scholarly journals Abdominal Aortic Aneurysms, Increasing Infrarenal Aortic Diameter, and Risk of Total Mortality and Incident Cardiovascular Disease Events

Circulation ◽  
2008 ◽  
Vol 117 (8) ◽  
pp. 1010-1017 ◽  
Author(s):  
Matthew S. Freiberg ◽  
Alice M. Arnold ◽  
Anne B. Newman ◽  
Matthew S. Edwards ◽  
Kevin L. Kraemer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Total Mortality ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Abdominal Aortic ◽  
Incident Cardiovascular Disease

Abstract 919: Suppression of Abdominal Aortic Aneurysms in the Angiotensin II-infused ApoE Deficient Mice by Treatment with Chymase Inhibitor

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Nao Inoue ◽  
Michiko Muramatsu ◽  
Denan Jin ◽  
Shinji Takai ◽  
Tetsuya Hayashi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Abdominal Aortic Aneurysms ◽  
Treated Group ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Vehicle Group ◽  
Control Group ◽  
Abdominal Aortic ◽  
Chymase Inhibitor ◽  
Deficient Mice

Chymase promotes not only angiotensin II production but also matrix metalloproteinase (MMP)-9 activation, which have a critical role on development of abdominal aortic aneurysms (AAAs). The purpose of this study is to examine the effects of chymase inhibitor, NK3201, on the MMP-9 activity and development of AAA in the angiotensin II-induced apolipoprotein E (apoE)-deficient mice. Method: Angiotensin II (1000ng/kg/min) (vehicle group) or saline (control group) were infused into 16-week-old male apoE-deficient mice for 4 weeks. To examine the effect of chymase inhibition for AAA, we administered NK3201 (30mg/kg/day) to angiotensin II-infused group (NK3201-treated group) for the same period. At the end of angiotensin II infusion, we measured the diameters of suprarenal and infrarenal aorta. AAA severities were scored using the suprarenal aortic diameter/infrarenal aortic diameter ratio and presence of thrombus formation, i.e. under 2.0 was 0, from 2.0 to 2.5 was 1, from 2.5 to 3.0 was 2, over 3.0 was 3, and presence of thrombus was 4. We also determined the chymase and MMP-9 activities using total aorta. Results: The scores that reflected the progression and severity of AAA were increased in vehicle group compared with control group ( 2.35±0.30 vs. 0.27±0.12, p<0.01). This progression was inhibited in NK3201-treated group compared with vehicle group (1.13±0.35, p<0.05 vs. vehicle group). Chymase activity was significantly increased in vehicle group compared with control group. MMP-9 activity was also increased in vehicle group, however it was decreased significantly in NK3201-treated group.Discussion: We demonstrated that chymase inhibition could reduce AAA progression through inhibition of MMP-9 in angiotensin II-induced apoE-deficient mice. Chymase inhibitor might be a novel strategy for preventing AAAs.

scholarly journals Maximal aortic diameter affects outcome after endovascular repair of abdominal aortic aneurysms

2017 ◽  
Vol 65 (5) ◽  
pp. 1313-1322.e4 ◽  
Author(s):  
Ying Huang ◽  
Peter Gloviczki ◽  
Audra A. Duncan ◽  
Manju Kalra ◽  
Gustavo S. Oderich ◽  
...  
Keyword(s):  
Endovascular Repair ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Abdominal Aortic

Differences in observer variability of ultrasound measurements of the proximal and distal abdominal aorta

1998 ◽  
Vol 5 (2) ◽  
pp. 104-108 ◽  
Author(s):  
H J C M Pleumeekers ◽  
A W Hoes ◽  
P G H Mulder ◽  
E van der Does ◽  
A Hofman ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Abdominal Aorta ◽  
Screening Programme ◽  
Interobserver Variability ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Observer Variability ◽  
Abdominal Aortic ◽  
Ultrasound Measurements

Objective To assess the observer variability of ultrasound measurements of the abdominal aorta and to study whether observer variability is influenced by the site of measurement or cardiovascular risk factors. Setting Population based screening programme for abdominal aortic aneurysms. Methods For 135 subjects taking part in a screening programme for abdominal aortic aneurysms, two of the three ultrasonographers measured the distal and proximal ultrasound diameter of the abdominal aorta, using B-mode ultrasound, according to the Rotterdam study scanning protocol. Results The mean difference between two different observers was 0.06 mm (95% CI –0.15 to 0.27) for measurements of the distal aorta and 0.32 mm (95% CI 0.09 to 0.55) for the proximal aorta. Maximal differences between observers for measurements of both the distal and proximal aortic diameter were 4.0 mm. Interobserver variability in the proximal and distal measurements of the abdominal aorta was not related to the level of the major cardiovascular risk indicators. However, interobserver variability in ultrasound measurements of the proximal aorta increased with increasing waist circumference and increasing diameter of the proximal aorta. Conclusion Ultrasonographic readings of the distal and proximal aortic measurements can be interpreted within a range of plus or minus 3 mm. Ultrasound measurements are more accurate for the distal than for the proximal measurement. Definition of the aortic diameter based on a combination of both distal and proximal measurement may be more accurate.

scholarly journals Advanced Research of Abdominal Aortic Aneurysms on Metabolism

2021 ◽  
Vol 8 ◽  
Author(s):  
Yangfeng Hou ◽  
Wenjun Guo ◽  
Tianfei Fan ◽  
Bolun Li ◽  
Weipeng Ge ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Aortic Aneurysm ◽  
Theoretical Basis ◽  
Abdominal Aortic Aneurysms ◽  
The Body ◽  
Aortic Aneurysms ◽  
Research Progress ◽  
Risk Of Death ◽  
Abdominal Aortic ◽  
The Relationship

Abdominal aortic aneurysm (AAA) is a cardiovascular disease with a high risk of death, seriously threatening the life and health of people. The specific pathogenesis of AAA is still not fully understood. In recent years, researchers have found that amino acid, lipid, and carbohydrate metabolism disorders play important roles in the occurrence and development of AAA. This review is aimed to summarize the latest research progress of the relationship between AAA progression and body metabolism. The body metabolism is closely related to the occurrence and development of AAA. It is necessary to further investigate the pathogenesis of AAA from the perspective of metabolism to provide theoretical basis for AAA diagnosis and drug development.

scholarly journals Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease.

1996 ◽  
Vol 7 (11) ◽  
pp. 2483-2486
Author(s):  
R Torra ◽  
C Nicolau ◽  
C Badenas ◽  
C Brú ◽  
L Pérez ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Polycystic Kidney ◽  
Abdominal Aortic ◽  
Healthy Family ◽  
Autosomal Dominant Polycystic Kidney

Although cases of autosomal dominant polycystic kidney disease (ADPKD) associated with abdominal aortic aneurysm have been repeatedly reported in the literature, no systematic studies of the aortas of these patients have been performed. In the study presented here, a sonographic study of the abdominal aorta in 139 ADPKD patients and in 149 healthy family members was carried out. For both groups, an increase in aortic diameter related to age and sex, (being wider in men than women) was found. In ADPKD patients, neither a wider aortic diameter nor a higher prevalence of abdominal aortic aneurysms could be found in any age group. It was concluded that, although these patients are prone to develop aortic aneurysms because of hypertension and associated connective tissue disorders, the presence of abdominal aortic aneurysms should be questioned as a frequent feature of ADPKD.

Cardiovascular risk in patients with small and medium abdominal aortic aneurysms, and no history of cardiovascular disease

2014 ◽  
Vol 101 (10) ◽  
pp. 1238-1243 ◽  
Author(s):  
S. Sohrabi ◽  
S. Wheatcroft ◽  
J. H. Barth ◽  
M. A. Bailey ◽  
A. Johnson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
History Of

Assessment of the criteria for elective surgery in screen-detected abdominal aortic aneurysms

2005 ◽  
Vol 12 (3) ◽  
pp. 150-154 ◽  
Author(s):  
R Alan P Scott ◽  
Lois G Kim ◽  
Hilary A Ashton ◽  
Keyword(s):  
Direct Evidence ◽  
Elective Surgery ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Rapid Expansion ◽  
Aortic Diameter ◽  
Abdominal Aortic ◽  
Screening Study ◽  
Accepted Practice

Objectives: Apart from aortic diameter, two other widely used criteria for considering surgery in screen-detected abdominal aortic aneurysms (AAAs) - annual aortic expansion ≥1.0 cm and presence of symptoms attributable to the AAA 0 are based on accepted practice and AAA expansion rates, rather than direct evidence. The Multi-centre Aneurysm Screening Study (MASS) enables assessment of their contribution to this risk reduction. Methods: MASS employs three criteria for referral for considering elective open surgery: maximum aortic diameter ≥5.5 cm, rapid aortic expansion (≥1.0 cm/year), and/or the presence of symptoms attributable to the AAA. Data from MASS are used to examine the value of these criteria in practice. Results: No patients were referred for symptoms alone. Of those referred for rapid expansion, 88% were returned to surveillance, compared with only 12% of those referred for diameter ≥5.5 cm at initial scan, and 34% of those referred for diameter ≥5.5 cm at a follow-up scan. Return to surveillance following referral for rapid expansion was strongly associated with aortic diameter (age-adjusted odds ratio for return 0.89 per mm, 95% confidence interval 0.79-1.00). Of those 5.0-5.4 cm at the time of referral for rapid expansion who were returned, 31% reached 5.5 cm during a median post-referral follow-up of 0.9 years. Among those referred for expansion, the rupture rate was only 8 per 1000 person-years of follow-up prior to reaching 5.5 cm. Conclusions: A single criterion for considering elective surgery is recommended in screen-detected AAA, based on a maximum aortic diameter of ≥5.5 cm. This criterion detects the majority of those at risk from rupture, and is simple to assess.

scholarly journals Accuracy of Ultrasound in a Screening Programme for Abdominal Aortic Aneurysms

1994 ◽  
Vol 1 (1) ◽  
pp. 3-6 ◽  
Author(s):  
P R S Thomas ◽  
J C Shaw ◽  
H A Ashton ◽  
D N Kay ◽  
R A P Scott
Keyword(s):  
Screening Programme ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Diameter ◽  
Ultrasound Measurement ◽  
Abdominal Aortic ◽  
Interobserver Error ◽  
Ultrasound Measurements ◽  
Method Of Measurement ◽  
Ct Measurement

To assess the accuracy of ultrasound in the measurement of aortic diameter. A general practice based screening programme for abdominal aortic aneurysm. (a) comparison of ultrasound with computed tomography (CT) measurement; (b) two period crossover study to assess interobserver error; (c) comparison of ultrasound measurements by technicians and radiologists. In 36 patients where CT showed clear maxima in anteroposterior diameter, the measurement by ultrasound was consistently less than by CT scan (mean ultrasound — CT difference — 4·4 mm, range —12·3 to 2·4 mm). There was no difference in the measurements made by different ultrasonographers, but their method of measurement produced a reading for aortic diameter less than that obtained by a vascular radiologist. These' results show that ultrasound measurement is less accurate for smaller aneurysms, consistently gives a smaller reading for aortic diameter when compared with CT measurement, but was reproducible between ultrasonographers. Monitoring and audit of aneurysm screening programmes to assess accuracy and reproducibility of ultrasound measurement is recommended.

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