Abstract 3021: Fatigue as a symptom of Acute Myocardial Infarction

Purpose: Fatigue may be a commonly experienced symptom of acute myocardial infarction (AMI); however, there is a disturbing lack of data about the fatigue that occurs among men and women at the time of AMI. The purpose of this study was to characterize the fatigue experienced among men and women during AMI using three validated fatigue questionnaires. Method: Ninety AMI patients were recruited from six Midwestern hospitals. The Profile of Mood States (POMS), Fatigue Severity Index (FSI), and the Short Form 36 Health Survey (SF-36) were completed by each hemodynamically stable subject. Results: The sample included 76% men (mean age = 61, SD = 10), 24% women (mean age = 59, SD = 13); 78% non-Hispanic white. Subjects scored 1.7 on the POMS fatigue subscale (0 = none, 4 = extremely), 47.3 on the SF-36 vitality subscale (0 = most, 100 = least), and 6.4 on the “most fatigued” item of the FSI (0 = not fatigued at all, 10 = as fatigued as I could be). Scores from AMI subjects were compared to published scores in other populations. Compared to older adult male subjects, AMI subjects had higher levels of fatigue on the POMS fatigue subscale (M = 0.71, t = 7.2, p < 0.001) and the SF-36 vitality subscale (M = 51.0, t = 2.85, p < 0.01). In addition, AMI patients were more fatigued on the “most fatigued” item of the FSI compared to cancer patients in active treatment (M = 5.5, t = 2.28, p = 0.05). Men and women reported similar levels of fatigue across all three measures; however, women reported that fatigue caused more disruption of activities of daily living (p < 0.001), more difficulty with physical activities (p < 0.01), poorer rating of general health (p < 0.05), and more interference with social activities (p < 0.05). Conclusion: To date, fatigue as a symptom of AMI has focused on using qualitative methods in women. This study used three well-established measures of fatigue to demonstrate that fatigue is commonly experienced by both men and women and at levels that are higher than a healthy older adult sample and cancer patients. Interestingly, fatigue had a greater negative impact on women’s lives.

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Contemporary Determinants of Delayed Benchmark Timelines in Acute Myocardial Infarction in Men and Women

The American Journal of Cardiology ◽

10.1016/j.amjcard.2017.07.085 ◽

2017 ◽

Vol 120 (10) ◽

pp. 1715-1719 ◽

Cited By ~ 5

Author(s):

Hilmi Alnsasra ◽

Doron Zahger ◽

Diklah Geva ◽

Shlomi Matetzky ◽

Roy Beigel ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Men And Women

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Abstract 110: Long-Term Health Status Outcomes in Young Women with Acute Myocardial Infarction: Results from the VIRGO Study

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.7.suppl_1.110 ◽

2014 ◽

Vol 7 (suppl_1) ◽

Author(s):

Rachel P Dreyer ◽

Kelly M Strait ◽

Judith H Lichtman ◽

Nancy Lorenze ◽

Gail D'Onofrio ◽

...

Keyword(s):

Quality Of Life ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Health Status ◽

Young Women ◽

Short Form ◽

P Values ◽

Poor Outcome

Background: Despite the excess risk of mortality in young women following acute myocardial infarction (AMI), little effort has been made to describe their long-term outcomes, particularly with respect to their health status (symptoms, function and quality of life). Accordingly, we assessed gender differences in 1-year health status outcomes after AMI. Methods: Data was used from the VIRGO study, an observational cohort of patients aged ≤55 years with AMI in the US and Spain (n=3,501, 67% women). Clinical data was abstracted from medical records and health status was obtained through patient interviews at the time of hospitalization and at 1-year later [Short Form 12 (SF-12) and the Seattle Angina Questionnaire (SAQ)]. Patient scores were categorized as “bad” if they had below average scores on the SF-12 components, had a score below 100 on the SAQ physical limitations (PL) or the SAQ angina frequency (AF), or had a score below 75 on the SAQ quality of life (QOL) at either baseline or 1-year. Patients were classified as having a “poor” outcome for a measure if they had a “bad” score at both baseline and 1-year or had a “bad” score at 1-year. Logistic regression models were used to assess factors associated with having a “poor” outcome for each scale. Results: The median age was 48 years (IQR: 44, 52). Women were more likely to present with diabetes (39% vs. 27%), obesity (51% vs. 45%), stroke (5% vs. 2%), heart failure (5% vs. 2%), lung disease (13% vs. 5%), and depression (48% vs. 24%, all P values <0.0001). Women were more likely to have “poor outcomes” compared with men (SF-12 PCS 46% vs. 30%; SF-12 MCS 47% vs. 30%; SAQ AF 32% vs. 25%; SAQ PL 29% vs. 20%; SAQ QOL 42% vs. 28%, all p-values <0.001). Female gender, prior AMI/percutaneous coronary intervention/coronary artery bypass grafting, and smoking within 30 days were independent predictors of having a “poor” outcome for all health status measures. Specifically, women had an increased odds of having a “poor” outcome on the SF-12 PCS (OR=2.05; 95% CI 1.69, 2.48), MCS (OR=1.98; 95% CI 1.65, 2.39), SAQ AF (OR=1.39; 95% CI 1.15, 1.67), SAQ PL (OR=1.62; 95% CI 1.32, 1.99) and the SAQ QOL scale (OR=1.84; 95% CI 1.53, 2.22), as compared with men. Conclusion: Compared with men, young women are more likely to have “poor” health status outcomes after AMI. This information is critically important in developing targets for gender-specific interventions to improve young women’s recovery post AMI.

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Concerning gender and therapy after acute myocardial infarction: are there differences between men and women?

European Heart Journal ◽

10.1053/euhj.1999.1901 ◽

2000 ◽

Vol 21 (4) ◽

pp. 261-262 ◽

Cited By ~ 1

Author(s):

J Alpert

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Men And Women

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Effect of the WeChat Platform Health Management and Refined Continuous Nursing Model on Life Quality of Patients with Acute Myocardial Infarction after PCI

Journal of Healthcare Engineering ◽

10.1155/2021/5034269 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Meifang Xu ◽

Xiaofang Yang ◽

Lin Liu ◽

Yunlang Dai ◽

Mingzhu Xu ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Research Group ◽

Health Management ◽

Reference Group ◽

Medication Compliance ◽

Life Quality ◽

Nursing Satisfaction ◽

Sf 36

The purpose was to explore the effect of the WeChat platform health management and refined continuous nursing model on life quality of patients with acute myocardial infarction (AMI) after PCI. 100 AMI patients treated in the cardiovascular medicine of the First Affiliated Hospital of Soochow University from June 2018 to June 2019 were selected as the study subjects and randomly divided into research group and reference group, with 50 cases in each group. The reference group received routine nursing after PCI, while the research group received WeChat platform health management and continuous refined nursing. There were no significant differences in sex ratio, age, BMI, complications, education level, and residence between the two groups of patients ( P > 0.05 ). The MPR values of patients in the two groups after intervention were significantly higher than those before intervention ( P < 0.05 ), and the MPR value in the research group after intervention was significantly higher than that in the reference group ( P < 0.05 ). The SF-36 scores of patients in the two groups after intervention were significantly higher than those before intervention ( P < 0.001 ), and the SF-36 score in the research group after intervention was higher than that in the reference group ( P < 0.001 ). The emotional, physical, and economic dimensions of patients in the research group after intervention were significantly lower than those in the reference group ( P < 0.001 ). The HAMA and HAMD scores of patients in the research group after intervention were significantly lower than those in the reference group ( P < 0.001 ). The nursing satisfaction score of patients in the research group was significantly higher than that in the reference group ( P < 0.001 ). The total incidence of complications of patients in the research group after intervention was significantly lower than that in the reference group ( P < 0.05 ). The WeChat platform health management and refined continuous nursing model can effectively improve the medication compliance of patients after PCI, improve the life quality, alleviate depression and anxiety, and reduce postoperative complications, with a definite effect, which is worthy of promotion and application.

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Abstract 327: Gender Differences In The Association Between Hemoglobin Change After Acute Myocardial Infarction And Outcomes

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.6.suppl_1.a327 ◽

2013 ◽

Vol 6 (suppl_1) ◽

Author(s):

Lauren E Thompson ◽

Frederick A Masoudi ◽

Kensey L Gosch ◽

Pamela N Peterson ◽

Adam C Salisbury ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Similar Magnitude ◽

Men And Women ◽

Absolute Change ◽

Hospitalization Rates ◽

Lower Baseline ◽

The Relationship ◽

Baseline Hemoglobin

Background: Hemoglobin decline following acute myocardial infarction (AMI) is associated with long-term morbidity. Since women have lower baseline hemoglobin levels than men, whether the same absolute change in hemoglobin after AMI similarly affects outcomes in women and men is unknown. Methods: We examined patients discharged after AMI in the TRIUMPH registry between 2005 and 2008 who had admission and discharge hemoglobin levels. We compared the relationship between absolute change in hemoglobin during hospitalization with 6- and 12-month mortality and re-hospitalization by gender after adjusting for clinical variables including admission hemoglobin. Results: Of the 4,243 patients with AMI, 33% (1,400 of 4,243) were women. Women were older, had more co-morbidities, and were less likely to present with STEMI, or receive catheterization. Women had lower admission hemoglobin (12.9 g/dL ± 1.9 vs 14.5 ± 2.0, p= <0.01) and a smaller mean absolute change in hemoglobin during hospitalization (-1.5 g/dL ± 1.8 vs -1.6 ±1.8, p = 0.01) compared to men. The association between hemoglobin declines during hospitalization and mortality and re-hospitalization rates at 6 and 12-months were of a similar magnitude between men and women (all interaction p > 0.05). (Figure 1) Conclusion: Although women with AMI had lower admission hemoglobin values, similar declines in hemoglobin during hospitalization were associated with increases in mortality and re-hospitalization in women and men. These findings suggest that absolute change in hemoglobin is equally important at predicting outcomes in women and men, regardless of admission hemoglobin levels.

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Characteristics of Breakthrough Pain and Its Impact on Quality of Life in Terminally Ill Cancer Patients

Integrative Cancer Therapies ◽

10.1177/1534735419859095 ◽

2019 ◽

Vol 18 ◽

pp. 153473541985909 ◽

Cited By ~ 5

Author(s):

Silvia Gonella ◽

Riccardo Sperlinga ◽

Veronica Sciannameo ◽

Valerio Dimonte ◽

Sara Campagna

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Negative Impact ◽

Breakthrough Pain ◽

Short Form ◽

Terminally Ill ◽

Severe Problem ◽

Terminally Ill Cancer Patients ◽

Time To Peak

Purpose. This study aimed to characterize breakthrough pain (BTP) and investigate its impact on quality-of-life (QoL) in terminally-ill cancer patients. Similarities and differences between high and low predictable BTP were also tested. Methods. Secondary analysis of a multicenter longitudinal observational study included 92 patients at their end-of-life. BTP was assessed with a short form of the Italian version of the Alberta Breakthrough Pain Assessment Tool. QoL was assessed with the Palliative Outcome Scale (0-40). Patients were stratified by self-reported BTP predictability into unpredictable BTP (never or rarely able to predict BTP) and predictable BTP (sometimes to always able to predict BTP). Results. In all, 665 BTP episodes were recorded (median 0.86 episodes/day). A median duration of 30 minutes and a median peak intensity score of 7 out of 10 were reported. Time to peak was <10 minutes, 10 to 30 minutes, and ≥30 minutes in 267 (41.1%), 259 (39.9%), and 30 (4.6%) of the episodes, respectively. Onset of relief occurred after a median of 30 minutes. Time to peak ( P < .001) and duration ( P = .046) of BTP was shorter in patients with predictable pain ( n = 31), who usually were younger than those with unpredictable pain ( P = .03). The mean (SD) QoL score was 14.6 (4.6). No difference in QoL between patients with predictable and unpredictable BTP was found ( P = .49). Conclusions. In terminally-ill cancer patients, BTP is a severe problem with a negative impact on QoL and has different characteristics according to its predictability.

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