Cardiovascular Health Profile at Age 25 Years in Adults Born Extremely Preterm or Extremely Low Birthweight

Being born extremely preterm (EP; <28 weeks’ gestation) or extremely low birthweight (ELBW; <1000 g birthweight) may predict increased cardiometabolic risk in adulthood, but other early life predictors are less well described. We aimed to (1) compare cardiovascular health profiles between 165 adults born EP/ELBW and 127 controls at age 25 years, drawn from a prospective longitudinal cohort study, recruited at birth in 1991 to 1992; and (2) in the EP/ELBW group, determine early life associations of cardiovascular health. Cardiovascular health profiles were calculated individually for measures of anthropometry, abdominal visceral fat, blood pressure, fasting plasma glucose, insulin, lipids, C-reactive protein, vascular indices, exercise tolerance and smoking status, and summed for an overall score. Cardiovascular health profiles were compared between groups; using logistic regression (individual scores) and the Mann-Whitney U test (cumulative score). Compared with controls, adults born EP/ELBW had less favorable cardiovascular health profiles; individually for abdominal visceral fat (odds ratio, 0.56 [95% CI, 0.33–0.96], P =0.03), blood pressure (odds ratio 0.38 [95% CI, 0.23–0.63], P <0.001), exercise capacity (odds ratio 0.37 [95% CI, 0.22–0.63], P <0.001), and fasting glucose (odds ratio 0.51 [95% CI, 0.31–0.84], P =0.01) and overall (median [interquartile range] 10 [7–11] versus 11 [9–12], P =0.007). Male sex predicted unfavorable abdominal visceral fat, blood pressure and fasting glucose, and favorable exercise capacity. Greater increases in weight Z scores between 2 and 8, and 8 and 18 years predicted less favorable profiles of exercise capacity and visceral fat. Longer-term follow-up is critical to determine the cardiovascular sequelae of adults born EP/ELBW.

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High Blood Pressure in Young Adult Survivors Born Extremely Preterm or Extremely Low Birthweight in the Post Surfactant Era

Hypertension ◽

10.1161/hypertensionaha.119.13780 ◽

2020 ◽

Vol 75 (1) ◽

pp. 211-217 ◽

Cited By ~ 4

Author(s):

Anjali Haikerwal ◽

Lex W. Doyle ◽

Michael M. Cheung ◽

John D. Wark ◽

Gillian Opie ◽

...

Keyword(s):

Blood Pressure ◽

Young Adult ◽

High Blood Pressure ◽

Low Birthweight ◽

Adult Survivors ◽

Extremely Preterm ◽

Young Adult Survivors ◽

Extremely Low Birthweight

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AMBULATORY BLOOD PRESSURE PROFILE IN YOUNG ADULT SURVIVORS BORN EXTREMELY PRETERM OR EXTREMELY LOW BIRTHWEIGHT: THE VICTORIAN INFANT COLLABORATIVE STUDY (VICS)

Journal of Paediatrics and Child Health ◽

10.1111/jpc.14409_54 ◽

2019 ◽

Vol 55 (S1) ◽

pp. 22-22

Keyword(s):

Blood Pressure ◽

Young Adult ◽

Low Birthweight ◽

Collaborative Study ◽

Adult Survivors ◽

Pressure Profile ◽

Blood Pressure Profile ◽

Extremely Preterm ◽

Young Adult Survivors ◽

Extremely Low Birthweight

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Faculty Opinions recommendation of Bone health in young adult survivors born extremely preterm or extremely low birthweight in the post surfactant era.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738703397.793579589 ◽

2020 ◽

Author(s):

Madhusmita Misra

Keyword(s):

Young Adult ◽

Bone Health ◽

Low Birthweight ◽

Adult Survivors ◽

Extremely Preterm ◽

Young Adult Survivors ◽

Extremely Low Birthweight

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Relationship between abdominal visceral fat and blood pressure response during exercise in normotensive population

Atherosclerosis ◽

10.1016/j.atherosclerosis.2017.06.442 ◽

2017 ◽

Vol 263 ◽

pp. e138-e139

Author(s):

Hyung Joon Joo ◽

Sang-A. Cho ◽

Jae-Young Cho ◽

Seung Hun Lee ◽

Jae Hyoung Park ◽

...

Keyword(s):

Blood Pressure ◽

Visceral Fat ◽

Blood Pressure Response ◽

Pressure Response ◽

Abdominal Visceral Fat

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Blood pressure rhythms during the perinatal period in very immature, extremely low birthweight neonates

Early Human Development ◽

10.1016/s0378-3782(99)00034-1 ◽

1999 ◽

Vol 56 (1) ◽

pp. 49-56 ◽

Cited By ~ 6

Author(s):

Gabriel Dimitriou ◽

Anne Greenough ◽

Vasiliki Kavvadia ◽

Stephanos Mantagos

Keyword(s):

Blood Pressure ◽

Low Birthweight ◽

Perinatal Period ◽

Extremely Low Birthweight

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Blood pressure changes during the first 24 hours of life and the association with the persistence of a patent ductus arteriosus and occurrence of intraventricular haemorrhage

PLoS ONE ◽

10.1371/journal.pone.0260377 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0260377

Author(s):

Robert Boldt ◽

Pauliina M. Mäkelä ◽

Lotta Immeli ◽

Reijo Sund ◽

Markus Leskinen ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Patent Ductus Arteriosus ◽

Gestational Age ◽

Odds Ratio ◽

Low Birthweight ◽

Ductus Arteriosus ◽

Intraventricular Haemorrhage ◽

Vlbw Infants ◽

Patent Ductus

Very low birthweight (VLBW) infants are at risk of intraventricular haemorrhage (IVH) and delayed closure of ductus arteriosus. We investigated mean arterially recorded blood pressure (MAP) changes during the first day of life in VLBW infants as potential risk factors for a patent ductus arteriosus (PDA) and IVH. This retrospective cohort study exploring MAP changes during adaption and risk factors for a PDA and IVH comprised 844 VLBW infants admitted to the Helsinki University Children’s Hospital during 2005–2013. For each infant, we investigated 600 time-points of MAP recorded 4–24 hours after birth. Based on blood pressure patterns revealed by a data-driven method, we divided the infants into two groups. Group 1 (n = 327, mean birthweight = 1019 g, mean gestational age = 28 + 1/7 weeks) consisted of infants whose mean MAP was lower at 18–24 hours than at 4–10 hours after birth. Group 2 (n = 517, mean birthweight = 1070 g, mean gestational age = 28 + 5/7 weeks) included infants with a higher mean MAP at 18–24 hours than at 4–10 hours after birth. We used the group assignments, MAP, gestational age at birth, relative size for gestational age, surfactant administration, inotrope usage, invasive ventilation, presence of respiratory distress syndrome or sepsis, fluid intake, and administration of antenatal steroids to predict the occurrence of IVH and use of pharmacological or surgical therapy for a PDA before 42 weeks of gestational age. Infants whose mean MAP is lower at 18–24 hours than at 4–10 hours after birth are more likely to undergo surgical ligation of a PDA (odds ratio = 2.1; CI 1.14–3.89; p = 0.018) and to suffer from IVH (odds ratio = 1.83; CI 1.23–2.72; p = 0.003).

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