Elucidating the catalytic degradation of enrofloxacin by copper oxide nanoparticles through the identification of the reactive oxygen species

Chemosphere ◽  
2020 ◽  
Vol 258 ◽  
pp. 127266 ◽  
Author(s):  
Ishai Dror ◽  
Lea Fink ◽  
Lev Weiner ◽  
Brian Berkowitz
Keyword(s):  
Reactive Oxygen Species ◽  
Copper Oxide ◽  
Reactive Oxygen ◽  
Copper Oxide Nanoparticles ◽  
Catalytic Degradation ◽  
Oxide Nanoparticles ◽  
Oxygen Species

scholarly journals Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 824 ◽  
Author(s):  
Eugene Baeg ◽  
Kanidta Sooklert ◽  
Amornpun Sereemaspun
Keyword(s):  
Reactive Oxygen Species ◽  
Copper Oxide ◽  
Reactive Oxygen ◽  
Copper Oxide Nanoparticles ◽  
The Body ◽  
Model Systems ◽  
In Vivo Model ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Dose Dependent

Copper oxide nanoparticles (CuONPs) have attracted considerable attention, because of their biocide potential and capability for optical imaging, however CuONPs were shown to be highly toxic in various experimental model systems. In this study, mechanism underlying CuONP-induced toxicity was investigated using Drosophila as an in vivo model. Upon oral route of administration, CuONPs accumulated in the body, and caused a dose-dependent decrease in egg-to-adult survivorship and a delay in development. In particular, transmission electron microscopy analysis revealed CuONPs were detected inside the intestinal epithelial cells and lumen. A drastic increase in apoptosis and reactive oxygen species was also observed in the gut exposed to CuONPs. Importantly, we found that inhibition of the transcription factor Nrf2 further enhances the toxicity caused by CuONPs. These observations suggest that CuONPs disrupt the gut homeostasis and that oxidative stress serves as one of the primary causes of CuONP-induced toxicity in Drosophila.

Fabrication of magnesium oxide nanoparticles by solvent alteration and their bactericidal applications

2019 ◽  
Vol 7 (26) ◽  
pp. 4141-4152 ◽  
Author(s):  
Proma Bhattacharya ◽  
Sarpras Swain ◽  
Lopamudra Giri ◽  
Sudarsan Neogi
Keyword(s):  
Reactive Oxygen Species ◽  
Magnesium Oxide ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Mgo Nanoparticles ◽  
Antibacterial Ability ◽  
Ctab Solution ◽  
Magnesium Oxide Nanoparticles

MgO nanoparticles are synthesized using water, ethanol and aqueous CTAB solution. The nanoparticles synthesized in ethanol exhibited smallest size, maximum reactive oxygen species generation and maximum antibacterial ability, and low haemolysis.

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