Multifunctional Biomedical Applications of Nitrogen and Sulfur Co-Doped Carbon Dots

2021 ◽  
Vol 17 (8) ◽  
pp. 1598-1611
Author(s):  
Dan Zhao ◽  
Rui Zhang ◽  
Mengyu Xu ◽  
Xincai Xiao ◽  
Haiyan Zhao ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Biomedical Application ◽  
Carbon Sources ◽  
Sulfur Source ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
One Step ◽  
Onion Epidermal Cells ◽  
Doped Carbon Dots ◽  
Co Doped

Multifunctional carbon dots have drawn considerable attention due to their potential biomedical application value. We report the preparation of blue-green fluorescence-emitting, multifunctional, nitrogen-and-sulfur co-doped carbon dots (N, S-CDs) synthesized via a one-step process using 1-thioglycerol as a sulfur source, glucose and citric acid as carbon sources, and polyethyleneimine as a nitrogen source. Because of abundant amino and sulfur content, the CDs exhibited high sensibility and selectivity for detecting Cu2+ (detection limit: 0.01 μM, linear range: 0.025 to 50 μM). Fast and sensitive detection of tiopronin was also achieved on the basis of the fluorescence “off-on” mode considering the strong affinity between tiopronin and Cu2+. The N, S-CDs exhibited good biocompatibility as determined by fluorescence imaging using onion epidermal cells and gram-positive bacteria. The CDs also exhibited excellent antimicrobial ability against the gram-positive bacteria. Our results indicate that these novel N, S-CDs could be ideal candidates for several biochemical applications such as antibacterial treatment and detection of small biomolecules.

scholarly journals B- and N-doped carbon dots by one-step microwave hydrothermal synthesis: tracking yeast status and imaging mechanism

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bo Tian ◽  
Tianxin Fu ◽  
Yang Wan ◽  
Yun Ma ◽  
Yanbo Wang ◽  
...  
Keyword(s):  
Yeast Cell ◽  
Carbon Dots ◽  
Biomedical Application ◽  
Basic Research ◽  
Growth Status ◽  
Dose Time ◽  
Microwave Hydrothermal ◽  
One Step ◽  
Doped Carbon Dots ◽  
Energy Dependent

Abstract Background Carbon dots (CDs) are widely used in cell imaging due to their excellent optical properties, biocompatibility and low toxicity. At present, most of the research on CDs focuses on biomedical application, while there are few studies on the application of microbial imaging. Results In this study, B- and N-doped carbon dots (BN-CDs) were prepared from citric acid, ethylenediamine, and boric acid by microwave hydrothermal method. Based on BN-CDs labeling yeast, the dead or living of yeast cell could be quickly identified, and their growth status could also be clearly observed. In order to further observe the morphology of yeast cell under different lethal methods, six methods were used to kill the cells and then used BN-CDs to label the cells for imaging. More remarkably, imaging of yeast cell with ultrasound and antibiotics was significantly different from other imaging due to the overflow of cell contents. In addition, the endocytosis mechanism of BN-CDs was investigated. The cellular uptake of BN-CDs is dose, time and partially energy-dependent along with the involvement of passive diffusion. The main mechanism of endocytosis is caveolae-mediated. Conclusion BN-CDs can be used for long-term stable imaging of yeast, and the study provides basic research for applying CDs to microbiol imaging. Graphical Abstract

Nitrogen and sulfur co-doped carbon dots synthesis via one step hydrothermal carbonization of green alga and their multifunctional applications

2019 ◽  
Vol 147 ◽  
pp. 1038-1047 ◽  
Author(s):  
Yuehai Li ◽  
Fengjiao Liu ◽  
Jiabai Cai ◽  
Xuguang Huang ◽  
Luxiu Lin ◽  
...  
Keyword(s):  
Green Alga ◽  
Carbon Dots ◽  
Hydrothermal Carbonization ◽  
One Step ◽  
Doped Carbon Dots ◽  
Co Doped

A nanosensor made of sulfur–nitrogen co-doped carbon dots for “off–on” sensing of hypochlorous acid and Zn(ii) and its bioimaging properties

2018 ◽  
Vol 42 (19) ◽  
pp. 15895-15904 ◽  
Author(s):  
Zhengwei Zhang ◽  
Ke Pei ◽  
Qiulian Yang ◽  
Jiayu Dong ◽  
Zhengyu Yan ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Hypochlorous Acid ◽  
One Step ◽  
Doped Carbon Dots ◽  
Co Doped

In this study, we present a facile one-step solvothermal strategy for the fabrication of sulfur–nitrogen co-doped carbon dots (SNCDs) using p-phenylenediamine and cysteamine hydrochloride as the precursors.

Highly sensitive fluorescent carbon dots probe with ratiometric emission for the determination of ClO−

The Analyst ◽  
2020 ◽  
Vol 145 (6) ◽  
pp. 2212-2218 ◽  
Author(s):  
Huilin Zhang ◽  
Yifang Gao ◽  
Yuan Jiao ◽  
Wenjing Lu ◽  
Shaomin Shuang ◽  
...  
Keyword(s):  
Hydrothermal Method ◽  
Carbon Dots ◽  
Highly Sensitive ◽  
One Step ◽  
Doped Carbon Dots ◽  
Fluorescent Carbon Dots ◽  
Co Doped ◽  
Fluorescent Carbon

A ratiometric fluorescent N,S co-doped carbon dots (N,S-CD) probe for ClO− has been facilely obtained via a one-step hydrothermal method.

One-step synthesis of S,B co-doped carbon dots and their application for selective and sensitive fluorescence detection of diethylstilbestrol

2018 ◽  
Vol 42 (4) ◽  
pp. 2857-2864 ◽  
Author(s):  
Chunxi Zhao ◽  
Yang Jiao ◽  
Lei Zhang ◽  
Yaling Yang
Keyword(s):  
Fluorescence Detection ◽  
Carbon Dots ◽  
One Step ◽  
Doped Carbon Dots ◽  
Co Doped

S,B co-doped carbon dots were synthesized, and their application in the detection of diethylstilbestrol.

Simple and Green Synthesis of Boron-, Sulfur-, and Nitrogen-Co-Doped Carbon Dots as Fluorescent Probe for Selective and Sensitive Detection of Sunset Yellow

NANO ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. 1750123 ◽  
Author(s):  
Ying Huang ◽  
Zhengjun Cheng
Keyword(s):  
Carbon Dots ◽  
Sensitive Detection ◽  
Sunset Yellow ◽  
Transmission Electron ◽  
One Step ◽  
Water Dispersibility ◽  
Doped Carbon Dots ◽  
Electron Microscope Image ◽  
Bright Blue ◽  
Co Doped

Herein, we have reported the synthesis of boron-, sulfur-, and nitrogen-co-doped carbon dots (B/S/N-CDs) by one-step hydrothermal method using D-([Formula: see text])-maltose monohydrate, boracic acid, and thiocarbamide as the precursors. The prepared B/S/N-CDs possess good water dispersibility, excellent pH stabilities, and resistance to photobleaching. Furthermore, the transmission electron microscope image indicates that the B/S/N-CDs are homogeneously spherical and show good dispersion. Noticeably, the B/S/N-CDs show bright blue photoluminescence with a quantum yield of 8.9% in aqueous solution and can be used as a potent photoluminescent probe for selective and sensitive detection of sunset yellow (SY). Compared with other food colors, SY can dramatically quench the fluorescence of B/S/N-CDs. Meanwhile, the fluorescence intensity displays a good linear response with SY concentration in the range of 0–70[Formula: see text][Formula: see text]M ([Formula: see text]) and the detection limit is as low as 4.65[Formula: see text]nM. The B/S/N-CDs can also be applied for the detection of SY in mineral water and business drink with satisfactory recovery. Our study has demonstrated that the B/S/N-CDs may have wide application values in medical detection, environmental monitoring, and related researches.

A hydrothermal route for synthesizing highly luminescent sulfur- and nitrogen-co-doped carbon dots as nanosensors for Hg2+

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86436-86442 ◽  
Author(s):  
Chunfeng Wang ◽  
Dong Sun ◽  
Yujuan Chen ◽  
Kelei Zhuo
Keyword(s):  
Graphene Oxide ◽  
Fluorescent Probe ◽  
Hydrothermal Treatment ◽  
Carbon Dots ◽  
Hydrothermal Route ◽  
One Step ◽  
The One ◽  
Doped Carbon Dots ◽  
Co Doped

Sulfur- and nitrogen-co-doped carbon dots were synthesized by the one step hydrothermal treatment of pyritinol hydrochloride in the presence of graphene oxide, and could be used as an effective fluorescent probe for the detection of Hg2+.

Sign in / Sign up

Export Citation Format

Share Document