Abstract 188: Differences in Quality of Life Across Modified Rankin Scale Categories in IMS-3

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Srikant Rangaraju ◽  
Raul Nogueira ◽  
Diogo Haussen ◽  
Fadi Nahab ◽  
Michael Frankel
Keyword(s):  
Quality Of Life ◽  
Secondary Analysis ◽  
Modified Rankin Scale ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
Degree Of Disability ◽  
Definition Of ◽  
Eq5d Index

Background: Modified Rankin Scale (mRS) score 0-2 is frequently used as a definition of good outcome in ischemic stroke trials. Patients with mRS 3 are frequently grouped with mRS 4-6 as having poor outcome yet there is limited data on health-related quality of life (QOL) across mRS scores. Objective: Determine QOL and levels of disability across mRS scores and to specifically compare mRS 2 and 3 outcome categories. Methods: A secondary analysis of the Interventional Management of Stroke 3 (IMS3) trial was performed. Patients with documented mRS, degree of disability assessed by Barthel Index (BI) and patient-completed EQ5D-3L quality of life questionnaires at 3 months after stroke were included. EQ5D index was calculated using utility weights published for the US population. Median and mean BI and EQ5D were compared across mRS categories. Multiple pairwise comparisons were performed and Bonferroni corrected p-values were used. No imputations were performed. Results: 423 patients were included (mean age 64±13 years, median ASPECTS 8 [IQR 6-10], median baseline NIHSS 16 [IQR 12-19], mean BI 84.1±25.3 and mean EQ5D index 0.727±0.24. Overall, there were inverse correlations between mRS and BI (Rho=-0.78, p<0.001) and between mRS and EQ5D (Rho=-0.69, p<0.001). While significant differences in BI were observed across several mRS categories including 1 vs 2, 2 vs 3 and 3 vs 4 (Fig A), there was no difference in QOL between mRS 2 (N=82) and 3 (N=88) categories (Fig B). Based on BI and EQ5D indices, mRS 3 had greater similarity to mRS 2 than to mRS 4 (Fig C). Conclusion: Health-related QOL is similar in patients who achieve mRS of 2 and 3 despite differences in degree of disability. If preservation of quality of life is the ultimate goal of acute stroke therapies, our results question the commonly used mRS 0-2 cut point used to dichotomize stroke outcomes.

Food intake, physical activity and quality of life among children and youth

Work ◽  
2021 ◽  
pp. 1-10
Author(s):  
Emília Martins ◽  
Rosina Fernandes ◽  
Francisco Mendes ◽  
Cátia Magalhães ◽  
Patrícia Araújo
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Healthy Lifestyle ◽  
Eating Habits ◽  
Age Groups ◽  
Related Quality ◽  
Health Related ◽  
Life Habits ◽  
Definition Of

BACKGROUND: The health-related quality of life construct (QoL) implies a relationship with eating habits (EA) and physical activity (PA). Sociodemographic and anthropometric variables (gender, age and Body Mass Index - BMI) are highlighted in the definition of healthy lifestyle habits promotion strategies. OBJECTIVE: We aim to characterize and relate PA, EA and QoL in children/youth and explore gender, age and BMI influences. METHODS: It is a non-experimental study, with 337 children/youth, ages between 8 and 17 years (12.61±2.96), mostly from the rural inland of Portugal. In data collection we used a sociodemographic and anthropometric questionnaire, a weekly register table of EA and Kid-Kindl (QoL). Statistical analysis (p <  0.05) were performed in SPSS-IBM 25. RESULTS: Lower BMI was associated with better EA (p <  0.001), PA (p <  0.05) and self-esteem (p <  0.01) and worse scores on family subscale of QoL. Female showed higher fruit intake (p <  0.05). The older has shown better results. PA is positively correlated with QoL (p <  0.01) and EA (p <  0.05). CONCLUSIONS: It is important to explore other relevant social and family dimensions, to promote intervention programs with parents, school and community, as well as healthy practices policies. The intervention in these age groups is critical for a longer-term impact in improving healthy life habits.

scholarly journals Quality of Life and Health for Patients with Chronic Periodontitis: A Qualitative Study

2020 ◽  
Author(s):  
Jeehee Pyo ◽  
Ji-Hyun Lee ◽  
Mina Lee ◽  
Minsu Ock
Keyword(s):  
Quality Of Life ◽  
Periodontal Disease ◽  
Dental Care ◽  
Dental Health ◽  
The Elderly ◽  
Health Related Quality ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

Abstract Background: Disease burden created by periodontal disease has been recognized as a global challenge. The burden of medical expenses is expected to increase continuously, parallel to the growth of the elderly population. Periodontal disease causes tooth loss if not treated early, and advanced periodontitis can cause a decline in chewing ability and word pronunciation as well as aesthetic function. These results diminish the health-related quality of life (QOL) for various populations, particularly the elderly, adults, pregnant women, and workers. Thus, not only is early detection and management of the disease necessary, but also a systematic strategy for the prevention of periodontal diseaseMethods: Adults 19 years of age or older diagnosed with chronic gingivitis (K05.1) or chronic periodontitis (K05.3) under the ICD-10 codes were selected to participate in the study. Among the patients visiting the dental outpatient department, the study participants were chosen for our sample. A total of 20 participants were informed of the purpose of the study and gave consent to participate in in-depth interviews.Results: The analysis results were summarized into the four upper categories of ‘Interfering Element for Dental Care,’ ‘Declined Quality of Life caused by Dental Disease,’ ‘Satisfaction Elements after Treatment of Dental Disease,’ ‘Improvements for Voluntary Dental Care.’ The treatment of periodontal disease has improved the health-related quality of life and enabled the participants to have positive health behaviors for dental care. Furthermore, they recognized the severity of periodontal disease and the importance of dental examinations. It enabled them to be aware of the need of societal effort for dental care awareness.Conclusions: This study was an in-depth examination of the health-related QOL of periodontal patients through qualitative research methodology. The experiences of periodontal disease identified by this study can not only help to assess the adequacy of the current dental health-related QOL assessment tools but also recognize unmet needs regarding periodontal disease and, ultimately, to raise the awareness of periodontal disease among the general public. Based on this research, we expect that research on health-related QOL on periodontal disease would expand and revitalize the dental health system and practices.

Quality of Life in Childhood Cancer: Meaning, Methods, and Missing Pieces

2006 ◽  
Author(s):  
Rachel B. Levi
Keyword(s):  
Quality Of Life ◽  
Pediatric Oncology ◽  
Survival Rates ◽  
Well Being ◽  
Related Quality ◽  
Health Related ◽  
Domains Of Life ◽  
Definition Of ◽  
Health Organization

It is only in the last three decades that the quality of the lives of children and adolescents treated for cancer and their families has become a major focus in the field of pediatric oncology. This shift from helping families to tolerate arduous treatments and prepare for early death is a result of advances in treatment and survival rates for most pediatric disease categories. One result of this paradigm shift is that quality of life (QOL) has become a critical construct within the field of pediatric oncology. The construct of QOL was initially developed for use with adult populations and was based on the definition of health generated in 1948 by the World Health Organization (WHO): “a state of complete physical, mental, and social well being, and not merely the absence of disease or infirmity.” Although there remains no universally adopted definition of QOL, the WHO’s definition of QOL as an “individual’s perceptions of their position in life in the context of the culture and value system in which they live and in relation to their goals, standards, and concerns” is frequently employed (WHO, 1993). This definition includes several domains that are considered central to the QOL construct: physical, mental/emotional, and social. This initial construct has been expanded with adult populations to include physical symptoms and functioning, functional status (i.e., ability to participate in daily and life activities), psychological functioning, and social functioning (e.g., Ware, 1984). This more expansive definition is referred to as health-related quality of life (HRQOL). HRQOL emphasizes the impact of health on one’s QOL but looks further to include other domains of life functioning that are also potentially affected by health/illness states (Jenney, 1998). The HRQOL construct was initially developed for populations of adults living with chronic illness to assess the impacts of illness/injury/disability, medical treatment, or health care policy on an individual’s life quality (for reviews, see Aaronson et al., 1991; Patrick&Erikson, 1993; Speith&Harris, 1996). Over time, there have been modifications and developments in the construct, approaches to measurement, and the measures themselves (Wilson & Cleary, 1994).

scholarly journals Effects of Euglena gracilis EOD-1 Ingestion on Salivary IgA Reactivity and Health-Related Quality of Life in Humans

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1144 ◽  
Author(s):  
Ken-ichi Ishibashi ◽  
Machiko Nishioka ◽  
Nobuteru Onaka ◽  
Madoka Takahashi ◽  
Daisuke Yamanaka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Euglena Gracilis ◽  
Health Related Quality ◽  
Salivary Iga ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
Antibody Titers ◽  
Iga Antibody

Euglena gracilis EOD-1, a microalgal strain known for high yields of the β-1, 3-glucan paramylon, is suggested to function as a dietary fiber and enhance immunity. Here, we aimed to investigate the effects of E. gracilis EOD-1 biomass (EOD1BM) ingestion on immunoglobulin A (IgA) antibody titers in saliva, its reactivity, and the health-related quality of life (QOL) in humans. Reacting human immunoglobulin preparations and saliva with paramylon granules revealed the presence of anti-paramylon antibodies in the blood and saliva. We conducted a placebo-controlled, double-blind, crossover study involving 13 healthy subjects who ingested the placebo or EOD1BM for 4 weeks. Saliva was collected from each subject before and after ingestion, and IgA titers and E. gracilis EOD-1 paramylon (EOD1PM) reactivity were compared. In the EOD1BM Ingestion group, the anti-EOD1PM IgA content and titer increased after EOD1BM ingestion. No such change was observed in the Placebo group. Furthermore, the health-related QOL, especially mental health, increased in the EOD1BM Ingestion group. Thus, EOD1BM ingestion led to the production of paramylon (PM)-specific IgA antibody and increased salivary IgA antibody titers. We demonstrate that EOD1BM ingestion enhanced the immunity in the mucosal surface, evoked an antigen-specific response, and increased the health-related QOL, thereby contributing to health improvement.

scholarly journals Restarting antiplatelet therapy after spontaneous intracerebral hemorrhage

Neurology ◽  
2018 ◽  
Vol 91 (1) ◽  
pp. e26-e36 ◽  
Author(s):  
Ching-Jen Chen ◽  
Dale Ding ◽  
Thomas J. Buell ◽  
Fernando D. Testai ◽  
Sebastian Koch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intracerebral Hemorrhage ◽  
Functional Outcomes ◽  
Primary Outcome ◽  
Modified Rankin Scale ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Secondary Outcomes

ObjectiveTo compare the functional outcomes and health-related quality of life metrics of restarting vs not restarting antiplatelet therapy (APT) in patients presenting with intracerebral hemorrhage (ICH) in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) study.MethodsAdult patients aged 18 years and older who were on APT before ICH and were alive at hospital discharge were included. Patients were dichotomized based on whether or not APT was restarted after hospital discharge. The primary outcome was a modified Rankin Scale score of 0–2 at 90 days. Secondary outcomes were excellent outcome (modified Rankin Scale score 0–1), mortality, Barthel Index, and health status (EuroQol–5 dimensions [EQ-5D] and EQ-5D visual analog scale scores) at 90 days.ResultsThe APT and no APT cohorts comprised 127 and 732 patients, respectively. Restarting APT was associated with lower rates of good functional outcome (36.5% vs 40.8%; p = 0.021) and lower Barthel Index scores at 90 days (p = 0.041). The 2 cohorts were then matched in a 1:1 ratio, and the matched cohorts each comprised 107 patients. No difference in primary outcome was observed between restarting vs not restarting APT (35.5% vs 43.9%; p = 0.105). There were also no differences between the secondary outcomes of the 2 cohorts.ConclusionRestarting APT in patients with ICH of mild to moderate severity after acute hospitalization is not associated with worse functional outcomes or health-related quality of life at 90 days. In patients with significant cardiovascular risk factors who experience an ICH, restarting APT remains the decision of the treating practitioner.

scholarly journals Associations between markers of health and playing golf in an Australian population

2019 ◽  
Vol 5 (1) ◽  
pp. e000517 ◽  
Author(s):  
Brad Stenner ◽  
Amber D Mosewich ◽  
Jonathan D Buckley ◽  
Elizabeth S Buckley
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Secondary Analysis ◽  
Health Related Quality ◽  
Australian Population ◽  
Physically Active ◽  
Related Quality ◽  
Health Related ◽  
Activity Survey

ObjectiveTo investigate associations between markers of health and playing golf in an Australian population.MethodsSecondary analysis of data from the Australian National Nutrition and Physical Activity Survey to compare selected health outcomes between golfers (n=128) and non-golfers (n=4999).ResultsGolfers were older than non-golfers (mean±SD 57.7±14.2 years, 48.5±17.6 years, p<0.05). A higher proportion of golfers were overweight or obese compared with non-golfers (76% vs 64%, p<0.05), and golfers were more likely to have been diagnosed with ischaemic heart disease (IHD) at some time in their life (OR 2.8, 95% CI 1.0 to 7.8). However, neither the risk of being overweight or obese (OR 1.4, 95% CI 0.9 to 2.2) or having been diagnosed with IHD (OR 2.1, 95% CI 0.8 to 5.8), were significant after controlling for age. Golfers were more physically active than non-golfers (8870±3810 steps/day vs 7320±3640 steps/day, p<0.05) and more likely to report high health-related quality of life (HRQoL) than non-golfers (OR 1.8; 95% CI 1.0 to 3.3), but not after adjusting for physical activity (OR 1.4, 95% CI 0.9 to 2.2).ConclusionCompared with non-golfers, golfers were more likely to be overweight or obese and to have been diagnosed with IHD, but not after adjusting for golfers being older. Golfers were more likely to report a higher HRQoL, but not after adjusting for golfers being more physically active. There may be an association between golfers being more physically active than non-golfers and reporting a higher HRQoL.

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