Effectiveness of MicroShunt in Patients with Primary Open-Angle and Pseudoexfoliative Glaucoma

Background/Aim. Trabeculectomy is a safe procedure which effectively reduces the intraocular pressure (IOP). IOP is the most frequent indicator of success after glaucoma surgery. The aim of this work was to evaluate the long-term pressure control in primary open-angle glaucoma (POAG) and in pseudoexfoliative glaucoma (XFG) after primary trabeculectomy without the use of mitomycin-C (MMC), 3 to 5 years after trabeculectomy. Methods. This study involved a retrospective evaluation of 332 consecutive patients (352 eyes), 174 patients (188 eyes) with POAG (mean age of 64.0 ? 8.6 years) and 158 patients (164 eyes) with XFG (mean age of 70.7 ? 8.9 years) who underwent primary trabeculectomy between January 2007 and December 2009 at the Clinic for Eye Diseases, Clinical Center of Serbia in Belgrade. A successful control of IOP was defined as achieving IOP ? 21 mmHg without medication (complete success), or with a single topical medication (qualified success). Results. According to the type of glaucoma POAG/XFG preoperative IOP was 28.4 ? 6.3/30.4 ? 8.4 mmHg, respectively (p = 0.311) and last postoperative IOP was 16.9 ? 5.2/18.7 ? 5.9 mmHg, respectively (p = 0.681). According to the Kaplan-Meier survival curve, the complete success in the group with POAG in 1, 3 and 5 years were 85%, 75% and 58% and in the group with XFG were 82%, 70% and 56%, respectively. There was no statistically significant difference in the complete success rates between the patients with POAG and XFG. Conclusion. The primary goal of surgery was to achieve a sufficiently low IOP without additional medication, thus preventing progression of glaucomatous damage. In our study, the complete success in the group with POAG was achieved in 75% and 58% of the patients in the period of 3 and 5 years after surgery, respectively and in the group with XFG complete success was achieved in 70% and 56% of the patients respectively.

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MicroRNA-related polymorphisms in pseudoexfoliation syndrome, pseudoexfoliative glaucoma, and primary open-angle glaucoma

Ophthalmic Genetics ◽

10.1080/13816810.2018.1509352 ◽

2018 ◽

Vol 39 (5) ◽

pp. 603-609 ◽

Cited By ~ 4

Author(s):

Anthoula Chatzikyriakidou ◽

Panayiota Founti ◽

Angeliki Melidou ◽

Fani Minti ◽

Emmanouil Bouras ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Pseudoexfoliation Syndrome ◽

Open Angle ◽

Pseudoexfoliative Glaucoma

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Diode Laser Trabeculoplasty in Patients with Pseudoexfoliative Glaucoma

European Ophthalmic Review ◽

10.17925/eor.2013.07.01.14 ◽

2013 ◽

Vol 07 (01) ◽

pp. 14

Author(s):

Nikola Babić ◽

Aleksandar Miljković ◽

Veljko Andreić ◽

◽

...

Keyword(s):

Diode Laser ◽

Open Angle Glaucoma ◽

Spot Size ◽

Open Angle ◽

Pseudoexfoliative Glaucoma ◽

Laser Trabeculoplasty ◽

Significant Difference ◽

Before And After ◽

One Year ◽

A Prospective Study

Aim:A prospective study was carried out to examine the efficacy of diode laser trabeculoplasty (DLT) in the treatment of pseudoexfoliative glaucoma (XFG).Material and Methods:Laser trabeculoplasty was performed by Zeiss VISULAS 532s diode pumped solid state laser on 69 eyes of 40 patients with XFG and primary open-angle glaucoma. Power of 6001,200 mW was used, with a spot size of 100 microns and a pulse of 0.10 second. One hour before DLT brimonidine 0.1 % was administered and during seven days after the treatment Dexamethasone 1 % was administered. All patients underwent complete ophthalmic evaluation before and at intervals after treatment (seven days, one, three and six months and one year postoperatively). During the follow-up period, patients were treated with the same topical anti-glaucoma medicaments as before diode laser trabeculoplasty.Results:Before treatment in XFG patients mean intraocular pressure (IOP) was 23.7±2.6 mmHg and seven days after DLT it was 16.8 ± 2.1 mmHg that is 26.9 % decrease from the baseline, on day 30 it was 14.3 ± 2.2 mmHg which is 38.3 % decrease from the baseline, after 3 months 13.9 ± 2.4 mmHg (39.0 % decrease from the baseline), after six months 13.8 ± 2.7 mmHg or 39.9 % decrease from the baseline and after one year 15.1 ± 3.1 mmHg that makes 36.3 % decrease from the baseline. No side effects (either objective or subjective) were present in examined patients.Conclusions:There is statistically significant difference between IOP before and after diode laser trabeculoplasty, so it is concluded that diode laser trabeculoplasty is an effective mode of treatment for eyes with open-angle glaucoma especially in patients with XFG.

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Helicobacter pylori Infection as a Risk Factor for Both Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma in Thessaloniki Eye Study

American Journal of Ophthalmology ◽

10.1016/j.ajo.2011.07.031 ◽

2011 ◽

Vol 152 (6) ◽

pp. 1079-1080 ◽

Cited By ~ 5

Author(s):

Jannis Kountouras ◽

Christos Zavos ◽

Georgios Sakkias ◽

Georgia Deretzi ◽

Ioannis Venizelos ◽

...

Keyword(s):

Helicobacter Pylori ◽

Risk Factor ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Helicobacter Pylori Infection ◽

Open Angle ◽

Pseudoexfoliative Glaucoma

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Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma

Journal of Ophthalmology ◽

10.1155/2021/3897952 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Fan Li ◽

Yiming Huo ◽

Lihua Ma ◽

Qing Zhang ◽

Hengli Zhang ◽

...

Keyword(s):

Axial Length ◽

Choroidal Thickness ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Control Group ◽

Open Angle ◽

Healthy Individuals ◽

Pseudoexfoliative Glaucoma ◽

The Mean ◽

Choroidal Volume

Purpose. To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls. Methods. A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG group and the POAG group, respectively, in this case-control study. A total of 54 age-, gender-, IOP-, and axial length-matched healthy individuals (54 eyes) were selected as the control group. Enhanced-depth imaging-optical coherence tomography (EDI-OCT) was used to measure and analyze the choroidal thicknesses and volumes in 9 macular regions of all subjects. Results. The choroidal thicknesses in the central subfield (CSM), temporal inner macula (TIM), inferior inner macula (IIM), and temporal outer macula (TOM) and the mean macular choroidal thickness were significantly thinner in the PXG group than in the control group (all P < 0.05 ). The choroidal volumes in the TIM, IIM, and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the control group (all P < 0.05 ). The choroidal thicknesses in the CSM and IIM and the mean macular choroidal thickness were significantly thinner in the PXG group than in the POAG group (all P < 0.05 ). The choroidal volumes in the IIM and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the POAG group (all P < 0.05 ). Multivariable linear regression analysis showed that the mean macular choroidal thickness was significantly thinner in association with older subjects and longer axial length eyes. There was no association between the macular choroidal thickness of various macular regions and visual field mean defect (MD) in groups PXG and POAG (all P > 0.05 ). Conclusions. The macular choroidal thicknesses and volumes (inferior and temporal) in PXG patients were thinner and smaller than those in POAG patients and healthy individuals. The role of choroidal thickness changes in the course of PXG remains unclear. A future prospective study is needed to better define these changes in PXG patients.

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Proinflammatory cytokine profile differences between primary open angle and pseudoexfoliative glaucoma

Ophthalmic Research ◽

10.1159/000519816 ◽

2021 ◽

Author(s):

Beatriz Vidal-Villegas ◽

Bárbara Burgos-Blasco ◽

Jose Luis Santiago Alvarez ◽

Laura Espino-Paisán ◽

Jose Fernández-Vigo ◽

...

Keyword(s):

Proinflammatory Cytokine ◽

Cytokine Profile ◽

Open Angle ◽

Pseudoexfoliative Glaucoma

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Selective laser trabeculoplasty in patients with pseudoexfoliative glaucoma vs primary open angle glaucoma: a one-year comparative study

International Journal of Ophthalmology ◽

10.18240/ijo.2016.03.14 ◽

2016 ◽

Keyword(s):

Comparative Study ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Selective Laser Trabeculoplasty ◽

Pseudoexfoliative Glaucoma ◽

Laser Trabeculoplasty ◽

One Year

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The clinical features in patients with newly diagnosed pseudoexfoliative glaucoma in Serbia

European Journal of Ophthalmology ◽

10.1177/1120672119831532 ◽

2019 ◽

Vol 30 (3) ◽

pp. 513-524

Author(s):

Vesna D Maric ◽

Anita D Grgurevic ◽

Andja M Cirkovic ◽

Ivan S Marjanovic ◽

Marija M Bozic

Keyword(s):

Intraocular Pressure ◽

Clinical Features ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Systemic Disease ◽

Pseudoexfoliation Syndrome ◽

Mean Deviation ◽

Open Angle ◽

Newly Diagnosed ◽

Pseudoexfoliative Glaucoma

Purpose: To evaluate the clinical characteristics of newly diagnosed pseudoexfoliative glaucoma and compare them with those pertaining to newly diagnosed primary open-angle glaucoma as well as pseudoexfoliation syndrome. Methods: This case–control study involved 306 participants, including patients with newly diagnosed pseudoexfoliative glaucoma, age- and sex-matched normal controls, patients with newly diagnosed primary open-angle glaucoma, and subjects with pseudoexfoliation syndrome. The study was conducted at the Glaucoma Department of Clinic for Eye Diseases, Clinical Center of Serbia, as the referral center for glaucoma in Serbia. Results: The mean age in the pseudoexfoliative glaucoma, primary open-angle glaucoma, pseudoexfoliation syndrome, and normal control groups was 73.61 ± 8.46, 65.50 ± 8.97, 74.81 ± 6.80, and 73.58 ± 9.34 years, respectively (pseudoexfoliative glaucoma vs primary open-angle glaucoma, p < 0.001). Unilateral pseudoexfoliative glaucoma was diagnosed in 35 patients (42.2%). The intraocular pressure was higher in the eyes affected by pseudoexfoliative glaucoma (32.0 ± 9.5 mmHg) than that in the primary open-angle glaucoma eyes (28.8 ± 5.9 mmHg) (p < 0.001). In pseudoexfoliative glaucoma and primary open-angle glaucoma eyes, glaucoma severity was determined via the vertical cup-to-disk ratio (C/D) 0.65 (0.45–1.0) versus 0.60 (0.45–1.0), p = 0.048 and visual field mean deviation −5.68 (−1.58 to −30.9) versus −4.70 (−1.39 to −31.0), p = 0.045. Alzheimer’s was the only systemic disease associated with pseudoexfoliative glaucoma in the study sample, with an odds ratio of 0.021 (95% confidence interval = 0.00−21.52, p = 0.022). Conclusion: At the time of diagnosis, pseudoexfoliative glaucoma exhibits different clinical features compared with primary open-angle glaucoma. Higher intraocular pressure, narrow or occludable angle, increased trabecular pigmentation, phacodonesis, and poorer pupillary dilatation emerged as the factors associated with pseudoexfoliative glaucoma.

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Micropulse transscleral cyclophotocoagulation: clinical outcomes of treatment of early stages open-angle glaucoma

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-2-36-41 ◽

2021 ◽

pp. 36-41

Author(s):

Y.V. Milasheuski ◽

◽

T.A. Imshanetskaya ◽

Keyword(s):

Visual Acuity ◽

Open Angle Glaucoma ◽

Laser Exposure ◽

Open Angle ◽

Pseudoexfoliative Glaucoma ◽

Early Stages ◽

Corrected Visual Acuity ◽

Transscleral Cyclophotocoagulation ◽

Best Corrected Visual Acuity ◽

Observation Period

Purpose. To evaluate treatment efficiency of open-angle glaucoma with micropulse transscleral cyclophotocoagulation, to determine the optimal total energy of laser exposure and to assess the stability of the glaucoma process after treatment. Material and methods. A prospective study was carried out. It included 34 (21 patients) with primary open-angle and pseudoexfoliative glaucoma of stages 1-3, which undergone micropulse transscleral cyclophotocoagulation. The patients were divided into subgroups 1 and 2, depending on the total amount of laser energy (100 J and 150 J, respectively). At different periods of observation, the intraocular pressure, best corrected visual acuity, visual fields, cup-to-disc ratio and the number of antiglaucoma drugs were determined. Results. In the general group, all operated patients achieved a decrease in IOP to a tolerant level, from a median value of 27 [25; 28] in the preoperative period, up to 17.5 [15; 20] at the end of the observation period. The number of used drugs decreased statistically significantly, from 3.0 [3.0; 3.0] to 2.0 [1.0; 2.0]. There was a statistically significant increase in the mean deviation of the retinal photosensitivity, from –4.85 [–8.25; –2.17] to –4.36 [–7.06; –2.37] after 18 months. Indicators of best corrected visual acuity and CDR remained stable throughout the observation period. In subgroup 2 (150J), a statistically more significant decrease in IOP level (p=0.033) and the number of used drugs (p=0.001) was achieved compared with subgroup 1 (100J). Conclusion. Micropulse transscleral cyclophotocoagulation is an effective and safe method of treating open-angle glaucoma in patients with early stages of the disease and high values of best corrected visual acuity. Using a total amount of energy in 150J contributes to a more pronounced decrease in IOP and a decrease in the number of applied drugs than an energy in 100J. Key words: open-angle glaucoma, pseudoexfoliative glaucoma, micropulse cyclophotocoagulation.

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