scholarly journals Inhibition-related Activation in the Right Inferior Frontal Gyrus in the Absence of Inhibitory Cues

2011 ◽  
Vol 23 (11) ◽  
pp. 3388-3399 ◽  
Author(s):  
Agatha Lenartowicz ◽  
Frederick Verbruggen ◽  
Gordon D. Logan ◽  
Russell A. Poldrack

The right inferior frontal gyrus (rIFG) has been hypothesized to mediate response inhibition. Typically response inhibition is signaled by an external stop cue, which provides a top–down signal to initiate the process. However, recent behavioral findings suggest that response inhibition can also be triggered automatically by bottom–up processes. In the present study, we evaluated whether rIFG activity would also be observed during automatic inhibition, in which no stop cue was presented and no motor inhibition was actually required. We measured rIFG activation in response to stimuli that were previously associated with stop signals but which required a response on the current trial (reversal trials). The results revealed an increase in rIFG (pars triangularis) activity, suggesting that it can be activated by associations between stimuli and stopping. Moreover, its role in inhibition tasks is not contingent on the presence of an external stop cue. We conclude that rIFG involvement in stopping is consistent with a role in reprogramming of action plans, which may comprise inhibition, and its activity can be triggered through automatic, bottom–up processing.

2019 ◽  
Author(s):  
Rémy Masson ◽  
Yohana Lévêque ◽  
Geneviève Demarquay ◽  
Hesham ElShafei ◽  
Lesly Fornoni ◽  
...  

AbstractObjectivesTo evaluate alterations of top-down and/or bottom-up attention in migraine and their cortical underpinnings.Methods19 migraineurs between attacks and 19 matched control participants performed a task evaluating jointly top-down and bottom-up attention, using visually-cued target sounds and unexpected task-irrelevant distracting sounds. Behavioral responses and MEG/EEG were recorded. Event-related potentials and fields (ERPs/ERFs) were processed and source reconstruction was applied to ERFs.ResultsAt the behavioral level, neither top-down nor bottom-up attentional processes appeared to be altered in migraine. However, migraineurs presented heightened evoked responses following distracting sounds (orienting component of the N1 and Re-Orienting Negativity, RON) and following target sounds (orienting component of the N1), concomitant to an increased recruitment of the right temporo-parietal junction. They also displayed an increased effect of the cue informational value on target processing resulting in the elicitation of a negative difference (Nd).ConclusionsMigraineurs appear to display increased bottom-up orienting response to all incoming sounds, and an enhanced recruitment of top-down attention.SignificanceThe interictal state in migraine is characterized by an exacerbation of the orienting response to attended and unattended sounds. These attentional alterations might participate to the peculiar vulnerability of the migraine brain to all incoming stimuli.HighlightsMigraineurs performed as well as healthy participants in an attention task.However, EEG markers of both bottom-up and top-down attention are increased.Migraine is also associated with a facilitated recruitment of the right temporo-parietal junction.


2007 ◽  
Vol 19 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Junichi Chikazoe ◽  
Seiki Konishi ◽  
Tomoki Asari ◽  
Koji Jimura ◽  
Yasushi Miyashita

The go/no-go task, which effectively taps the ability to inhibit prepotent response tendency, has consistently activated the lateral prefrontal cortex, particularly the right inferior frontal gyrus (rIFG). On the other hand, rIFG activation has rarely been reported in the antisaccade task, seemingly an oculomotor version of the manual go/no-go task. One possible explanation for the variable IFG activation is the modality difference of the two tasks: The go/no-go task is performed manually, whereas the antisaccade task is performed in the oculomotor modality. Another explanation is that these two tasks have different task structures that require different cognitive processes: The traditional antisaccade task requires (i) configuration of a preparatory set prior to antisaccade execution and (ii) response inhibition at the time of antisaccade execution, whereas the go/no-go task requires heightened response inhibition under a minimal preparatory set. To test these possibilities, the traditional antisaccade task was modified in the present functional magnetic resonance imaging study such that it required heightened response inhibition at the time of antisaccade execution under a minimal preparatory set. Prominent activation related to response inhibition was observed in multiple frontoparietal regions, including the rIFG. Moreover, meta-analyses revealed that the rIFG activation in the present study was observed in the go/no-go tasks but not in the traditional antisaccade task, indicating that the rIFG activation was sensitive to the task structure difference, but not to the response modality difference. These results suggest that the rIFG is part of a network active during response inhibition across different response modalities.


2019 ◽  
Vol 50 (12) ◽  
pp. 2075-2084
Author(s):  
Sabrina Golde ◽  
Katja Wingenfeld ◽  
Antje Riepenhausen ◽  
Nina Schröter ◽  
Juliane Fleischer ◽  
...  

AbstractBackgroundAcross psychopathologies, trauma-exposed individuals suffer from difficulties in inhibiting emotions and regulating attention. In trauma-exposed individuals without psychopathology, only subtle alterations of neural activity involved in regulating emotions have been reported. It remains unclear how these neural systems react to demanding environments, when acute (non-traumatic but ordinary) stress serves to perturbate the system. Moreover, associations with subthreshold clinical symptoms are poorly understood.MethodsThe present fMRI study investigated response inhibition of emotional faces before and after psychosocial stress situations. Specifically, it compared 25 women (mean age 31.5 ± 9.7 years) who had suffered severe early life trauma but who did not have a history of or current psychiatric disorder, with 25 age- and education-matched trauma-naïve women.ResultsUnder stress, response inhibition related to fearful faces was reduced in both groups. Compared to controls, trauma-exposed women showed decreased left inferior frontal gyrus (IFG) activation under stress when inhibiting responses to fearful faces, while activation of the right anterior insula was slightly increased. Also, groups differed in brain–behaviour correlations. Whereas stress-induced false alarm rates on fearful stimuli negatively correlated with stress-induced IFG signal in controls, in trauma-exposed participants, they positively correlated with stress-induced insula activation.ConclusionNeural facilitation of emotion inhibition during stress appears to be altered in trauma-exposed women, even without a history of or current psychopathology. Decreased activation of the IFG in concert with heightened bottom-up salience of fear related cues may increase vulnerability to stress-related diseases.


2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
S. Borgwardt ◽  
P. Allen ◽  
S. Bhattacharyya ◽  
P. Fusar-Poli ◽  
J.A. Crippa ◽  
...  

Background:This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.Methods:Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.Results:Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.Conclusions:These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.


eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Michael Schaum ◽  
Edoardo Pinzuti ◽  
Alexandra Sebastian ◽  
Klaus Lieb ◽  
Pascal Fries ◽  
...  

Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt to rapidly changing environments. Despite over a decade of research on the neural mechanisms of response inhibition, it remains unclear, how exactly response inhibition is initiated and implemented. Using a multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that response inhibition is initiated by the right inferior frontal gyrus (rIFG) as a form of attention-independent top-down control that involves the modulation of beta-band activity. Furthermore, stopping performance was predicted by beta-band power, and beta-band connectivity was directed from rIFG to pre-supplementary motor area (pre-SMA), indicating rIFG’s dominance over pre-SMA. Thus, these results strongly support the hypothesis that rIFG initiates stopping, implemented by beta-band oscillations with potential to open up new ways of spatially localized oscillation-based interventions.


Author(s):  
Anton Fedosov

Online social networks have made sharing personal experiences with others mostly in form of photos and comments a common activity. The convergenceof social, mobile, cloud and wearable computing expanded the scope of usergeneratedand shared content on the net from personal media to individual preferencesto physiological details (e.g., in the form of daily workouts) to informationabout real-world possessions (e.g., apartments, cars). Once everydaythings become increasingly networked (i.e., the Internet of Things), future onlineservices and connected devices will only expand the set of things to share. Given that a new generation of sharing services is about to emerge, it is of crucialimportance to provide service designers with the right insights to adequatelysupport novel sharing practices. This work explores these practices within twoemergent sharing domains: (1) personal activity tracking and (2) sharing economyservices. The goal of this dissertation is to understand current practices ofsharing personal digital and physical possessions, and to uncover correspondingend-user needs and concerns across novel sharing practices, in order to map thedesign space to support emergent and future sharing needs. We address this goalby adopting two research strategies, one using a bottom-up approach, the otherfollowing a top-down approach.In the bottom-up approach, we examine in-depth novel sharing practices within two emergent sharing domains through a set of empirical qualitative studies.We offer a rich and descriptive account of peoples sharing routines and characterizethe specific role of interactive technologies that support or inhibit sharingin those domains. We then design, develop, and deploy several technology prototypesthat afford digital and physical sharing with the view to informing the design of future sharing services and tools within two domains, personal activitytracking and sharing economy services.In the top-down approach, drawing on scholarship in human-computer interaction (HCI) and interaction design, we systematically examine prior workon current technology-mediated sharing practices and identify a set of commonalitiesand differences among sharing digital and physical artifacts. Based uponthese findings, we further argue that many challenges and issues that are presentin digital online sharing are also highly relevant for the physical sharing in thecontext of the sharing economy, especially when the shared physical objects havedigital representations and are mediated by an online platform. To account forthese particularities, we develop and field-test an action-driven toolkit for designpractitioners to both support the creation of future sharing economy platformsand services, as well as to improve the user experience of existing services.This dissertation should be of particular interest to HCI and interaction designresearchers who are critically exploring technology-mediated sharing practicesthrough fieldwork studies, as well to design practitioners who are building and evaluating sharing economy services.


2020 ◽  
Author(s):  
Iris Duif ◽  
Joost Wegman ◽  
Kees de Graaf ◽  
Paul A.M. Smeets ◽  
Esther Aarts

AbstractDistracted eating can lead to increased food intake, but it is unclear how. We hypothesized that distraction affects the change in motivated responses for food reward after satiation. To investigate this, 38 healthy normal-weight participants (28F, 10M) performed a detection task varying in attentional load (high or low distraction) during fMRI. Simultaneously, they exerted effort for food rewards (sweet or savory) by repeated button presses. Two fMRI runs were separated by outcome devaluation (satiation) of one of the reward outcomes, to assess outcome-sensitive, i.e. goal-directed, responses. Behavioral results showed no effect of distraction on effort for food reward following outcome devaluation. At an uncorrected threshold (p<0.001), distraction decreased goal-directed responses (devalued versus valued) in the right inferior frontal gyrus (rIFG). Importantly, these distraction-sensitive rIFG responses correlated negatively (r = - 0.40, p = 0.014) with the effect of distraction on the number of button presses. Specifically, decreased rIFG responses due to distraction related to increased button presses for food reward after satiation, in line with the rIFG’s established role in response inhibition. Furthermore, distraction decreased functional connectivity between the rIFG (seed) and left putamen for valued versus devalued food rewards (pFWE(cluster)<0.05). Our results suggest that distraction attenuates the ability to inhibit responses for food reward after satiation by affecting the rIFG. Furthermore, distraction attenuated connectivity between two regions involved in response inhibition – rIFG and putamen – after outcome devaluation. These results may explain why distraction can lead to overeating in our current, distracting, environment. The study was preregistered at: https://osf.io/ad2qk.


2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Hannah Brauer ◽  
Navah Ester Kadish ◽  
Anya Pedersen ◽  
Michael Siniatchkin ◽  
Vera Moliadze

Response inhibition is the cognitive process required to cancel an intended action. During that process, a “go” reaction is intercepted particularly by the right inferior frontal gyrus (rIFG) and presupplementary motor area (pre-SMA). After the commission of inhibition errors, theta activity (4–8 Hz) is related to the adaption processes. In this study, we intend to examine whether the boosting of theta activity by electrical stimulation over rIFG reduces the number of errors and the reaction times in a response inhibition task (Go/NoGo paradigm) during and after stimulation. 23 healthy right-handed adults participated in the study. In three separate sessions, theta tACS at 6 Hz, transcranial random noise (tRNS) as a second stimulation condition, and sham stimulation were applied for 20 minutes. Based on behavioral data, this study could not show any effects of 6 Hz tACS as well as full spectrum tRNS on response inhibition in any of the conditions. Since many findings support the relevance of the rIFG for response inhibition, this could mean that 6 Hz activity is not important for response inhibition in that structure. Reasons for our null findings could also lie in the stimulation parameters, such as the electrode montage or the stimulation frequency, which are discussed in this article in more detail. Sharing negative findings will have (1) positive impact on future research questions and study design and will improve (2) knowledge acquisition of noninvasive transcranial brain stimulation techniques.


2015 ◽  
Vol 86 (9) ◽  
pp. e3.33-e3 ◽  
Author(s):  
Muhlert ◽  
Nils ◽  
Boy ◽  
Frederick ◽  
Lawrence ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document