scholarly journals Reference Values for Umbilical Artery Lactate by Mode of Delivery and Gestational Age: A Retrospective Observational Study

Neonatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Vincent D. Gaertner ◽  
Dirk Bassler ◽  
Roland Zimmermann ◽  
Jehudith R. Fontijn
Keyword(s):  
Observational Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Umbilical Artery ◽  
Mode Of Delivery ◽  
Neonatal Morbidity ◽  
Retrospective Observational Study ◽  
Reference Ranges ◽  
Lactate Levels ◽  
Comprehensive Reference

<b><i>Introduction:</i></b> Umbilical artery cord blood provides information about the intrauterine metabolism during labor. Umbilical artery lactate is a useful parameter in predicting neonatal morbidity, but data on normal values are limited. We aimed to provide reference ranges of umbilical artery lactate values across the combination of gestational age and mode of delivery. <b><i>Methods:</i></b> A single-center retrospective observational study of liveborn infants born between 23 and 42 completed weeks gestation was conducted. Lactate, base deficit (BD), and pH from arterial cord blood were assessed between June 2018 and November 2020 and compared across gestational ages and modes of delivery. <b><i>Results:</i></b> Overall, there were 3,353 infants with evaluable data. Lactate values at the 50th, 90th, and 97th percentile were 3.4, 7.0, and 9.0 mmol/L. Lactate was inversely correlated with pH (<i>r</i> = −0.77, <i>p</i> &#x3c; 0.001) and positively correlated with BD (<i>r</i> = 0.63, <i>p</i> &#x3c; 0.001). Lactate values changed significantly across gestational age (Kruskal-Wallis test, <i>p</i> &#x3c; 0.001) which was attributable to an increase in lactate at 39–41 weeks gestational age. Also, lactate values were different across modes of delivery (Kruskal-Wallis test, <i>p</i> &#x3c; 0.001) with lowest values in elective CS and highest values in vaginal instrumental deliveries. Comprehensive reference ranges across modes of delivery and gestational ages could be established. <b><i>Discussion:</i></b> Mode of delivery and gestational age contribute to lactate levels with highest values occurring in vaginal instrumental deliveries and between 39 and 41 weeks gestational age. Based on these observations, we provide detailed reference ranges for clinical use.

Outcome of ligation of the persistently patent arterial duct in neonates as performed by an outreach surgical team

2007 ◽  
Vol 17 (5) ◽  
pp. 541-544 ◽  
Author(s):  
Shanmugasundaram Sivakumar ◽  
Lleona Lee ◽  
Angela Tillett ◽  
Francis Wells ◽  
Jon Dunning ◽  
...  
Keyword(s):  
Observational Study ◽  
Gestational Age ◽  
Retrospective Observational Study ◽  
Surgical Team ◽  
Arterial Duct ◽  
Gestational Age At Birth ◽  
Patent Arterial Duct ◽  
Age At Birth

AbstractAimOur aim was to review the outcome of ligation of the persistently patent arterial duct in neonates as performed outside a paediatric cardiothoracic centre by an outreach surgical team.MethodsA retrospective observational study of all ligations of the persistently patent arterial duct performed in Cambridge between January, 1988, and December, 2002.ResultsOver the period of 15 years studied, a persistently patent arterial duct was ligated in 43 neonates. The median gestational age at birth was 26 weeks, with a range from 23 to 35 weeks, and median weight at birth was 722 grams, with a range from 500 to 2100 grams. Median age at ligation, was 25 days, with a range from 10 to 89 days, and their weight was 963 grams, with a range from 568 to 2221 grams. Ligation was successful in 42 babies (98%), mortality at 30 days of 5%, and 29 of the babies (67%) surviving to be discharged from the hospital. The late deaths were due to complications of prematurity, rather than the procedure of ligation.ConclusionThe persistently patent arterial duct can successfully be ligated by an outreach surgical team outside a paediatric cardiothoracic centre. There was an excellent 30 day survival.

scholarly journals Prenatal lead exposure and cord blood DNA methylation in PROGRESS: an epigenome-wide association study

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jonathan A Heiss ◽  
Martha M Téllez-Rojo ◽  
Guadalupe Estrada-Gutiérrez ◽  
Lourdes Schnaas ◽  
Chitra Amarasiriwardena ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Gestational Age ◽  
Lead Exposure ◽  
Inductively Coupled Plasma ◽  
Maternal Education ◽  
Association Studies ◽  
Mode Of Delivery ◽  
Underlying Mechanisms ◽  
Prenatal Lead Exposure

Abstract The effects of prenatal lead exposure on child development include impaired growth and cognitive function. DNA methylation might be involved in the underlying mechanisms and previous epigenome-wide association studies reported associations between lead exposure during pregnancy and cord blood methylation levels. However, it is unclear during which developmental stage lead exposure is most harmful. Cord blood methylation levels were assayed in 420 children from a Mexican pre-birth cohort using the Illumina Infinium MethylationEPIC microarray. Lead concentrations were measured in umbilical cord blood as well as in blood samples from the mothers collected at 2nd and 3rd trimester and delivery using inductively coupled plasma-mass spectrometry. In addition, maternal bone lead levels were measured in tibia and patella using X-ray fluorescence. Comprehensive quality control and preprocessing of microarray data was followed by an unbiased restriction to methylation sites with substantial variance. Methylation levels at 202 111 cytosine-phosphate-guanine sites were regressed on each exposure adjusting for child sex, leukocyte composition, batch variables, gestational age, birthweight-for-gestational-age, maternal age, maternal education and mode of delivery. We find no association between prenatal lead exposure and cord blood methylation. This null result is strengthened by a sensitivity analysis showing that in the same dataset known biomarkers for birthweight-for-gestational-age can be recovered and the fact that phenotypic associations with lead exposure have been described in the same cohort.

Neonatal morbidity in second twin according to gestational age at birth and mode of delivery

2004 ◽  
Vol 191 (3) ◽  
pp. 773-777 ◽  
Author(s):  
Shi Wu Wen ◽  
Fung Karen Fung Kee ◽  
Oppenheimer Lawrence ◽  
Demissie Kitaw ◽  
Yang Qiuying ◽  
...  
Keyword(s):  
Gestational Age ◽  
Mode Of Delivery ◽  
Neonatal Morbidity ◽  
Gestational Age At Birth ◽  
Age At Birth ◽  
Second Twin

The impact of mode of delivery and gestational age on cord blood hematopoietic stem/progenitor cells

2006 ◽  
Vol 85 (6) ◽  
pp. 381-385 ◽  
Author(s):  
Helen Dimitriou ◽  
Chryssoula Perdikogianni ◽  
Eftichia Stiakaki ◽  
Pelagia Vorgia ◽  
Eleftheria Hatzidaki ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Gestational Age ◽  
Mode Of Delivery ◽  
Hematopoietic Stem ◽  
The Impact

scholarly journals Study on neonatal morbidity in infants of diabetic mothers

2020 ◽  
Vol 7 (3) ◽  
pp. 473
Author(s):  
Ravisankar Muthiah ◽  
Karamath S. Pyarejan
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Age ◽  
Tamil Nadu ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Neonatal Morbidity ◽  
First Trimester ◽  
Mortality Pattern ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Background: Many infants of diabetic mothers (IDMs) born with specific characteristics like macrosomia, hypoglycemia, respiratory distress syndrome (RDS) and other morbidity risks. The present study was done with the aim to determine morbidity and mortality pattern amongst IDMs admitted into the neonatal intensive care units (NICU) of our tertiary care center.Methods: Descriptive study was done on 86 infants in the NICU of Government RSRM lying in Hospital and Institute of Social Pediatrics, Govt Stanley Hospital, Chennai Tamil Nadu during the period from August 2007 to October 2008. Data on mode of delivery, gestational age, birth weight, other associated morbidities and investigation results were noted.Results: Among the 85 mothers, 67 mothers had gestational diabetes mellitus and 18 had diabetes mellitus preceding pregnancy. Among the 86 IDMs, 15 infants were macrosomic, 11 infants were premature, 12 had mild to severe RDS, 11 infants had hypoglycemia, 3 had hypocalcemia, 2 had birth injuries, 3 infants were born as small for gestational age. Polycythemia observed in 3 IDMs, hyperbilirubinemia in 8 infants, external congenital malformations in two infants and congenital heart disease in three infants.Conclusions: IDMs developed many complications in the study. Macrosomia was the major among them. Perinatal morbidities can be reduced by screening of diabetic mothers from first trimester, maintaining good glycaemic control and adequate management of their infants.

scholarly journals Effect of gestational age and mode of delivery on CD4+ T cells and regulatory T cells (Treg) in neonatal cord blood

2013 ◽  
Vol 4 ◽  
Author(s):  
Mukhopadhyay Dhriti ◽  
Weaver Laura ◽  
Tobin Richard ◽  
Jupiter Daniel ◽  
Newell-Rogers Martha ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cord Blood ◽  
Gestational Age ◽  
Cd4 T Cells ◽  
Mode Of Delivery

scholarly journals Perinatal variables influencing cord blood thyroid stimulating hormone

2018 ◽  
Vol 5 (4) ◽  
pp. 1537 ◽  
Author(s):  
Manasi D. Garg ◽  
Poornima Kumar ◽  
Sakthi Abirami ◽  
Manikandan M. ◽  
Lalitha Krishnan
Keyword(s):  
Newborn Screening ◽  
Cord Blood ◽  
Congenital Hypothyroidism ◽  
Gestational Age ◽  
Maternal Age ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Stimulating Hormone

Background: Newborn screening using cord blood Thyroid Stimulating Hormone (TSH) is an effective and an easy way to screen babies for congenital hypothyroidism. Congenital hypothyroidism is a common preventable and treatable cause of mental retardation. Early diagnosis with the help of newborn screening aids in timely management and decreased morbidity. Various maternal and neonatal variables can affect cord blood TSH level thereby affecting the accurate diagnosis of congenital hypothyroidism. This study aims at studying the perinatal variables affecting cord blood TSH.Methods: In a retrospective cross-sectional study conducted in a tertiary care hospital, the hospital case records of 1465 newborn and their mother were studied for variables including cord blood TSH, maternal age, mode of delivery, parity, gender of baby, gestational age and growth of baby. The effect of these perinatal variables on cord blood TSH was analysed statistically. P value below 0.05 was considered as statistically significant. The statistical analysis was done used the SPSS software version 18.0.Results: The median cord blood TSH was 8 microIU/ml (IQR= 6-12) with 8.1% newborns having values more than 20 microIU/ml. Cord blood TSH was significantly raised in male babies (p <0.01) and in neonates born by assisted vaginal delivery (p <0.01).  Significant increase in cord blood TSH (p <0.02) was observed in neonates born to primiparous mothers. Maternal age, gestational age of the newborn and growth of the newborn did not have significant effect on cord blood TSH values.Conclusions: The mode of delivery, parity and gender of the baby were found to be significant variables affecting cord blood TSH values. Hence, cord blood TSH values should be interpreted in the light of these perinatal variables.

Gestational Age-Specific Reference Ranges of Hepcidin in Cord Blood

Neonatology ◽  
2014 ◽  
Vol 106 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Laila Lorenz ◽  
Johanna Herbst ◽  
Corinna Engel ◽  
Andreas Peter ◽  
Harald Abele ◽  
...  
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Specific Reference ◽  
Reference Ranges
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