Abstract 3696: Decreased Number Of Circulating Progenitor Cells In Obesity -Beneficial Effects Of Weight Reduction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Jochen Muller-Ehmsen ◽  
Daniela Braun ◽  
Thorsten Schneider ◽  
Roman Pfister ◽  
Franziska Grundmann ◽  
...  
Keyword(s):  
Weight Loss ◽  
Endothelial Function ◽  
Progenitor Cells ◽  
Weight Reduction ◽  
Progenitor Cell ◽  
Inverse Correlation ◽  
Intima Media Thickness ◽  
Double Positive ◽  
Media Thickness ◽  
Cell Counts

Aims: Cardiovascular risk factors are associated with decreased levels of circulating progenitor cells (CPC). The aim of this study was to determine whether the number of CPC is an independent correlate of Body-Mass-Index (BMI) and whether weight loss leads to an increase of CPC. Methods: CD34 positive and KDR/CD34, CD133/CD34 and CD117/CD34 double positive cells were measured by FACS in peripheral blood of 149 volunteers (52.5±0.1 years, BMI 21.5–52.7 kg/m 2 , mean 31.6±0.03 kg/m 2 ) participating in a weight reduction program offered by German pharmacies. In addition, carotid intima media thickness and brachial artery flow mediated dilatation were determined. After a diet and sports program for 6 months, 86 representing subjects were re-evaluated (mean weight loss 5.8±0.1 kg). Results: There was an inverse correlation between BMI and CPC. For subjects with BMI>34.1 compared to BMI<28.1 (4 th vs. 1 st quartile) cell counts were: CD34+: 137.7±1.6 vs. 187.0±1.8; KDR/CD34: 17.3±0.7 vs. 55.8±2.0; CD133/CD34: 70.2±1.6 vs. 129.2±1.7; CD117/CD34: 93.1±2.1 vs. 142.7±1.7, all per million leucocytes; p< 0.01 for all parameters). The decrease in CPC in obesity held true not only for the absolute cell numbers, but also for the relative fractions of KDR, CD133 and CD117 positive cells within the CD34 + cells, indicating a specific down regulation of these progenitor cell types. Intima media thickness increased in dependence from BMI (p< 0.001) and was inversely correlated with the number of circulating CD34 positive cell (p< 0.05). After diet, there was a significant increase of CD34 and CD117/CD34 positive cells in subjects whose reduction in BMI was greater than 2.5 kg/m 2 (4 th quartile), which was accompanied by a decrease in intima media thickness (p< 0.05) and an improvement in forearm dilatory response (p < 0.01). Increase in the number of CPC was independent from whether weight loss was achieved by increased physical exercise or by reduced calory intake only. Conclusions: Obesity is associated with decreased numbers of CPC, increased intima media thickness and impaired endothelial function. Diet and weight loss lead to an increase in circulating progenitor cell count, which might contribute to regression of intima media thickness and improved endothelial function.

scholarly journals Endothelial Function, But Not Carotid Intima-Media Thickness, Is Affected Early in Menopause and Is Associated with Severity of Hot Flushes

2010 ◽  
Vol 95 (3) ◽  
pp. 1199-1206 ◽  
Author(s):  
Aris Bechlioulis ◽  
Sophia N. Kalantaridou ◽  
Katerina K. Naka ◽  
Anthoula Chatzikyriakidou ◽  
Karim A. Calis ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Hot Flushes ◽  
Media Thickness

scholarly journals Association of Physical Activity With Vascular Endothelial Function and Intima-Media Thickness

Circulation ◽  
2011 ◽  
Vol 124 (18) ◽  
pp. 1956-1963 ◽  
Author(s):  
Katja Pahkala ◽  
Olli J. Heinonen ◽  
Olli Simell ◽  
Jorma S.A. Viikari ◽  
Tapani Rönnemaa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Media Thickness

Abstract 3610: Comparative Effects of 3 Popular Diets on Lipids, Endothelial Function and Biomarkers of Atherothrombosis in the Absence of Weight Loss

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Michael Miller ◽  
Valerie Beach ◽  
Charles Mangano ◽  
Jeffrey Rhyne ◽  
Christina Dobmeier ◽  
...  
Keyword(s):  
Weight Loss ◽  
Endothelial Function ◽  
Cardiovascular Health ◽  
Dietary Intervention ◽  
Saturated Fat ◽  
Inverse Correlation ◽  
Monounsaturated Fat ◽  
The South ◽  
Atkins Diet ◽  
Total Fat

Background : While the effect of popular diets on weight loss has been extensively studied, less is known in the absence of weight loss. We hypothesized that a diet high in total and saturated fat would be associated with adverse effects on LDL-C, endothelial function and biomarkers of atherothrombosis compared to lower fat diets. Methods : We tested 3 popular diets, including Atkins (50% fat), South Beach (30% fat) and Ornish (10% fat) in a randomized and counterbalanced, crossover study. Subjects completed each of the three 4-week dietary intervention phases followed by a 4-week washout period. They were weighed weekly and caloric adjustments made if weight change exceeded 1 kg. At the completion of each dietary phase, 3-day food records were analyzed, fasting blood was sampled and brachial artery reactivity testing (BART) performed. Results : Eighteen of 26 adults (mean age: 30.6 ± 9.6 yrs, 50% female) completed all 3 dietary phases. There were no changes in weight at the conclusion of each phase. However, non-significant increases in LDL-C occurred during the Atkins phase (pre: 96.5, post: 112.9 mg/dL; P=0.12 ), whereas LDL-C was reduced during the Ornish (pre: 110.1, post: 84.6 mg/dL; P=0.006 ) and South Beach phases (pre: 101.7, post: 91.5 mg/dL; P=0.01 ). BART testing revealed a significant inverse correlation between flow-mediated vasodilation and intake of total fat (r 2 =−0.29; P=0.03 ), saturated fat (r 2 =−0.31; P=0.02 ) and monounsaturated fat (r 2 =−0.35; P=0.01 ). Microarray analysis demonstrated increased expression of several leukocyte biomarkers including, ICAM2 (37%; P=0.002 ), SELL (26%; P=0.007 ) and SOD1 (42%; P=0.04 ) at the completion of the Atkins diet compared to baseline. In contrast, expression of atherothrombotic biomarkers was not increased after the South Beach or Ornish phase. Conclusions: In the absence of weight loss, the high fat Atkins diet is associated with increased LDL-C, reduced endothelial vasoreactivity and increased expression of biomarkers of atherothrombosis. As such, these data suggest that isocaloric conversion to the Atkins diet may negatively impact cardiovascular health as compared to the South Beach or Ornish Diet.

Endothelial function and carotid intima media thickness in obstructive sleep apnea without comorbidity

2016 ◽  
Vol 21 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Faraz A. Farooqui ◽  
Surendra K. Sharma ◽  
Atin Kumar ◽  
Manish Soneja ◽  
Kalaivani Mani ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Obstructive Sleep

scholarly journals Weight loss and carotid intima-media thickness-a meta-analysis

Obesity ◽  
2016 ◽  
Vol 25 (2) ◽  
pp. 357-362 ◽  
Author(s):  
Michael R. Skilton ◽  
Si Qin Yeo ◽  
Jia Yi Anna Ne ◽  
David S. Celermajer ◽  
Ian D. Caterson ◽  
...  
Keyword(s):  
Weight Loss ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness
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