scholarly journals Interleukin-6 in Amniotic Fluid: A Reliable Marker for Adverse Outcomes in Women in Preterm Labor and Intact Membranes

2021 ◽  
pp. 1-8
Author(s):  
Alfredo Leaños-Miranda ◽  
Ana Graciela Nolasco-Leaños ◽  
Reyes Ismael Carrillo-Juárez ◽  
Carlos José Molina-Pérez ◽  
Irma Isordia-Salas ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Delivery ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Adverse Outcomes ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Increased Risk ◽  
Reliable Marker ◽  
Suitable Marker

<b><i>Introduction:</i></b> Amniotic fluid (AF) interleukin-6 (IL-6) concentration has been associated to preterm delivery and perinatal morbidity and mortality in women with preterm labor and intact membranes. Nevertheless, the clinical significance of this biomarker of intra-amniotic inflammation (IAI) is still unclear due in part to the paucity of large studies. <b><i>Methods:</i></b> AF IL-6 concentrations were determined in 452 consecutive women with preterm labor and intact membranes, categorized into 3 groups: 302 without IAI (IL-6 of &#x3c;2.6 ng/mL), 64 with mild IAI (IL-6 of 2.6–11.2 ng/mL), and 86 with severe IAI (IL-6 of ≥11.3 ng/mL). <b><i>Results:</i></b> The severe IAI group had a short pregnancy duration from amniocentesis to delivery (median 3 days) than in without IAI group (median 45 days); meanwhile, the mild IAI group had a latency that was intermediate to the severe and without IAI groups (median 9.5 days). As compared to women without IAI, women with mild and severe IAI had higher rates of preterm delivery at both &#x3c;34 and &#x3c;37 weeks of gestation and perinatal morbidity and mortality. Furthermore, the risk of various individual adverse outcomes (short latency from amniocentesis to delivery [at ≤3 days, ≤7 days, and ≤14 days], preterm delivery at both &#x3c;34 and &#x3c;37 weeks of gestation, histologic chorioamnionitis, respiratory distress syndrome, and congenital sepsis) was higher in women with severe IAI (OR ≥ 2.8), compared with women without IAI. <b><i>Conclusions:</i></b> AF IL-6 concentrations appear to be suitable marker to assess the degree of IAI and are associated with increased risk of adverse outcomes.

Medically indicated late preterm delivery and its impact on perinatal morbidity and mortality: a retrospective population-based cohort study

2018 ◽  
Vol 32 (19) ◽  
pp. 3278-3287 ◽  
Author(s):  
Limor Besser ◽  
Liat Sabag-Shaviv ◽  
Maayan Yitshak-Sade ◽  
Salvatore Andrea Mastrolia ◽  
Danielle Landau ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Delivery ◽  
Population Based ◽  
Late Preterm ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity

scholarly journals Maternal and fetal outcome in oligohydramnios after 34 weeks of gestation

2018 ◽  
Vol 7 (11) ◽  
pp. 4604
Author(s):  
Mahantappa A. Chiniwar ◽  
Joe Kaushik M. ◽  
Sharada B. Menasinkai
Keyword(s):  
Amniotic Fluid ◽  
Fetal Outcome ◽  
Morbidity And Mortality ◽  
Research Centre ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Perinatal Morbidity ◽  
Amniotic Fluid Index ◽  
Chi Square

Background: Oligohydramnios is one of the major causes of maternal and perinatal morbidity and mortality. It is a clinical condition characterized by Amniotic Fluid Index (AFI) ≤5 cm by sonographic assessment. The aim of present study is to know the maternal and fetal outcome in oligohydramnios after 34 weeks of gestation compared with women who had normal volume of amniotic fluid.Methods: Study was done for the period of 21 months from November 2014-July 2016 at Adichunchanagiri Institute of Medical Sciences, Hospital and Research Centre Bellur. 50 antenatal cases with > 34 weeks of gestation with AFI ≤5 cm by ultrasonographic estimation were included as study group and 50 women with normal AFI were included as control group. Maternal and fetal outcome of the women with oligohydramnios were analyzed and compared with control group.Results: Results were analyzed statistically using parameters like mean, SD, Chi Sq test, P value. Amniotic fluid was clear in 32% in study and 78% in control group, thin meconium stained in 30% in study group and 14%in control group and was thick meconium stained in 38% in study group and 8% in control group (Chi square =22.31, p<0.0001). Induction of labour was done in 54% in study group and 20% in control group. Cesarean delivery was done in 58% in study group women and 28% in control group women. Regarding the birth weight of babies 62% were < 2.5 kg in study group and 18% in control group with p<0.001. 10% of babies in study group required NICU admission and perinatal mortality was 2%.Conclusions: Due to increased perinatal morbidity and mortality and increased rate of LSCS, timely decision during labour is important to reduce perinatal morbidity and mortality.

Amniotic Fluid Interleukin-18 and Interleukin-6 in Preterm Labor with Intraamnionic Infection

2002 ◽  
Vol 99 (Supplement) ◽  
pp. 8S
Author(s):  
Chaur-Dong Hsu ◽  
Jacqueline A. Pavlik ◽  
Jiann-Hwa Wang ◽  
Athanasios Ninios ◽  
Hassan Harirah
Keyword(s):  
Amniotic Fluid ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Interleukin 18

scholarly journals EFFECTIVENESS AND SAFETY DIFFERENCES OF ISOXSUPRINE AND NIFEDIPINE AS TOCOLYTICS IN THE RISK OF PRETERM LABOR

2017 ◽  
Vol 53 (4) ◽  
pp. 242
Author(s):  
Nur Oktavia ◽  
Yulistiani Yulistiani ◽  
Unedo H Markus ◽  
Hendriette Irene Mamo
Keyword(s):  
Observational Study ◽  
Preterm Labor ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Premature Labor ◽  
The Difference

Premature labor is a cause of high rates of perinatal morbidity and mortality. The use of tocolytics is one of the efforts to handle the risk of preterm labor. Tocolytics which are widely used in Indonesia is isoxsuprine and nifedipine. The purpose of this study was to identify the difference of effectiveness and safety of isoxsuprine as tocolytics in the risk of preterm labor. This was an observational study in the form of a case study that was done in detail and depth to the patients who were diagnosed as imminent preterm labor. In conclusion, there were differences in the effectiveness and safety of isoxsuprine and nifedipine as tocolytics in the risk of preterm labor.

Prolonged pregnancy

2020 ◽  
pp. 389-394
Author(s):  
Kate F. Walker ◽  
Jim G. Thornton
Keyword(s):  
Caesarean Section ◽  
Pregnancy Loss ◽  
Expectant Management ◽  
Induction Of Labour ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Increased Risk ◽  
Oxytocin Infusion ◽  
Prolonged Pregnancy ◽  
Overall Risk

Prolongation of gestation beyond 42+0 weeks (or 294 days) affects about 6% of pregnancies. It is associated with an increased risk of perinatal morbidity and mortality; the overall risk of pregnancy loss (stillbirth plus death occurring up to the age of 1 year) increases eightfold between 37 weeks and 43 weeks. Since trials comparing induction of labour with expectant management suggest that induction does not increase the rate of caesarean section, many clinicians offer it for pregnancies beyond 41 weeks. Induction of labour is usually performed using prostaglandin ripening followed, if necessary, by amniotomy and oxytocin infusion.

Amniotic Fluid Interleukin-6 and Interleukin-8 Levels Predict the Success of Tocolysis in Patients With Preterm Labor

1994 ◽  
Vol 1 (4) ◽  
pp. 264-268 ◽  
Author(s):  
John R. Allbert ◽  
Robert W. Naef ◽  
Kenneth G. Perry ◽  
Everett F. Magann ◽  
Neil S. Whitworth ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Interleukin 8

Ultrasonography of the uterine cervix and preterm delivery

1999 ◽  
Vol 11 (1) ◽  
pp. 7-16
Author(s):  
Vilho Hiilesmaa ◽  
Pekka Taipale
Keyword(s):  
Preterm Delivery ◽  
Premature Birth ◽  
Clinical History ◽  
Premature Delivery ◽  
Perinatal Morbidity ◽  
Second Trimester ◽  
Uterine Contractions ◽  
The Past ◽  
Increased Risk ◽  
Digital Evaluation

The incidence of premature delivery (at less than 37 completed weeks) has been stable at between 5–10% of deliveries over the past 20 years despite intensive research in this field. Preterm delivery is a major cause of perinatal morbidity and mortality. The identification of women at increased risk for this condition has traditionally been based on clinical history (e.g. previous premature birth or second-trimester miscarriage), digital evaluation of the cervix and the occurrence of uterine contractions.

Anesthesia-Related Factors Associated with Preterm Labor and Delivery after Open Fetal Surgery

2020 ◽  
pp. 1-8
Author(s):  
Titilopemi A.O. Aina ◽  
Huirong Zhu ◽  
Jonathan Kim ◽  
Kobby A. Wiafe ◽  
Ahmed A. Nassr ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Preterm Labor ◽  
Diastolic Pressure ◽  
Anesthetic Management ◽  
Fetal Surgery ◽  
In Utero ◽  
Labor And Delivery ◽  
Maternal Complications ◽  
Related Factors ◽  
Increased Risk

<b><i>Background:</i></b> Fetal surgery, such as for meningomyelocele repair, has a clear clinical fetal benefit. In patients who undergo in utero repair of meningomyelocele, for example, there is reduced long-term disease morbidity. However, despite the beneficial effects of early intervention, women who undergo fetal interventions have an increased risk of preterm labor and delivery. Several surgery-related factors have been described but no specific anesthesia-related factors. <b><i>Objective:</i></b> The aim of this study was to determine if any aspects of the perioperative anesthetic management influenced maternal complications following in utero surgery. <b><i>Methods:</i></b> This was a retrospective chart review of the anesthetic management of mothers and fetuses who presented for open and fetoscopic myelomeningocele repair, between 2011 and 2015, at Texas Children’s Fetal Center®. <b><i>Results:</i></b> Forty-six women underwent open or fetoscopic repair of neural tube defects at our institution. We found the maternal heart rate in the postoperative period to be associated with a higher likelihood of preterm labor, but not delivery. The odds of having preterm delivery was higher for nulliparous patients and those with lower intraoperative diastolic pressure. <b><i>Conclusions:</i></b> Our findings confirm what has been previously reported regarding the association of nulliparity with preterm delivery. Additionally, this study highlights the importance of maintaining stable perioperative hemodynamics during the intraoperative and postoperative phases of care for patients undergoing in utero surgery.

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