scholarly journals Effect of Religious Fasting in Ramadan on Blood Pressure: Results From LORANS (London Ramadan Study) and a Meta‐Analysis

2021 ◽  
Author(s):  
Rami Al‐Jafar ◽  
Maria Zografou Themeli ◽  
Sadia Zaman ◽  
Sharmin Akbar ◽  
Victor Lhoste ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Meta Analysis ◽  
Religious Practice ◽  
Ramadan Fasting ◽  
Beneficial Effects ◽  
Lower Blood ◽  
Blood Pressures ◽  
Pressure Independent ◽  
Total Body

Background Ramadan fasting is practiced by hundreds of millions every year. This ritual practice changes diet and lifestyle dramatically; thus, the effect of Ramadan fasting on blood pressure must be determined. Methods and Results LORANS (London Ramadan Study) is an observational study, systematic review, and meta‐analysis. In LORANS, we measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) of 85 participants before and right after Ramadan. In the systematic review, studies were retrieved from PubMed, Embase, and Scopus from inception to March 3, 2020. We meta‐analyzed the effect from these studies and unpublished data from LORANS. We included observational studies that measured SBP and/or DBP before Ramadan and during the last 2 weeks of Ramadan or the first 2 weeks of the month after. Data appraisal and extraction were conducted by at least 2 reviewers in parallel. We pooled SBP and DBP using a random‐effects model. The systematic review is registered with PROSPERO (International Prospective Register of Systematic Reviews; CRD42019159477). In LORANS, 85 participants were recruited; mean age was 45.6±15.9 years, and 52.9% ( n =45) of participants were men. SBP and DBP after Ramadan fasting were lower by 7.29 mm Hg (−4.74 to −9.84) and 3.42 mm Hg (−1.73 to −5.09), even after adjustment for potential confounders. We identified 2778 studies of which 33 with 3213 participants were included. SBP and DBP after/before Ramadan were lower by 3.19 mm Hg (−4.43 to −1.96, I 2 =48%) and 2.26 mm Hg (−3.19 to −1.34, I 2 =66%), respectively. In subgroup analyses, lower blood pressures were observed in the groups who are healthy or have hypertension or diabetes but not in patients with chronic kidney disease. Conclusions Our study suggests beneficial effects of Ramadan fasting on blood pressure independent of changes in weight, total body water, and fat mass and supports recommendations for some governmental guidelines that describe Ramadan fasting as a safe religious practice with respect to blood pressure.

scholarly journals Safety and Efficacy of Imidapril in the Treatment of Essential Hypertension

2011 ◽  
Vol 3 ◽  
pp. CMT.S7662
Author(s):  
Masashi Okamura ◽  
Susumu Ogawa ◽  
Sadayoshi Ito
Keyword(s):  
Blood Pressure ◽  
Current Knowledge ◽  
Meta Analysis ◽  
Renin Angiotensin System ◽  
Ace Inhibition ◽  
Angiotensin Ii Receptor ◽  
Converting Enzyme Inhibitors ◽  
Beneficial Effects ◽  
Pressure Independent ◽  
Ras Inhibitors

Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are one of the renin angiotensin system (RAS) inhibitors widely used for the treatment of hypertension. Recently, Blood Pressure Lowering Treatment Trialists’ Collaboration (BPLTTC) meta-analysis showed that ACEIs had the blood pressure independent beneficial effects on coronary heart events. In this review, we summarized our current knowledge about ACEIs especially imidapril and re-evaluated ACEIs among other RAS inhibitors (RASIs) because ACEIs have wide ranges of beneficial effects in addition to the ACE inhibition which other RASIs do not have such as the up-regulation of bradykinin level, substance P level, the inhibition of matrix metalloproteinase (MMP) activity and stabilization of coronary plaque.

Postpartum NSAID Use and Adverse Outcomes among Women with Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-analysis

2020 ◽  
Vol 38 (01) ◽  
pp. 001-009
Author(s):  
Ashish Premkumar ◽  
Nina K. Ayala ◽  
Corinne H. Miller ◽  
William A. Grobman ◽  
Emily S. Miller
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Random Effect ◽  
Hypertensive Disorders Of Pregnancy ◽  
Inclusion Criteria ◽  
Hypertensive Disorders ◽  
Blood Pressures ◽  
Secondary Outcomes

Objective This study was aimed to perform a systematic review and meta-analysis of the association between postpartum nonsteroidal anti-inflammatory drug (NSAID) use among women with hypertensive disorders of pregnancy (HDP) and risks of adverse postpartum outcomes. Study Design Studies were eligible if they included women who had been diagnosed with HDP and were postpartum, reported exposure to NSAIDs, were written in English, and were published between January 2000 and November 2019. Assessment of bias was performed using the Newcastle–Ottawa scale for observational studies or the Cochrane Collaborative tool for randomized trials. The primary outcome was maternal blood pressure ≥ 150 mm Hg systolic and/or 100 mm Hg diastolic. Secondary outcomes were persistent blood pressures ≥ 160 mm Hg systolic and/or 110 mm Hg diastolic, mean arterial pressure (MAP), initiation or up-titration of antihypertensive medication, length of hospital stay, rehospitalization for blood pressure control, and postpartum opioid use. A random-effect meta-analysis was performed using RevMan, with a p-value < 0.05 used to indicate statistical significance (PROSPERO CRD no.: 42019127043). Results Among 7,395 abstracts identified, seven studies (four randomized and three cohort studies, n = 777 patients) met inclusion criteria. All cohort analyses exhibited low levels of bias, while two randomized controlled trials exhibited a high risk of bias in blinding and inclusion criteria. There was no association between NSAID use and blood pressures ≥ 150 mm Hg systolic and/or 100 mm Hg diastolic (risk ratio [RR]: 1.21, 95% confidence interval [CI]: 0.89–1.64). Conversely, NSAID use was associated with a statistically significant, but clinically insignificant, increase in length of postpartum stay (0.21 days, 95% CI: 0.05–0.38). No other secondary outcomes were significantly different between groups. Conclusion Postpartum NSAID use among women with HDP was not associated with maternal hypertension exacerbation. These findings support the recent American College of Obstetricians and Gynecologists' guideline change, wherein preeclampsia is no longer a contraindication to postpartum NSAID use. Key Points

Does the benefit from treating to lower blood pressure targets vary with age? A systematic review and meta-analysis

2019 ◽  
Vol 37 (8) ◽  
pp. 1558-1566 ◽  
Author(s):  
George C. Roush ◽  
Ayla Zubair ◽  
Kevin Singh ◽  
William J. Kostis ◽  
Domenic A. Sica ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Meta Analysis ◽  
Lower Blood Pressure ◽  
Blood Pressure Targets ◽  
Lower Blood

The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2019 ◽  
Vol 25 (12) ◽  
pp. 1372-1384 ◽  
Author(s):  
Omid R. Tamtaji ◽  
Alireza Milajerdi ◽  
Ehsan Dadgostar ◽  
Fariba Kolahdooz ◽  
Maryam Chamani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Endothelial Function ◽  
Randomized Controlled Trials ◽  
Adhesion Molecule ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Blood Pressures

Background: This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders. Methods: We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results: Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14; 95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38). Conclusions: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders.

Does ginger supplementation lower blood pressure? A systematic review and meta‐analysis of clinical trials

2019 ◽  
Vol 33 (6) ◽  
pp. 1639-1647 ◽  
Author(s):  
Hossein Hasani ◽  
Arman Arab ◽  
Amir Hadi ◽  
Makan Pourmasoumi ◽  
Abed Ghavami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Clinical Trials ◽  
Meta Analysis ◽  
Lower Blood Pressure ◽  
Lower Blood

Effect of Vitamin K Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 19 (1) ◽  
pp. 13-25 ◽  
Author(s):  
Hitesh Verma ◽  
Rajeev Garg
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Blood Pressure ◽  
Vitamin K ◽  
Cardiometabolic Risk ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Beneficial Effects ◽  
Present Systematic Review

Background: Multiple cross sectional and longitudinal studies reported the benefits of vitamin K intake for management of cardiometabolic risk factors so as to minimize the risk of cardiovascular diseases. Objective: In present systematic review and meta-analysis, we aimed to evaluate the effect of vitamin K supplementation on cardiometabolic risk factors. Methodology: A systematic literature search of PubMed, Cochrane central, Clinicaltrials.gov, Google Scholar, Web of Science, EBSCO and Scopus databases was done from inception to November, 2017. A total of 13 trials were selected for inclusion into the present systematic review to evaluate the effect of vitamin K supplementation on cardiometabolic risk factors in healthy or in population at high risk of cardiovascular diseases. Results: Significant beneficial effects of vitamin K supplementation were found only in case of Creactive protein (p = 0.01) and insulin sensitivity index (p <0.001), while no significant effects of vitamin K supplementation were found in case of total cholesterol (p=0.857), low density lipoprotein – cholesterol (p=0.964), high density lipoprotein – cholesterol (p=0.998), interleukin – 6 (p=0.766), systolic blood pressure (p=0.660), diastolic blood pressure (p=0.818), fasting plasma glucose (p=0.362), fasting plasma insulin (p=0.928) and homeostasis model assessment for insulin resistance (p=0.672). Conclusion: Presently available evidence are insufficient to ascertain the beneficial effects of vitamin K supplementation for the management of cardiometabolic risk factors. In order to explore the true potential of vitamin K supplementation for management of cardiometabolic diseases, large randomized placebo controlled trials are required in population with disturbed cardiometabolic profile. Present systematic review and meta-analysis is registered with PROSPERO (Registration number: CRD42018084608).

scholarly journals Does omega-3 lower blood pressure? a protocol for systematic review and meta-analysis

2020 ◽  
Author(s):  
Liyu Tao ◽  
Yiru Wang ◽  
Yifan Zhang ◽  
Ping Liu ◽  
Xiaohong Chen
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Meta Analysis ◽  
Lower Blood Pressure ◽  
Omega 3 ◽  
Lower Blood
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