scholarly journals A History of the Cell Theory of Cancer Metastasis

Gesnerus ◽  
1963 ◽  
Vol 20 (1-2) ◽  
pp. 90-95
Author(s):  
Wilson I.B. Onuigbo
Keyword(s):  
Cancer Metastasis ◽  
Cell Theory ◽  
History Of

TMJ pain as a presentation of metastatic breast cancer to the right mandibular condyle

2021 ◽  
Vol 14 (3) ◽  
pp. e241601
Author(s):  
Victor Ken On Chang ◽  
Samuel Thambar
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Head And Neck ◽  
Cancer Metastasis ◽  
Mandibular Condyle ◽  
Metastatic Breast ◽  
Neck Region ◽  
Head And Neck Region ◽  
History Of ◽  
The Right

Cancer metastasis to the oral and maxillofacial region is uncommon, and metastasis to the mandibular condyle is considered rare. We present a case of a 56-year-old woman with a history of invasive ductal cell carcinoma of the right breast, 10 years in remission, presenting with a 6-month history of symptoms typical of temporomandibular joint (TMJ) dysfunction. Imaging revealed an osteolytic lesion of her right TMJ and subsequent open biopsy confirmed the diagnosis of metastatic breast cancer. Despite the rarity of metastatic cancer to the head and neck region, it is still important for clinicians from both medical and dental backgrounds to consider this differential diagnosis, particularly in patients with a history of hormonal positive subtype of breast cancer. Given that bony metastasis can manifest even 10 years after initial diagnosis, surveillance which includes examination of the head and neck region is important, and may include routine plain-film imaging surveillance with an orthopantomogram (OPG).

The 1869 controversy of cellular theory: Goodsir versus Virchow

2020 ◽  
pp. 096777202094273
Author(s):  
Michael T Tracy
Keyword(s):  
Mental Illness ◽  
Eighteenth Century ◽  
Medical Education ◽  
Royal Society ◽  
General Meeting ◽  
Cell Theory ◽  
Late Professor ◽  
Medical Establishment ◽  
History Of ◽  
Scientific Dispute

The Royal Society of Edinburgh (RSE) is Scotland’s national academy of science and letters and has been in existence since the eighteenth century. On 23 November 1868, a general meeting was held by the RSE at which members nominated the German academic, Professor Rudolf Virchow, as an Honorary Fellow in recognition of his key contributions to cellular theory. This nomination was opposed by the Reverend Joseph Taylor Goodsir, brother of the late Professor of Anatomy at Edinburgh University, John Goodsir. Reverend Goodsir went on to accuse the German professor of plagiarising his late brother’s pioneering work in the formulation of cell theory. The resultant furore created by the Reverend Goodsir led to an acrimonious scientific dispute in the Edinburgh medical establishment, then one of the leading centres of medical education. The current work describes the history of cellular theory as it pertains to John Goodsir and Rudolf Virchow, discusses the history behind the scientific dispute and interprets Reverend Joseph Taylor Goodsir’s role relating his actions to his continuing battle with mental illness, and the aftermath of the dispute as it affected the reputation of John Goodsir.

scholarly journals Unusual Skin Metastasis from Gastric Cancer: A Case Report

2020 ◽  
Vol 32 (2) ◽  
pp. 163
Author(s):  
Vicky Sumarki Budipramana
Keyword(s):  
Gastric Cancer ◽  
Cancer Metastasis ◽  
Benign Lesion ◽  
Ligamentum Teres ◽  
Skin Metastasis ◽  
Unusual Site ◽  
Abdominal Skin ◽  
Initial Appearance ◽  
History Of ◽  
In The Beginning

Background: Skin metastasis from gastric cancer are relatively rare, but they have important clinical significance because they usually indicate a worse prognosis. Skin metastasis from gastric cancer may spread through lymphatic ducts, blood vessels in the ligamentum teres, contiguous extension, or embryologic remnants of the umbilicus. Purpose: To report an unusual skin metastasis from gastric cancer that clinically resembles as a benign lesion of skin papules. Case: A rare metastasis from gastric cancer origin in a 61-year-old male in the abdominal skin. Gastric cancer metastasis in an unusual site such as the abdominal skin often resembles as dermatitis, especially in the early course of metastatic spreading, which looked like common papules on the skin. Discussion: In the beginning, the skin papules were not suspected to be a metastatic process because there was no palpable or no tenderness in the subcutan or fascia underneath. The appearance resembled common dermatitis. However, as papules rapidly spread to the surrounding skin, the malignancy was then suspected. The incisional biopsy from the papules was performed and showed that it was metastatic diffuse-type gastric adenocarcinoma. Conclusion:  The skin metastasis was different from general nodules, but rather as skin papules of general dermatitis in initial appearance. The surgeon and dermatologist should be alert if they find any benign appearance of a skin lesion on the abdominal wall in a patient with a history of gastric cancer surgery.

scholarly journals AFP and CA-125 as an accurate risk factor to predict eye metastasis in hypertension patients with liver Carcinoma： A STROBE-compliant article

2021 ◽  
Author(s):  
Jing Tang ◽  
Li-Juan Zhang ◽  
Yan-Cheng Huang ◽  
Rong Huang ◽  
Hui-Ye Shu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Liver Cancer ◽  
Cancer Metastasis ◽  
Binary Logistic Regression ◽  
Receiver Operating Curve ◽  
Ca 125 ◽  
Liver Carcinoma ◽  
Binary Logistic Regression Analysis ◽  
History Of ◽  
Ocular Metastasis

Abstract Purpose Primary liver carcinoma is a common malignant tumor. In this study, we analyzed the differences between hypertension patients with ocular metastasis of liver cancer and those with metastases to other sites, the correlation between history of HBV and liver cancer metastasis, and independent risk factors for ocular metastasis. METHODS We used treatment records from 488 patients with metastases of primary liver cancer from August 2001 to May 2015, divided into two groups based on metastatic sites: OM (ocular metastasis) and NOM (non-ocular, other sites of metastasis) groups. The Student’s t-test and Chi-square test were used to assess the significance of differences between the groups and define the relationship between history of HBV and ocular metastasis of liver cancer. Binary logistic regression analysis was used to identify indicators of ocular metastasis of liver cancer and receiver operating curve (ROC) analyses to estimate their diagnostic value. RESULTS No significant differences in sex, age, tumor stage, pathological type, or treatment were identified between the OM and NOM groups, while the prevalence of HBV was higher in the former than that in latter, confirming the association between history of HBV and ocular metastasis. Binary logistic regression demonstrated that AFP and CA-125 were independent indicators of liver metastasis (both P < 0.001). ROC curve analyses generated cut-off values for AFP and CA-125 of 957.2 ng/ml and 114.25 U/ml, respectively, with corresponding AUC values of 0.739 and 0.810. The specificity of the combination of AFP and CA-125 was higher than either factor separately.

scholarly journals Reminder of an important clinical lesson: breast cancer metastasis to the parotid gland

2019 ◽  
Vol 12 (10) ◽  
pp. e226494
Author(s):  
Amisha Jakharia-Shah ◽  
Hugh Wheatley ◽  
Matthew Beesley
Keyword(s):  
Parotid Gland ◽  
Facial Nerve ◽  
Cancer Metastasis ◽  
Ductal Carcinoma ◽  
Primary Tumour ◽  
Breast Cancer Metastasis ◽  
Her2 Receptor ◽  
Significant Family History ◽  
History Of ◽  
The Right

A 59-year-old woman presented to an otolaryngology clinic with an 8-week history of a painless lump over her left parotid gland. Her medical history included an invasive ductal carcinoma (33 mm) and a ductal carcinoma in situ (70 mm) of the right breast, for which she had a mastectomy and various adjuvant therapies. The primary tumour presented 8 years prior to the metachronous metastasis. This patient was a non-smoker and had no significant family history. Post-superficial parotidectomy pathology revealed the parotid gland tumour to be oestrogen receptor-positive and HER2 receptor-positive, thus ruling out the initial differential diagnosis of a pleomorphic adenoma. A consequential total parotidectomy with a posterolateral neck dissection was performed with sparing of the facial nerve. The patient recovered well having only encountered a self-resolving salivary fistula. She portrayed no signs of facial nerve palsy and subsequent imaging scans showed no abnormalities.

An Updated Review of Disulfiram: Molecular Targets and Strategies for Cancer Treatment

2019 ◽  
Vol 25 (30) ◽  
pp. 3248-3256 ◽  
Author(s):  
Qingzhu Yang ◽  
Yao Yao ◽  
Kai Li ◽  
Lin Jiao ◽  
Jiazhen Zhu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Anticancer Agents ◽  
Molecular Mechanisms ◽  
Cancer Metastasis ◽  
Ubiquitin Proteasome System ◽  
Cancer Therapies ◽  
History Of ◽  
Ubiquitin Proteasome ◽  
Delivery Strategies ◽  
Approved Drugs

Repurposing already approved drugs as new anticancer agents is a promising strategy considering the advantages such as low costs, low risks and less time-consumption. Disulfiram (DSF), as the first drug for antialcoholism, was approved by the U.S. Food and Drug Administration (FDA) over 60 years ago. Increasing evidence indicates that DSF has great potential for the treatment of various human cancers. Several mechanisms and targets of DSF related to cancer therapy have been proposed, including the inhibition of ubiquitin-proteasome system (UPS), cancer cell stemness and cancer metastasis, and alteration of the intracellular reactive oxygen species (ROS). This article provides a brief review about the history of the use of DSF in humans and its molecular mechanisms and targets of anticancer therapy, describes DSF delivery strategies for cancer treatment, summarizes completed and ongoing cancer clinical trials involving DSF, and offers strategies to better use DSF in cancer therapies.

Prostate cancer metastasis to the testis: an unexpected presentation of a solitary recurrence

2021 ◽  
Vol 14 (3) ◽  
pp. e237853
Author(s):  
Conor McCann ◽  
Anna Doherty ◽  
Ciaran Flynn ◽  
Colin Mulholland
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
External Beam Radiotherapy ◽  
New Left ◽  
Specific Antigen ◽  
Metastatic Spread ◽  
Histopathological Analysis ◽  
Good Recovery ◽  
Prostate Cancer Metastasis ◽  
History Of

A 74-year-old man with a history of prostate cancer was referred to the urology team with a new left sided testicular lump. He had a background of prostate cancer 4 years previous which had been treated with external beam radiotherapy and androgen deprivation therapy, both of which had been completed. Concurrently, he also had evidence of biochemical recurrence of prostate cancer with a rising prostate-specific antigen (PSA). He underwent a left radical orchidectomy. Following histopathological analysis, this was found to be metastatic spread from his prostate cancer. Subsequent staging showed no evidence of metastatic spread elsewhere. The patient made a good recovery following surgery and his PSA levels returned to undetectable levels. He received no further treatment for metastatic prostate cancer.

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