scholarly journals Content Word Production during Discourse in Aphasia: Deficits in Word Quantity, Not Lexical–Semantic Complexity

2021 ◽  
pp. 1-18
Author(s):  
Reem S. W. Alyahya ◽  
Ajay D. Halai ◽  
Paul Conroy ◽  
Matthew A. Lambon Ralph
Keyword(s):  
Full Range ◽  
Content Word ◽  
Word Production ◽  
Connected Speech ◽  
Lexical Semantic ◽  
Reduced Word ◽  
Discourse Production ◽  
Wide Range ◽  
Semantic Complexity ◽  
Lesion Symptom Mapping

Abstract Although limited and reduced connected speech production is one, if not the most, prominent feature of aphasia, few studies have examined the properties of content words produced during discourse in aphasia, in comparison to the many investigations of single-word production. In this study, we used a distributional analysis approach to investigate the properties of content word production during discourse by 46 participants spanning a wide range of chronic poststroke aphasia and 20 neurotypical adults, using different stimuli that elicited three discourse genres (descriptive, narrative, and procedural). Initially, we inspected the discourse data with respect to the quantity of production, lexical–semantic diversity, and psycholinguistic features (frequency and imageability) of content words. Subsequently, we created a “lexical–semantic landscape,” which is sensitive to subtle changes and allowed us to evaluate the pattern of changes in discourse production across groups. Relative to neurotypical adults, all persons with aphasia (both fluent and nonfluent) showed significant reduction in the quantity and diversity of production, but the lexical–semantic complexity of word production directly mirrored neurotypical performance. Specifically, persons with aphasia produced the same rate of nouns/verbs, and their discourse samples covered the full range of word frequency and imageability, albeit with reduced word quantity. These findings provide novel evidence that, unlike in other disorders (e.g., semantic dementia), discourse production in poststroke aphasia has relatively preserved lexical–semantic complexity but demonstrates significantly compromised quantity of content word production. Voxel-wise lesion-symptom mapping using both univariate and multivariate approaches revealed left frontal regions particularly the pars opercularis, IC, and central and frontal opercular cortices supporting word retrieval during connected speech, irrespective of word class or their lexical–semantic complexity.

The Major Transitions in Evolution

1997 ◽  
Author(s):  
John Maynard Smith ◽  
Eors Szathmary
Keyword(s):  
Full Range ◽  
Evolution Of Cooperation ◽  
Major Transitions ◽  
Insect Societies ◽  
Wide Range ◽  
Major Transition ◽  
Life Itself ◽  
History Of ◽  
Emergence Of Cooperation ◽  
Multicellular Organisms

Over the history of life there have been several major changes in the way genetic information is organized and transmitted from one generation to the next. These transitions include the origin of life itself, the first eukaryotic cells, reproduction by sexual means, the appearance of multicellular plants and animals, the emergence of cooperation and of animal societies, and the unique language ability of humans. This ambitious book provides the first unified discussion of the full range of these transitions. The authors highlight the similarities between different transitions--between the union of replicating molecules to form chromosomes and of cells to form multicellular organisms, for example--and show how understanding one transition sheds light on others. They trace a common theme throughout the history of evolution: after a major transition some entities lose the ability to replicate independently, becoming able to reproduce only as part of a larger whole. The authors investigate this pattern and why selection between entities at a lower level does not disrupt selection at more complex levels. Their explanation encompasses a compelling theory of the evolution of cooperation at all levels of complexity. Engagingly written and filled with numerous illustrations, this book can be read with enjoyment by anyone with an undergraduate training in biology. It is ideal for advanced discussion groups on evolution and includes accessible discussions of a wide range of topics, from molecular biology and linguistics to insect societies.

Oxford Studies in Medieval Philosophy Volume 7

2019 ◽  
Keyword(s):  
Late Antiquity ◽  
Full Range ◽  
Current Work ◽  
Medieval Philosophy ◽  
Original Essays ◽  
Wide Range ◽  
Extended Review

Oxford Studies in Medieval Philosophy annually collects the best current work in the field of medieval philosophy. The various volumes print original essays, reviews, critical discussions, and editions of texts. The aim is to contribute to an understanding of the full range of themes and problems in all aspects of the field, from late antiquity into the Renaissance, and extending over the Jewish, Islamic, and Christian traditions. Volume 6 includes work on a wide range of topics, including Davlat Dadikhuda on Avicenna, Christopher Martin on Abelard’s ontology, Jeremy Skrzypek and Gloria Frost on Aquinas’s ontology, Jean‐Luc Solère on instrumental causality, Peter John Hartman on Durand of St.‐Pourçain, and Kamil Majcherek on Chatton’s rejection of final causality. The volume also includes an extended review of Thomas Williams of a new book on Aquinas’s ethics by Colleen McCluskey.

scholarly journals Lexical Semantic Knowledge of Children with ASD—a Review Study

2021 ◽  
Author(s):  
Nufar Sukenik ◽  
Laurice Tuller
Keyword(s):  
Children With Autism ◽  
Semantic Knowledge ◽  
Future Studies ◽  
Lexical Semantic ◽  
Children With Asd ◽  
Wide Range ◽  
Lexical Semantic Knowledge ◽  
Review Study ◽  
Linguistic Impairment ◽  
Semantic Skills

AbstractStudies on the lexical semantic abilities of children with autism have yielded contradicting results. The aim of the current review was to explore studies that have specifically focused on the lexical semantic abilities of children with ASD and try to find an explanation for these contradictions. In the 32 studies reviewed, no single factor was found to affect lexical semantic skills, although children with broader linguistic impairment generally, but not universally, also showed impaired lexical semantic skills. The need for future studies with young ASD participants, with differing intellectual functioning, longitudinal studies, and studies assessing a wide range of language domains are discussed.

Compressor Performance and Operability in Swirl Distortion

2010 ◽  
Author(s):  
Yogi Sheoran ◽  
Bruce Bouldin ◽  
P. Murali Krishnan
Keyword(s):  
Gas Turbine ◽  
Complex Geometry ◽  
Full Range ◽  
Axial Compressor ◽  
Cfd Model ◽  
Generator System ◽  
Sliding Mesh ◽  
Wide Range ◽  
Compressor Performance ◽  
The Impact

Inlet swirl distortion has become a major area of concern in the gas turbine engine community. Gas turbine engines are increasingly installed with more complicated and tortuous inlet systems, like those found on embedded installations on Unmanned Aerial Vehicles (UAVs). These inlet systems can produce complex swirl patterns in addition to total pressure distortion. The effect of swirl distortion on engine or compressor performance and operability must be evaluated. The gas turbine community is developing methodologies to measure and characterize swirl distortion. There is a strong need to develop a database containing the impact of a range of swirl distortion patterns on a compressor performance and operability. A recent paper presented by the authors described a versatile swirl distortion generator system that produced a wide range of swirl distortion patterns of a prescribed strength, including bulk swirl, twin swirl and offset swirl. The design of these swirl generators greatly improved the understanding of the formation of swirl. The next step of this process is to understand the effect of swirl on compressor performance. A previously published paper by the authors used parallel compressor analysis to map out different speed lines that resulted from different types of swirl distortion. For the study described in this paper, a computational fluid dynamics (CFD) model is used to couple upstream swirl generator geometry to a single stage of an axial compressor in order to generate a family of compressor speed lines. The complex geometry of the analyzed swirl generators requires that the full 360° compressor be included in the CFD model. A full compressor can be modeled several ways in a CFD analysis, including sliding mesh and frozen rotor techniques. For a single operating condition, a study was conducted using both of these techniques to determine the best method given the large size of the CFD model and the number of data points that needed to be run to generate speed lines. This study compared the CFD results for the undistorted compressor at 100% speed to comparable test data. Results of this study indicated that the frozen rotor approach provided just as accurate results as the sliding mesh but with a greatly reduced cycle time. Once the CFD approach was calibrated, the same techniques were used to determine compressor performance and operability when a full range of swirl distortion patterns were generated by upstream swirl generators. The compressor speed line shift due to co-rotating and counter-rotating bulk swirl resulted in a predictable performance and operability shift. Of particular importance is the compressor performance and operability resulting from an exposure to a set of paired swirl distortions. The CFD generated speed lines follow similar trends to those produced by parallel compressor analysis.

scholarly journals State of the Science in Dried Blood Spots

2018 ◽  
Vol 64 (4) ◽  
pp. 656-679 ◽  
Author(s):  
Jeffrey D Freeman ◽  
Lori M Rosman ◽  
Jeremy D Ratcliff ◽  
Paul T Strickland ◽  
David R Graham ◽  
...  
Keyword(s):  
Systematic Approach ◽  
Full Range ◽  
Dried Blood Spots ◽  
Blood Spots ◽  
Highly Sensitive ◽  
Wide Range ◽  
Potential Applications ◽  
Review Of Reviews ◽  
Near Term ◽  
State Of The Science

Abstract BACKGROUND Advancements in the quality and availability of highly sensitive analytical instrumentation and methodologies have led to increased interest in the use of microsamples. Among microsamples, dried blood spots (DBS) are the most well-known. Although there have been a variety of review papers published on DBS, there has been no attempt at describing the full range of analytes measurable in DBS, or any systematic approach published for characterizing the strengths and weaknesses associated with adoption of DBS analyses. CONTENT A scoping review of reviews methodology was used for characterizing the state of the science in DBS. We identified 2018 analytes measured in DBS and found every common analytic method applied to traditional liquid samples had been applied to DBS samples. Analytes covered a broad range of biomarkers that included genes, transcripts, proteins, and metabolites. Strengths of DBS enable its application in most clinical and laboratory settings, and the removal of phlebotomy and the need for refrigeration have expanded biosampling to hard-to-reach and vulnerable populations. Weaknesses may limit adoption in the near term because DBS is a nontraditional sample often requiring conversion of measurements to plasma or serum values. Opportunities presented by novel methodologies may obviate many of the current limitations, but threats around the ethical use of residual samples must be considered by potential adopters. SUMMARY DBS provide a wide range of potential applications that extend beyond the reach of traditional samples. Current limitations are serious but not intractable. Technological advancements will likely continue to minimize constraints around DBS adoption.

Précis ofUnified theories of cognition

1992 ◽  
Vol 15 (3) ◽  
pp. 425-437 ◽  
Author(s):  
Allen Newell
Keyword(s):  
Cognitive Science ◽  
Full Range ◽  
Cognitive Architecture ◽  
Convincing Evidence ◽  
Syllogistic Reasoning ◽  
Human Cognition ◽  
Unified Theory ◽  
Theoretical Concepts ◽  
Wide Range ◽  
Unified Theories

AbstractThe book presents the case that cognitive science should turn its attention to developing theories of human cognition that cover the full range of human perceptual, cognitive, and action phenomena. Cognitive science has now produced a massive number of high-quality regularities with many microtheories that reveal important mechanisms. The need for integration is pressing and will continue to increase. Equally important, cognitive science now has the theoretical concepts and tools to support serious attempts at unified theories. The argument is made entirely by presenting an exemplar unified theory of cognition both to show what a real unified theory would be like and to provide convincing evidence that such theories are feasible. The exemplar is SOAR, a cognitive architecture, which is realized as a software system. After a detailed discussion of the architecture and its properties, with its relation to the constraints on cognition in the real world and to existing ideas in cognitive science, SOAR is used as theory for a wide range of cognitive phenomena: immediate responses (stimulus-response compatibility and the Sternberg phenomena); discrete motor skills (transcription typing); memory and learning (episodic memory and the acquisition of skill through practice); problem solving (cryptarithmetic puzzles and syllogistic reasoning); language (sentence verification and taking instructions); and development (transitions in the balance beam task). The treatments vary in depth and adequacy, but they clearly reveal a single, highly specific, operational theory that works over the entire range of human cognition, SOAR is presented as an exemplar unified theory, not as the sole candidate. Cognitive science is not ready yet for a single theory – there must be multiple attempts. But cognitive science must begin to work toward such unified theories.

scholarly journals Performance Criteria for Testosterone Measurements Based on Biological Variation in Adult Males: Recommendations from the Partnership for the Accurate Testing of Hormones

2012 ◽  
Vol 58 (12) ◽  
pp. 1703-1710 ◽  
Author(s):  
Yeo-Min Yun ◽  
Julianne Cook Botelho ◽  
Donald W Chandler ◽  
Alex Katayev ◽  
William L Roberts ◽  
...  
Keyword(s):  
Total Error ◽  
Full Range ◽  
Biological Variation ◽  
Analytical Performance ◽  
Performance Criteria ◽  
Performance Goals ◽  
Adult Males ◽  
Large Variability ◽  
Wide Range ◽  
Variation Data

BACKGROUND Testosterone measurements that are accurate, reliable, and comparable across methodologies are crucial to improving public health. Current US Food and Drug Administration–cleared testosterone assays have important limitations. We sought to develop assay performance requirements on the basis of biological variation that allow physiologic changes to be distinguished from assay analytical errors. METHODS From literature review, the technical advisory subcommittee of the Partnership for the Accurate Testing of Hormones compiled a database of articles regarding analytical and biological variability of testosterone. These data, mostly from direct immunoassay-based methodologies, were used to specify analytical performance goals derived from within- and between-person variability of testosterone. RESULTS The allowable limits of desirable imprecision and bias on the basis of currently available biological variation data were 5.3% and 6.4%, respectively. The total error goal was 16.7%. From recent College of American Pathologists proficiency survey data, most currently available testosterone assays missed these analytical performance goals by wide margins. Data from the recently established CDC Hormone Standardization program showed that although the overall mean bias of selected certified assays was within 6.4%, individual sample measurements could show large variability in terms of precision, bias, and total error. CONCLUSIONS Because accurate measurement of testosterone across a wide range of concentrations [approximately 2–2000 ng/dL (0.069–69.4 nmol/L)] is important, we recommend using available data on biological variation to calculate performance criteria across the full range of expected values. Additional studies should be conducted to obtain biological variation data on testosterone from women and children, and revisions should be made to the analytical goals for these patient populations.

Application of LWD Multipole Sonic for Quantitative Cement Evaluation – Well Integrity in the Norwegian Continental Shelf

2021 ◽  
Author(s):  
Subhadeep Sarkar ◽  
Mathias Horstmann ◽  
Tore Oian ◽  
Piotr Byrski ◽  
George Lawrence ◽  
...  
Keyword(s):  
Continental Shelf ◽  
Time Window ◽  
Full Range ◽  
Hybrid Approach ◽  
Bond Quality ◽  
Bond Index ◽  
Early Evaluation ◽  
Well Integrity ◽  
Wide Range ◽  
Norwegian Continental Shelf

Abstract One of the crucial components of well integrity evaluation in offshore drilling is to determine the cement bond quality assuring proper hydraulic sealing. On the Norwegian Continental Shelf (NCS) an industry standard as informative reference imposes verification of cement length and potential barriers using bonding logs. Traditionally, for the last 50 years, wireline (WL) sonic tools have been extensively used for this purpose. However, the applicability of logging-while-drilling (LWD) sonic tools for quantitative cement evaluation was explored in the recent development drilling campaign on the Dvalin Field in the Norwegian Sea, owing to significant advantages on operational efficiency and tool conveyance in any well trajectory. Cement bond evaluation from conventional peak-to-peak amplitude method has shown robust results up to bond indexes of 0.6 for LWD sonic tools. Above this limit, the casing signal is smaller than the collar signal and the amplitude method loses sensitivity to bonding. This practical challenge in the LWD realm was overcome through the inclusion of attenuation rate measurements, which responds accordingly in higher bonding environments. The two methods are used in a hybrid approach providing a full range quantitative bond index (QBI) introduced by Izuhara et al. (2017). In order to conform with local requirements related to well integrity and to ascertain the QBI potential from LWD monopole sonic, a wireline cement bond log (CBL) was acquired in the first well of the campaign for comparison. This enabled the strategic deployment of LWD QBI service in subsequent wells. LWD sonic monopole data was acquired at a controlled speed of 900ft/h. The high-fidelity waveforms were analyzed in a suitable time window and both amplitude- and attenuation-based bond indexes were derived. The combined hybrid bond index showed an excellent match with the wireline reference CBL, both in zones of high as well as lower cement bonding. The presence of formation arrivals was also in good correlation with zones of proper bonding distinguishable on the QBI results. This established the robustness of the LWD cement logging and ensured its applicability in the rest of the campaign which was carried out successfully. While the results from LWD cement evaluation service are omnidirectional, it comes with a wide range of benefits related to rig cost or conveyance in tough borehole trajectories. Early evaluation of cement quality by LWD sonic tools helps to provide adequate time for taking remedial actions if necessary. The LWD sonic as part of the drilling BHA enables this acquisition and service in non-dedicated runs, with the possibility of multiple passes for observing time-lapse effects. Also, the large sizes of LWD tools relative to the wellbore ensures a lower signal attenuation in the annulus and more effective stabilization, thereby providing a reliable bond index.

scholarly journals Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes

2018 ◽  
Vol 115 (47) ◽  
pp. 11958-11963 ◽  
Author(s):  
Christian Kubitza ◽  
Florian Bittner ◽  
Carsten Ginsel ◽  
Antje Havemeyer ◽  
Bernd Clement ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Catalytic Mechanism ◽  
Full Range ◽  
3D Structure ◽  
Cytochrome P450 Enzymes ◽  
Oxygenated Compounds ◽  
Online Databases ◽  
Starting Point ◽  
Wide Range ◽  
Nitrogen Containing Compounds

Biotransformation enzymes ensure a viable homeostasis by regulating reversible cycles of oxidative and reductive reactions. The metabolism of nitrogen-containing compounds is of high pharmaceutical and toxicological relevance because N-oxygenated metabolites derived from reactions mediated by cytochrome P450 enzymes or flavin-dependent monooxygenases are in some cases highly toxic or mutagenic. The molybdenum-dependent mitochondrial amidoxime-reducing component (mARC) was found to be an extremely efficient counterpart, which is able to reduce the full range of N-oxygenated compounds and thereby mediates detoxification reactions. However, the 3D structure of this enzyme was unknown. Here we present the high-resolution crystal structure of human mARC. We give detailed insight into the coordination of its molybdenum cofactor (Moco), the catalytic mechanism, and its ability to reduce a wide range of N-oxygenated compounds. The identification of two key residues will allow future discrimination between mARC paralogs and ensure correct annotation. Since our structural findings contradict in silico predictions that are currently made by online databases, we propose domain definitions for members of the superfamily of Moco sulfurase C-terminal (MOSC) domain-containing proteins. Furthermore, we present evidence for an evolutionary role of mARC for the emergence of the xanthine oxidase protein superfamily. We anticipate the hereby presented crystal structure to be a starting point for future descriptions of MOSC proteins, which are currently poorly structurally characterized.

Performance-Based Probabilistic Seismic Slope Displacement Procedure

2018 ◽  
Vol 34 (2) ◽  
pp. 673-695 ◽  
Author(s):  
Jorge Macedo ◽  
Jonathan Bray ◽  
Norman Abrahamson ◽  
Thaleia Travasarou
Keyword(s):  
Seismic Performance ◽  
Full Range ◽  
Assessment Procedure ◽  
Seismic Displacement ◽  
Earth Systems ◽  
Crustal Earthquakes ◽  
Wide Range ◽  
Earth Structures ◽  
Hazard Level ◽  
Slope Displacement

Engineers often use simplified seismic slope displacement procedures to evaluate the seismic performance of earth structures and natural slopes. Current state of practice procedures typically separate the estimation of the ground motion intensity measure ( IM) from the estimate of seismic displacement ( D), given the selected IM hazard level. Thus D is estimated based on a single IM value. A straightforward performance-based seismic slope assessment procedure is proposed, which considers the full range of potential IM values to estimate seismic slope displacements directly related to a hazard level. Seismic performance is assessed through either a Newmark-type seismic displacement estimate or a calibrated seismic coefficient that can be used in pseudostatic slope stability analyses. The procedures were developed for a wide range of earth systems for shallow crustal earthquakes and subduction zone earthquakes. Currently employed simplified slope displacement procedures do not provide consistent assessments of the actual seismic slope displacement hazard. The proposed procedures can be readily used in practice to perform rigorous performance-based seismic slope displacement hazard assessments.

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