Unpalatable truths: Commitment to eating meat is associated with strategic ignorance of food-animal minds

Animal minds are of central importance to debates about their rights and welfare. Remaining ignorant of evidence that animals have minds is therefore likely to facilitate their mistreatment. Studying samples of adults and students from the UK and US we found that, consistent with motivational perspectives on meat consumption, those who were more (vs. less) committed to eating meat were more motivated to avoid exposure to information about food-animals’ sentience (Studies 1), showed less interest in exposure to articles about intelligent food animals (Studies 2a and 2b), and were quicker to terminate exposure to internet pop-ups containing information about food-animals’ minds (Studies 3a and 3b). At the same time, those who were more (vs. less) committed to eating meat approached information about companion-animals’ minds (Studies 2a-3b) and unintelligent food animals (Studies 2a and 2b) in largely the same ways. The findings demonstrate that, within the UK and US, the desire to eat meat is associated with strategies to avoid information that is likely to challenge meat consumption.

Museums and Digital Culture: From Reality to Digitality in the Age of COVID-19

Museums increasingly recognize the need to address advances in digital culture which impact the expectations and needs of their audiences. Museum collections of real objects need to be presented both on their own premises and digitally online, especially as digital and social media becomes more and more influential in people’s everyday lives. From interdisciplinary perspectives across digital culture, art, and technology, we investigate these challenges magnified by advances in digital and computational media and culture, looking particularly at recent and relevant reports on changes in the ways museums interact with the public. We focus on human digital behavior, experience, and interaction in museums in the context of art, artists, and human engagement with art, using the observational perspectives of the authors as a basis for discussion. Our research shows that the COVID-19 pandemic has accelerated many of the changes driving museum transformation, about which this paper presents a landscape view of its characteristics and challenges. Our evidence shows that museums will need to be more prepared than ever to adapt to unabated technological advances set in the midst of cultural and social revolution, now intrinsic to the digital landscape in which museums are inevitably connected and participating across the global digital ecosystem where they inevitably find themselves entrenched, underscoring the central importance of an inclusive integrative museum model between physical and digital reality.

How to think about pain with the whole person in mind

Too often, pain is reduced to a simple symptom of illness or injury – a puzzle piece to fit into the differential diagnostic jigsaw. Pain reports that fit the emerging pathoanatomical picture are validated and treated accordingly. But many reports don’t fit this picture, and the widespread stigma associated with persistent pain is most commonly directed toward these individuals, whose symptoms aren’t well explained by known pain mechanisms. A root problem is not seeing the person in pain or the suffering they experience. This presentation aims to help participants develop a more comprehensive perspective on pain that better integrates its complexities within clinical practice. Participants will be introduced to the Multi-modal Assessment model of Pain (MAP; Wideman et al, Clinical Journal of Pain 2019; 35(3): 212). MAP offers a novel framework to understand the fundamentally subjective natures of pain and suffering and how they can be best addressed within clinical practice. MAP aims to help clinicians view pain, first and foremost, as an experience (like sadness), which may or may not correspond to specific pathology or diagnostic criteria (like clinical depression). MAP aims to facilitate a more compassionate approach to pain management by providing a rationale for why all reported pain should be validated, even when poorly understood. Viewing pain in this manner helps highlight the central importance of listening to patients’ narrative reports, trying to understand the meaning and context for their experiences of pain and using this understanding to help alleviate suffering.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

Leaf morphology is one of the most important features of the ideal plant architecture. However, the genetic and molecular mechanisms controlling leaf morphology in crops remain largely unknown, despite their central importance. Here we demonstrate that the APC/CTAD1-WL1-NAL1 pathway regulates leaf width in rice, and mutation of WL1 leads to width leaf variation. WL1 interacts with TAD1 and is degraded by APC/CTAD1, with the loss of TAD1 function resulting in narrow leaves. The WL1 protein directly binds to the regulatory region of NAL1 and recruits the corepressor TOPLESS-RELATED PROTEIN to inhibit NAL1 expression by down-regulating the level of histone acetylation of chromatin. Furthermore, biochemical and genetic analyses revealed that TAD1, WL1, and NAL1 function in a common pathway to control leaf width. Our study establishes an important framework for the APC/CTAD1-WL1-NAL1 pathway-mediated control of leaf width in rice and introduces novel perspectives for using this regulatory pathway for improving crop plant architecture.

Belief revision as a problem of scientific epistemology

The fundamental question that must be answered by any theory of knowledge that claims to be adequate is the question of how it is possible to change our knowledge. The very fact of change undoubtedly takes place, and the problem is to theoretically explicate this fact. The methodological significance of this issue is due to the fact that changing knowledge means nothing more than its development, namely, the question of the ways and means of developing our knowledge is of central importance both for the logic and methodology of science, and for general epistemology. This work is of a review character, and aims to draw the reader’s attention to a new promising direction in the modern theory of knowledge called “belief revision”.

The field of solidarity in times of a pandemic

Despite its central importance, solidarity is seldom analysed in a comprehensive manner. The majority of related studies target only specific aspects of its complex mechanisms, such as the functioning of redistributive systems; the related values; the private networks of care; or the civil society. Our study aims at providing a comprehensive analysis by understanding solidarity as a field in Bourdieu’s sense: it involves supportive interactions; competition for the related symbolic capital; illusions providing legitimate frames of deservingness and respectability; and divergent habitus depending on the broader structural position. In order to understand the contemporary solidarity field of Hungary, these dimensions are mapped in parallel: types of problems and needs; sources of received support; the problematic aspects of support; types of support provided to family members and friends; types of support provided to generalised others constitute the dimensions of a cluster analysis describing the idealtypical positions. These positions are analysed from the perspective of their structural background and the solidarity related attitudes. From a sociological perspective, situations like the pandemic provide unique opportunity for analysing otherwise tacit patterns of solidarity. Beside this opportunity, the pandemic is also used as a comparative framework: in the final section, the changes occurring in the various positions are also overviewed in order to highlight the dynamics of the solidarity field.

Exploring the Catalytic Mechanism of the RNA Cap Modification by nsp16-nsp10 Complex of SARS-CoV-2 through a QM/MM Approach

The inhibition of key enzymes that may contain the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have assumed central importance in drug discovery projects. Nonstructural proteins (nsps) are essential for RNA capping and coronavirus replication since it protects the virus from host innate immune restriction. In particular, nonstructural protein 16 (nsp16) in complex with nsp10 is a Cap-0 binding enzyme. The heterodimer formed by nsp16-nsp10 methylates the 5′-end of virally encoded mRNAs to mimic cellular mRNAs and thus it is one of the enzymes that is a potential target for antiviral therapy. In this study, we have evaluated the mechanism of the 2′-O methylation of the viral mRNA cap using hybrid quantum mechanics/molecular mechanics (QM/MM) approach. It was found that the calculated free energy barriers obtained at M062X/6-31+G(d,p) is in agreement with experimental observations. Overall, we provide a detailed molecular analysis of the catalytic mechanism involving the 2′-O methylation of the viral mRNA cap and, as expected, the results demonstrate that the TS stabilization is critical for the catalysis.

The Origins and Dynamics of Inequality

Whereas President Barack Obama identified inequality as “the defining challenge of our time,” this book claims more: it is the defining issue of all human history. The struggle over inequality has been the underlying force driving human history’s unfolding. Drawing on the dynamics of inequality, this book reinterprets history and society. Beyond according inequality the central role in human history, this book is novel in two other respects. First, transcending the general failure of social scientists and historians to anchor their work in explicit theories of human behavior, this book grounds the origins and dynamics of inequality in evolutionary psychology, or, more specifically, Darwin’s theory of sexual selection. Second, this book is novel in according central importance to the critical historical role of ideology in legitimating inequality, a role typically ignored or given little attention by social scientists and historians. Because of the central role of inequality in history, inequality’s explosion over the past 45 years has not been an anomaly. It is a return to the political dynamics by which elites have, since the rise of the state, taken practically everything for themselves, leaving all others with little more than the means with which to survive. Due to elites’ persuasive ideology, even after workers in advanced capitalist countries gained the franchise to become the overwhelming majority of voters, inequality continued to increase. The anomaly is that the only intentional politically driven decline in inequality occurred between the 1930s and 1970s following the Great Depression’s partial delegitimation (this should remain delegitimation globally) of elites’ ideology.

Introduction

The history of German philosophy’s thinking about guilt deserves our attention for: (i) German philosophy was more consistently interested in guilt than other European philosophical traditions; (ii) it presents different approaches to the phenomenon of guilt and thus provides an opportunity to survey the phenomenon from three distinct perspectives, metaphysical (Kant, Schelling, Schopenhauer), naturalist (Rée, Nietzsche), and phenomenological-existential (Heidegger); (iii) no sustained examination of the history of the philosophy of guilt with special emphasis on the German tradition has appeared. A main claim is formulated in this introductory chapter the examination of the history of German philosophy reveals that the different approaches to guilt embodied by the three perspectives follow upon each other in dialectical fashion. Some conceptual clarifications and methodological reflections are presented. Of central importance is the distinction between empirical or factical guilt (guilt for specific misdeeds) and ontological guilt (guilt in one’s very being).

Personalistic family educational conditions in the context of parental professional aspirations

The aim of this article is to answer the question of how parental professional aspirations influence the upbringing level, realized in the Polish families. This problem is most acute in the context of labour migration, hence this issue is of central importance in this study. A personalistic view of the issue allows for drawing more profound conclusions than sociological research.