Coordinate Activation Of Classical And Alternative NF-kappa B Pathways In Lung Epithelial Cells Dictates The Strength And Nature Of Lipopolyssacharide-Induced Pro-Inflammatory Mediators

2012 ◽  
Author(s):  
Jane E. Tully ◽  
James D. Nolin ◽  
Sidra M. Hoffman ◽  
Amy Guala ◽  
Karolyn G. Lahue
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Mediators ◽  
Lung Epithelial Cells ◽  
Nf Kappa B ◽  
Lung Epithelial

Differential Regulation of Inflammation by Inflammatory Mediators in Cystic Fibrosis Lung Epithelial Cells

2013 ◽  
Vol 33 (3) ◽  
pp. 121-129 ◽  
Author(s):  
Motohiro Tsuchiya ◽  
Parameet Kumar ◽  
Sharmistha Bhattacharyya ◽  
Sangbrita Chattoraj ◽  
Meera Srivastava ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Epithelial Cells ◽  
Inflammatory Mediators ◽  
Differential Regulation ◽  
Lung Epithelial Cells ◽  
Cystic Fibrosis Lung ◽  
Lung Epithelial

scholarly journals Macrophage-Mediated Inflammation and Disease: A Focus on the Lung

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Emily Gwyer Findlay ◽  
Tracy Hussell
Keyword(s):  
Extracellular Matrix ◽  
Particulate Matter ◽  
Gas Exchange ◽  
Epithelial Cells ◽  
Immune Cells ◽  
Inflammatory Mediators ◽  
Lung Epithelial Cells ◽  
Vast Array ◽  
Lung Epithelial ◽  
Suppressive Phenotype

The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution. Cells present in the airways must therefore be maintained in a generally suppressive phenotype so that excessive responses to nonserious irritants do not occur; these result in bystander damage to lung architecture, influx of immune cells to the airways, and consequent impairment of gas exchange. To this end, the resident cells of the lung, which are predominantly macrophages, are kept in a dampened state. However, on occasion the suppression fails and these macrophages overreact to antigenic challenge, resulting in release of inflammatory mediators, induction of death of lung epithelial cells, deposition of extracellular matrix, and development of immunopathology. In this paper, we discuss the mechanisms behind this macrophage-mediated pathology, in the context of a number of inflammatory pulmonary disorders.

Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells

Inflammation ◽  
2015 ◽  
Vol 39 (1) ◽  
pp. 138-147 ◽  
Author(s):  
Rajeshwari H. Patil ◽  
R. L. Babu ◽  
M. Naveen Kumar ◽  
K. M. Kiran Kumar ◽  
Shubha M. Hegde ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Mediators ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Anti Inflammatory ◽  
Human Lung Epithelial Cells ◽  
Inflammatory Effect
Sign in / Sign up

Export Citation Format

Share Document