruano-Zaragoza ◽  
Maria Luisa Somoza ◽  
Teodorikez Wilfox Jiménez-Rodriguez ◽  
Victor Soriano-Gomis ◽  
Purificación González-Delgado ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Oral Allergy Syndrome ◽  
Skin Tests ◽  
Food Allergies ◽  
Lipid Transfer ◽  
Cross Sectional ◽  
Positive Skin ◽  
Pru P 3

<b><i>Background:</i></b> Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. <b><i>Objective:</i></b> The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. <b><i>Methods:</i></b> This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. <b><i>Results:</i></b> Our sample consisted of 421 people with a mean age of 33.25 years (range 16–68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. <b><i>Conclusion:</i></b> Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.

scholarly journals The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area

2021 ◽  
Vol 21 (2) ◽  
Author(s):  
Stephan Scheurer ◽  
Ronald van Ree ◽  
Stefan Vieths
Keyword(s):  
Mediterranean Area ◽  
Food Allergies ◽  
Lipid Transfer ◽  
Pollen Allergens ◽  
Lipid Transfer Proteins ◽  
High Exposure ◽  
The Mediterranean ◽  
Specific Lipid ◽  
Pru P 3

Abstract Purpose of Review To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. Recent Findings LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. Summary Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear.

scholarly journals Treatment with lipid transfer protein sublingual immunotherapy: slowing down new sensitizations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Irene García-Gutiérrez ◽  
Dasha Roa Medellín ◽  
Blanca Noguerado-Mellado ◽  
Mª Carmen Lillo Ordoñez ◽  
María Gabriela Abreu ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
Slowing Down

The role of profilin and lipid transfer protein in strawberry allergy in the Mediterranean area

2006 ◽  
Vol 36 (5) ◽  
pp. 666-675 ◽  
Author(s):  
L. Zuidmeer ◽  
E. Salentijn ◽  
M. F. Rivas ◽  
E. G. Mancebo ◽  
R. Asero ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Mediterranean Area ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
The Mediterranean

scholarly journals Energy Landscapes of Ligand Motion Inside the Tunnel-Like Cavity of Lipid Transfer Proteins: The Case of the Pru p 3 Allergen

2019 ◽  
Vol 20 (6) ◽  
pp. 1432
Author(s):  
Bruno Cuevas-Zuviría ◽  
María Garrido-Arandia ◽  
Araceli Díaz-Perales ◽  
Luis Pacios
Keyword(s):  
Lipid Transfer Protein ◽  
Protein A ◽  
Major Allergen ◽  
Cross Reactivity ◽  
Food Sources ◽  
Carrier Protein ◽  
Binding Modes ◽  
Lipid Transfer ◽  
Collective Variables ◽  
Pru P 3

Allergies are a widespread problem in western countries, affecting a large part of the population, with levels of prevalence increasingly rising due to reasons still not understood. Evidence accumulated in recent years points to an essential role played by ligands of allergen proteins in the sensitization phase of allergies. In this regard, we recently identified the natural ligand of Pru p 3, a lipid transfer protein, a major allergen from peach fruit and a model of food allergy. The ligand of Pru p 3 has been shown to play a key role in the sensitization to peach and to other plant food sources that provoke cross-reactivity in a large proportion of patients allergic to peach. However, the question of which is the binding pose of this ligand in its carrier protein, and how it can be transferred to receptors of the immune system where it develops its function as a coadjuvant was not elucidated. In this work, different molecular dynamics simulations have been considered as starting points to study the properties of the ligand–protein system in solution. Besides, an energy landscape based on collective variables that describe the process of ligand motion within the cavity of Pru p 3 was obtained by using well-tempered metadynamics. The simulations revealed the differences between distinct binding modes, and also revealed important aspects of the motion of the ligand throughout its carrier protein, relevant to its binding–unbinding process. Our findings are potentially interesting for studying protein–ligand systems beyond the specific case of the allergen protein dealt with here.

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