scholarly journals Correlation analysis of gas and acid-base indices of arterial blood in the pathogenesis of experimental hepatopulmonary syndrome

2017 ◽  
Author(s):  
I. Ya. Krynytska
Keyword(s):  
Correlation Analysis ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Moderate Correlation ◽  
Plasma Osmolarity ◽  
Acid Base ◽  
Common Bile Duct Ligation ◽  
Strong Negative Correlation ◽  
Arterial Blood ◽  
Duct Ligation

The correlation analysis of indices of gas and acid-base composition of arterial blood in the pathogenesis of experimental hepatopulmonary syndrome was studied in the article. It was established a strong negative correlation between partial pressure of oxygen and AaDO2, positive moderate correlation between the plasma osmolarity and AaDO2 in animals of both experimental groups, the positive moderate correlation between the concentration of lactic acid and AaDO2 in animals with carbon tetrachloride-induced cirrhosis and strong correlation interaction between these parameters in rats the on 31st day after common bile duct ligation.

Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome

1997 ◽  
Vol 272 (4) ◽  
pp. G779-G784 ◽  
Author(s):  
M. B. Fallon ◽  
G. A. Abrams ◽  
J. W. McGrath ◽  
Z. Hou ◽  
B. Luo
Keyword(s):  
Portal Hypertension ◽  
Bile Duct ◽  
Gas Exchange ◽  
Common Bile Duct ◽  
Lung Injury ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Common Bile Duct Ligation ◽  
Arterial Blood ◽  
Duct Ligation

Hepatopulmonary syndrome (HPS) causes impaired oxygenation due to intrapulmonary vasodilatation in patients with cirrhosis. Chronic common bile duct ligation (CBDL) in the rat results in gas-exchange abnormalities similar to HPS, but intrapulmonary vasodilatation has not been evaluated. We assess intrapulmonary vasodilatation, measured in vivo, after CBDL. Sham, 2- and 5-wk CBDL, and 3-wk partial portal vein ligated (PVL) rats had hepatic and lung injury, portal pressure, and arterial blood gases assessed. The pulmonary microcirculation was evaluated by injecting microspheres (size range 5.5-10 microm) intravenously and measuring the size and number of microspheres bypassing the lungs in arterial blood. CBDL animals developed progressive hepatic injury and portal hypertension accompanied by gas-exchange abnormalities and intrapulmonary vasodilatation. PVL animals, with a similar degree of portal hypertension, did not develop intrapulmonary vasodilatation or abnormal gas exchange. No lung injury was observed. CBDL, but not PVL, causes progressive intrapulmonary vasodilatation, which accompanies worsening arterial gas exchange. These findings validate CBDL as a model to study HPS.

scholarly journals Effects of Caffeine Treatment on Hepatopulmonary Syndrome in Biliary Cirrhotic Rats

2019 ◽  
Vol 20 (7) ◽  
pp. 1566
Author(s):  
Ching-Chih Chang ◽  
Chiao-Lin Chuang ◽  
Ming-Hung Tsai ◽  
I.-Fang Hsin ◽  
Shao-Jung Hsu ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Liver Fibrosis ◽  
Portal Pressure ◽  
Hepatopulmonary Syndrome ◽  
Gas Analysis ◽  
Common Bile Duct Ligation ◽  
Arterial Blood ◽  
Duct Ligation ◽  
Intrapulmonary Shunting ◽  
Protein Expressions

Hepatopulmonary syndrome (HPS) is a lethal complication of cirrhosis characterized by hypoxia and overt intrapulmonary shunting. In this study, we investigated the effect of caffeine in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS. CBDL rats were randomly allocated to receive caffeine or vehicle for 14 days. On the 28th day after CBDL, mortality rate, hemodynamics, liver, and renal biochemistry parameters and arterial blood gas analysis were evaluated. Lung and liver were dissected for the evaluation of inflammation, angiogenesis and protein expressions. In another series with parallel groups, the intrapulmonary shunting was determined. Caffeine significantly reduced portal pressure (caffeine vs. control: 10.0 ± 3.7 vs. 17.0 ± 8.1 mmHg, p < 0.05) in CBDL rats. The mortality rate, mean arterial pressure, biochemistry data and hypoxia were similar between caffeine-treated and control groups. Caffeine alleviated liver fibrosis and intrahepatic angiogenesis but intrapulmonary inflammation and angiogenesis were not ameliorated. The hepatic VEGF/Rho-A protein expressions were down-regulated but the pulmonary inflammation- and angiogenesis-related protein expressions were not significantly altered by caffeine. Caffeine did not reduce the intrapulmonary shunting, either. Caffeine has been shown to significantly improve liver fibrosis, intrahepatic angiogenesis and portal hypertension in cirrhotic rats, however, it does not ameliorate HPS.

Caspase-3 inhibition prevents the development of hepatopulmonary syndrome in common bile duct ligation rats by alleviating pulmonary injury

2014 ◽  
Vol 35 (4) ◽  
pp. 1373-1382 ◽  
Author(s):  
Bing Chen ◽  
Jiao L. Ning ◽  
Jian T. Gu ◽  
Jian Cui ◽  
Yong Yang ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Caspase 3 ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Pulmonary Injury ◽  
Common Bile Duct Ligation ◽  
Duct Ligation

scholarly journals Study of the relation between biliary cirrhosis and hepatopulmonary syndrome and its reversibility among young rats submitted to common bile duct ligation

2018 ◽  
Vol 97 (3) ◽  
pp. 376-377
Author(s):  
Leonardo Ervolino Corbi ◽  
Maria Julia De Aro Braz ◽  
Ana Cristina Aoun Tannuri ◽  
Maria Cecília De Mendonça Coelho ◽  
Suellen Serafini ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Biliary Cirrhosis ◽  
Common Bile Duct Ligation ◽  
Young Rats ◽  
Duct Ligation

A comparison of two common bile duct ligation methods to establish hepatopulmonary syndrome animal models

2014 ◽  
Vol 49 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Y Yang ◽  
B Chen ◽  
Y Chen ◽  
B Zu ◽  
B Yi ◽  
...  
Keyword(s):  
Bile Duct ◽  
Animal Models ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Hepatopulmonary Syndrome ◽  
Common Bile Duct Ligation ◽  
Duct Ligation

scholarly journals Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94550 ◽  
Author(s):  
Fumiaki Shikata ◽  
Tomohisa Sakaue ◽  
Koh-ichi Nakashiro ◽  
Mikio Okazaki ◽  
Mie Kurata ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Lung Injury ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation
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