scholarly journals Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma

2019 ◽  
Vol 44 (2) ◽  
pp. 37-42
Author(s):  
Seung Hwa Son ◽  
◽  
Won-Yoon Chung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

scholarly journals Correlation of Histopathological Metastatic Invasive Prognosticators with Five Years Survival of Oral Squamous Cell Carcinoma

2021 ◽  
pp. 326-333
Author(s):  
Swati K. Patil
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Potential Consequence ◽  
Bone Invasion ◽  
Binocular Microscope ◽  
Muscle Invasion

Background: OSCC is the 3rd widespread malignancy in India followed by cervical and breast cancer. Histopathological findings in the tumor are the most prominent factors identified for OSCC progression. Clinical and histopathological prognosis in OSCC like perineural invasion, vascular invasion, lymph node invasion have been studied extensively by many researchers separately or in combination since many years. Bone invasion, muscle invasion and salivary gland invasion are explored less. In order to collectively correlate the role of all prognosticators with 5 years survival, the later prognosticators are included in our study in isolation which may predict accurately the probability of 5 year survival of OSCC. Also we have to search role of the prognosticator which is most commonly affecting 5 years survival of OSCC cases so that it may modify the potential consequence of management of OSCC. Objectives: The aim of this study is to assess the relevance of histopathological invasive prognosticators on 5 years survival of oral squamous cell carcinoma (OSCC) patients visiting Sharad Pawar Dental College and Hospital, Sawangi, Wardha (MS). Methodology: Departmental reports will be screened and specimen mounted slides of histopathologically diagnosed 200 OSCC patients, who undergone surgical resection will be observed under binocular microscope. Data of dead and survived OSCC patients undergone surgery 5 years back will be collected by telecommunication. Histopathological invasive prognosticators will be analyzed and correlated with 5-years survival after treatment. Expected Results: Collectively correlating the role of histopathological invasive prognosticators in our study may predict the probability of 5 years survival of OSCC cases more accurately. Discovering diversed histopathological patterns of all metastatic prognosticators and their correlation with 5 years survival. Identification of most effective histopathological invasive prognosticator predicting 5 year survival. Conclusion: The most commonly found prognosticators in OSCC patients who died within 5 years versus others who survived for 5 years will be discovered. In addition the most common histopathological pattern related to dead and survived patients after 5 years will be found which can modify the potential consequence of management of OSCC.

scholarly journals FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma

2020 ◽  
Author(s):  
Yilong Hao ◽  
rui liu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Mechanistic Study ◽  
Therapeutic Effects ◽  
Mesenchymal Transition

Abstract Background Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 500,000 new cases each year. The high risk of lymph node metastasis and local invasion are the main causes to cripples and death of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) not only exert biological effects for primary epithelial cells, but also make FGF signaling susceptible to being hijacked by cancer cells. However, the precise role of FGF8 and the therapeutic effects of FGF8 in OSCC need to be further investigated. Methods Immunohistochemical staining was performed using in human OSCC tissues. Bioinformatics analysis was performed to analyze the potential FGF8-associated proteins. Migration and invasion of OSCC cells was examined by wounding healing assay and Matrigel assay. Expression of EMT related markers Was examined by immunoblot. Results In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression was related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrated that FGF8 induces epithelial-mesenchymal transition in OSCC cells. Conclusions These results highlight a pro-metastatic role of FGF8, and underscore the role of FGF8 in OSCC development.

Rediscussing the Role of Traditional Risk Factors in Young Adults With Oral Squamous Cell Carcinoma

2020 ◽  
Vol 40 (12) ◽  
pp. 6987-6995
Author(s):  
NORBERT NECKEL ◽  
MARCO MICHAEL ◽  
DANIEL TROELTZSCH ◽  
JONAS WÜSTER ◽  
STEFFEN KOERDT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Young Adults ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Traditional Risk Factors

scholarly journals Role of viruses in oral squamous cell carcinoma

2012 ◽  
Vol 6 (2) ◽  
pp. 21 ◽  
Author(s):  
Rashmi Metgud ◽  
Madhusudan Astekar ◽  
Meenal Verma ◽  
Ashish Sharma
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Susceptibility ◽  
Squamous Cell ◽  
Oncogenic Viruses ◽  
Exact Role ◽  
Carcinogenic Effects

The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on co-factors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC.

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