scholarly journals Left Ventricular Mass and the Risk of Sudden Cardiac Death: A Population‐Based Study

2014 ◽  
Vol 3 (6) ◽  
Author(s):  
Jari A. Laukkanen ◽  
Hassan Khan ◽  
Sudhir Kurl ◽  
Peter Willeit ◽  
Jouni Karppi ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricular Mass ◽  
Cardiac Death ◽  
Population Based ◽  
Left Ventricular ◽  
Population Based Study ◽  
Ventricular Mass

scholarly journals No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy

2006 ◽  
Vol 111 (6) ◽  
pp. 365-372 ◽  
Author(s):  
Wolfgang Lieb ◽  
Juliane Bolbrinker ◽  
Angela Döring ◽  
Hans-Werner Hense ◽  
Jeanette Erdmann ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Left Ventricular Mass ◽  
Posterior Wall ◽  
Pressure Control ◽  
Population Based ◽  
Left Ventricular ◽  
Genotype Distribution ◽  
Cytochrome P450 3A ◽  
Ventricular Mass

A polymorphism in the cytochrome P450 3A CYP3A5 enzyme has been implicated in BP (blood pressure) control and arterial hypertension. Carriers of the CYP3A5*1 allele had high, whereas homozygous carriers of the CYP3A5*3 allele exhibit low, CYP3A5 expression in the kidney, where CYP3A5 represents the major CYP3A enzyme. The aim of the present study was to investigate the association of the CYP3A5*1 allele with BP, arterial hypertension, LVM [(left ventricular) mass] and LV geometry in a large Caucasian-population-based cohort. We compared BP, LVM and the prevalence of hypertension between carriers (CYP3A5*1/*1 and CYP3A5*1/*3 genotypes) and non-carriers (CYP3A5*3/*3 genotype) of the CYP3A5*1 allele in the echocardiographic substudy of the third MONICA (MONItoring trends and determinants in CArdiovascular disease) Augsburg survey. After exclusion of 269 individuals who were taking antihypertensive medication, 530 women and 554 men were available for analysis, revealing allele frequencies of 5.8 and 94.2% for the CYP3A5*1 and CYP3A5*3 alleles respectively. Overall, the presence of the CYP3A5*1 allele exhibited no effect on systolic or diastolic BP in either gender. One-third of the individuals in this cohort were hypertensive (BP ≥140/90 mmHg), and the genotype distribution between normotensive and hypertensive individuals revealed no association between CYP3A5*1 and hypertension after adjustment for age, BMI and gender (odds ratio, 1.02; P=0.92). Moreover, no effect of CYP3A5*1 on LVM, thickness of the septal and posterior wall and LV end-diastolic diameter was found. We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy.

Contribution of sudden cardiac death to total mortality in India — A population based study

2012 ◽  
Vol 154 (2) ◽  
pp. 163-167 ◽  
Author(s):  
B. Hygriv Rao ◽  
B.K.S. Sastry ◽  
Sumeet S. Chugh ◽  
Sharada Kalavakolanu ◽  
Johann Christopher ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Total Mortality ◽  
Population Based ◽  
Population Based Study

scholarly journals Serum Long-Chain n-3 Polyunsaturated Fatty Acids, Mercury, and Risk of Sudden Cardiac Death in Men: A Prospective Population-Based Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41046 ◽  
Author(s):  
Jyrki K. Virtanen ◽  
Jari A. Laukkanen ◽  
Jaakko Mursu ◽  
Sari Voutilainen ◽  
Tomi-Pekka Tuomainen
Keyword(s):  
Fatty Acids ◽  
Sudden Cardiac Death ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Population Based ◽  
Population Based Study ◽  
Long Chain

scholarly journals Association Between Pulse Pressure and the Risk of Sudden Cardiac Death in Middle-Aged Men: A 26-Year Follow-up Population-Based Study

2020 ◽  
Vol 95 (9) ◽  
pp. 2044-2046
Author(s):  
Sae Young Jae ◽  
Sudhir Kurl ◽  
Setor K. Kunutsor ◽  
Kevin S. Heffernan ◽  
Jeong Bae Park ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Pulse Pressure ◽  
Cardiac Death ◽  
Population Based ◽  
Middle Aged ◽  
Population Based Study

Abstract 1199: Low Serum Magnesium Concentrations Predict Increase in Left Ventricular Mass Over Five Years Independently of Common Cardiovascular Risk Factors: Study of Health in Pomerania

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Thorsten Reffelmann ◽  
Marcus Dörr ◽  
Till Ittermann ◽  
Henry Völzke ◽  
Jörg Ruppert ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Antihypertensive Drugs ◽  
Smoking Status ◽  
Serum Magnesium ◽  
Experimental Studies ◽  
Population Based ◽  
Left Ventricular ◽  
Reactive Protein ◽  
Ventricular Mass ◽  
The Difference

Increased cardiac left ventricular mass (LVM) is a significant predictor of adverse cardiovascular events. Experimental studies suggest a pathophysiological role of magnesium (Mg ++ ) in the development of arterial hypertension and left ventricular hypertrophy (LVH). Subjects, aged 45 – 79 years, from the population-based, epidemiological, longitudinal “Study of Health in Pomerania” with complete echocardiographic data (n = 1 348 after exclusion of aortic valve disease) were grouped into five quintiles according to serum Mg ++ at baseline (0.790±0.003 mmol/l, mean±SEM). In the lowest Mg ++ -quintile (Mg ++ <<26>0.73 mmol/l), LVM (187.4±3.1 g at baseline) increased by 14.9±1.2 g over the following five years, while in the highest Mg ++ -quintile (Mg ++ <<0.85 mmol/l) LVM (186.7±3.4 g at baseline) decreased by −0.5±2.8 g (p<0.0001 between quintiles). After five years, LVM was significantly higher in the lowest Mg ++ -quintile (LVM: 202.2±3.4 g) in comparison to the highest Mg ++ -quintile (187.2±3.5 g, p<0.003 between quintiles). Mg ++ inversely correlated with the difference in LVM over five years (p<0.0001, females: p<0.002, males: p<0.024) and also with differences in Sokolow-Lyon-index over five years (p<0.01). Unlike age, gender, presence of hypertension or diabetes mellitus, body mass index, smoking status, renal function, high-sensitive C-reactive protein and use of various antihypertensive drugs including diuretics, only Mg ++ (p<0.0001), pulse pressure (p<0.002) and use of β-blockers (p<0.04) were identified as independent predictors of difference in LVM over five years. Hypomagnesemia is one of the strongest predictors of increase in LVM over the following five years. It should initiate decisive preventive measures in subjects prone to developing LVH.

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