scholarly journals Magnesium Sulfate Does Not Increase Ventricular Cerebrospinal Fluid Ionized Magnesium Concentration in Patients with Intracranial Hypertension

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 375-375
Author(s):  
Randall P Brewer ◽  
Augusto Parra ◽  
Michael B Hopkins ◽  
Cecil O Borel ◽  
James R Reynolds
Keyword(s):  
Cerebrospinal Fluid ◽  
Data Analysis ◽  
Subarachnoid Hemorrhage ◽  
Intracranial Hypertension ◽  
Magnesium Sulfate ◽  
Closed Head Injury ◽  
Magnesium Concentration ◽  
Closed Head ◽  
Ct Data ◽  
Post Hoc

P197 Background: Magnesium sulfate (MgSO4) has attracted interest as a neuroprotective agent during cerebral ischemia. Passage of Mg ion into the CNS has been poorly examined. The present study assessed the passage of ionized (physiologically-active)Mg into the cerebrospinal fluid (CSF) of patients with intracranial hypertension after MgSO4 infusion. Design: After IRB approval, patients requiring CSF drainage received IV MgSO 4 (5g)in 125 cc NS over 30 min. Plasma and CSF samples were taken hourly for 4 hrs. Intraventricular catheter placement was confirmed by CT. Data analysis involved ANOVA followed by Dunnet’s post hoc test for a significant F statistic (p < 0.05). Results: Nine patients (5/4, male/female; mean age=52) with closed head injury (n=3), subarachnoid hemorrhage (n=2), intracerebral hemorrhage (n=2), hydrocephalus (n=1), and subdural hematoma (n=1) were studied. Mean (±SD)Mg values are presented (table). Baseline Mg was higher in CSF. Although plasma Mg increased, CSF Mg was unchanged. Conclusions: Although the CSF to plasma Mg gradient is maintained in patients with intracranial hypertension, intravenous infusion of 5g MgSO4 does not further increase CSF Mg. This suggests systemic infusion of MgSO4 may not be an effective route of administration for neuroprotection.

Increased intracranial pressure is associated with elevated cerebrospinal fluid ADH levels in closed-head injury

2010 ◽  
Vol 32 (10) ◽  
pp. 1021-1026 ◽  
Author(s):  
Marsha A. Widmayer ◽  
Jeffrey L. Browning ◽  
Shankar P. Gopinath ◽  
Claudia S. Robertson ◽  
David S. Baskin
Keyword(s):  
Cerebrospinal Fluid ◽  
Head Injury ◽  
Intracranial Pressure ◽  
Closed Head Injury ◽  
Increased Intracranial Pressure ◽  
Closed Head

scholarly journals Prognostic value of the Marshall computed tomography classification for traumatic subarachnoid hemorrhage

2014 ◽  
Vol 8 (5) ◽  
pp. 609-614
Author(s):  
Fang Wang ◽  
Xin Huang ◽  
Liang Wen ◽  
Jiang-biao Gong ◽  
Hao Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Subarachnoid Hemorrhage ◽  
Closed Head Injury ◽  
Prognostic Variables ◽  
Prognostic Effect ◽  
Closed Head ◽  
Diffuse Injury ◽  
Traumatic Subarachnoid Hemorrhage ◽  
Ct System

Abstract Background: The Marshall computed tomography (CT) system for classification of traumatic brain injury (TBI) includes the most important independent prognostic variables except for traumatic subarachnoid hemorrhage (tSAH). Objectives: To evaluate the prognostic effect of tSAH on different injury types based on the Marshall CT system. Methods: We performed a retrospective study. All patients with severe closed head injury admitted from February 2011 to July 2012 were included. Their scans were classified into two groups: localized injury and diffuse injury using the Marshall classification. Outcomes were compared between patients with tSAH and those without tSAH among the two groups. Results: Ninety-six patients were included in this study. Seventy-two (75%) were found to have tSAH, and outcomes significantly negatively correlated with tSAH in both localized injury and diffused injury groups. Conclusions: tSAH had an important effect on the patients’ outcome. Although the Marshall classification includes important independent prognostic variables, tSAH should also be added.

scholarly journals BRAIN MOTION AND DEFORMATION DURING CLOSED HEAD INJURY IN THE PRESENCE OF CEREBROSPINAL FLUID

2005 ◽  
Vol 05 (02) ◽  
pp. 277-306 ◽  
Author(s):  
CHARLES F. BABBS
Keyword(s):  
Cerebrospinal Fluid ◽  
Head Injury ◽  
High Speed ◽  
Closed Head Injury ◽  
Biomechanical Analysis ◽  
Viscoelastic Deformation ◽  
Brain Motion ◽  
Brain Substance ◽  
Closed Head ◽  
The Brain

This paper presents a new analysis of the physics of closed head injury following brief, intense acceleration of the head. It focuses upon the buoyancy of the brain in cerebrospinal fluid, which protects against damage; the propagation of strain waves through the brain substance, which causes damage; and the concentration of strain in critical anatomic regions, which magnifies damage. Numerical methods are used to create animations or "movies" of brain motion and deformation. Initially, a 1 cm gap filled with cerebrospinal fluid (CSF) separates the brain from the skull. Whole head acceleration induces artificial gravity within the skull. The brain accelerates, because its density differs slightly from that of CSF, strikes the inner aspect of the skull, and then undergoes viscoelastic deformation. The computed pattern of brain motion correlates well with published high-speed photographic studies. The sites of greatest deformation correlate with sites of greatest pathological damage. This fresh biomechanical analysis allows one to visualize events within the skull during closed head injury and may inspire new approaches to prevention and treatment.

Sign in / Sign up

Export Citation Format

Share Document