scholarly journals Effect of Delayed Cord Clamping on Neurodevelopment at 3 Years: A Randomized Controlled Trial

Neonatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Johan Henrik Martin Berg ◽  
Manuela Isacson ◽  
Omkar Basnet ◽  
Rejina Gurung ◽  
Kalpana Subedi ◽  
...  
Keyword(s):  
At Risk ◽  
Motor Development ◽  
Controlled Trial ◽  
Delayed Cord Clamping ◽  
Pronounced Difference ◽  
Gross Motor ◽  
Iron Stores ◽  
Gross Motor Development ◽  
Cord Clamping ◽  
Ages And Stages Questionnaire

<b><i>Introduction:</i></b> Iron deficiency (ID) is associated with poor neurodevelopment. We have previously shown that delayed umbilical cord clamping (CC) improves iron stores at 8 months and neurodevelopment at 1 year in term, healthy infants in Nepal. <b><i>Objective:</i></b> The aim of this study was to assess the effects of delayed CC (≥180 s) compared to early CC (≤60 s) on neurodevelopment using the Ages and Stages Questionnaire (ASQ) at age 3 years. <b><i>Methods:</i></b> In 2014, 540 healthy Nepalese infants born at term were randomized in a 1:1 ratio to delayed or early CC. At 3 years of age, ASQ assessment was performed by phone interviews with parents. A score &#x3e;1 standard deviation below the mean was defined as “at risk” for developmental impairment. <b><i>Results:</i></b> At 3 years of age, 350 children were followed up, 170 (63.0%) in the early CC group and 180 (66.7%) in the delayed CC group. No significant differences in ASQ scores in any domains between groups were found. However, more girls were “at risk” for affected gross motor development in the early CC group: 14 (18.9%) versus 6 (6.3%), <i>p</i> = 0.02. <b><i>Conclusion:</i></b> There were no significant differences in ASQ scores in any domains between groups. In the subgroup analysis, fewer girls who underwent delayed CC were “at risk” for delayed gross motor development. Due to the pronounced difference in iron stores at 8 months postpartum in this cohort, follow-up studies at an older age are motivated since neurodevelopmental impairment after early ID may be more detectable with increasing age.

scholarly journals Gross Motor Development of Children with Congenital Heart Disease Receiving Early Systematic Surveillance and Individualized Intervention: Brief Report

2019 ◽  
Author(s):  
Solène Fourdain ◽  
Marie-Noëlle Simard ◽  
Lynn Dagenais ◽  
Manuela Materassi ◽  
Amélie Doussau ◽  
...  
Keyword(s):  
At Risk ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Physical Therapy ◽  
Motor Development ◽  
Congenital Heart ◽  
Gross Motor ◽  
Motor Abilities ◽  
Gross Motor Development ◽  
Risk Patients

Objective: In this pilot study, we described the gross motor development of infants aged 4 to 24 months with congenital heart disease (CHD) and assessed through a systematic develop&shy;mental screening programme, with individualised motor interventions. Methods: Thirty infants who had cardiac repair underwent gross motor evaluations using the AIMS at 4 months, and the Bayley-III at 12 and 24 months. Results: Based on AIMS, 80% of 4-month-old infants had a delay in gross motor development and required physical therapy. Gross motor abilities significantly improved by 24 months. Infants who benefited from regular physiotherapy tended to show better improvement in motor scores. Conclusion: Our study highlights the importance of early motor screening in infants with CHD and suggests a potential benefit of early physical therapy in those at-risk. Further research is needed to assess the effectiveness of systematic developmental screening and individualized inter&shy;vention programmes at identifying at risk patients, and their impact on developmental outcomes.

Effect of cerebrolysin on neurodevelopmental outcome of high risk preterm infants: A randomized controlled trial

2021 ◽  
pp. 1-9
Author(s):  
A. Samir ◽  
N. Nasef ◽  
K. Fathy ◽  
A-H. El-Gilany ◽  
S. Yahia
Keyword(s):  
High Risk ◽  
Preterm Infants ◽  
Motor Development ◽  
Intervention Program ◽  
Controlled Trial ◽  
Intervention Group ◽  
Fine Motor ◽  
Early Intervention Program ◽  
Gross Motor ◽  
Gross Motor Development

BACKGROUND: A significant proportion of preterm infants experience developmental delay despite receiving a post discharge early interventional care. Cerebrolysin is a peptide mixture which acts similar to endogenous neurotrophic factors through promoting neurogenesis and enhancing neuronal plasticity. OBJECTIVE: To compare the effect of Cerebrolysin plus routine intervention program versus routine intervention program alone on the outcome of preterm infants at high risk for neurodevelopmental delay. METHODS: In a randomized controlled trial, high-risk preterm infants <  32 weeks’ gestation who have abnormal neurological assessment at two months corrected post-natal age were randomized at 6 months corrected post natal age to receive either early intervention program or early intervention program plus Cerebrolysin injection of 0.1 mL/kg body weight every week for 3 months as an adjuvant therapy. The primary outcome was the rate of failure of the gross motor assessment at 12 months of corrected age and secondary outcomes included fine motor, language, and personal social development at 12 months corrected post-natal age as assessed by Denver Developmental Screening Test II. RESULTS: Cerebrolysin group had a significant lower number of infants diagnosed with failed gross motor development compared to infants in the routine intervention group [10 (33%) versus 21 (70%), p = 0.009]. Cerebrolysin group had a significant lower number of infants diagnosed with failed fine motor, language and personal social development compared to infants in the routine intervention group. CONCLUSION: Cerebrolysin, as an adjuvant therapy to routine early interventional care, may improve gross motor development of high-risk preterm infants at 12 months corrected post-natal age.

scholarly journals Birth month and infant gross motor development: Results from the Japan Environment and Children’s Study (JECS)

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251581
Author(s):  
Kahoko Yasumitsu-Lovell ◽  
Lucy Thompson ◽  
Elisabeth Fernell ◽  
Masamitsu Eitoku ◽  
Narufumi Suganuma ◽  
...  
Keyword(s):  
Motor Development ◽  
Influenza Infection ◽  
Adjusted Relative Risk ◽  
Gross Motor ◽  
Maternal Vitamin ◽  
Gross Motor Development ◽  
Birth Month ◽  
Seasonal Factors ◽  
Motor Problems ◽  
Ages And Stages Questionnaire

The association between birth month and neurodevelopmental or psychiatric disorders has been investigated in a number of previous studies; however, the results have been inconsistent. This study investigated the association between birth month and child gross motor development at 6 and 12 months of age in a large cohort of infants (n = 72,203) participating in the Japan Environment and Children’s Study (JECS). Gross motor development was assessed using the Ages and Stages Questionnaire (ASQ-3). At 6 months and 12 months, 20.7% and 14.2%, respectively, had ASQ-3 indications of gross motor problems. Birth month was strongly associated with gross motor development at both time points, particularly at 6 months. Summer-born infants had the worst outcomes at both 6 months and 12 months of age. This outcome applied to the ASQ-3 score itself and to the adjusted Relative Risk (aRR), with the highest aRRs (relative to January-born) among August-born (aRR 2.51; 95%CI 2.27–2.78 at 6 months), and June-born (aRR 1.84; 95%CI 1.63–2.09 at 12 months). Boys had better scores than girls both at 6 and 12 months of age. We speculate that seasonal factors—such as maternal vitamin D deficiency and influenza infection—affecting the fetus in early pregnancy might account for the findings.

Gross Motor Development of Asian and European Children on Four Motor Assessments: A Literature Review

2007 ◽  
Vol 19 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Tanja Anick Mayson ◽  
Susan R. Harris ◽  
Catherine L. Bachman
Keyword(s):  
Literature Review ◽  
Motor Development ◽  
Gross Motor ◽  
Gross Motor Development
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