Decreased Surfactant Phospholipids in COPD Patients Correlate with Pulmonary Function

Background/Aim. Peripheral muscle weakness and nutritional disorders, firstly loss of body weight, are common findings in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to analyse the impact of pulmonary function parameters, nutritional status and state of peripheral skeletal muscles on exercise tolerance and development of dyspnea in COPD patients. Methods. Thirty COPD patients in stable state of disease were analyzed. Standard pulmonary function tests, including spirometry, body pletysmography, and measurements of diffusion capacity were performed. The 6-minute walking distance test (6MWD) was done in order to assess exercise tolerance. Level of dyspnea was measured with Borg scale. In all patients midthigh muscle cross-sectional area (MTCSA) was measured by computerized tomography scan. Nutritional status of patients was estimated according to body mass index (BMI). Results. Statistically significant correlations were found between parameters of pulmonary function and exercise tolerance. Level of airflow limitation and lung hyperinflation had significant impact on development of dyspnea at rest and especially after exercise. Significant positive correlation was found between MTCSA and exercise tolerance. Patients with more severe airflow limitation, lung hyperinflation and reduced diffusion capacity had significantly lower MTCSA. Conclusion. Exercise tolerance in COPD patients depends on severity of bronchoobstruction, lung hyperinflation and MTCSA. Severity of bronchoobstruction and lung hyperinflation have significant impact on dyspnea level.

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Effects of cardiopulmonary bypass on pulmonary function in COPD patients undergoing beating heart coronary artery bypass surgery

CardioVascular Journal of Africa ◽

10.5830/cvja-2019-030 ◽

2019 ◽

Vol 30 (6) ◽

pp. 336-340

Author(s):

Erdem Çetin ◽

Levent Altınay

Keyword(s):

Cardiopulmonary Bypass ◽

Coronary Artery ◽

Pulmonary Function ◽

Coronary Artery Bypass ◽

Coronary Artery Bypass Surgery ◽

Bypass Surgery ◽

Artery Bypass ◽

Beating Heart ◽

Copd Patients

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Reduction of pulmonary function after resection: less than expected in COPD patients

European Journal of Anaesthesiology ◽

10.1097/00003643-200406001-00042 ◽

2004 ◽

Vol 21 (Supplement 33) ◽

pp. 16

Author(s):

M. J. Jiménez ◽

J. M. Gimferrer ◽

G. Fita ◽

I. Rovira ◽

C. Gomar ◽

...

Keyword(s):

Pulmonary Function ◽

Copd Patients

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Krónikus légzőszervi betegek tápláltsági állapotának vizsgálata – klinikai megfigyelések

Orvosi Hetilap ◽

10.1556/650.2019.31386 ◽

2019 ◽

Vol 160 (23) ◽

pp. 908-913

Author(s):

Mónika Fekete ◽

Vince Pongor ◽

Ágnes Fehér ◽

Márta Veresné Bálint ◽

János Tamás Varga ◽

...

Keyword(s):

Nutritional Status ◽

Pulmonary Function ◽

Respiratory Muscles ◽

Prognostic Indicator ◽

Chronic Obstructive ◽

Forced Expiration ◽

Record System ◽

Severity Of Disease ◽

Copd Patients ◽

System Inclusion

Abstract: Introduction: The increased metabolism of nutrients and the low energy intake may lead to malnutrition among chronic obstructive pulmonary disease (COPD) patients. Aim: The goal of our study was to examine the nutritional status of our population aged over 40, and its relationship with the severity of the disease. Method: We conducted a retrospective study at the National Korányi Institute of Pulmonology in 2017. Pulmonary function and anthropometric data were obtained from the electronic health record system. Inclusion criteria were age over 40 and the diagnosis of COPD. Severity of disease was assessed by forced expiration volume and categorized according to GOLD stages. We used SPSS Statistics V22.0 for data analysis. Results: The mean age of participants was 66; 49.3% were men, 50.7% were women. Average BMI was 27.14 kg/m², with values comprising cachexia and severe obesity. According to the FEV1%pred results of the 3236 patients, 30% fell in the GOLD I, 40% in the GOLD II, 23% in the GOLD III, and 7% in the GOLD IV categories. Pearson coefficient found positive correlation between FEV1 and nutritional status (H = 0.2297, r = 0.1401), specifically between severity of cachexia and severity of disease. The analysis of variance showed significant correlation between severity of disease and nutritional status; patients with higher BMI had better pulmonary function. Conclusion: Malnutrition had an adverse effect on pulmonary functions and performance of respiratory muscles, whereas higher BMI had a positive effect on FEV1. Our results suggest that BMI could be used as a lung function prognostic indicator for COPD patients. Orv Hetil. 2019; 160(23): 908–913.

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Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

BMC Pulmonary Medicine ◽

10.1186/s12890-019-0955-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Minmin Yin ◽

Haibao Wang ◽

Xianwei Hu ◽

Xiaoshu Li ◽

Guanghe Fei ◽

...

Keyword(s):

Lung Function ◽

Pulmonary Function ◽

Grey Matter ◽

Inferior Frontal Gyrus ◽

Structural Alteration ◽

Functional Impairments ◽

Copd Patients ◽

Significant Difference ◽

Function Impairment ◽

Different Levels

Abstract Background To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI). Methods A total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed. Results There was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1. Conclusions These findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.

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