Crucifixion and related bodily suspension penalties were widely employed in Antiquity for the punishment of criminals and in times of war. Jesus of Nazareth is the most famous victim of the cross, and many scholars of crucifixion approach the topic with interest in Jesus’ death; however, scholarship on crucifixion also provides insights into (among other fields) ancient warfare, criminal law, political history, and cultural imagery. Invariably, such a subject requires multidisciplinary study. Current areas of discussion include the definition of crucifixion itself, especially in light of the range of use of ancient terminology. Further debates concern the origins of the punishment, the cessation of its practice (at least in the West), the precise means of death, and whether certain cultures (e.g., Second Temple Judaism) endorsed the penalty. A large portion of this article examines the many issues related to crucifixion as a form of execution in Antiquity. The topic of crucifixion in the ancient world includes a variety of issues: Near Eastern suspensions, Greek and Roman extreme penalties and crucifixion, the practice of penal suspension and crucifixion in Second Temple Judaism, the terminology for crucifixion and suspension, crucifixion in the New Testament, the practice of crucifixion in Late Antiquity, crucifixion and law in the ancient world, the question of crucifixion and martyrdom, Greco-Roman imagery of crucifixion and related punishments, Christian iconography of the crucifixion of Jesus, and the later history of the punishment. The last sections of this article then turn to understandings of Jesus’ crucifixion in the New Testament and other early Christian literature.