Abstract P542: Association of Psychosocial Factors With Heart Rate Variability: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Anish Shah ◽  
Alvaro Alonso ◽  
Eric A Whitsel ◽  
Elsayed Z SOLIMAN ◽  
Viola Vaccarino ◽  
...  
Keyword(s):  
Social Support ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Psychosocial Factors ◽  
Community Sample ◽  
Linear Regression Models ◽  
Atherosclerosis Risk In Communities ◽  
Vital Exhaustion ◽  
Cardiovascular Morbidity And Mortality ◽  
Atherosclerosis Risk

Introduction: Psychosocial factors are associated with cardiovascular morbidity and mortality, but our understanding of causal mechanisms is limited. Understanding such mechanisms may help formulate prevention strategies. We therefore sought to evaluate potential physiologic effects of psychosocial factors by studying their associations with heart rate variability (HRV), a measure of autonomic function, in the Atherosclerosis Risk in Communities (ARIC) study. Hypothesis: Higher psychosocial stress levels are associated with lower HRV cross-sectionally in a diverse community sample. Methods: We included ARIC cohort participants with information on psychosocial factors in 1990-1992 into our analysis. Psychosocial factors were assessed using validated instruments, including: 1) vital exhaustion, a somatic manifestation of chronic stress and depression, 2) anger proneness, a personality trait, and 3) perceived social support, a potential buffering factor for stress. Short-term time and frequency domain HRV were measured from a two-minute electrocardiographic recording in 1987-1989. Linear regression models adjusted for sociodemographic and cardiovascular risk factors. Results: We included 9,332 participants (mean age 54.4 ± 5.7 years, 55% women, and 25% black) in the analysis. Only vital exhaustion was consistently associated with HRV, as per the table, which shows the change in ln(HRV) per point increase in score. Compared to the lowest quartile, the highest quartile of vital exhaustion was associated with a 13.3% (95% CI, 3.9% - 21.3%) decrease in low frequency HRV in adjusted models. By comparison, each year of added age was associated with a 3.7% (95% CI, 3.1% to 4.2%) decrease in LF HRV. Conclusion: A high level of vital exhaustion was associated with low HRV, while anger proneness and social support were not. The inverse vital exhaustion-HRV association raises concern regarding the somatic manifestations of stress, a potential target for preventive interventions.

scholarly journals Association of Psychosocial Factors With Short‐Term Resting Heart Rate Variability: The Atherosclerosis Risk in Communities Study

2021 ◽  
Vol 10 (5) ◽  
Author(s):  
Anish S. Shah ◽  
Alvaro Alonso ◽  
Eric A. Whitsel ◽  
Elsayed Z. Soliman ◽  
Viola Vaccarino ◽  
...  
Keyword(s):  
Social Support ◽  
Heart Rate ◽  
Psychosocial Factors ◽  
Perceived Social Support ◽  
Low Frequency ◽  
Resting Heart Rate ◽  
Short Term ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Over Time

Background Psychosocial factors predict heart disease risk, but our understanding of underlying mechanisms is limited. We sought to evaluate the physiologic correlates of psychosocial factors by measuring their relationships with heart rate variability (HRV), a measure of autonomic health, in the ARIC (Atherosclerosis Risk in Communities) study. We hypothesize that increased psychosocial stress associates with lower HRV. Methods and Results We studied 9331 participants in ARIC with short‐term HRV data at visits 2 and 4. The mean (SD) age was 54.4 (5.7) years, 55% were women, and 25% were Black. Psychosocial factors included: (1) vital exhaustion (VE), (2) anger proneness, a personality trait, and (3) perceived social support. Linear models adjusted for sociodemographic and cardiovascular risk factors. Low frequency HRV (ln ms 2 ) was significantly lower in the highest versus lowest quartiles of VE (B=−0.14, 95% CI, −0.24 to −0.05). When comparing this effect to age (B=−0.04, 95% CI, −0.05 to −0.04), the difference was equivalent to 3.8 years of accelerated aging. Perceived social support associated with lower time‐domain HRV. High VE (versus low VE) also associated with greater decreases in low frequency over time, and both anger and VE associated with greater increases in resting heart rate over time. Survival analyses were performed with Cox models, and no evidence was found that HRV explains the excess risk found with high VE and low perceived social support. Conclusions Vital exhaustion, and to a lesser extent anger and social support, were associated with worse autonomic function and greater adverse changes over time.

Abstract MP48: Social Network, Social Support, and the Risk of Incident Stroke: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Mako Nagayoshi ◽  
Susan A Everson-Rose ◽  
Hiroyasu Iso ◽  
Thomas H Mosley ◽  
Kathryn M Rose ◽  
...  
Keyword(s):  
Social Support ◽  
Social Network ◽  
Short Form ◽  
Network Size ◽  
Community Dwelling ◽  
Men And Women ◽  
Atherosclerosis Risk In Communities ◽  
Vital Exhaustion ◽  
Increased Risk ◽  
Atherosclerosis Risk

Background and Purpose: Having a small social network and lack of social support have been associated with incident coronary heart disease, but little is known about their association with incident stroke. Thus, we assessed the association of a small social network and lack of social support with risk of incident stroke and evaluated whether the relation was mediated by vital exhaustion and inflammation. Methods: The Atherosclerosis Risk in Communities (ARIC) Study measured social network and social support in 13,686 men and women (mean, 57 ± 5.7 years, 56% female, 24% black; 76% white) initially free of stroke. The 10-item Lubben Social Network Scale and 16-item Interpersonal Support Evaluation List-Short Form were used to assess social network size and social support, respectively. Results: Over a median follow-up of 18.6-years, 905 incident strokes occurred. Relative to participants with a large social network, those with a small social network had a higher risk of stroke [HR (95% CI): 1.43 (1.03-2.00)] after adjustment for demographic and socioeconomic characteristics and marital status ( Table ). Further adjustment for other potential confounders attenuated the association slightly. Vital exhaustion, but not inflammation, partly mediated the association between a small social network and stroke. Social support was unrelated to incident stroke. Conclusions: In this sample of US community-dwelling men and women, having a small social network was associated with excess risk of incident stroke. As with other cardiovascular conditions, having a small social network appears to be associated with modestly increased risk of incident stroke.

scholarly journals Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

2015 ◽  
Vol 77 (5) ◽  
pp. 877-883 ◽  
Author(s):  
Alvaro Alonso ◽  
Xuemei Huang ◽  
Thomas H. Mosley ◽  
Gerardo Heiss ◽  
Honglei Chen
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Parkinson Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Diabetes, Glucose, Insulin, and Heart Rate Variability: The Atherosclerosis Risk in Communities (ARIC) study

Diabetes Care ◽  
2005 ◽  
Vol 28 (3) ◽  
pp. 668-674 ◽  
Author(s):  
E. B. Schroeder ◽  
L. E. Chambless ◽  
D. Liao ◽  
R. J. Prineas ◽  
G. W. Evans ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

Abstract P365: Psychosocial Factors and Subsequent Risk of Peripheral Artery Disease: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Yasuyuki Honda ◽  
Yejin Mok ◽  
Lena Mathews ◽  
Jeremy Van’t Hof ◽  
Gail Daumit ◽  
...  
Keyword(s):  
Social Support ◽  
Social Network ◽  
Psychosocial Factors ◽  
Peripheral Artery Disease ◽  
Trait Anger ◽  
Peripheral Artery ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Artery Disease ◽  
Aric Study

Background and aims: Psychosocial factors such as depression, character traits, and lack of social support have been associated with increased risk of cardiovascular disease (CVD). However, data of peripheral artery disease (PAD) in this regard are sparse. Since risk factor profiles differ across atherosclerotic CVD (ASCVD) subtypes, to appreciate the contribution of psychosocial factors to overall ASCVD, we aimed to comprehensively explore the association of psychosocial factors with the risk of PAD and ASCVD in a community cohort. Methods: We included 12,090 participants from the Atherosclerosis Risk in Communities (ARIC) Study (mean age 56.7 [SD 5.7] years) free of PAD and ASCVD at baseline (1990-1992). Depressive symptom was evaluated by the Maastricht Questionnaire (MQ). Trait anger was assessed by the Spielberger Trait Anger Scale. Social support was measured by the Interpersonal Support Evaluation List, while the extent of social networks was evaluated by the Lubben Social Network Scale. PAD events were defined as hospitalizations with PAD diagnosis and procedures. ASCVD included adjudicated myocardial infarction, fatal coronary disease, and ischemic stroke events. Results: We observed 429 PAD and 2,539 ASCVD events during a median follow-up of 23.1 years. The cumulative incidence of PAD was highest in the highest quartile of MQ score. This association remained after adjusting for traditional CVD risk factors, socioeconomic status, and physical activity. A weaker association was observed for ASCVD. Social support also showed independent association with incident PAD, but not with ASCVD. Trait anger and social network were not significantly associated with either PAD or ASCVD (Table). Conclusions: Psychosocial factors demonstrated more evident associations with PAD than ASCVD. Our results suggest the importance of considering PAD when assessing the overall impact of those factors on CVD. Future studies are needed to explore potential mechanisms behind our observation.

Abstract 51: Heart Rate Variability and its Association with Cognitive Decline Over 20 years: The Atherosclerosis Risk in Communities - Neurocognitive Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Faye L Lopez ◽  
Lin Y Chen ◽  
Elsayed Z Soliman ◽  
Jennifer A Deal ◽  
Rebecca F Gottesman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Word Recall ◽  
Atherosclerosis Risk In Communities ◽  
Increased Risk ◽  
Atherosclerosis Risk

Background: Heart rate variability (HRV) reflects activity of the sympathetic and parasympathetic nervous systems. Low HRV is associated with an increased risk of heart disease and mortality, and risk factors for lower HRV are also linked to cognitive impairment. We assessed whether HRV measures are associated with cognitive decline in the Atherosclerosis Risk in Communities (ARIC) study. Methods: We studied 10,623 individuals (23% African-American, 57% female, mean age 54). HRV measures were obtained from 2-minute electrocardiogram rhythm strips in 1987-89 and include the standard deviation of all normal RR intervals (SDNN), root mean square of successive differences (rMSSD), low frequency (LF) and high frequency (HF) spectral power, and the LF/HF ratio. Cognitive function was measured in 1990-92, 1996-98 and 2011-2013 using 3 neuropsychological tests: Delayed Word Recall (DWR), Digit Symbol Substitution (DSS), and Word Fluency (WF). Scores were standardized and their average was used as a test of global cognitive function. HRV measures were log-transformed and we used linear regression models fit with generalized estimating equations to evaluate associations with cognitive performance over time, which was modeled as a linear spline with a knot at year 6 of follow-up. Results: At baseline, lower levels of HRV were significantly associated with reduced scores in all cognitive tests. Lower baseline levels of HRV measures of sympathetic activity (LF and LF/HF ratio) were associated with faster decline in tests evaluating executive function and language (DSST and WF) (table). We did not observe associations between parasympathetic nervous system measures (rMSSD and HF) and cognitive decline. Conclusion: In this large population-based study, markers of cardiac sympathetic dysfunction measured in mid-life were associated with a faster decline in executive function, which is more frequently affected in cognitive impairment of vascular origin. Additional research should explore the mechanism for this association.

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