Abstract 11539: Impact of Adipose Tissue Composition on Cardiovascular Risk Assessment

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ayako Kunimura ◽  
Tadayuki Uetani ◽  
Takashi Kataoka ◽  
Masahiro Takeshita ◽  
Kazuhiro Harada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Visceral Adipose Tissue ◽  
Cardiovascular Outcome ◽  
Tissue Composition ◽  
Event Free Survival ◽  
Free Survival ◽  
Visceral Adipose

Background: Visceral adipose tissue (VAT) , unlike subcutaneous adipose tissue (SAT), has been shown to be highly correlated with cardiovascular risk factors. The aim of this study was to evaluate the predictive value of adipose tissue composition measured by computed tomography for cardiovascular outcome. Method: 369 consecutive patients without history of cardiovascular disease who underwent 64-slice computed tomography angiography (CTA) were recruited. The ratio of visceral adipose tissue to the total adipose tissue (%VAT) was calculated as VAT/ (VAT + SAT) х 100. Patients were divided into three groups in accordance with tertiles of %VAT (tertile1, <35.1%; tertile2, 35.1 to 45.0%; tertile3, 45.1%≤). The investigated risk factors were hypertension, hyperglycemia, and dyslipidemia. We analyzed the incidence of major adverse cardiac events (MACE), including cardiovascular death, myocardial infarction, and any revascularization. Result: The rate of patients who have two or more concomitant risk factors was significantly increased across tertiles of %VAT (p=0.001). During the median follow-up of 1973 days, 96 events occurred. Event-free survival was significantly associated with %VAT tertiles, with worse event-free survival in tertile 3 (log-rank p=0.001). In Cox analysis, the hazard ratio (HR) of %VAT (per tertile) for MACE was 1.39 (95% confident interval [CI] 1.05-1.82, p=0.02). Among patients with tertile 3, HR for MACE was 1.81 (95% CI 1.01-3.23, p=0.045) compared to tertile 1 after adjustment for confounding factors. Conclusion: %VAT is independently associated with MACE, indicating that adipose tissue composition is a useful predictor of cardiovascular outcome.

Relation of Visceral Adipose Tissue to Coronary Artery Calcium in Thai Patients

2020 ◽  
Vol 103 (5) ◽  
pp. 434-441
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Visceral Adipose Tissue ◽  
Coronary Artery Calcium ◽  
Abdominal Fat ◽  
Visceral Adipose

Objective: To determine the relationship among body mass index (BMI), waist circumference (WC), abdominal fat area of visceral (VFA), and subcutaneous fat (SFA) on coronary artery calcium (CAC) using a multidetector computed tomography (MDCT) in asymptomatic Thai patients, and describe the prevalence of CAC in Thai patients. Materials and Methods: Participants (n=1,900, mean age 61 years, 64% women) who were moderate to high risk for coronary artery disease (CAD) according to the RAMA-EGAT score, underwent a MDCT for CAD screening between January and December 2012. BMI, WC, CAC score, abdominal fat area, and cardiovascular risk factors were determined for all patients. Results: The prevalence of CAC in all patients was 56.7% (67.9% men, 50.3% women). Using multivariate logistic regression analysis adjusting for traditional cardiovascular risk factors and abdominal fat measurement, VFA as visceral to total fat ratio represented an independent risk factor of the presence of CAC (OR 1.55, 95% CI 1.12 to 2.00, p=0.001). Similar relationships were observed across gender, age, WC, history hypertension, and serum fasting blood sugar (FBS). Conclusion: The authors found that visceral adiposity measured by MDCT is significantly associated with the presence of CAC as a marker of subclinical atherosclerosis in Thai patients. Keywords: Visceral adipose tissue, Coronary artery calcification, Computed tomography

Visceral adipose tissue and cardiovascular risk factors in obese children

1998 ◽  
Vol 133 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Scott Owens ◽  
Bernard Gutin ◽  
Michael Ferguson ◽  
Jerry Allison ◽  
Warren Karp ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Visceral Adipose Tissue ◽  
Obese Children ◽  
Visceral Adipose

scholarly journals Association between visceral adipose tissue volume, measured using computed tomography, and cardio-metabolic risk factors

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Wook Yi ◽  
Keunyoung Kim ◽  
Myungsoo Im ◽  
Soree Ryang ◽  
Eun Heui Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Parameters ◽  
Oral Glucose ◽  
Slice Thickness ◽  
Metabolic Risk ◽  
Visceral Adipose

AbstractWe evaluated the associations between metabolic parameters with visceral adipose tissue (VAT) volume in women with prediabetes or type 2 diabetes (T2DM), and we compared the VAT volume with the VAT area. We enrolled women aged > 20 years with prediabetes or T2DM, who underwent oral glucose tolerance test and whose VAT was evaluated using computed tomography (CT) at our institution between 2017 and 2019. All participants underwent unenhanced spiral CT with a 3-mm slice thickness from the level of the diaphragm to the level of the mid-thigh. The two VAT areas were defined as the free drawn area on the levels of the umbilicus and L2 vertebra. The VAT areas were also manually drawn from the level of the diaphragm to the level of the pelvic floor and were used to calculate the VAT volumes by summing all areas with a slice thickness of 3 mm after setting the attenuation values from −45 to −195 Hounsfield Unit. All metabolic characteristics, except blood pressure, were significantly correlated with the VAT volume. The VAT areas measured at the level of the L2 vertebra and umbilicus were correlated with serum triglyceride, high-density lipoprotein cholesterol, and Framingham steatosis index alone. Multivariable regression analyses revealed that the VAT volume was significantly associated with several metabolic parameters. In conclusion, in women with prediabetes and T2DM, the VAT volume acquired from CT-based calculation has more significant correlations with metabolic risk factors compared with the VAT area.

scholarly journals Sex Differences in the Associations of Visceral Adipose Tissue and Cardiometabolic and Cardiovascular Disease Risk: The Framingham Heart Study

2021 ◽  
Author(s):  
Andreas A. Kammerlander ◽  
Asya Lyass ◽  
Taylor F. Mahoney ◽  
Joseph M. Massaro ◽  
Michelle T. Long ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Computed Tomography ◽  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Cardiometabolic Risk ◽  
Anthropometric Measures ◽  
Heart Study ◽  
Visceral Adipose

Background Men and women are labeled as obese on the basis of a body mass index (BMI) using the same criterion despite known differences in their fat distributions. Subcutaneous adipose tissue and visceral adipose tissue (VAT), as measured by computed tomography, are advanced measures of obesity that closely correlate with cardiometabolic risk independent of BMI. However, it remains unknown whether prognostic significance of anthropometric measures of adiposity versus VAT varies in men versus women. Methods and Results In 3482 FHS (Framingham Heart Study) participants (48.1% women; mean age, 50.8±10.3 years), we tested the associations of computed tomography–based versus anthropometric measures of fat with cardiometabolic and cardiovascular disease (CVD) risk. Mean follow‐up was 12.7±2.1 years. In men, VAT, as compared with BMI, had a similar strength of association with incident cardiometabolic risk factors (eg, adjusted odds ratio [OR], 2.36 [95% CI, 1.84–3.04] versus 2.66 [95% CI, 2.04–3.47] for diabetes mellitus) and CVD events (eg, adjusted hazard ratio [HR], 1.32 [95% CI, 0.97–1.80] versus 1.74 [95% CI, 1.14–2.65] for CVD death). In women, however, VAT, when compared with BMI, conferred a markedly greater association with incident cardiometabolic risk factors (eg, adjusted OR, 4.51 [95% CI, 3.13–6.50] versus 2.33 [95% CI, 1.88–3.04] for diabetes mellitus) as well as CVD events (eg, adjusted HR, 1.85 [95% CI, 1.26–2.71] versus 1.19 [95% CI, 1.01–1.40] for CVD death). Conclusions Anthropometric measures of obesity, including waist circumference and BMI, adequately capture VAT‐associated cardiometabolic and cardiovascular risk in men but not in women. In women, abdominal computed tomography–based VAT measures permit more precise assessment of obesity‐associated cardiometabolic and cardiovascular risk.

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