scholarly journals Ideal Cardiovascular Health and Incident Cardiovascular Disease: Heterogeneity Across Event Subtypes and Mediating Effect of Blood Biomarkers: The PRIME Study

2017 ◽  
Vol 6 (12) ◽  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Mediating Effect ◽  
Blood Biomarkers ◽  
Disease Heterogeneity ◽  
Ideal Cardiovascular Health ◽  
Incident Cardiovascular Disease

Abstract 381: Ideal Cardiovascular Health and Cardiovascular Disease: Heterogeneity Across Event Phenotype and Contribution of Multiple Biomarkers

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Bamba Gaye ◽  
Muriel Tafflet ◽  
Dominique Arveil ◽  
Frank Kee ◽  
Alun Evans ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lower Risk ◽  
Cardiovascular Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Mediating Effect ◽  
Blood Biomarkers ◽  
Disease Heterogeneity ◽  
Ideal Cardiovascular Health

Aims: To investigate whether or not the association between baseline cardiovascular health (CVH) and incident cardiovascular disease (CVD) differs by event phenotypes and to address the mediating effect of inflammatory and haemostatic blood biomarkers. Methods: The association of ideal CVH with outcomes was computed in 9312 middle-aged men from Northern Ireland and France (whole cohort) in multivariable Cox proportional hazards regression analysis. The mediating effect of baseline blood biomarkers was evaluated in a case control study nested within the cohort after 10 years of follow-up. Results: After a median follow-up of 10 years, 614 first CHD events and 117 first stroke events were adjudicated. Compared to those with poor CVH, those with an ideal CVH profile at baseline had a 72% lower risk of CHD (HR=0.28; 95% CI: 0.17; 0.46) and a 76% lower risk of stroke (HR=0.24; 95% CI: 0.06; 0.98). No heterogeneity was detected across main CHD and main stroke phenotypes. While significantly lower mean concentrations of hs-CRP, IL-6 (inflammatory markers), and fibrinogen, von Willbrandt factor (haemostatic factors) were noted in the controls with higher CVH status, the association of CVH with incident CHD was not attenuated upon adjustment for these biomarkers. Conclusion: these results support the universal promotion of ideal CVH for CVD in general and suggest that the lower risk of CHD associated with ideal CVH is independent from inflammatory and haemostatic biomarkers.

scholarly journals Ideal Cardiovascular Health and Incident Cardiovascular Disease Among Adults: A Systematic Review and Meta-analysis

2018 ◽  
Vol 93 (11) ◽  
pp. 1589-1599 ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
José M. Saavedra ◽  
Felipe Lobelo ◽  
Carlos A. Celis-Morales ◽  
Borja del Pozo-Cruz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Meta Analysis ◽  
Ideal Cardiovascular Health ◽  
Incident Cardiovascular Disease

Abstract 12944: Geographical Variations in Cardiovascular Health in China: A Nationwide Population-based Survey of 74,771 Adults

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Mei Zhang ◽  
Yu Shi ◽  
Oumin Shi ◽  
Zhenping Zhao ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Health Behavior ◽  
Health Behaviors ◽  
Cardiovascular Health ◽  
Significant Heterogeneity ◽  
Chinese Adults ◽  
Ideal Cardiovascular Health ◽  
Geographical Variations ◽  
Health Factors

Background: Cardiovascular disease is the leading cause of death in China. Objectives: We aimed to evaluate the levels of cardiovascular health among Chinese adults and to understand the geographic patterns based on a nationally and provincially representative survey. Methods: In 2015, a total of 74,771 respondents aged ≥ 20 years with no history of cardiovascular disease were randomly sampled from 298 counties/districts of 31 provinces in mainland China and were interviewed. Seven metrics, including smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and fasting glucose, were determined. Ideal cardiovascular health was defined as the simultaneous presence of all metrics at the ideal level. A score ranging from 0 to 14 was calculated as the sum of all seven metrics for each province. Scores for four health behaviors and four health factors were also calculated. Results: The age-adjusted prevalence of ideal cardiovascular health was only 1.13% among Chinese adults above 20 years old in 2015 (0.50% among men and 1.77% among women; 1.63% among urban residents and 0.68% among rural residents). The age-adjusted prevalence varied greatly across provinces, ranging from 0.05% in Qinghai to 2.97% in Heilongjiang. Ideal diet (7.4%) was the least common among seven cardiovascular health metrics and ideal blood pressure (32.2%) was the second least one. We also saw significant heterogeneity among provinces in age-adjusted cardiovascular health score, health behavior score, and health factors score. In all provinces, women had higher scores than men for cardiovascular health, health behaviors and health factors. Differences in cardiovascular health and health behavior scores between urban and rural areas were associated with levels of socio-economic development. Conclusions: Strategies for addressing poor cardiovascular health require geographic targeting and localized consideration.

scholarly journals Association between ideal cardiovascular health and markers of subclinical cardiovascular disease

2018 ◽  
Vol 41 (12) ◽  
pp. 1593-1599 ◽  
Author(s):  
Daniel Shpilsky ◽  
Claudia Bambs ◽  
Kevin Kip ◽  
Sanjay Patel ◽  
Aryan Aiyer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Ideal Cardiovascular Health ◽  
Subclinical Cardiovascular Disease

scholarly journals One-year Risks and Burdens of Incident Cardiovascular Disease in COVID-19: Cardiovascular Manifestations of Long COVID

2021 ◽  
Author(s):  
Ziyad Al-Aly ◽  
Benjamin Bowe ◽  
Yan Xie ◽  
Evan Xu
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Acute Infection ◽  
Cerebrovascular Disorders ◽  
Cardiovascular Complications ◽  
Department Of Veterans Affairs ◽  
Increased Risk ◽  
Health And Disease ◽  
One Year ◽  
Incident Cardiovascular Disease

Abstract The cardiovascular complications of acute COVID-19 are well described; however, a comprehensive characterization of the post-acute cardiovascular manifestations of COVID-19 at one year has not been undertaken. Here we use the US Department of Veterans Affairs national healthcare databases to build a cohort of 151,195 people with COVID-19, 3,670,087 contemporary and 3,656,337 historical controls to estimate risks and 1-year burdens of a set of pre-specified incident cardiovascular outcomes. We show that beyond the first 30 days of infection, people with COVID-19 are at increased risk of incident cardiovascular disease spanning several categories including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, and thromboembolic disease. The risks and burdens were evident among those who were non-hospitalized during the acute phase of the infection and increased in a graded fashion according to care setting of the acute infection (non-hospitalized, hospitalized, and admitted to intensive care). Taken together, our results provide evidence that risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of people who survived the acute episode of COVID-19 should include attention to cardiovascular health and disease.

Abstract MP22: Ideal Cardiovascular Health and Lifetime Risk of Cardiovascular Disease: the Cardiovascular Disease Lifetime Risk Pooling Project

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Joshua D Bundy ◽  
Hongyan Ning ◽  
Amanda E Paluch ◽  
Victor W Zhong ◽  
Donald M Lloyd-Jones ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Lifetime Risk ◽  
Risk Pooling ◽  
Ideal Cardiovascular Health
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