Friend matters: sex differences in social language during autism diagnostic interviews

Background Autistic individuals frequently experience social communication challenges. Girls are diagnosed with autism less often than boys even when their symptoms are equally severe, which may be due to insufficient understanding of the way autism manifests in girls. Differences in the behavioral presentation of autism, including how people talk about social topics, could contribute to these persistent problems with identification. Despite a growing body of research suggesting that autistic girls and boys present distinct symptom profiles in a variety of domains, including social attention, friendships, social motivation, and language, differences in the way that autistic boys and girls communicate verbally are not yet well understood. Closely analyzing boys’ and girls’ socially-focused language during semi-structured clinical assessments could shed light on potential sex differences in the behavioral presentation of autistic individuals that may prove useful for identifying and effectively supporting autistic girls. Here, we compare social word use in verbally fluent autistic girls and boys during the interview sections of the ADOS-2 Module 3 and measure associations with clinical phenotype. Methods School-aged girls and boys with autism (N = 101, 25 females; aged 6–15) were matched on age, IQ, and parent/clinician ratings of autism symptom severity. Our primary analysis compared the number of social words produced by autistic boys and girls (normalized to account for differences in total word production). Social words are words that make reference to other people, including friends and family. Results There was a significant main effect of sex on social word production, such that autistic girls used more social words than autistic boys. To identify the specific types of words driving this effect, additional subcategories of friend and family words were analyzed. There was a significant effect of sex on friend words, with girls using significantly more friend words than boys. However, there was no significant main effect of sex on family words, suggesting that sex differences in social word production may be driven by girls talking more about friends compared to boys, not family. To assess relationships between word use and clinical phenotype, we modeled ADOS-2 Social Affect (SA) scores as a function of social word production. In the overall sample, social word use correlated significantly with ADOS-2 SA scores, indicating that participants who used more social words were rated as less socially impaired by clinicians. However, when examined in each sex separately, this result only held for boys. Limitations This study cannot speak to the ways in which social word use may differ for younger children, adults, or individuals who are not verbally fluent; in addition, there were more autistic boys than girls in our sample, making it difficult to detect small effects. Conclusions Autistic girls used significantly more social words than boys during a diagnostic assessment—despite being matched on age, IQ, and both parent- and clinician-rated autism symptom severity. Sex differences in linguistic markers of social phenotype in autism are especially important in light of the late or missed diagnoses that disproportionately affect autistic girls. Specifically, heightened talk about social topics could complicate autism referral and diagnosis when non-clinician observers expect a male-typical pattern of reduced social focus, which autistic girls may not always exhibit.

Embodied Word Production of Persons with Parkinson’s Disease in Distinct Motor Conditions

Embodied cognition theories posit direct interactions between sensorimotor and mental processing. Various clinical observations have been interpreted in this controversial framework, amongst others, low verb generation in word production tasks performed by persons with Parkinson’s disease (PD). If this were a sequel of reduced motor simulation of prevalent action semantics in this word class, reduced PD pathophysiology should result in increased verb production and a general shift of lexical contents towards particular movement-related meanings. 17 persons with PD and bilateral Deep Brain Stimulation (DBS) of the subhtalamic nucleus (STN) and 17 healthy control persons engaged in a semantically unconstrained, phonemic verbal fluency task, the former in both DBS-off and DBS-on states. The analysis referred to the number of words produced, verb use, and the occurrence of different dimensions of movement-related semantics in the lexical output. Persons with PD produced fewer words than controls. In the DBS-off, but not in the DBS-on condition, the proportion of verbs within this reduced output was lower than in controls. Lowered verb production went in parallel with a semantic shift. In persons with PD in the DBS-off, but not the DBS-on condition, the relatedness of produced words to own body-movement was lower than in controls. In persons with PD, DBS induced-changes of the motor condition appear to go along with formal and semantic shifts in word production. The results support the idea of a direct connection between the motor system and lexical processing.

Lexical Competition Effects in Aphasia

<p>Some aphasic patients show single word production deficits in some situations where object naming is required (e.g., they perform well when objects are presented in unrelated groups (e.g., Cat, Fork, Bread...), but deteriorate when the same items are presented in semantically related groups (e.g., Cat, Cow, Dog...)) (see Wilshire & McCarthy, 2002). We investigated whether context-sensitive single-word production impairments reflect an impaired ability to resolve lexical competition. Three groups of participants (non-fluent aphasics, fluent aphasics, and older controls) completed four tasks that manipulated lexical competition: 1) A category exemplar task, where a high competition condition involved generating items from broad categories (e.g., Animals: "Cat. Dog" etc.), and a low competition condition involved generating items from narrow categories (e.g., Pets: Cat. Dog" etc); 2) A verb generation task, where participants were presented with objects and were required to generate related verbs. The high competition objects were related to a range of verbs (e.g., Penny: Spend"/"Pay"/"Buy" etc), and the low competition objects were related to one dominant verb (e.g., Scissors: "Cut"); 3) A name agreement task where a high competition condition involved naming low name agreement objects (e.g., Artist/Painter), and a low competition condition involved naming of high name agreement objects (e.g., Anchor), and; 4) A sentence completion task, where extrinsic competition was introduced via presentation of auditory distracters. The low competition distracters did not make sense (e.g., Barry wisely chose to pay the RANGE: "Bill"/"Cashier" etc), whereas the high competition distracters did (e.g., Barry wisely chose to pay the FINE: "Bill"/Cashier" etc). Our first hypothesis was that all participants would show high competition costs in increased response latencies and/or decreased accuracy. At the group level, this hypothesis was supported in all four tasks. At the individual level, there was mixed support as some participants showed predicted effects on the verb generation, name agreement, and sentence completion tasks. The second hypothesis was that exaggerated competition costs would occur in some or all non-fluent aphasics. At the group level this hypothesis was not clearly supported on any task. At the individual level there was mixed support, with some indications that non-fluents may be more likely to show significant competition effects than fluents. The third hypothesis was that non-fluent aphasics with relatively well preserved single word production but relatively impaired sentence production may be most likely to show exaggerated lexical competition effects. There was little support for this hypothesis. It was concluded that the data do not support the hypothesis that context-sensitive single-word production impairments are symptomatic of an impaired ability to resolve lexical competition. However, we have gained information on how heterogeneous aphasics perform on tasks that manipulate lexical competition, and we have gained some insights that may direct future research down a path towards more informative results, and increased knowledge on the complex process of speech production.</p>

Lexical Competition Effects in Aphasia

<p>Some aphasic patients show single word production deficits in some situations where object naming is required (e.g., they perform well when objects are presented in unrelated groups (e.g., Cat, Fork, Bread...), but deteriorate when the same items are presented in semantically related groups (e.g., Cat, Cow, Dog...)) (see Wilshire & McCarthy, 2002). We investigated whether context-sensitive single-word production impairments reflect an impaired ability to resolve lexical competition. Three groups of participants (non-fluent aphasics, fluent aphasics, and older controls) completed four tasks that manipulated lexical competition: 1) A category exemplar task, where a high competition condition involved generating items from broad categories (e.g., Animals: "Cat. Dog" etc.), and a low competition condition involved generating items from narrow categories (e.g., Pets: Cat. Dog" etc); 2) A verb generation task, where participants were presented with objects and were required to generate related verbs. The high competition objects were related to a range of verbs (e.g., Penny: Spend"/"Pay"/"Buy" etc), and the low competition objects were related to one dominant verb (e.g., Scissors: "Cut"); 3) A name agreement task where a high competition condition involved naming low name agreement objects (e.g., Artist/Painter), and a low competition condition involved naming of high name agreement objects (e.g., Anchor), and; 4) A sentence completion task, where extrinsic competition was introduced via presentation of auditory distracters. The low competition distracters did not make sense (e.g., Barry wisely chose to pay the RANGE: "Bill"/"Cashier" etc), whereas the high competition distracters did (e.g., Barry wisely chose to pay the FINE: "Bill"/Cashier" etc). Our first hypothesis was that all participants would show high competition costs in increased response latencies and/or decreased accuracy. At the group level, this hypothesis was supported in all four tasks. At the individual level, there was mixed support as some participants showed predicted effects on the verb generation, name agreement, and sentence completion tasks. The second hypothesis was that exaggerated competition costs would occur in some or all non-fluent aphasics. At the group level this hypothesis was not clearly supported on any task. At the individual level there was mixed support, with some indications that non-fluents may be more likely to show significant competition effects than fluents. The third hypothesis was that non-fluent aphasics with relatively well preserved single word production but relatively impaired sentence production may be most likely to show exaggerated lexical competition effects. There was little support for this hypothesis. It was concluded that the data do not support the hypothesis that context-sensitive single-word production impairments are symptomatic of an impaired ability to resolve lexical competition. However, we have gained information on how heterogeneous aphasics perform on tasks that manipulate lexical competition, and we have gained some insights that may direct future research down a path towards more informative results, and increased knowledge on the complex process of speech production.</p>

Socio-Affective Word Production by Early Childhood Educators: Lexical Densities, Clusters, and Predictors

This article presents a quantitative characterization of the language of early childhood educators, with the goal of identifying their lexical preferences and typical uses in the socio-affective domain. In this cross-sectional, descriptive study, 20 participants were selected by convenience sampling and provided continuous audio recordings, which were transcribed and categorized using LIWC2015 software. The findings show that the greatest lexical densities are associated with the categories “cognitive processes”, “relativity”, “social processes”, “affective processes”, and “perceptual processes”, and a number of subcategories like “motion” and “positive emotion”. Lower densities were found in “anxiety”, “sadness”, health”, “religion”, and “death”. Furthermore, two commonly used clusters were identified: one centered on words with an emotional connotation, and another centered on words with a social connotation. Lastly, the categories “body”, “health”, “motion”, “ingestion”, “causation”, “exclusion”, and “sexual” are good predictors of socio-affective word production. Our findings suggest a distinctive and prominent use of a number of semantic categories associated with the socio-affective domain. Future research directions and their potential to contribute to formative processes in early childhood education are also discussed.

The Changes in Concentration of Cerebral Oxygenated Hemoglobin During Single Event-Related Japanese Shiritori Task in Patients With Major Depression Disorder: Comparison With Healthy Subjects

Patients with major depressive disorder (MDD) have been reported to show cognitive impairments in attention, cognition control, and motivation. The purpose of this study is to compare and examine the characteristics of frontal and temporal cortical activity in outpatients with MDD during the word production task (Shiritori) using a single event-related Near-Infrared Spectroscopy (NIRS) measurement method that was originally devised. The subjects were 29 MDD patients and 29 age matched healthy controls. In this task, one session consisted of two contrasting conditions (word production task, control condition), and all subjects alternated between these conditions. Each word was visually presented by a monitor for 0.3 s as an activation task and a fixed circle was presented for 12 s. In the activation task, subjects had to immediately generate a noun that starts with the last syllable of the presented word and they were required to say only creatures. From the data obtained at each measurement point during the 20 trials, and averaged waveform during activation task (20 trials) was calculated for each channel. During the word production task, the MDD patients showed significantly smaller activation than the controls in the prefrontal cortex area and inferior parietal area, especially in the left area. In addition, there was a significant negative correlation between Δoxy-Hb at the bilateral temporal lobe area and HAM-D total score in the MDD patients. These findings suggest that a single event-related NIRS measurement during Japanese shiritori tasks may be useful tool for evaluating psychophysiological indices in MDD patients, that relationship between activation and symptom may be of help in predicting functional outcome in patients.

Proactive language control during bilingual sentence production

Aims and objectives/purpose/research questions: While evidence for proactive language control processes has been found during single word production, very little and conflicting evidence has been observed for such control processes during sentence production. So, the main goal of this study was to investigate whether proactive language control can occur during sentence production. Design/methodology/approach: To investigate proactive language control during sentence production, we relied on a description task in single and mixed language blocks. Data and analysis: Mixing costs and the reversed language dominance effect of language intrusions and filled pauses were used to examine proactive language control. Findings/conclusions: Evidence for proactive language control during sentence production came from the mixing cost effect observed with both language intrusions and filled pauses. Whereas no reversed language dominance effect was observed in mixed language blocks, a significant difference in language pattern was observed between single and mixed language blocks, indicating that proactive language control of the first language might be implemented in mixed language blocks during sentence production. Originality: Unlike the vast majority of studies investigating language control, this study relied on sentence production instead of single word production. Moreover, to the best of our knowledge, this is the first study to examine filled pauses to gain insight into language control. Significance/implications: These data indicate that proactive language control can be implemented during bilingual sentence production.