scholarly journals Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications

2020 ◽  
Vol 8 (2) ◽  
pp. 40
Author(s):  
Sadaf Sarfraz ◽  
Akmal Javed ◽  
Shahzad Sharif Mughal ◽  
Muzammil Bashir ◽  
Abdul Rehman ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Copper Oxide ◽  
Biomedical Applications ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

scholarly journals Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 824 ◽  
Author(s):  
Eugene Baeg ◽  
Kanidta Sooklert ◽  
Amornpun Sereemaspun
Keyword(s):  
Reactive Oxygen Species ◽  
Copper Oxide ◽  
Reactive Oxygen ◽  
Copper Oxide Nanoparticles ◽  
The Body ◽  
Model Systems ◽  
In Vivo Model ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Dose Dependent

Copper oxide nanoparticles (CuONPs) have attracted considerable attention, because of their biocide potential and capability for optical imaging, however CuONPs were shown to be highly toxic in various experimental model systems. In this study, mechanism underlying CuONP-induced toxicity was investigated using Drosophila as an in vivo model. Upon oral route of administration, CuONPs accumulated in the body, and caused a dose-dependent decrease in egg-to-adult survivorship and a delay in development. In particular, transmission electron microscopy analysis revealed CuONPs were detected inside the intestinal epithelial cells and lumen. A drastic increase in apoptosis and reactive oxygen species was also observed in the gut exposed to CuONPs. Importantly, we found that inhibition of the transcription factor Nrf2 further enhances the toxicity caused by CuONPs. These observations suggest that CuONPs disrupt the gut homeostasis and that oxidative stress serves as one of the primary causes of CuONP-induced toxicity in Drosophila.

Fabrication of magnesium oxide nanoparticles by solvent alteration and their bactericidal applications

2019 ◽  
Vol 7 (26) ◽  
pp. 4141-4152 ◽  
Author(s):  
Proma Bhattacharya ◽  
Sarpras Swain ◽  
Lopamudra Giri ◽  
Sudarsan Neogi
Keyword(s):  
Reactive Oxygen Species ◽  
Magnesium Oxide ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Mgo Nanoparticles ◽  
Antibacterial Ability ◽  
Ctab Solution ◽  
Magnesium Oxide Nanoparticles

MgO nanoparticles are synthesized using water, ethanol and aqueous CTAB solution. The nanoparticles synthesized in ethanol exhibited smallest size, maximum reactive oxygen species generation and maximum antibacterial ability, and low haemolysis.

Dose-dependent genotoxicity of copper oxide nanoparticles stimulated by reactive oxygen species in human lung epithelial cells

2013 ◽  
Vol 32 (5) ◽  
pp. 809-821 ◽  
Author(s):  
Mohammad Javed Akhtar ◽  
Sudhir Kumar ◽  
Hisham A Alhadlaq ◽  
Salman A Alrokayan ◽  
Khalid M Abu-Salah ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Copper Oxide ◽  
Human Lung ◽  
Copper Oxide Nanoparticles ◽  
Lung Epithelial Cells ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Lung Epithelial ◽  
Dose Dependent ◽  
Human Lung Epithelial Cells

scholarly journals Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy

2017 ◽  
Vol 11 (2) ◽  
pp. 278-288 ◽  
Author(s):  
Carlos Angelé-Martínez ◽  
Khanh Van T. Nguyen ◽  
Fathima S. Ameer ◽  
Jeffrey N. Anker ◽  
Julia L. Brumaghim
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Epr Spectroscopy ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxide Nanoparticles ◽  
Oxygen Species

Роль оксида азота в реализации антиоксидантного эффекта неопиатного аналога лей-энкефалина в сердце новорожденных белых крыс

2019 ◽  
pp. 61-64
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Postnatal Period ◽  
Oxide System ◽  
No Synthase ◽  
Albino Rats ◽  
Oxygen Species ◽  
Control Parameters ◽  
Synthase Inhibitor

The eff ect of the non-opiate analog of leu-enkephalin (peptide NALE: Phe – D – Ala – Gly – Phe – Leu – Arg) on the reactive oxygen species generation in the heart of albino rats in the early postnatal period was studied. Peptide NALE was administered intraperitoneally in the dose of 100 μ/kg daily from 2 to 6 days of life. Reactive oxygen species generation was assessed by chemiluminescence in the heart homogenates of 7-day-old animals. Decreasing of reactive oxygen species generation nearly by 30 % and an increasing in antioxidant system activity by the 20-27 %, compared with the control parameters, were found. The antioxidant eff ect of peptide NALE is associated with the presence of the amino acid Arg in the structure of the peptide. An analogue of NALE peptide, devoid of Arg (peptide Phe – D – Ala – Gly – Phe – Leu – Gly), had a signifi cant lower antioxidant eff ect. The NO-synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the dose 50 mg/kg, administered with NALE peptide, reduced the severity of the NALE antioxidant eff ect. The results of the study suggest that the pronounced antioxidant eff ect of NALE peptide in the heart of albino rats, at least in part, is due to the interaction with the nitric oxide system.

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