Abstract TP203: Serum Uric Acid is Associated With Arterial Stiffness, Pulse Pressure and Stroke in Apparently Healthy Population

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Kwang-Yeol Park ◽  
Jeong-Min Kim ◽  
Won-Tae Yoon ◽  
Pil-Wook Chung
Keyword(s):  
Uric Acid ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Pulse Pressure ◽  
Healthy Population ◽  
Apparently Healthy

Genetically Elevated Serum Uric Acid and Renal Function in an Apparently Healthy Population

2019 ◽  
Vol 104 (3-4) ◽  
pp. 277-282
Author(s):  
Ji-Yong Ge ◽  
Yuan Ji ◽  
Zhen-Yan Zhu ◽  
Xun Li
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Healthy Population ◽  
Apparently Healthy

The relationship between elevated serum uric acid and arterial stiffness in a healthy population

Vascular ◽  
2020 ◽  
Vol 28 (4) ◽  
pp. 494-501 ◽  
Author(s):  
Ye Jiang ◽  
Ji-Yong Ge ◽  
Yu-Yan Zhang ◽  
Fang-Fang Wang ◽  
Yuan Ji ◽  
...  
Keyword(s):  
Uric Acid ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Healthy Population ◽  
Diabetic Mellitus ◽  
The Relationship ◽  
Circulating Levels ◽  
Randomization Method

Objective This study aims to investigate the relationship between serum uric acid and arterial stiffness in a healthy population. Methods Among the 979 participants, baPWV was non-invasively measured, the circulating levels of uric acid were tested, and the uric acid polymorphisms (rs2231142 and rs11722228) were genotyped. Then, the Mendelian randomization method was employed to test the relationship between serum uric acid and arterial stiffness in a healthy population. Results After adjusting for age, gender, antihypertensive medication, body mass index, waist-to-hip ratio, urea nitrogen, creatinine and diabetic mellitus, there was a significant allelic difference in uric acid levels for each genotype ( P <  0.0001 for rs2231142; P =  0.007 for rs11722228). However, there were no differences on the potential confounders between the genotypes of rs2231142 and rs11722228 ( P >  0.05). The baPWV was significantly associated with circulating levels of uric acid after adjusting for cardiovascular risk factors and other potential confounders ( P =  0.002). However, neither the single polymorphism, nor the accumulation of culprit alleles was associated with baPWV ( P =  0.92 for rs2231142; P =  0.60 for rs11722228; P for trend = 0.77 for the combined analysis of culprit alleles). Conclusion These results do not support the causal role of circulating levels of uric acid in the development of arterial stiffness.

scholarly journals SP403SEVELAMER DECREASES SERUM URIC ACID LEVELS AND IMPROVES ARTERIAL STIFFNESS IN HEMODIALYSIS PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii512-iii512
Author(s):  
Siren Sezer ◽  
Bahar Gurlek Demirci ◽  
Emre Tutal ◽  
Zeynep Bal ◽  
Mehtap Erkmen Uyar ◽  
...  
Keyword(s):  
Uric Acid ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Hemodialysis Patients

Association of High Serum Uric Acid and Increased Arterial Stiffness is Dependent on Cardiovascular Risk Factors in Female Population

2019 ◽  
Vol 51 (06) ◽  
pp. 367-374 ◽  
Author(s):  
Yin Yuan ◽  
Feng Huang ◽  
Fan Lin ◽  
Min Lin ◽  
Pengli Zhu
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Cardiovascular Risk Factors ◽  
Serum Uric Acid ◽  
Pulse Wave ◽  
Elevated Serum ◽  
High Serum ◽  
Female Population

AbstractAn elevated serum uric acid (SUA) level is closely associated with increased arterial stiffness. However, whether this association is independent of conventional cardiovascular risk factors is controversial. This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m2. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular risk factors. In female subjects with more than two cardiovascular risk factors, compared with the first quartile of SUA, higher SUA quartiles were associated with a higher probability of increased baPWV (OR=1.500, 1.478, 1.774 for SUA Q2–Q4). In further stratified association analysis, compared with Q1, SUA quartiles showed a graded association with increased baPWV in subjects with TC≥5.2 mmol/l (OR=1.758, 1.942, 2.354 for Q2, Q3, and Q4 respectively), LDL-C≥3.3 mmol/l (OR=1.510, 2.255 for Q3 and Q4) and FBG≥7.0 mmol/l (OR=1.516, 1.748 for Q3 and Q4). In the Chinese coastal female population, the association of high SUA and increased arterial stiffness is dependent on the coexistence of at least one cardiovascular risk factor, especially hypercholesterolemia.

Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals

2007 ◽  
Vol 192 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Nobukazu Ishizaka ◽  
Yuko Ishizaka ◽  
Ei-Ichi Toda ◽  
Hideki Hashimoto ◽  
Ryozo Nagai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Arterial Stiffness ◽  
Serum Uric Acid

High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects

2017 ◽  
Vol 37 ◽  
pp. 38-42 ◽  
Author(s):  
Arrigo F.G. Cicero ◽  
Martina Rosticci ◽  
Federica Fogacci ◽  
Elisa Grandi ◽  
Sergio D'Addato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
High Serum

scholarly journals A STUDY OF MULTIPARAMETER ANALYSIS OF SERUM URIC ACID LEVELS -A STUDY IN APPARENTLY HEALTHY JAPANESE MEN AND WOMEN-

2020 ◽  
Vol 111 (1) ◽  
pp. 22-29
Author(s):  
Tomoyuki Shimabukuro ◽  
Chietaka Ohmi ◽  
Koji Shiraishi ◽  
Hideyasu Matsuyama
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Japanese Men ◽  
Men And Women ◽  
Multiparameter Analysis ◽  
Apparently Healthy

scholarly journals Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study

2019 ◽  
Vol 89 (1) ◽  
Author(s):  
Francesco Antonini-Canterin ◽  
Concetta Di Nora ◽  
Marco Pellegrinet ◽  
Olga Vriz ◽  
Salvatore La Carrubba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Stiffness Index ◽  
Artery Stiffness ◽  
Echo Tracking ◽  
Carotid Arterial

Serum uric acid (UA) has been shown to be a predictor of cardiovascular (CV) morbidity and mortality, and it may play a role in the pathogenesis of CV disease affecting vascular structure and function. However, there is limited evidence of its specific association with carotid artery stiffness and structure. The aim of our study was to evaluate whether UA is associated with early signs of atherosclerosis, namely local carotid arterial stiffness and intima-media thickening. We evaluated 698 consecutive asymptomatic patients, referred to the Cardiovascular Department for risk factors evaluation and treatment. All patients underwent carotid artery ultrasonography with measurement of common carotid intima-media thickness (IMT) and echo-tracking carotid artery stiffness index Beta. Patients with hyperuricemia (defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women) had higher IMT (0.97±0.22 vs 0.91±0.18, p<0.001) and stiffness index Beta (8.3±3.2 vs 7.5±2.7, p=0.005). UA levels correlated with both IMT (r=0.225; p<0.001) and stiffness index Beta (r=0.154; p<0.001); the correlations were statistically significant in males and females. In a multivariate model which included age, arterial pressure, serum glucose and LDL-cholesterol, serum UA emerged as an independent explanatory variable of IMT and stiffness index Beta. Carotid IMT and local arterial stiffness are related to UA independently of established CV risk factors; UA may play a role in the early development of atherosclerosis.

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