Abstract 469: Influences of Dietary Weight Reduction on the Atrial Natriuretic Peptide System in Obese Subjects

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Sven Haufe ◽  
Stefan Engeli ◽  
Ralf Lichtinghagen ◽  
Wolfgang Utz ◽  
Jeanette Schulz-Menger ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Weight Reduction ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Obese Women ◽  
Obese Subjects ◽  
Atrial Natriuretic

In obese individuals, reduced atrial natriuretic peptide (ANP) bioavailability appears to promote arterial hypertension and type 2 diabetes likely through direct metabolic actions. Mid-regional pro-ANP is cleaved off during ANP processing, thus, serving as ANP release marker. We hypothesized that dietary weight reduction improves ANP release. In 75 overweight and obese women and men who had lost >5% body weight during six months hypocaloric dieting (-9.1±3.8 kg), we analyzed venous mid-regional pro-ANP and natriuretic peptide receptor (NPR) expression in abdominal subcutaneous adipose tissue before and after the intervention. Participants underwent ambulatory blood pressure (ABPM) monitoring and cardiac magnetic resonance imaging. ABPM decreased from 118±9/73±7 to 115±9/71±6 mm Hg and left ventricular mass from 92±20 to 86±19 g (p<0.05 for all). End-diastolic and end-systolic volumes remained unchanged. Mid-regional pro-ANP plasma concentrations did not respond to weight loss (before: 51±24 pmol/; after 53± 24 pmol/l) and increased similarly during exercise testing. Adipose NPR-A mRNA expression remained unchanged whereas NPR-C receptor mRNA decreased from 1.2±0.7 to 1.0±0.5 (p<0.05). Our data suggest that dietary weight loss does not augment ANP release in overweight and obese subjects. However, weight loss could improve ANP bioavailability through decreased clearance. Possible mechanisms are reduced fat mass and reduced expression of adipose tissue ANP scavenger receptor NPR-C.

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

2016 ◽  
Vol 130 (13) ◽  
pp. 1105-1114 ◽  
Author(s):  
Kenneth Verboven ◽  
Dominique Hansen ◽  
Cedric Moro ◽  
Bert O. Eijnde ◽  
Nicole Hoebers ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Exercise Response ◽  
Obese Subjects ◽  
Type 2 Diabetic ◽  
Atrial Natriuretic

Subjects with obesity seem to display a suboptimal exercise response, which might be due to hormonal disturbances. In the present study, we show the adipose tissue of obese subjects to be less sensitive to atrial natriuretic peptide, a cardiac hormone important during exercise.

Postnatal weight loss and contraction of the extracellular compartment is triggered by atrial natriuretic peptide

2000 ◽  
Vol 59 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Neena Modi ◽  
Pierre Bétrémieux ◽  
Julian Midgley ◽  
Gary Hartnoll
Keyword(s):  
Weight Loss ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Extracellular Compartment ◽  
Atrial Natriuretic

Diurnal change in plasma atrial natriuretic peptide concentrations

1987 ◽  
Vol 73 (5) ◽  
pp. 489-495 ◽  
Author(s):  
A. M. Richards ◽  
G. Tonolo ◽  
R. Fraser ◽  
J. J. Morton ◽  
B. J. Leckie ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Antidiuretic Hormone ◽  
Natriuretic Peptide ◽  
Plasma Concentrations ◽  
Dietary Sodium ◽  
Sodium Balance ◽  
Diurnal Changes ◽  
Renin Angiotensin ◽  
Atrial Natriuretic

1. Diurnal changes in plasma concentrations of atrial natriuretic peptide (ANP), renin, angiotensin II, aldosterone, Cortisol and antidiuretic hormone were investigated in seven normal volunteers studied under standardized conditions of dietary sodium, posture and physical activity. After completion of the diurnal study serial measurements of these variables were continued during, and on recovery from, a 2 day period of severe sodium depletion. 2. Clear diurnal variations in plasma concentrations of renin, angiotensin II, aldosterone, Cortisol and antidiuretic hormone were observed. 3. Plasma ANP concentrations also varied significantly over 24 h. Values peaked about mid-day and a distinct trough in peptide concentrations occurred in the early evening. However, variations in plasma ANP values were of relatively small amplitude and not clearly independent of modest parallel shifts in sodium balance. 4. Changes in plasma ANP concentrations both within the diurnal study period and during sodium deprivation were closely and positively correlated with concomitant changes in cumulative sodium balance. 5. No simple parallel or reciprocal relationships between plasma concentrations of ANP, on the one hand, and concurrent plasma concentrations of other hormones or in the rate of urinary sodium excretion, on the other, were observed during the 25 h of the diurnal study.

Atrial natriuretic peptide, B-type natriuretic peptide, and serum collagen markers after acute myocardial infarction

2004 ◽  
Vol 96 (4) ◽  
pp. 1306-1311 ◽  
Author(s):  
Jarkko Magga ◽  
Mikko Puhakka ◽  
Seppo Hietakorpi ◽  
Kari Punnonen ◽  
Paavo Uusimaa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Type I Collagen ◽  
Left Ventricular ◽  
Type I ◽  
Amino Terminal ◽  
Collagen Markers ◽  
Atrial Natriuretic

Experimental data suggest that atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) act locally as antifibrotic factors in heart. We investigated the interrelationships of natriuretic peptides and collagen markers in 93 patients receiving thrombolytic treatment for their first acute myocardial infarction (AMI). Collagen formation following AMI, evaluated as serum levels of amino terminal propeptide of type III procollagen, correlated with NH2-terminal proANP ( r = 0.45, P < 0.001), BNP ( r = 0.55, P < 0.001) and NH2-terminal proBNP ( r = 0.50, P < 0.01) on day 4 after thrombolysis. Levels of intact amino terminal propeptide of type I procollagen decreased by 34% ( P < 0.001), and levels of carboxy terminal cross-linked telopeptide of type I collagen (ICTP) increased by 65% ( P < 0.001). ICTP levels correlated with NH2-terminal proBNP ( r = 0.25, P < 0.05) and BNP ( r = 0.28, P < 0.05) on day 4. Our results suggest that ANP and BNP may act as regulators of collagen scar formation and left ventricular remodeling after AMI in humans. Furthermore, degradation of type I collagen is increased after AMI and may be regulated by BNP.

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