Abstract 12027: Peripheral Endothelial Dysfunction Independently Correlated With Cardiovascular Events in Patients Following Coronary Stent Implantation

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Noriaki Tabata ◽  
Seiji Hokimoto ◽  
Tomonori Akasaka ◽  
Yuichiro Arima ◽  
Koichi Kaikita ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Cardiovascular Event ◽  
Stent Implantation ◽  
Cardiovascular Events ◽  
Reactive Hyperemia ◽  
Coronary Stent ◽  
Coronary Stent Implantation ◽  
Peripheral Arterial

Introduction: Percutaneous coronary intervention (PCI) is performed in patients with coronary heart disease to improve symptoms and clinical prognosis. Despite optimal therapies after PCI, some patients experience one or more adverse outcome. Therefore, to evaluate the determinants of the residual risk of cardiovascular events is still important. Endothelial dysfunction has been reported to correlate with adverse cardiovascular events in coronary heart disease. Hypothesis: We hypothesized that endothelial dysfunction could predict future cardiovascular events in patients following coronary stent implantation. Methods: We conducted a prospective cohort study of 435 patients after coronary stent implantation. All patients received aspirin and clopidogrel in addition to other optimal medications. Peripheral endothelial dysfunction was expressed as reactive hyperemia index (RHI) using reactive hyperemia peripheral arterial tonometry, and we used the median value of the RHI (0.54) to divide patients into low (n=218, male 70.2%) and high (n=217, male 70%) RHI groups. We followed cardiovascular events after coronary stent implantation. Results: There was no significant difference in clinical characteristics between the low and high group. A total of 64 patients had a cardiovascular event. The incidence of cardiovascular event was significantly higher in the low RHI group (20.2% versus 9.2%; P=0.007). Kaplan-Meier analysis demonstrated a significantly higher probability of cardiovascular events in the low RHI group than in the high RHI group (mean follow-up: 70 months; log-rank test: P=0.002). Multivariate Cox hazard analysis among various clinical factors demonstrated that body mass index (hazard ratio [HR]: 0.906; 95% confidence interval [CI]: 0.838 to 0.980; P=0.014), peripheral arterial disease (HR: 1.834; 95% CI: 1.003 to 3.351; P=0.049), Cytochrome P450 loss-of-function allele carriage (HR: 2.005; 95% CI: 1.101 to 3.651; P=0.023), and RHI (HR: 0.149; 95% CI: 0.044 to 0.502; P=0.002) as independent and significant determinants of clinical outcome. Conclusions: Peripheral endothelial dysfunction independently correlated with future cardiovascular events in patients following coronary stent implantation.

Expression of inflammatory and apoptosis factors following coronary stent implantation in coronary heart disease patients

2011 ◽  
Vol 11 (11) ◽  
pp. 1850-1854 ◽  
Author(s):  
Li-Li Liu ◽  
Li-Rong Lin ◽  
Cheng-Xiang Lu ◽  
Jian-Guo Fu ◽  
Peng-Li Chao ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Stent Implantation ◽  
Coronary Stent ◽  
Coronary Stent Implantation

Abstract P251: Relationship Between Reactive Hyperemia Index in Patients with Coronary Artery Disease With the Cardiac Function and Prognosis

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Liu Tianhu ◽  
Yu Chaoping ◽  
Xu Fengcheng
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Correlation Analysis ◽  
Cardiac Function ◽  
Cardiovascular Events ◽  
Reactive Hyperemia ◽  
Reactive Hyperemia Index ◽  
Health Group ◽  
The Relationship

Objective: To investigate the relationship between reactive hyperemia index(RHI) in patients with coronary heart disease (CHD) with the cardiac function and prognosis, intervention so as to provide guidance for coronary heart disease severity and prognosis assessment. Methods: 500 cases of volunteers had coronary artery angiography by Judkins method in our hospital. coronary angiography showing one or more quarantine branch of coronary artery stenosis lower than 50% or more were taken as the standard for coronary heart disease diagnosis, and the volunteers were divided into CHD group (n=81) and health group (n=419). RHI and left ventricular ejection fraction (LVEF) of two groups were detected. The CHD group were followed up for 1 year and survival prognosis and cardiovascular events prognosis of the patients were statistically analyzed and the relationship between RHI and LVEF, cardiovascular events rate and mortality were analyzed. Results: Compared with health group, RHI and LVEF of CHD group were lower ( P <0. 05). RHI of patient in CHD group with LVEF ≥ 50% were higher than that of patient with LVEF < 50% ( P <0. 05). Pearson correlation analysis results showed that RHI and LVEF of CHD patients were positively correlated (r=0.827, P <0. 05). Coronary heart disease group were followed up for 1 year and the cardiovascular events rates and mortality rates were 28.40% and 9.88% respectively, and RHI and LVEF of patient with cardiovascular events were lower than that of patients without coronary heart disease, and RHI and LVEF of death patients were also lower than that of survived patients ( P <0. 05). Spearman unconditionally correlation analysis results showed that the RHI and cardiovascular events and mortality in patients with CHD are negatively correlated (r=-0.794, -0.762, P <0. 05). Conclusion: RHI in CHD patients is lower and closely related to the cardiac function and prognosis, this may be related to RHI reflecting endothelial function and endothelial function damage of CHD associating with disease development, therefore, RHI may be reference indicators of disease severity and prognosis assessment of CHD.

scholarly journals Preprocedural C-reactive protein levels and cardiovascular events after coronary stent implantation

2001 ◽  
Vol 37 (3) ◽  
pp. 839-846 ◽  
Author(s):  
Dirk H Walter ◽  
Stephan Fichtlscherer ◽  
Marc Sellwig ◽  
Wolfgang Auch-Schwelk ◽  
Volker Schächinger ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Cardiovascular Events ◽  
Coronary Stent ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Coronary Stent Implantation

scholarly journals Endothelial dysfunction in patients with chronic obstructive pulmonary disease in combination with coronary heart disease

2019 ◽  
Vol 91 (3) ◽  
pp. 22-26
Author(s):  
N A Karoli ◽  
A P Rebrov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Pulmonary Disease ◽  
Reactive Hyperemia ◽  
Vascular Wall ◽  
Chronic Obstructive ◽  
Chronic Coronary Artery Disease ◽  
Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease is associated with increased cardiovascular mortality. Endothelial dysfunction may underpin this association. Vascular endothelial dysfunction is known to be an important prognostic marker for cardiovascular events. The aim of this study was to evaluate the state of the vascular wall in patients with chronic obstructive pulmonary disease (COPD) combined with chronic coronary artery disease (CAD). Materials and methods. The study included 108 patients: 37 patients with COPD and CAD and 71 patients with COPD without CAD. Endothelial function was studied in tests with reactive hyperemia and nitroglycerin. The number of blood plasma desquamated endotheliocytes were determined by the Hladovec method. In patients with COPD identified are signs of vascular wall remodeling: thickening wall of the brachial artery, reduction of the flow-mediated vasodilation. Patients with COPD in combination with CHD demonstrated higher impairments of the vasoregulatory dysfunction of endothelial of the vascular wall. Conclusion. In patients with COPD combined with chronic coronary heart disease more pronounced endothelial dysfunction with disturbance of endothelium-dependent vasomotor reactions.

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