Abstract 13944: J Relationship of Body Mass Index of 22-year Cardiovascular Disease Mortality versus Body Mass Index

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
William J Kostis ◽  
Javier Cabrera ◽  
Fei Wang ◽  
Sara J Guterl ◽  
Dhammika Amaratunga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Systolic Hypertension ◽  
Female Gender ◽  
The Elderly ◽  
Linear Term ◽  
Quadratic Term ◽  
All Cause Mortality ◽  
Cv Disease

Introduction: J relationships of body mass index (BMI) with mortality have been described. However, little data are available on long-term follow-up in controlled clinical trials with respect to cardiovascular (CV) and all cause mortality. Hypothesis: We tested whether there is a J shape relationship between BMI with CV and all cause mortality at 22 years in the Systolic Hypertension in the Elderly Program (SHEP). Methods: SHEP was a placebo controlled, randomized clinical trial of antihypertensive therapy in patients with isolated systolic hypertension aged 60 and older. The relationship between CV and all cause mortality with baseline BMI was examined in 4,211 SHEP participants. Results: In unadjusted analyses, a J relationship was observed for all-cause mortality (linear term p=0.0318, quadratic term p=0.3217 and tricubic term p=0.0046) and for CV mortality (linear term p=0.0962, quadratic term p=0.6866 and tricubic term p=0.0908, left figure). The lowest risk was at a BMI of 25.9 for all-cause and 25.5 for CV mortality. The J shaped relationship between BMI and mortality was attenuated after adjustment for age, gender, comorbidities (e.g. diabetes, heart failure) and risk factors for CV disease (e.g. smoking and dyslipidemia, right figure). Age and gender were significant predictors of both all- cause and CV mortality: age p<0.0001, female gender p=0.0063 for all-cause mortality and p<0.0001 for age and p=0.0004 for female gender for CV mortality. <br/Conclusions: This study indicates that both very low and very high BMI are markers of high risk. The J relationship between BMI and mortality is mediated by age, female gender, comorbidities and risk factors for CV disease.

Interactions between C-reactive protein and traditional risk factors in predicting mortality of older adults

VASA ◽  
2017 ◽  
Vol 46 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Henrik Rudolf ◽  
Naemi Wall ◽  
Renate Klaassen-Mielke ◽  
Ulrich Thiem ◽  
Curt Diehm ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Hazard Ratio ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
High Level

Abstract. Background: Elevated levels of C-reactive protein (CRP) are known to be associated with cardiovascular (CV) morbidity and mortality in older adults, however, there seems to be heterogeneity of this association across subsets of individuals. We aim to assess the effects of interactions between CRP and one of the following traditional CV risk factors regarding all-cause mortality in unselected elderly men and women: age, sex, body mass index, diabetes, and hypertension. Patients and methods: Three hundred and forty-four general practitioners all over Germany enrolled 6,817 unselected participants, aged 65 years or older, and performed thorough examinations, including CRP measurement at baseline (getABI study). All-cause mortality was determined in the following seven years. Cox regression analyses were done using uni- and multivariable models. Results: At baseline 4,172 participants of this cohort had a CRP value of ≤ 3 mg/L (low level CRP group), 2,645 participants had a CRP value of > 3 mg/L (high level CRP group). The unadjusted hazard ratio for all-cause death of the high level CRP group compared to the low level CRP group was 1.49 (95 % confidence interval [95 %CI] 1.34 to 1.66). After adjustment for sex, age, education, peripheral artery disease/media sclerosis, other prior vascular events, smoking status, diabetes, systolic blood pressure, antihypertensive medication, body mass index, cholesterol, and statin use, the hazard ratio was 1.34 (95 %CI 1.20 to 1.50). Significant interactions with CRP were found for sex (adjusted hazard ratio 1.38, 95 %CI 1.11 to 1.72), age (0.75, 95 %CI 0.60 to 0.94), and baseline systolic blood pressure (0.64, 95 % CI 0.51 to 0.81). The interactions of CRP with body mass index and of CRP with diabetes were not significant. Conclusions: In older German adults, there seem to be effect modifications by age, sex, and arterial hypertension regarding the effect of CRP in the prediction of all-cause mortality.

Malnutrition of the elderly patient in hospital: risk factors, detection and management

2001 ◽  
Vol 11 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Yee Kiat Teo ◽  
HA Wynne
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Nutritional Status ◽  
Body Mass ◽  
The Elderly ◽  
Skinfold Thickness ◽  
Community Dwelling ◽  
Nutritional Risk ◽  
Admission Rates ◽  
Healthy Elderly

Dietary, biochemical and anthropometric data indicate good nutritional status, in general, in community-dwelling, healthy elderly people, at least in the USA. In a sample of 209 men over 65 years of age without acute disease-related nutritional risk factors, mean intake of nutrients generally met or exceeded the recommended dietary values, with the exception of calories, although 7% of subjects consumed inadequate amounts of thiamine, vitamin A, vitamin C and calcium. Few subjects were extremely underweight or obese, although body fat, as assessed by skinfold thickness, fell over the two years of evaluation. The prevalence of malnutrition in patients with chronic disease living in the community in the UK is estimated to be around 8%, however. In this study of more than 11 000 men and women aged 18 years or over, consultation rates in general practice and prescription rates were lowest amongst patients with a body-mass index between 20 and 25. Hospital outpatient referral rates were not related to nutritional status, but both hospital admission rates and mortality were greatest in people with a body-mass index(BMI) (kg/m2) below 20, and declined as BMI increased.

scholarly journals Association of Body Mass Index and Weight Change with All-Cause Mortality in the Elderly

2006 ◽  
Vol 163 (10) ◽  
pp. 938-949 ◽  
Author(s):  
María M. Corrada ◽  
Claudia H. Kawas ◽  
Farah Mozaffar ◽  
Annlia Paganini-Hill
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Weight Change ◽  
The Elderly ◽  
All Cause Mortality

scholarly journals Factors Associated With Being Overweight or Obese in Suriname

2021 ◽  
Vol 66 ◽  
Author(s):  
Jeetendra Khadan ◽  
Nekeisha Spencer ◽  
Eric Strobl ◽  
Theophiline Bose-Duker
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Health Care Systems ◽  
The Elderly ◽  
Safety Net ◽  
Public Health Issue ◽  
Adult Body Mass ◽  
Care Systems ◽  
Demographic Risk

Objective: To identify the socio-demographic risk factors that are associated with adult Body Mass Index.Methods: We apply probit and ordinal probit models to a sample of 3,803 adults aged 20 and above from the 2016/17 round of the Suriname Survey of Living Conditions.Results: Women, the elderly, and couples who are either married and/or living together are more likely to be obese or overweight. This is also true for individuals who have chronic illnesses. We also find that individuals who engage in a sport or in other forms of exercise, even if modest, have lower odds of being overweight or obese. Interestingly, our findings indicate that individuals who benefit from government social safety net programs are less likely to be associated with being overweight or obese.Conclusion: Obesity could become a serious public health issue if not addressed appropriately. Policymakers should promptly develop a national strategy to help health care systems cope with the outcomes of obesity and to tackle the risk factors that have the greatest impacts on individual Body Mass Index.

scholarly journals Changes in Cardiovascular Risk Factors and Cardiovascular Events in the Elderly Population

2021 ◽  
Author(s):  
Pil‐Sung Yang ◽  
Eunsun Jang ◽  
Hee Tae Yu ◽  
Tae‐Hoon Kim ◽  
Hui‐Nam Pak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Lower Risk ◽  
Elderly Population ◽  
The Elderly ◽  
Very Elderly ◽  
All Cause Mortality

Background This study examines changes in the ideal cardiovascular health (CVH) status and whether these changes are associated with incident cardiovascular disease (CVD) and mortality in the elderly Asian population. Methods and Results In the Korea National Health Insurance Service–Senior cohort aged ≥60 years, 208 673 participants without prior CVD, including 109 431 who showed changes in CVH status, were assessed. The association of the changes in cardiovascular risk factors with incident CVD was assessed from 2004 to 2014 in the elderly (aged 60–74 years) and very elderly (≥75 years) groups. During the follow‐up period (7.1 years for CVD and 7.2 years for mortality), 19 429 incident CVD events and 24 225 deaths occurred. In both the elderly and very elderly participants, higher CVH status resulted in a lower risk of CVD and mortality. In the very elderly participants, compared with consistently low CVH, consistently high CVH (subhazard ratio, 0.41; 95% CI, 0.23–0.73) was associated with a lower risk of CVD. This trend was consistently observed in the elderly population. In the very elderly participants, total cholesterol level was not informative enough for the prediction of CVD events. In both the elderly and very elderly groups, body mass index and total cholesterol were not informative enough for the prediction of all‐cause mortality. Conclusions In both the elderly and very elderly Asian populations without CVD, a consistent relationship was observed between the improvement of a composite metric of CVH and the reduced risk of CVD. Body mass index and total cholesterol were not informative enough for the prediction of all‐cause mortality in both the elderly and very elderly groups.

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