Proinflammatory cytokine profile differences between primary open angle and pseudoexfoliative glaucoma

Background/Aim. Trabeculectomy is a safe procedure which effectively reduces the intraocular pressure (IOP). IOP is the most frequent indicator of success after glaucoma surgery. The aim of this work was to evaluate the long-term pressure control in primary open-angle glaucoma (POAG) and in pseudoexfoliative glaucoma (XFG) after primary trabeculectomy without the use of mitomycin-C (MMC), 3 to 5 years after trabeculectomy. Methods. This study involved a retrospective evaluation of 332 consecutive patients (352 eyes), 174 patients (188 eyes) with POAG (mean age of 64.0 ? 8.6 years) and 158 patients (164 eyes) with XFG (mean age of 70.7 ? 8.9 years) who underwent primary trabeculectomy between January 2007 and December 2009 at the Clinic for Eye Diseases, Clinical Center of Serbia in Belgrade. A successful control of IOP was defined as achieving IOP ? 21 mmHg without medication (complete success), or with a single topical medication (qualified success). Results. According to the type of glaucoma POAG/XFG preoperative IOP was 28.4 ? 6.3/30.4 ? 8.4 mmHg, respectively (p = 0.311) and last postoperative IOP was 16.9 ? 5.2/18.7 ? 5.9 mmHg, respectively (p = 0.681). According to the Kaplan-Meier survival curve, the complete success in the group with POAG in 1, 3 and 5 years were 85%, 75% and 58% and in the group with XFG were 82%, 70% and 56%, respectively. There was no statistically significant difference in the complete success rates between the patients with POAG and XFG. Conclusion. The primary goal of surgery was to achieve a sufficiently low IOP without additional medication, thus preventing progression of glaucomatous damage. In our study, the complete success in the group with POAG was achieved in 75% and 58% of the patients in the period of 3 and 5 years after surgery, respectively and in the group with XFG complete success was achieved in 70% and 56% of the patients respectively.

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Intrahepatic type II natural killer T cells switch to a proinflammatory cytokine profile in patients with autoimmune hepatitis

Journal of Hepatology ◽

10.1016/s0168-8278(18)31161-9 ◽

2018 ◽

Vol 68 ◽

pp. S458-S459

Author(s):

M. Sebode ◽

C. Schramm ◽

L. Fischer ◽

A. Lohse ◽

P. Arrenberg

Keyword(s):

T Cells ◽

Autoimmune Hepatitis ◽

Natural Killer ◽

Proinflammatory Cytokine ◽

Natural Killer T Cells ◽

Cytokine Profile ◽

Type Ii ◽

Killer T Cells ◽

Natural Killer T

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Proinflammatory cytokine profile in head and neck squamous cell carcinoma patients: Preliminary report

Annals of Tropical Pathology ◽

10.4103/atp.atp_49_18 ◽

2019 ◽

Vol 10 (1) ◽

pp. 40

Author(s):

VictorI Akinmoladun ◽

ClaraA Akinyamoju ◽

Fabian Edem ◽

EniolaJ Ezeyi ◽

OlatubosunG Arinola

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Proinflammatory Cytokine ◽

Preliminary Report ◽

Cytokine Profile ◽

Neck Squamous Cell Carcinoma

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MicroRNA-related polymorphisms in pseudoexfoliation syndrome, pseudoexfoliative glaucoma, and primary open-angle glaucoma

Ophthalmic Genetics ◽

10.1080/13816810.2018.1509352 ◽

2018 ◽

Vol 39 (5) ◽

pp. 603-609 ◽

Cited By ~ 4

Author(s):

Anthoula Chatzikyriakidou ◽

Panayiota Founti ◽

Angeliki Melidou ◽

Fani Minti ◽

Emmanouil Bouras ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Pseudoexfoliation Syndrome ◽

Open Angle ◽

Pseudoexfoliative Glaucoma

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Atorvastatin favorably modulates proinflammatory cytokine profile in patients following deep vein thrombosis

Thrombosis Research ◽

10.1016/j.thromres.2013.04.026 ◽

2013 ◽

Vol 132 (1) ◽

pp. e31-e35 ◽

Cited By ~ 4

Author(s):

Marek Żółciński ◽

Mariola Cieśla-Dul ◽

Daniel P. Potaczek ◽

Anetta Undas

Keyword(s):

Deep Vein Thrombosis ◽

Proinflammatory Cytokine ◽

Cytokine Profile ◽

Vein Thrombosis ◽

Deep Vein

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Diode Laser Trabeculoplasty in Patients with Pseudoexfoliative Glaucoma

European Ophthalmic Review ◽

10.17925/eor.2013.07.01.14 ◽

2013 ◽

Vol 07 (01) ◽

pp. 14

Author(s):

Nikola Babić ◽

Aleksandar Miljković ◽

Veljko Andreić ◽

◽

...

Keyword(s):

Diode Laser ◽

Open Angle Glaucoma ◽

Spot Size ◽

Open Angle ◽

Pseudoexfoliative Glaucoma ◽

Laser Trabeculoplasty ◽

Significant Difference ◽

Before And After ◽

One Year ◽

A Prospective Study

Aim:A prospective study was carried out to examine the efficacy of diode laser trabeculoplasty (DLT) in the treatment of pseudoexfoliative glaucoma (XFG).Material and Methods:Laser trabeculoplasty was performed by Zeiss VISULAS 532s diode pumped solid state laser on 69 eyes of 40 patients with XFG and primary open-angle glaucoma. Power of 6001,200 mW was used, with a spot size of 100 microns and a pulse of 0.10 second. One hour before DLT brimonidine 0.1 % was administered and during seven days after the treatment Dexamethasone 1 % was administered. All patients underwent complete ophthalmic evaluation before and at intervals after treatment (seven days, one, three and six months and one year postoperatively). During the follow-up period, patients were treated with the same topical anti-glaucoma medicaments as before diode laser trabeculoplasty.Results:Before treatment in XFG patients mean intraocular pressure (IOP) was 23.7±2.6 mmHg and seven days after DLT it was 16.8 ± 2.1 mmHg that is 26.9 % decrease from the baseline, on day 30 it was 14.3 ± 2.2 mmHg which is 38.3 % decrease from the baseline, after 3 months 13.9 ± 2.4 mmHg (39.0 % decrease from the baseline), after six months 13.8 ± 2.7 mmHg or 39.9 % decrease from the baseline and after one year 15.1 ± 3.1 mmHg that makes 36.3 % decrease from the baseline. No side effects (either objective or subjective) were present in examined patients.Conclusions:There is statistically significant difference between IOP before and after diode laser trabeculoplasty, so it is concluded that diode laser trabeculoplasty is an effective mode of treatment for eyes with open-angle glaucoma especially in patients with XFG.

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Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected byMycobacterium tuberculosis

Clinical and Developmental Immunology ◽

10.1155/2011/841346 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

Elena Giacomini ◽

Maria Elena Remoli ◽

Marta Scandurra ◽

Valérie Gafa ◽

Manuela Pardini ◽

...

Keyword(s):

Gene Expression ◽

Transcription Factor ◽

Proinflammatory Cytokine ◽

Cytokine Profile ◽

Signalling Pathways ◽

Regulatory Factor ◽

Innate Response ◽

Important Target ◽

Molecular Events ◽

Immunological Pathogenesis

Knowledge of the molecular events regulating the innate response toMycobacterium tuberculosis(Mtb) is critical for understanding immunological pathogenesis and protection from tuberculosis. To this aim, the regulation and the expression of regulatory and proinflammatory cytokines were investigated in human primary monocytes upon Mtb infection. We found that Mtb-infected monocytes preferentially express a proinflammatory cytokine profile, including IL-6, TNF-α, and IL-1β. Conversely, among the regulatory cytokines, Mtb elicited IL-10 and IL-23 release while no expression of IL-12p70, IL-27, and IFN-βwas observed. The analysis of the signalling pathways leading to this selective cytokine expression showed that in monocytes Mtb activates MAPK and NF-κB but is unable to stimulate IRF-3 phosphorylation, a transcription factor required for IL-12p35 and IFN-βgene expression. Thus, by inducing a specific cytokine profile, Mtb can influence the immunoregulatory properties of monocytes, which represent important target of novel vaccinal strategies against Mtb infection.

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