scholarly journals Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women

Author(s):  
Tran Le ◽  
Shirley W. Flatt ◽  
Loki Natarajan ◽  
Bilge Pakiz ◽  
Elizabeth L. Quintana ◽  
...  
Metabolism ◽  
2016 ◽  
Vol 65 (11) ◽  
pp. 1605-1613 ◽  
Author(s):  
Cheryl L. Rock ◽  
Shirley W. Flatt ◽  
Bilge Pakiz ◽  
Elizabeth L. Quintana ◽  
Dennis D. Heath ◽  
...  

2021 ◽  
pp. 1-9
Author(s):  
M. Serra-Prat ◽  
M. Terradellas ◽  
I. Lorenzo ◽  
M. Arús ◽  
E. Burdoy ◽  
...  

Background: Obesity is a risk factor for frailty and muscle weakness, so weight loss in obese older adults may prevent frailty and functional decline. Objective: To assess the safety and efficacy of a multimodal weight-loss intervention in improving functional performance and reducing frailty risk in obese older adults. Design: Randomized controlled trial with 2 parallel arms. Setting and participants: Community-dwelling obese adults aged 65-75 years with body mass index (BMI) 30-39 kg/m2. Intervention: 6-month multimodal intervention based on diet and a physical activity program. Control group: Usual care. Main and secondary outcome measures: Frailty (Fried criteria) rate and functional performance at 6, 12, and 24 months of follow-up, respectively. Intermediate outcome measures: Weight loss, body composition changes, and metabolic and inflammatory biomarker changes. Results: N=305. The study intervention increased gait speed at 12 and 24 months of follow-up, but had no significant effect on frailty prevention. It was effective in reducing weight, BMI, fat mass, interleukin 6, and insulin resistance and improving self-reported quality of life. Conclusions: The study intervention was not demonstrated to be effective in preventing frailty in obese people aged 65-75 years at 24 months of follow-up. However, it allowed weight loss and a reduction in inflammatory and insulin resistance markers, which could have a long-term effect on frailty that requires further research.


2017 ◽  
Vol 08 (01) ◽  
Author(s):  
Badri NW ◽  
Flatt SW ◽  
Barkai HS ◽  
Pakiz B ◽  
Heath DD ◽  
...  

2016 ◽  
Vol 31 (3) ◽  
pp. 308-317 ◽  
Author(s):  
Mirian Samblas ◽  
Fermin I. Milagro ◽  
Purificación Gómez-Abellán ◽  
J. Alfredo Martínez ◽  
Marta Garaulet

2009 ◽  
Vol 161 (6) ◽  
pp. 845-852 ◽  
Author(s):  
Labros Melistas ◽  
Christos S Mantzoros ◽  
Meropi Kontogianni ◽  
Smaragdi Antonopoulou ◽  
Jose M Ordovas ◽  
...  

ObjectiveWe explored potential associations of two single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ; +45T>G, rs2241766 and +276G>T, rs1501299) with circulating total and high-molecular weight (HMW) adiponectin, insulin resistance (IR), and markers of obesity in a healthy Greek female population.Design and methodsThe two SNPs were genotyped in 349 women without diabetes (mean age: 47.0±12.1 years, mean body mass index: 28.9±5.6 kg/m2). Total and HMW adiponectin concentrations, body composition variables, IR parameters, and plasma lipid levels were determined.ResultsIn single SNP analysis adjusting for several potential confounders, SNP +276G>T was associated with higher fasting insulin levels (P=0.01) and higher homeostasis model assessment index for IR (HOMA-IR; P=0.009), and SNP +45T>G was associated with lower insulin levels and HOMA-IR (P=0.05 and P=0.07 respectively). No association with total or HMW adiponectin, plasma lipid levels, and body composition variables was observed; however, haplotype analysis revealed that subjects homozygous for the most common +45T/+276G haplotype had lower total adiponectin levels than did noncarriers of this haplotype (P=0.02). The observed differences in HOMA-IR were very significant among women with a higher body fat (BF) percentage (≥ the population median of 41%; all P≤0.005), but not among leaner individuals (P for interactions 0.01–0.07), thus suggesting that ADIPOQ effects on insulin sensitivity may depend upon BF status.ConclusionOur data suggest a significant role of ADIPOQ variants at positions +45 and +276 in the development of IR in healthy Greek women possibly through an interaction with BF.


2018 ◽  
Vol 43 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Dongmei Liu ◽  
Flor Elisa Morales ◽  
Heidi. B. IglayReger ◽  
Mary K. Treutelaar ◽  
Amy E. Rothberg ◽  
...  

Local inflammation in obese adipose tissue has been shown to contribute to insulin resistance; however, the role of macrophage infiltration within skeletal muscle is still debatable. This study aimed to evaluate the association of skeletal muscle macrophage gene expression with adiposity levels and insulin sensitivity in obese patients. Twenty-two nondiabetic obese patients and 23 healthy lean controls were included. Obese patients underwent a 3-month weight loss intervention. Macrophage gene expression in skeletal muscle (quantitative real-time polymerase chain reaction), body composition (dual-energy X-ray absorptiometry), and insulin sensitivity (homeostatic model assessment (HOMA) and oral glucose tolerance test) were compared between groups and their associations were analyzed. To validate skeletal muscle findings, we repeated the analyses with macrophage gene expression in adipose tissue. Expression levels of macrophage genes (CD68, CD11b, CD206, CD16, CD40, and CD163) were lower in skeletal muscle tissue of obese versus lean participants. Macrophage gene expression was also found to be inversely associated with adiposity, fasting insulin, and HOMA (r = −0.4 ∼ −0.6, p < 0.05), as well as positively associated with insulin sensitivity (r = 0.4 ∼ 0.8, p < 0.05). On the other hand, adipose tissue macrophage gene expression showed higher levels in obese versus lean participants, presenting a positive association with adiposity levels. Macrophage gene expression, in both skeletal and adipose tissue samples, was only minimally affected by the weight loss intervention. In contrast with the established positive relationship between adiposity and macrophage gene expression, an unexpected inverse correlation between these 2 variables was observed in skeletal muscle tissue. Additionally, muscle macrophage gene expression was inversely correlated with insulin resistance.


2003 ◽  
Vol 4 (2) ◽  
pp. 45
Author(s):  
Y. Takahashi ◽  
T. Ueno ◽  
A. Tsunemi ◽  
N. Yahara ◽  
H. Watanabe ◽  
...  

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Kim L. Dittus ◽  
Jean R. Harvey ◽  
Janice Y. Bunn ◽  
Nathan D. Kokinda ◽  
Karen M. Wilson ◽  
...  

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