European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis

Background: The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content (<50 g/day), 1–1.5 g of protein/kg of ideal body weight, 15–30 g of fat/day, and a daily intake of about 500–800 calories. Objectives: The aim of the current document is to suggest a common protocol for VLCKD and to summarize the existing literature on its efficacy in weight management and weight-related comorbidities, as well as the possible side effects. Methods: This document has been prepared in adherence with Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Literature searches, study selection, methodology development, and quality appraisal were performed independently by 2 authors and the data were collated by means of a meta-analysis and narrative synthesis. Results: Of the 645 articles retrieved, 15 studies met the inclusion criteria and were reviewed, revealing 4 main findings. First, the VLCKD was shown to result in a significant weight loss in the short, intermediate, and long terms and improvement in body composition parameters as well as glycemic and lipid profiles. Second, when compared with other weight loss interventions of the same duration, the VLCKD showed a major effect on reduction of body weight, fat mass, waist circumference, total cholesterol and triglyceridemia as well as improved insulin resistance. Third, although the VLCKD also resulted in a significant reduction of glycemia, HbA1c, and LDL cholesterol, these changes were similar to those obtained with other weight loss interventions. Finally, the VLCKD can be considered a safe nutritional approach under a health professional’s supervision since the most common side effects are usually clinically mild and easily to manage and recovery is often spontaneous. Conclusions: The VLCKD can be recommended as an effective dietary treatment for individuals with obesity after considering potential contra-indications and keeping in mind that any dietary treatment has to be personalized. Prospero Registry: The assessment of the efficacy of VLCKD on body weight, body composition, glycemic and lipid parameters in overweight and obese subjects: a meta-analysis (CRD42020205189).

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The effectiveness of technology-based distance weight loss interventions on body composition in health care: a systematic review, meta-analysis and meta-regression (Preprint)

10.2196/preprints.25906 ◽

2020 ◽

Author(s):

Heli Lahtio

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Body Composition ◽

Waist Circumference ◽

Body Fat ◽

Meta Analysis ◽

Body Fat Percentage ◽

Fat Percentage ◽

Meta Regression ◽

Weight Loss Interventions

BACKGROUND Overweight and obesity are major problems worldwide and they lead to an increased risk for several diseases. The use of technology in the treatment of obesity is promising, but there is considerable uncertainty regarding its efficacy in the current literature. OBJECTIVE The aim of this systematic review was to study the effectiveness of technology-based distance weight loss interventions in health care on body composition in comparison to control groups that do not use technology. The aim of the meta-regression was to evaluate the factors associated with the changes in body composition outcomes in a comprehensive PICOS -framework. METHODS Studies were searched from eight databases. The inclusion criteria were developed based on the PICOS-framework (population: 18-65 years; intervention: technology-based distance weight loss interventions; comparison: control groups without technology; outcome: BMI, waist circumference or body fat percentage; study design: randomized controlled trial). Meta-analysis and meta-regression were performed. RESULTS The meta-analysis included 30 studies. The quality of the studies was moderate (7/13). A statistically significant difference was observed in BMI (MD 0.83; 95% CI 0.51 to 1.15; P < .0001), waist circumference (MD 2.45; 95% CI 1.83 to 3.07; P < .0001), and body fat percentage (MD 1.07; 95% CI 0.74 to 1.41; P < .0001) in favor of the weight loss groups using technology. According to the findings of the meta-regression, interventions with personal feedback and higher quality of the studies may have been associated with a reduction in waist circumference and lower body fat percentage. CONCLUSIONS Technology-based distance weight loss interventions significantly reduced BMI, waist circumference, and body fat percentage. Future studies should focus on the comparability of the intervention content but also on the relations between the type of technology, behavioral change models, and biopsychosocial factors. CLINICALTRIAL This systematic review is registered in Prospero (CRD42016035831).

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The effectiveness of physical activity-promoting web- and mobile-based distance weight loss interventions on body composition in rehabilitation settings: a systematic review, meta-analysis, and meta-regression (Preprint)

Journal of Medical Internet Research ◽

10.2196/25906 ◽

2020 ◽

Author(s):

Heli Lahtio ◽

Aki Rintala ◽

Jaakko Immonen ◽

Tuulikki Sjögren

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Weight Loss ◽

Body Composition ◽

Meta Analysis ◽

Meta Regression ◽

Weight Loss Interventions

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Incidence of successful pregnancy after weight loss interventions in infertile women: a systematic review and meta-analysis of the literature

10.26226/morressier.573c1513d462b80296c988c4 ◽

2016 ◽

Author(s):

Loredana Maria Sosa Fernandez

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Meta Analysis ◽

Successful Pregnancy ◽

Infertile Women ◽

Weight Loss Interventions

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Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis

Systematic Reviews ◽

10.1186/s13643-019-1205-3 ◽

2019 ◽

Vol 8 (1) ◽

Cited By ~ 2

Author(s):

Denise Grotto ◽

Isabella Ferreira Camargo ◽

Katia Kodaira ◽

Lauren Giustti Mazzei ◽

Juliana Castro ◽

...

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Body Weight ◽

Animal Models ◽

Meta Analysis ◽

Experimental Studies ◽

Body Weight Loss ◽

Preclinical Research ◽

Medicinal Mushrooms ◽

Aquatic Mammal

Abstract Background Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body weight are uncertain. The aim of this systematic review is to determine the efficacy of mushrooms in weight loss in animal preclinical models. Method This is a systematic review of preclinical studies of animal models of obesity (any type of non-aquatic mammal), which were exposed to edible and medicinal mushrooms orally in comparison with the control. The following databases will be used: MEDLINE (PubMed), Web of Science, BIOSIS, SCOPUS, and gray literature. There will be no restriction of language, date, or publication status. The primary outcome will be body weight loss. And the secondary outcomes include the total amount of food consumed by the animals, analysis of metabolic parameters, inflammatory mediators, mortality for any causes, and any adverse effect reported. A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias risk (using SYstematic Review Centre for Laboratory animal Experimentation SYRCLE’s risk of bias tool and the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist). The standardized mean difference (SMD) will be calculated to measure treatment effect, with 95% confidence intervals (95% CI). The heterogeneity between-study will be calculated by I2 inconsistency values and Cochran’s Q statistical test, where I2 > 50% and/or p < 0.10 suggest high heterogeneity meta-analyses of random effects will be conducted as possible. Discussion Although many experimental studies about the effects of mushrooms on obesity have already been published, there is still no consensus in the literature. This study will provide evidences of preclinical research on mushrooms and their relation to body weight loss in animal models of obesity, being non-aquatic mammals. Also, this systematic review will show the limitations and strengths of the studies available in the literature, as well as it will to encourage the financing of new studies by public health managers and governmental entities. Systematic review registration PROSPERO (CRD42019125299).

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