HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids

2021 ◽  
pp. 1-6
Author(s):  
Bisu Singh ◽  
Dependra Chamlagai ◽  
Jiwan Gurung
Keyword(s):  
Principal Component Analysis ◽  
Indian Population ◽  
Principal Component ◽  
Hierarchical Cluster ◽  
Hla Typing ◽  
North Indian Population ◽  
Genetic Affinity ◽  
Hla Polymorphism ◽  
The North ◽  
Homogenous Population

<b><i>Objective:</i></b> Based on the HLA profile of Indian Gorkhas, Debnath and Chaudhuri (2006) proposed that Gorkhas are genetically closer to Mongoloids, and they may have originated from Mongolians or Tibetan stocks. However, the major limitation of the earlier study was that Gorkhas comprise 2 broad groups, i.e. Tibeto-Burmans and Indo-Aryans. Besides, Gorkhas have an assemblage of many sociocultural and linguistically distinct populations such as Rai, Magar, Limbu, Tamang, Newar, Bahun, Kami, and so on. Thus, the generalization of the findings on Gorkhas by considering them as a single homogenous population may not be free from biases. Therefore, the present study aims to understand the genetic affinity of a constituent population from the Gorkha community, i.e. Kami, based on HLA polymorphism. <b><i>Methods:</i></b> First field HLA typing was performed among 158 Kami individuals by PCR-SSP methods. <b><i>Results:</i></b> The most frequent genes observed were HLA-A*11, HLA-B*15, HLA-DRB1*15. The frequency of HLA-DRB1*15 reported here is the highest recorded among the North Indian population to date, which is a noteworthy finding of the study. The hierarchical cluster analysis and principal component analysis showed that the Kami population lies within the cluster of the Indian subcontinental population. <b><i>Conclusion:</i></b> The study refutes the earlier proposition of exclusive belongingness of all the Gorkhas to Mongoloids.

Quality evaluation of tugaksheeree samples by ATR-FTIR spectroscopy using multicomponent analysis

2020 ◽  
Vol 10 ◽  
Author(s):  
Nikunj D. Patel ◽  
Niranjan S. Kanaki
Keyword(s):  
Principal Component Analysis ◽  
Cluster Analysis ◽  
Quality Evaluation ◽  
Principal Component ◽  
Hierarchical Cluster ◽  
Attenuated Total Reflectance ◽  
Chemometric Methods ◽  
Total Reflectance ◽  
Fingerprint Region ◽  
Ftir Technique

Background: Numerous Ayurvedic formulations contains tugaksheeree as key ingredient. Tugaksheereeis the starch gained from the rhizomes of two plants, Curcuma angustifoliaRoxb. (Zingiberaceae) and Marantaarundinacea (MA) Linn. (Marantaceae). Objective: The primary concerns in quality assessment of Tugaksheeree occur due to adulteration or substitution. Method: In current study, Fourier transform infrared (FTIR) technique with attenuated total reflectance (ATR) facility was used to evaluate tugaksheeree samples. Total 10 different samples were studied and transmittance mode was kept to record the spectra devoid of pellets of KBR. Further treatment was given with multi component tools by considering fingerprint region of the spectra. Multivariate analysis was performed by various chemometric methods. Result: Multi component methods like Principal Component Analysis (PCA), and Hierarchical Cluster Analysis (HCA)were used to discriminate the tugaksheeree samples using Minitab software. Conclusion: This method can be used as a tool to differentiate samples of tugaksheeree from its adulterants and substitutes.

scholarly journals IL-10(-592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population

2018 ◽  
Vol 34 (3) ◽  
pp. 281-285 ◽  
Author(s):  
Surabhi Yadav ◽  
Salman Akhtar ◽  
Surendra K. Agarwal ◽  
Gauranga Majumdar ◽  
Suman Vimal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Indian Population ◽  
Postoperative Atrial Fibrillation ◽  
Gene Variant ◽  
North Indian Population ◽  
The North

Impact of Interaction of Polymorphic Forms of p53 Codon 72 and N-Acetylation Gene (NAT2) on the Risk of Lung Cancer in the North Indian Population

2009 ◽  
Vol 28 (9) ◽  
pp. 443-449 ◽  
Author(s):  
Ranbir C. Sobti ◽  
Pushpinder Kaur ◽  
Satinder Kaur ◽  
Ashok K. Janmeja ◽  
Surinder K. Jindal ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Indian Population ◽  
North Indian Population ◽  
P53 Codon 72 ◽  
Codon 72 ◽  
The North ◽  
Polymorphic Forms

scholarly journals Multivariate characteristics of selected grass varieties for seed production

2019 ◽  
Vol 55 (No. 2) ◽  
pp. 83-86
Author(s):  
Marzena Iwańska ◽  
Danuta Martyniak ◽  
Marcin Martyniak ◽  
Dariusz Gozdowski
Keyword(s):  
Principal Component Analysis ◽  
Growth Rate ◽  
Cluster Analysis ◽  
Seed Production ◽  
Plant Resistance ◽  
Hierarchical Cluster Analysis ◽  
Multivariate Analyses ◽  
Principal Component ◽  
Hierarchical Cluster ◽  
Festuca Rubra

Data were obtained in a field experiment carried out at Plant Breeding and Acclimatization Institute Radzikow (central Poland) in 2009–2011. The aim of this study was a multivariate evaluation of 13 advanced lines and cultivars of Festuca rubra, taking into account traits important in seed production. Eleven traits of the grasses and plant resistance to diseases were evaluated. On the basis of multivariate analyses, i.e. hierarchical cluster analysis and principal component analysis, groups of varieties were separated and described, relationships between the traits were evaluated as well. The traits with the biggest influence on multivariate diversity of examined varieties were correlated with the first principal component i.e. height of plants, seeds yield, growth rate of plants, leaf width and time to beginning of earing.  

scholarly journals Reference Interval for Renal Profile parameters in North Indian Population from Rajasthan

2015 ◽  
Vol 1 (5) ◽  
pp. 233
Author(s):  
Dharmveer Yadav ◽  
Monika Gupta ◽  
Sandhya Mishra ◽  
Praveen Sharma
Keyword(s):  
Uric Acid ◽  
Reference Values ◽  
Indian Population ◽  
Reference Interval ◽  
Progressive Increase ◽  
Reference Intervals ◽  
North Indian Population ◽  
The North ◽  
Indian Origin ◽  
Objective Reference

Objective: Reference intervals are an essential part of laboratory medicine. Current study was planned to evaluate renal parameters in the healthy defined group of individuals which would serve as reference values of renal parameters for the North Indian population from Rajasthan.Design & Methods: Present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Fasting samples were analyzed for Urea, Creatinine, Uric Acid, Sodium, Potassium and Chloride. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0.Result: RI for Urea, Creatinine and uric acid were lower in female (16-42mg/dl, 0.6-1.2mg/dl, 2.4-6.8mg/dl) as compared to male (17.00-44.35mg/dl, 0.7-1.5mg/dl, 2.8-7.2mg/dl). There was a progressive increase in urea, uric acid and Creatinine with increase in age. Though no appreciable differences could be observed in respect to most of renal parameters in rural versus urban, a wider range for uric acid was observed in urban population (2.50-7.20mg/dl). Except for Na+, K+ and Cl-, rest of parameters i.e. urea, creatinine, uric acid were higher range in obese as compared to non obese (17-45 Vs 17-44, 0.66-1.5 Vs 0.60-1.40, 2.5-7.4 Vs 2.5-7.0). Uric acid level was also found to be higher in non vegetarian population (2.6-7.5mg/dl).Conclusion: Findings of this study provide sex, age, BMI, habitat and diet specific renal function reference values to be used for North Indian population.

Seasonal and monthly variation of stroke and its subtypes in the north Indian population

2019 ◽  
Vol 405 ◽  
pp. 130
Author(s):  
S. Misra ◽  
P. Talwar ◽  
A. Mishra ◽  
A. Kumar ◽  
P. Kumar ◽  
...  
Keyword(s):  
Indian Population ◽  
North Indian Population ◽  
Monthly Variation ◽  
The North
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