Association of decreased sex hormone binding globulin and cardiovascular risk factors.

Abstract We determined sex-hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) by radioimmunoassay of serum samples from a group of 253 women, who were 54 or 60 years old when first studied in 1968-69. The SHBG concentration was highly significantly and inversely related to body mass, body mass index, waist-to-hip circumference ratio, and serum triglyceride concentration; CBG concentration was inversely related to body mass and body mass index. The concentration of neither protein was related to whether or not the subject smoked. Decrease in the concentration of SHBG, but not of CBG, was a significant risk factor for 12-year overall mortality. The plot of the 12-year incidence of myocardial infarction vs SHBG concentration was U-shaped. We recommend that SHBG be included when serum androgens or estrogens are being evaluated as risk factors for cardiovascular disease and death.

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Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study

Acta Endocrinologica ◽

10.1530/eje-13-1046 ◽

2014 ◽

Vol 170 (6) ◽

pp. 863-872 ◽

Cited By ~ 19

Author(s):

D Canoy ◽

T M Barber ◽

A Pouta ◽

A L Hartikainen ◽

M I McCarthy ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Disease Risk ◽

Young Men ◽

Hdl Cholesterol ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Inverse Association ◽

Hormone Binding ◽

Cvd Risk

ObjectiveReduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear. We examined the association between SHBG and cardiovascular risk factors, independently of total testosterone (TT), in young men.DesignObservational, cross-sectional study.SettingGeneral community.ParticipantsThe study included 2716 men aged 31 years in the Northern Finland Birth Cohort in 1996 with clinical examination data and fasting blood samples.Outcome variablesBlood pressure (BP), lipids and C-reactive protein (CRP) as biological CVD risk markers.ResultsSHBG concentration was significantly and inversely related to systolic and diastolic BP, triglycerides and CRP, but positively to HDL cholesterol after adjusting for insulin, BMI, waist circumference, smoking, education and physical activity (allP<0.05). These linearly graded associations persisted with additional adjustment for TT. SHBG was significantly associated with total cholesterol only with adjustment for covariates and TT (P<0.05). The direction and magnitude of associations between TT and risk factors were variable, but further adjustment for insulin, adiposity and SHBG showed positive associations between TT and BP, total and LDL-cholesterol and triglycerides and an inverse association with CRP (allP<0.05), but its relation with HDL-cholesterol was no longer significant.ConclusionsIn this cohort of young adult men, higher SHBG concentration was associated with a more favourable CVD risk profile, independently of TT. SHBG concentration modified the associations of TT with CVD risk factors.

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Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones

British Journal of Cancer ◽

10.1038/bjc.1987.262 ◽

1987 ◽

Vol 56 (5) ◽

pp. 661-666 ◽

Cited By ~ 43

Author(s):

JW Moore ◽

TJA Key ◽

RD Bulbrook ◽

GMG Clark ◽

DS Allen ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Sex Hormones ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Hormone Binding ◽

Normal Women

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Definition, prevalence, and risk factors of low sex hormone-binding globulin in US adults

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab416 ◽

2021 ◽

Author(s):

Yutang Wang

Keyword(s):

Risk Factors ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Chronic Obstructive ◽

Hormone Binding ◽

Obstructive Pulmonary Disease ◽

Health And Nutrition ◽

The Us ◽

Definition Of ◽

National Prevalence

Abstract Context Lower sex hormone-binding globulin (SHBG) is associated with many diseases including cardiovascular disease, cancer, polycystic ovarian syndrome, arthritis, and liver disease. However, the definition of low SHBG and its prevalence in US adults are unknown. Objective To define low SHBG and to determine its prevalence and risk factors in US adults. Design, Setting, And Participants This cohort study included adults ≥ 20 years from the US National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 who had fasting serum SHBG.Exposures Nhanes coverage during 2013-2016. Main Outcomes Measures Definition, prevalence, and risk factors of low SHBG. Results This study included 4 093 adults (weighted sample size of 204 789 616) with a mean (SD) age of 47.5 (17.0) years. In a “healthy” reference sub-cohort of 1 477 adults, low SHBG was defined as SHBG< 12.3 nmol/L in men <50 years, or < 23.5 nmol/L in men ≥50 years, or < 14.5 nmol/L in women <30 years, or < 21.9 nmol/L in women ≥30 years. The estimated US national prevalence of low SHBG was 3.3% in men, 2.7% in women, and 3.0% overall. Risk factors for this condition in both men and women included higher body mass index, diabetes, ethnicity (being other than Hispanic, non-Hispanic black, or non-Hispanic white), chronic obstructive pulmonary disease, coronary heart disease, and smoking. Conclusions This study established the criteria for low SHBG among US adults. The estimated US national prevalence of low SHBG was 3.3% in men and 2.7% in women.

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